Publication lists from our generation services. (2002〜)
2017.7.10 up to now
2017
  • Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017 Jun;23(6):723-732. doi: 10.1038/nm.4312.詳細
2016
  • Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward genetic analysis of sleep in randomly mutagenized mice. Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142.
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  • Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Nagata Y, Kitanaka A, Mizuno S, Tanaka Hi, Chiba K, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Aberrant PD-L1 expression via 3’-UTR disruption in multiple cancers. Nature. 2016 May 23;534 (7607): 402-6. doi: 10.1038/srep32453. 詳細
  • Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD. Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.
    J Clin Invest.
    Mar 1;126(3):865-78, 2016. 詳細
2015
  • Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.
    Nat Commun.,AUG 4;6, 7925, 2015. 詳細
2014
  • Suzuki K, Numata T, Suzuki H, Raga DD, ann Ipulan L, Yokoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, Kume S, Takahashi S, Yamada G. Sexually dimorphic gene, MafB, regulates 1 masculinization of the external genitalia.
    Proc Natl Acad Sci.Nov 18; 111(46): 16407-12. 2014. 詳細
  • Akiyama M, Hasegawa H, Hongu T, Frohman MA, Harada A, Sakagami H,Kanaho Y. Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2.
    Nat Commun. Aug 21;5:4744. 2014. 詳細
  • Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis.
    Nat Commun. 5, 3147, 2014. 詳細
  • Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K, Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii. Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.
    Cell Stem Cell. 14, 217-227, 2014. 詳細
  • Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan UA, Marvel J, Yoh K, Takahashi S, Prinz I, De Bernard S, Buffat L, Walzer T. T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and bone marrow.
    J Exp Med. 211, 563-577, 2014 . 詳細
2012
  • Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A. Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms.
    Cell Stem Cell. 9, 37-49, 2011. 詳細
2011
  • Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
    J Exp Med. 208, 949-960, 2011. 詳細
  • Kuroda T, Murayama A, Katagiri N, Ohta YM, Fujita E, Masumoto H, Ema M, Takahashi S, Kimura K, Yanagisawa J. RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
    EMBO J. 30, 1054-1066, 2011. 詳細
2010
  • Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S, Takayanagi H. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation.
    J Clin Invest.120, 3455-3465, 2010. 詳細
  • Togayachi A, Kozono Y, Ikehara Y, Ito H, Suzuki N, Tsunoda Y, Abe S, Sato T, Nakamura K, Suzuki M, Goda HM, Ito M, Kudo T, Takahashi S. Narimatsu H. Lack of lacto/neolacto-glycolipids enhances the formation of glycolipidenriched microdomains, resulting in hyperactivation of B cells.
    Proc Natl Acad Sci USA. 107,11900-119955, 2010. 詳細
  • Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M. Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.
    J Clin Invest.120, 768-777, 2010. 詳細
  • Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H. Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
    Proc Natl Acad Sci USA. 107, 3117-3122, 2010. 詳細
2009
  • Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P. Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
    Neuron. 64, 857-870, 2009. 詳細
  • Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T. The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.
    J Clin Invest. 119, 2257-2270, 2009. 詳細
  • Honda SI, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A. Enhanced humoral immune responses against T-independent antigens in Fc{alpha}/{micro}R-deficient mice.
    Proc Natl Acad Sci . 106, 11230-11235, 2009. 詳細
  • Matsuki T, Noniyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K-i, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T. Selective loss of GABAB receptors in Orexin-producing Neurons results in disrupted sleep/wakefulness architecture.
    Proc Natl Acad Sci. 106, 4459-4464, 2009. 詳細
2008
  • Yano M, Kuroda N, Han H, Horike M, nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M. Aire controls differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
    J Exp Med. 205, 2827-2838, 2008. 詳細
  • Iguchi-Manaka A, Kai H, Yamashita Y, Shibata K, Tahara-Hanaoka S, Honda S, Yasui T, Kikutani H, Shibuya K, Shibuya A. Accelerated tumor growth in mice deficient in DNAM-1 receptor.
    J Exp Med. 205, 2959-2964, 2008. 詳細
  • Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y. Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
    Cell Stem Cell. 3, 555-567, 2008. 詳細
2007
  • Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo.
    EMBO J. 26, 184-196, 2007. 詳細
2006
  • Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N. Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
    Cell Metab. 4, 143-154, 2006. 詳細
  • Suzuki N, Ohneda O, Minegishi N, Nishikawa S, Ohta T, Takahashi S, Engel JD, Yamamoto M. Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche.
    Proc Natl Acad Sci U S A. 103, 2202-2207, 2006. 詳細
  • Yanagita M, Okuda T, Endo S, Tanaka M, Takahashi K, Sugiyama F, Kunita S, Takahashi S, Fukatsu A, Yanagisawa M, Kita T, Sakurai T. Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury.
    J Clin Invest. 116, 70-79, 2006. 詳細
2005
  • Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama K, Shioda S, Yanagisawa M. Input of Orexin/Hypocretin neurons; revealed by a genetically encoded tracer in mice.
    Neuron. 46, 297-308, 2005. 詳細
2004
  • Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E, Ikebe D, Yamamoto M, Igarashi K. The transcriptional programme of antibody class switching involves the repressor Bach2. 
    Nature.  429, 566-571, 2004. 詳細
2003
  • Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, Imakado S, Kotsuji T, Ohtsuka F, Roop DR, Harada T, Engel DJ, Yamamoto M. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. 
    Nat Genet.  35, 238-245, 2003. 詳細
  • Moriguchi T, Motohashi H, Hosoya T, Nakajima O, Takahashi S, Ohsako S, Aoki Y, Nishimura N, Tohyama C, Fujii-Kuriyama Y, Yamamoto M.  Distinct response to dioxin in an arylhydrocarbon receptor (AhR)-humanized mouse. 
    Proc Nat Acad Sci. USA. 100, 5652-5657, 2003. 詳細
  • Hirotsune S, Yoshida N, Chen A, Garrett L, Sugiyama F, Takahashi S, Yagami K-i, Wynshaw-Boris A, Yoshiki A.  An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. 
    Nature.  423, 91-96, 2003. 詳細
2002
  • Hirasawa R, Shimizu R, Takahashi S, Osawa M, Takayanagi S, Kato Y, Onodera M, Minegishi N, Yamamoto M, Fukao K, Taniguchi H, Nakauchi H, Iwama A. Essential and instructive roles of GATA factors in eosinophil development. 
    J. Exp. Med. 195, 1379-1386, 2002. 詳細