CRISPR/Cas9を用いて作製した遺伝子改変マウス論文

2017.4.5現在
2017
  • Tokue M, Ikami K, Mizuno S, Takagi C, M Asuka, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Mark Taketo M, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S. SHISA6 confers resistance to differentiation-promoting Wnt/β-catenin signaling in mouse spermatogenic stem cells. Stem Cell Reports,doi.org/10.1016/j.stemcr. 2017.01.006.
2016
  • Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward genetic analysis of sleep in randomly mutagenized mice.Nature in press.
  • Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Han SI, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Isaka M, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H. Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system. Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857.(floxマウスの作製)詳細
  • Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata, W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazak Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S & Ogawa S. Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers. Nature. 2016 May 23; 534(7607): 402-6. 詳細
  • Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Takahashi S, Yoshiki A, Yagami K-i, Iseki H, Mizuno S, Sugiyama F. Generation of CRISPR/Cas9-mediated bicistronic knock-in Ins1-cre driver mice. Exp. Animal. 2016 Jul 29;65(3):319-27. doi: 10.1538/expanim.16-0016. Epub 2016 Apr 7 (knock-inマウスの作製)詳細
  • Ohmura S, Mizuno S, Oishi H, Ku C-J, Clifford M, Hosoya T, Takahashi S, Engel J D. The Gata3 TCE1 enhancer mediates T cell-specific activation through lineage affiliated transcription factors TCF-1, HEB and RBPJ. J Clin Invest. 2016. Mar.1:126(3):865-878. doi: 10.1172(ゲノム上からのGATA-3遺伝子制御領域を欠失させた論文) 詳細
2015
  • Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh T, Mizuno-Iijima S, Hasegawa Y, Takahashi S, Sugiyama F, Yagami K-i. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Sci Rep. 2015 Sep 8;5:13632. doi: 10.1038(Mb単位のゲノム欠損作製論文) 詳細
2014
  • Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, Yagami KI. Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome. 25, 327-334, 2014.(nullおよび点変異導入論文) 詳細