Our contract business is a creation of transgenic mouse by microinjection, mutated embryonic stem (ES) cells by homologous recombination, chimeric mouse by mutated embryonic stem (ES) cells, and vector generation for transgenesis.
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C57BL/6N, and C57BL/6J-derived ES cells are also available
Formulation of vector is also possible
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2004
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2005
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2006
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2007
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2008
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Transgenic mice
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36
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38
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26
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39
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29
|
|
Chimera mice
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26
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28
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35
|
27
|
24
|
|
Mutated embryo-stem cells
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8
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8
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10
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7
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8
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Vectors
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-
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-
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-
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9
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28
|
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Total
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70
|
74
|
71
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82
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89
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Requests from outside University of Tsukuba
| Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci . 106, 11230-11235, 2009. |
| Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron. 46, 297-308, 2005. |
| Muto A, Tashiro S, Nakajima O, Hoshino H, Takahashi S, Sakoda E, Ikebe D, Yamamoto M, Igarashi K. The transcriptional programme of antibody class switching involves the repressor Bach2. Nature. 429, 566-571, 2004. |
