Publication 2019
  1. Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M. Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells. PLoS One. 2019 Jan 2;14(1):e0210060. doi: 10.1371/journal.pone.0210060. eCollection 2019.

  2. Kitadate Y, Jörg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshida S. Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche. Cell Stem Cell. 2019 Jan 3;24(1):79-92.e6. doi: 10.1016/j.stem.2018.11.013. Epub 2018 Dec 20.

  3. Chang YH, Nishimura S, Oishi H, Kelly PV, Kuno A, Takahashi S. TRMT2A is a novel cell cycle regulator that suppresses cell proliferation. Biochemical and Biophysical Research Communications. Biochem Biophys Res Commun. 2019 Jan 8;508(2):410-415. doi: 10.1016/j.bbrc.2018.11.104. Epub 2018 Nov 28.

  4. Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui T, Kanai M, Mizuno S, Morito N, Takahashi S. Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients. Exp Anim. 2019 Feb 26;68(1):103-111. doi: 10.1538/expanim.18-0093. Epub 2018 Oct 26.

  5. Yoshimura Y, Taguchi A, Tanigawa S, Yatsuda J, Kamba T, Takahashi S, Kurihara H, Mukoyama M, Nishinakamura R. Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells. J Am Soc Nephrol. 2019 Feb;30(2):304-321. doi: 10.1681/ASN.2018070747. Epub 2019 Jan 11.

  6. Kuno A, Mizuno S, Takahashi S. KOnezumi: a web application for automating gene disruption strategies to generate knockout mice. Bioinformatics. 2019 Sep 15;35(18):3479-3481. doi: 10.1093/bioinformatics/btz090.

  7. Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A. The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells. Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27.

  8. Sakamoto T, Obara N, Nishikii H, Kato T, Luan CS, Fujimura R, Yagita H, Sakata-Yanagimoto M, Takahashi S, Chiba S. Notch signaling in Nestin-expressing cells in the bone marrow maintains erythropoiesis via macrophage integrity. Stem Cells.2019 Jul;37(7):924-936. doi: 10.1002/stem.3011. Epub 2019 Apr 15.

  9. Shawki HH, Ishikawa-Yamauchi Y, Kawashima A, Katoh Y, Matsuda M, Al-Soudy AS, Minisy FM, Kuno A, Gulibaikelamu X, Hirokawa T, Takahashi S, Oishi H. EFCAB2 is a novel calcium-binding protein in mouse testis and sperm. PLoS One. 2019 Apr 1;14(4):e0214687. doi: 10.1371/journal.pone. 0214687. eCollection 2019.

  10. Hayashi S, Matsuno Y, Tsunoda Y, Sakurai H, Kiwamoto T, Morishima Y, Ishii Y, Yoh K, Takahashi S, Hizawa N. Transcription Factor T-Bet Attenuates the Development of Elastase-Induced Emphysema in Mice. Am J Respir Cell Mol Biol.2019 Oct;61(4):525-536. doi: 10.1165/rcmb.2018-0109OC.

  11. Ishii T, Warabi E. Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR). Antioxidants (Basel). 2019 Mar 18;8(3). pii: E69. doi: 10.3390/antiox8030069.

  12. Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J.2019 Jul;33(7):8022-8032. doi: 10.1096/fj.201900133R. Epub 2019 Mar 26.

  13. Maimaiti S, Koshida R, Ojima M, Kulathunga K, Oishi H, Takahashi S. Neuron-specific Mafb knockout causes growth retardation accompanied by an impaired GH/IGF-I axis. Exp Anim. 2019 Nov 6;68(4):435-442. doi: 10.1538/expanim.18-0182. Epub 2019 May 16.

  14. Horie K, Sasanuma H, Kudo T, Fujita SI, Miyauchi M, Miyao T, Seki T, Akiyama N, Takakura Y, Shimbo M, Jeon H, Shirakawa M, Shiba D, Yoshida N, Muratani M, Takahashi S, Akiyama T. Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel. Sci Rep. 2019 May 21;9(1):7654. doi: 10.1038/s41598-019-44067-9.

  15. Hoshino T, Terunuma T, Takai J, Uemura S, Nakamura Y, Hamada M, Takahashi S, Yamamoto M, Engel JD, Moriguchi T. Spiral ganglion cell degeneration-induced deafness as a consequence of reduced GATA factor activity. Genes Cells.2019 Aug;24(8):534-545. doi: 10.1111/gtc.12705. Epub 2019 Jul 4.

  16. Tome S, Sasaki T, Takahashi S, Takei Y. Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic-polycytidylic acid in inducing fetal loss. Exp Anim.2019 Nov 6;68(4):491-497. doi: 10.1538/expanim.19-0038. Epub 2019 Jun 10.

  17. Xiafukaiti G, Maimaiti S, Ogata K, Kuno A, Kudo T, Shawki HH, Oishi H, Takahashi S. MafB is important for pancreatic ƒÀ-cell maintenance under a MafA deficient condition. Mol Cell Biol. 2019 Aug 12;39(17). pii: e00080-19. doi: 10.1128/MCB.00080-19. Print 2019 Sep 1.

  18. Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S. Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4. J Clin Invest. 2019 Jul 23;130. pii: 121955. doi: 10.1172/JCI121955.

  19. Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2.

  20. Matsumura T, Noda T, Muratani M, Okad R, Yamane M, Isotani, A, Kudo T, Takahashi S, Ikawa M. Male mice, caged in the International Space Station for 35 days, sire healthy offspring. Scientific Reports, 2019 9:13733, doi:10.1038/s41598-019-50128-w.

  21. Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H. Hepatocyte Elovl6 determines ceramide acyl-chain length and hepatic insulin sensitivity in mice. Hepatology. 2019 Sep 17. doi: 10.1002/hep.30953.

  22. Abhinav K, Feng L, Morrison E, Jung Y, Dear J, Takahashi S, Heck MMS. The conserved metalloprotease invadolysin is present in invertebrate haemolymph and vertebrate blood. Biol Open. 2019 Oct 15. pii: bio.044073. doi: 10.1242/bio.044073.

  23. Honda A, Miyazaki T, Iwamoto J, Hirayama T, Morishita Y, Monma T, Ueda H, Mizuno S, Sugiyama F, Takahashi S, Ikegami T. Regulations of bile acid metabolism in mouse models with hydrophobic bile acid composition. J Lipid Res. 2019 Oct 23. pii: jlr.RA119000395. doi: 10.1194/jlr.RA119000395.

  24. Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A.Clec10a regulates mite-induced dermatitis. Sci Immunol. 2019 Dec 6;4(42). pii: eaax6908. doi: 10.1126/sciimmunol.aax6908.

  25. Chang YH, Katoh MC, Abdellatif AM, Xiafukaiti G, Elzeftawy A, Ojima M, Mizuno S, Kuno A, Takahashi S. Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model. Exp Anim. 2020 Apr 24;69(2):178-188. doi: 10.1538/expanim.19-0105. Epub 2019 Dec 2. PMID: 31787710.

  26. Horie K, Kato T, Kudo T, Sasanuma H, Miyauchi M, Akiyama N, Miyao T, Seki T, Ishikawa T, Takakura Y, Shirakawa M, Shiba D, Hamada M, Jeon H, Yoshida N, Inoue JI, Muratani M, Takahashi S, Ohno H, Akiyama T. Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight. Sci Rep. 2019 Dec 27;9(1):19866. doi: 10.1038/s41598-019-56432-9.