業績

 

2017

Ishikawa C,Li^H,Ogura R,Yoshimura Y, Kudo T, Shirakawa M, Shiba D, Takahashi S, Morita H,and Shiga T. Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain. Plos One.

Ishikawa C, Shiga T. The postnatal 5-HT_1A receptor regulates adult anxiety and depression differently via multiple molecules Progress in neuro-psychopharmacology and biological psychiatry. 78(2017)66-74

Yoshimura Y, Ishikawa C, Kasegai H, Masuda M, Yoshikawa M, Shiga T. Roles of 5-HT1A receptor in the expression of AMPA receptor and BDNF in developing mouse cortical neurons.Neurosci. Res. 115(2017)13-20

Kozono N, Ohtani A, Shiga T. Roles of the serotonin 5-HT4 receptor in dendrite formation of the rat hippocampal neurons in vitro. Brain Res. 1655(2017)114-121.

 

2016

Ghosh S, Sahu S, Agrawal L, Shiga T, Bandyopadhyay A. Inventing a co-axial atomic resolution patch clamp to study a single resonating protein complex and ultra-low power communication deep inside a living neuron cell.  J. Integ. Neurosci., 15(4) (2016) 403-433.

Agrawal L, Sahu S, Ghosh S, Shiga T, Fujita D and Bandyopadhyay A.  Inventing atomic resolution scanning dielectric microscopy to see a single protein complex operation live at resonance in a neuron without touching or adulterating the cell. J. Integ. Neurosci., 15(4) (2016) 435-462.

Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang Y, Ito T, Kokubu Y, Noguchi T, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S. Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Experimental animals. 65(2016)175-187.

Yoshikawa M, Masuda T, Kobayashi A, Senzaki K, Ozaki S, Aizawa S, Shiga T. Runx1 contributes to the functional switching of bone morphogenetic protein 4 (BMP4) from neurite outgrowth promoting to suppressing in dorsal root ganglion. Mol. Cell. Neurosci. 72(2016)114-122.

 

2015

Yoshikawa M, Hirabayashi M, Ito R, Ozaki S, Aizawa S, Masuda T, Senzaki K, Shiga T. Contribution of the Runx1 transcription factor to axonal pathfinding and muscle innervation by hypoglossal motoneurons. Dev Neurobiol. 75(2015)1295-1314.

Ogihara Y, Masuda T, Ozaki S, Yoshikawa M, Shiga T. Runx3-regulated expression of two Ntrk3 transcript variants in dorsal root ganglion neurons. Dev Neurobiol. 76-3(2016)313-322

Akatsu S, Ishikawa C, Takemura K, Ohtani A, Shiga T. Effects of prenatal stress and neonatal handling on anxiety, spatial learning and serotonergic system of male offspring mice. Neurosci. Research. 101(2015)15-23.

 

2014

Ohtani A, Kozono N, Senzaki K, Shiga T. Serotonin 2A receptor regulates microtubule assembly and induces dynamics of dendritic growth cones in rat cortical neurons in vitro. Neurosci Res. 81-82 (2014)11-20.

 

2013

Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda M, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, and Ohtani-Kaneko R. Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female rodents. Dev Neurobiol. 73 (2013) 502-517.

Yoshikawa M, Murakami Y, Senzaki K, Masuda T, Ozaki O, Ito Y, and Shiga T. Co-expression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons. Dev Neurobiol. 73 (2013) 469-479.

Li F, Ohtani A, Senzaki K, and Shiga T. Receptor-dependent regulation of dendrite formation of noradrenaline and dopamine in non-GABAergic cerebral cortical neurons. Dev Neurobiol. 73 (2013) 370-383.

Yamamuro T, Hori M, Nakagawa Y, Hayashi T, Sakamoto S, Ohnishi J, Takeuchi S, Mihara Y, Shiga T, Murakami K, and Urayama O. Tickling stimulation causes the up-regulation of the kallikrein family in the submandibular gland of the rat. Behav Brain Res. 236 (2013) 236-243.

 

2012

Matsuda T, Sakuma C, Taniguchi M, Kanemoto A, Yoshizawa M, Satomi K, Tanaka T, Takeuchi K, Ueda S, Haginuma H, and Shiga T. Development of the dorsal ramus of the spinal nurve in the chick embryo. Brain Res. 1480 (2012) 30-40.

Ishikawa C and Shiga T. Massage changes babies' body, brain and behavior. Kansei Engineering International Journal. 11 (2012) 109-114.

Kobayashi A, Senzaki K, Ozaki S, Yoshikawa M, and Shiga T. Runx1promotes neuronal differentiation in dorsal root ganglion. Mol. Cell. Neurosci. 49 (2012) 223-231.

 

2011

Yoshida H, Kanamaru C, Ohtani A, Li F, Senzaki K, and Shiga T. Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro. Neurosci. Res. 71 (2011) 311-314.

Harigai Y, Natsme M, Li F, Ohtani A, Senzaki K, and Shiga T. Differential roles of calcitonin family peptides in the dendrite formation and spinogenesis of the cerebral cortex in vitro. Neuropeptides. 45 (2011) 263-272.

 

2010

Senzaki K, Ozaki S, Yoshikawa M, Ito Y, and Shiga T. Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons. Mol. Cell. Neurosci. 43 (2010) 296-307.

Suzuki H, Aoyama Y, Senzaki K, Vincler M, Wittenauer S, Yoshikawa M, Ozaki S, Oppenheim RW, and Shiga T. Characterization of sensory neurons in the dorsal root ganglia of Bax-deficient mice. Brain Res. 1362 (2010) 23-31.

Yamamuro T, Senzaki K, Iwamoto S, Nakagawa Y, Hayashi T, Hori M, Sakamoto S, Murakami K, Shiga T, and Urayama O. Neurogenesis in the dentate gyrus of the rat hippocampus enhanced by tickling stimulation with positive emotion. Neurosci. Res. 66 (2010) 285-289 (Yamamuro T & Senzaki K are equally contributed-first authors).

Iwakura T, Iwafuchi M Muraoka D, Yokosuka M, Shiga T, Watanabe C, Ohtani-Kaneko R. In vitro effects of bisphenol A on developing hypothalamic neurons. Toxicology. 272 (2010) 52-58.

Gandou C, Ohtani A, Senzaki K, and Shiga T. Neurotensin promotes the dendrite elongation and dendritic spine maturation of the cerebral cortex in vitro. Neurosci. Res. 66 (2010) 246-255.

Ohtani-Kaneko R, Iwafushi M, Iwakura T, Muraoka D, Yokosuka M, Shiga T, and Watanabe C. Effects of estrogen on synapsin I distribution in developing hypothalamic neurons. Neurosci. Res. 66 (2010) 180-188.

Hayashi T, Ohrani A, Onuki F, Natsume M, Li F, Satou T, Yoshikawa M, Senzaki, and Shiga T, Roles of serotonin 5-HT3 receptor in the formation of dendrites and axons in the rat cerebral cortex: An in vitro study. Neurosci. Res. 66 (2010) 22-29.

 

2009

Masuda T, Sakuma C, Kobayashi K, Kikuchi K, Soda E, Shiga T, Kobayashi K, and Yaginuma H. Laminin peptide YIGSR and its receptor regulate sensory axonal response to the chemoattractive guidance cue in the chick embryo. J. Neurosci. Res. 87 (2009) 353-359.

 

2008

Nakamura S, Senzaki K, Yoshikawa M, Nishimura M, Inoue K, Ito Y, Ozaki S, and Shiga T. Dynamic regulation of the expression of neurotrophin receptors by Runx3. Development 135 (2008) 1703-1711.

 

2007

Tomoyuki Masuda, Chie Sakuma, Masahiko Taniguchi, Kenta Kobayashi, Kazuto Kobayashi, Takashi Shiga, and Hiroyuki Yaginuma. Guidance cues from the embryonic dorsal spinal cord chemoattract dorsal root ganglion axons. Neuroreport 18 (2007) 1645-1649.


Yoshikawa M, Senzaki K, Yokomizo T, Takahashi S, Ozaki S & Shiga T. Runx1 regulates cell fate specification and axonal projections of dorsal root ganglion neurons. Dev. Biol. 303 (2007) 663-674.

 

Masuda T and Shiga T. Roles of chondroitin sulfate proteoglycans in the formation of axonal trajectories of dorsal root ganglion. In "Neural proteoglycans" Research Signpost, Kerala, India. (in press).

 

Kato T, Ohtani-Kaneko R, Shiga T. Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. Neurosci. Res. 58 (2007) 402-405.

    
志賀 隆. 生物学大事典(分担執筆)(東京化学同人、印刷中)

 

2006


Shiga T, Suda K, Yoshida H, Nakamura S, Natsume M, Yoshikawa M, Senzaki K. Serotonin: A key regulator for the development of brain and mind. Kansei Engineering International. 2 (2006) 19-24 (Review)

 

 

2005


Masuda T, Shiga T. Chemorepulsions and cell adhesion molecules in patterning initial trajectories of sensory axons. Neurosci. Res. 51 (2005) 334-347. (Review)


Kato T, Ohtani-Kaneko R, Ono K, Okado N, Shiga T. Developmental regulation of activated ERK expression in the spinal cord and dorsal root ganglion of the chick embryo. Neurosci. Res. 52 (2005) 11-19.


Ishiwata H, Shiga T, and Okado N. Selective serotonin reuptake inhibitor
treatment of early postnatal mice reverses their prenatal stress-induced brain dysfunction. Neuroscience 133 (2005) 893-901 (*Shiga T is a corresponding author).


Yamaguchi M, Suzuki T, Seki T, Namba T, Liu J, Arai H, Hori T, Shiga T. Decreased cell proliferation in the dentate gyrus of rats after repeated administration of cocaine. Synapse 58 (2005) 63-71.


Ichimura H, Shiga T, Abe I, Hara Y, Terui N, Tsujino A, Ochiai N. Distribution of sodium channels during nerve elongation in rat peripheral nerve. J. Orthop. Sci. 10 (2005) 214-220.


市村晴充、志賀隆、原友紀、Saijilafu、安部伊知朗、照井直人、落合直之. 末梢神経緩徐伸長による神経損傷の回復過程におけるナトリウムチャネルの発現・分布の動態. 末梢神経 16 (2005) 29-40.

 

2004


Masuda T, Fukamauchi F, Takeda Y, Fujisawa H, Watanabe K, Okado N, Shiga T. Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons. Mol. Cell. Neurosci. 25 (2004) 217-227.


Kondoh M, Shiga T, Okado N. Regulation of dendrite formation of Purkinje cells through serotonin 1A and 2A receptors in culture. Neurosci. Res. 48 (2004) 101-109. (*Shiga T is a corresponding author).


Maeshima T, Shiga T, Ito R, Okado N. An immunohistochemical localization of the 5-HT2A receptor in the developing rat cerebellum. Neurosci. Res. 50 (2004) 411-417.


Tada MN, Senzaki K, Tai Y, Morishita H, Tanaka YZ, Murata Y, Ishii Y, Asakawa S, Shimizu N, Sugino H, Yagi T. Genomic organization and transcripts of the zebrafish Protocadherin genes. Gene. 340(2) (2004) 197-211.


Mutoh T, Hamada S, Senzaki K, Murata Y, Yagi T. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with b1 integrin mediated through the RGD site of CNR1. Experimental Cell Research. 294 (2004) 494-508.


志賀 隆、発生過程における脊髄神経の投射路形成―神経回路形成の研究から軸索再生の研究へ  末梢神経 15(2004)39-46

 

2003


Masuda T, Tsuji H, Taniguchi M, Yagi T, Tessier-Lavigne M, Fujisawa H, Okado N, and Shiga T. Differential non-target-derived repulsive signals play a critical role in shaping initial axonal growth of dorsal root ganglion neurons. Dev. Biol. 254 (2003) 289-302.


Hara Y, Shiga T, Abe I, Tsujino A, Ichimura H, Okado N, and Ochiai N. PO mRNA expression increases during gradual nerve elongation in adult rats. Exp. Neurol. 184 (2003) 428-435.

 

2002


Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae S-C, Yamashita N, Itohara S, Kudo N, and Ito Y. Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nature Neurosci. 5 (2002) 946-954


Shiga T, Inoue K, and Masuda T. Differential expression of Islet-1 in limb bud of chick embryos. Anatomy and Embryology 205(2002)223-228.


Naka F, Shiga T, Yaguchi M, and Okado N. An enriched environment increases noradrehaline concentration in the mouse brain. Brain Res. 924 (2002) 124-126 (*Shiga T is a corresponding author).


Yagi T, Tada M, Tanaka Y, Senzaki K, Hirayama T, Hamada S, Sugino H. Diversity of the cadherin-related neuronal receptor family in the nervous system. International Congress Series 1246 (2002) 127-136. 

 

2001


Ugai H, Li H-O, Komatsu M, Tsutui H, Song J, Shiga T, Fearon E, Murata T, and Yokoyama KK. Interaction of myc-associated zinc finger protein (MAZ) with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Biochem. Biophys. Res. Commun. 286 (2001) 1087-1097.


Maxishima M, Shiga T, Shutoh F, Hamada S, Maeshima T, and Okado N. Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord. Brain Res. 889 (2001) 270-273. (*Shiga T is a corresponding author).


Inami S, Shiga T, Tsujino A, Yabuki T, Okado N, and Ochiai N. Immunohistochemical demonstration of nerve fibers in the synovial fold of the human cervical facet joint. J. Orthopaedic Res. 19 (2001) 593-596.


Takei Y, Hamada S, Senzaki K, Mutoh T, Sugino H, Yagi T. Two novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1 to 8. Genomics 72 (2001) 321-330.


先崎浩次 大脳皮質の層構造形成と関与分子群 生体の科学 52(3) (2001) 200-204.


先崎浩次 大脳皮質層構造形成と細胞移動 細胞工学 20(4) (2001) 503-507.

 

2000


Masuda T, Okado N, and Shiga T. The involvement of axonin-1/SC2 in mediating notochord-derived chemorepulsive activities for dorsal root ganglion neurites. Dev. Biol. 224 (2000) 112-121.


Ohtani-Kaneko R, Shiga T, Yamashita K, Masaki R, and Hirata K. Developmental changes in localization of phosphorylated c-Jun N-terminal kinase (JNK/SAPK) in chick spinal cord. J. Comp. Neurol. 426 (2000) 622-631 (*Shiga T is an equally contributed first author.)


Shiga T, Kawamoto M, and Shirai T. Longitudinal elongation of primary afferent axons in the dorsal funiculus of the chick embryo spinal cord. Dev. Brain Res. 124 (2000) 25-31.


Maruyama M, Sudou T, Kasuya Y, Shiga T, Hu B, and Osada H. Localization of p38 MAP kinase in mouse brain. Brain Res. 887 (2000) 352-360.


Shutoh F, Hamada S, Shibata M, Narita M, Shiga T, Azmitia E, and Okado N. Long term depletion of serotonin leads to selective changes in glutamate receptor subunits. Neurosci. Res. 38 (2000) 365-371.


先崎浩次、八木 健 CNR遺伝子の発見からみた脳 遺伝子医学 4(2) (2000) 76-85.


先崎浩次、小川正晴、八木 健 マウス大脳皮質層構造形成機構における新たな分子メカニズムの解明 −CNRファミリーはReelinの多重受容体である 実験医学 18(6) (2000) 784-787.

 

1999以前の主要論文等


Shiga T, Oppenheim RW. A close spatial-temporal relationship between Islet-1 expressing cells and growing primary afferent axons in the dorsal spinal cord of chick embryo. J. Comp. Neurol. 405 (1999) 388-393.


Senzaki K, Ogawa M, Yagi T. Proteins of the CNR family are multiple receptors for Reelin. Cell. 99(6) (1999) 635-47.


Nakamoto K, Shiga T. Tissues exhibiting inhibitory and repulsive activities during the initial stages of neurite outgrowth from the dorsal root ganglion in the chick embryo. Dev. Biol. 202 (1998) 304-314.


Senzaki K, Kohmura N, Hamada S, Kai N, Yasuda R, Watanabe M, Ishii H, Yasuda M, Mishina M, Yagi T. Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron. 20(6) (1998) 1137-51.


Hamada S, Senzaki K, Hamaguchi-Hamada K, Tabuchi K, Yamamoto H, Yamamoto T, Yoshikawa S, Okano H, Okado N. Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Brain Res Mol Brain Res. 54(2) (1998) 199-211.


Maeshima T, Shutoh F, Hamada S, Senzaki K, Hamaguchi-Hamada K, Ito R, Okado N. Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells. Neurosci Lett. 252(1) (1998) 72-4.


Maeshima T, Ito R, Hamada S, Senzaki K, Hamaguchi-Hamada K, Shutoh F, Okado N. The cellular localization of 5-HT2A receptors in the spinal cord and spinal ganglia of the adult rat. Brain Res. 797(1) (1998) 118-24.


Shiga T, Lustig M, Grumet M, Shirai T. Cell adhesion molecules regulate guidance of dorsal root ganglion axons in the marginal zone and their invasion into the mantle layer of embryonic spinal cord. Dev. Biol. 192 (1997) 136-148.


Shiga T, Gaur V, Yamaguchi K, Oppenheim RW. The development of interneurons in the chick embryo spinal cord following in vivo treatment with retinoic acid. J. Comp. Neurol. 360 (1995) 463-474.

 

Shiga T, Shirai T, Grumet M, Edelman GM, and Oppenheim RW. Differential expression of neuron-glia cell adhesion molecule (Ng-CAM) on developing axons and growth cones of interneurons in the chick embryo spinal cord: An immunoelectron microscopic study. J. Comp. Neurol. 329 (1993) 512-518.

 

志賀 隆. 脊髄一次求心性線維の投射路形成機構. ブレインサイエンス・レビュー. 1999 (伊藤、川合編) pp.111-124 (医学書院、1999)

 

志賀 隆、八木沼洋行. 脊髄介在ニューロンの軸索誘導. 生体の科学. 48 (1997) 570-572.

 

志賀 隆、白井敏雄. 脊髄伝導路の形成機序:一次求心性軸索の経路形成を中心にして. 神経の再生と機能再建. (志水他編) pp.31-45 (西村書店、1997)