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原著論文

    2017

    • Miura Y, Ngo TBV, Furuya M, Hasegawa H, Takahashi S, Katagiri N, Hongu T, Funakoshi Y, Ohbayashi N, Kanaho Y. The small G protein Arf6 expressed in keratinocytes by HGF stimulation is a regulator for skin wound healing. Sci Rep. 2017, 7, 46649. [Pubmed]
    • Ohbayashi N, Fukuda M, Kanaho Y. Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking. J Biochem. 2017, in press. [Pubmed]
    • Aoki Y, Manzano R, Lee Y, Dafinca R, Aoki M, Douglas AG, Varela MA, Sathyaprakash C, Scaber J, Barbagallo P, Vader P, Mager I, Ezzat K, Turner MR, Ito N, Gasco S, Ohbayashi N, El Andaloussi S, Takeda S, Fukuda M, Talbot K, Wood MJ. C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain. 2017, 140, 887-897. [Pubmed]
    • Yamauchi Y, Miura Y, Kanaho Y. Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs. Adv Biol Regul. 2017, 63, 115-121. [Pubmed]

    2016

    • Marubashi S, Ohbayashi N, Fukuda M. A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through Stabilization of Varp Protein in Mouse Melanocytes. J Invest Dermatol. 2016, 136, 1672-1680. [Pubmed]
    • Miura Y, Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, Kanaho Y. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Biochem J. 2016, 473, 2591-2602. [Pubmed]
    • Hongu T, Yamauchi Y, Funakoshi Y, Katagiri N, Ohbayashi N, Kanaho Y. Pathological functions of the small GTPase Arf6 in cancer progression: tumor angiogenesis and metastasis. Small GTPases. 2016, 7, 47-53. [Pubmed]
    • Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016, 291, 1427-1440. [Pubmed]
    • Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R. PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep. 2016, 6, 18979. [Pubmed]
    • Huang Y, Joshi S, Xiang B, Kanaho Y, Li Z, Bouchard BA, Moncman CL, Whiteheart SW. Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking. Blood. 2016, 127, 1459-1467. [Pubmed]

    2015

    • Kim JD, Park KE, Ishida J, Kako K, Hamada J, Kani S, Takeuchi M, Namiki K, Fukui H, Fukuhara S, Hibi M, Kobayashi M, Kanaho Y, Kasuya Y, Mochizuki N, Fukamizu A. PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination. Sci Adv. 2015, 1, e1500615. [Pubmed]
    • Okada R, Yamauchi Y, Hongu T, Funakoshi Y, Ohbayashi N, Hasegawa H, Kanaho Y. Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis. Sci Rep. 2015, 5, 14919. [Pubmed]
    • Akiyama.M, Kanaho Y. Physiological functions of the small GTPase Arf6 in the nervous system. Small GTPases. 2015, 6, 160-164. [Pubmed]
    • Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y. Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling. Nat Commun. 2015, 6, 7925. [Pubmed]
    • Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA, Huang P. Phospholipase D1 facilitates second phase myoblast fusion and skeletal muscle regeneration. Mol Biol Cell. 2015, 26, 506-517. [Pubmed]

    2014

    • Funakoshi Y, Chou MM, Kanaho Y, Donaldson JG. TRE17/USP6 regulates ubiquitination and trafficking of cargo proteins that enter cells by clathrin-independent endocytosis. J Cell Sci. 2014 Sep 1
    • Akiyama M, Hasegawa H, Hongu T, Frohman MA, Harada A, Sakagami H, Kanaho Y. Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated secretion of fibroblast growth factor-2. Nat Commun. 2014 Aug 21
    • Shinkai Y, Yamanaka I, Duong HH, Quynh NT, Kanaho Y, Kumagai Y. Garcinia vilersiana bark extract activates the Nrf2/HO-1 signaling pathway in RAW264.7 cells. J Toxicol Sci. . 2013 Dec.

    2013

    • Yamazaki M, Yamauchi Y, Goshima Y,Kanaho Y. Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons. Neurosci Lett.. 2013 May 14
    • Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA. Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. PLoS One. 2013 Jan 28.
    • Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Côté JF, Fukui Y. Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation. J Biol Chem.2013 Mar 22
    • Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY. Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location. J Biol Chem.2013 Feb
    • Sato T, Hongu T, Sakamoto M, Funakoshi Y, Kanaho Y.Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Mol Cell Biol.2013 Jan

    2012

    • NNeely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.2012 Dec 6.
    • Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, van der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA. Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal.2012 Nov 6.
    • Makyio H, Ohgi M, Takei T, Takahashi S, Takatsu H, Katoh Y, Hanai A, Ueda T, Kanaho Y, Xie Y, Shin HW, Kamikubo H, Kataoka M, Kawasaki M, Kato R, Wakatsuki S, Nakayama K. Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis. EMBO J. 2012 Apr 20
    • Hasegawa H, Noguchi J, Yamashita M, Okada R, Sugimoto R, Furuya M, Unoki T, Funakoshi Y, Baba T, Kanaho Y. Phosphatidylinositol 4-Phosphate 5-Kinase Is Indispensable for Mouse Spermatogenesis. Biol Reprod. 2012 Feb 8. [Epub ahead of print]
    • Takamitsu Unoki, Shinji Matsuda, Wataru Kakegawa, Ngo Thai Bich Van, Kazuhisa Kohda, Atsushi Suzuki, Yuji Funakoshi, Hiroshi Hasegawa, Michisuke Yuzaki, Yasunori Kanaho. NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P2 Is Essential for AMPA Receptor Endocytosis during LTD Neuron. 73, 135-148, 2012

    2011

    • Huang P, Yeku O, Zong H, Tsang P, Su W, Yu X, Teng S, Osisami M, Kanaho Y, Pessin JE, Frohman MA. Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice. Diabetes. 60(2):454-63, 2011

    • Watanabe H, Hongu T, Yamazaki M, Kanaho Y. Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth. Biochem Biophys Res Commun. 413(2):288-93, 2011

    2010

    • Nishida M., Suda R., Nagamatsu Y., Tanabe S., Onohara N., Nakaya M., Kanaho Y., Shibata T., Uchida K., Sumimoto H., Sato Y., Kurose H. Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. J. Biol. Chem. 285, 15268-15277, 2010

    • Suzuki A., Arikawa C., Kuwahara Y., Itoh K., Watanabe M., Watanabe H., Suzuki T., Funakoshi Y., Hasegawa H., Y. Kanaho. The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons. FEBS Lett. 584(13):2801-6, 2010

    • Volpicelli-Daley LA, Lucast L, Gong LW, Liu L, Sasaki J, Sasaki T, Abrams CS, Kanaho Y, De Camilli P. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 285(37):28708-14, 2010

    • Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song SY, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS One. 5(7):e11755, 2010
    • Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R. The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol. 344(2):1100-9, 2010
    • Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, Kato M, Hasegawa H, Kanaho Y. Tissue- and development-dependent expression of the small GTPase Arf6 in mice. Dev Dyn. 239(12):3416-35, 2010

    2009

    • Nishikimi A., Fukuhara H., Su W., Hongu T., Takasuga S., Mihara H., Cao Q., Sanematsu F., Kanai M., Hasegawa H., Tanaka Y., Shibasaki M., Kanaho Y., Sasaki T., Frohman M.A., Fukui Y. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science 324, 384-387, 2009

    • Anthonio EA, Brees C, Baumgart-Vogt E, Hongu T, Huybrechts SJ, Van Dijck P, Mannaerts GP, Kanaho Y, Van Veldhoven PP, Fransen M. Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6. BMC Cell Biol. 10:58.,2009

    • Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal. ;2(87):ra52, 2009

    2008

    • Wang Y., Litvinov RI., Chen X., Bach TL., Lian L., Petrich B.G., Monkley S.J., Kanaho Y., Critchley D.R., Sasaki T., Birnbaum M.J., Weisel J.W., Hartwig J., and Abrams C.S. Loss of PIP5KIg, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest. 118, 812-819, 2008

    • Wang Y., Chen X., Lian L., Tang T., Stalker TJ., Sasaki T., Kanaho Y., Brass LF., Choi J.K., Hartwig J.H., and Abrams C.S. Loss of PIP5KIb demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. USA. 105, 14064-16069, 2008

    • Maehama T., Tanaka M., Nishina H., Murakami M., Kanaho Y., and Hanada K. RalA functions as an indispensable signal mediator for nutrient sensing system. J. Biol. Chem. 283, 35053-35059, 2008

    2007

    • A. Nakano-Kobayashi, M. Yamazaki, T. Unoki, T. Hongu, C. Murata, R. Taguchi, T. Katada, M.A. Frohman, T. Yokozeki, an Y. Kanaho. Role of activation of PIP5Kg661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J. 26: 1105-1116, 2007
    • M. Nishio, K. Watanabe, J. Sasaki, C. Taya, S. Takasuga, R. Iizuka, T. Balla, M. Yamazaki, H. Watanabe, R. Itoh, S. Kuroda, Y. Horie, I. Forster, T.S. Mak, H. Yonekawa, J.M. Penninger, Y. Kanaho, A. Suzuki, T. Sasaki. Control of cell polarity and motility by the PtdIns(3,4,5)P(3) phosphatase SHIP1. Nat. Cell Biol. 9: 36-44, 2007

    2006

    • F. Okahara, K. Itoh, A. Nakagawara, M. Murakami, Y. Kanaho, and T. Maehama: Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. Mol. Biol. Cell. 17: 4888-4895, 2006
    • T. Suzuki, Y. Kanai, T. Hara, J. Sasaki, T. Sasaki, M. Kohara, T. Maehama, C. Taya, H. Shitara, H. Yonekawa, M.A. Frohaman, T. Yokozeki, and Y. Kanaho .Crucial role of the samll GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol. 26:6149-56, 2006
    • W. Su, P. Chardin, M. Yamazaki, Y. Kanaho, and G. Du: RhoA-mediated phospholipase D1 signaling is not required for the formation of stress fibers and focal adhesions. Cell Signal. 18:469-78, 2006

    2005

    • H. Miyazaki, M. Yamazaki, H. Watanabe, T. Maehama, T. Yokozeki, and Y. Kanaho. The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation. FEBS Lett. 579:6834-7, 2005
    • K. Emoto, H. Inadome, Y. Kanaho, S. Narumiya, and M. Umeda: Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. J. Biol. Chem. 280:37901-7, 2005
    • Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I alpha. J Exp Med. 201:859-70, 2005
    • Zhang Y, Kanaho Y, Frohman MA, Tsirka SE. Phospholipase D1-promoted release of tissue plasminogen activator facilitates neurite outgrowth. J Neurosci. 25:1797-805, 2005
    • Okahara F, Itoh K, Ebihara M, Kobayashi M, Maruyama H, Kanaho Y, Maehama T. Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein. Anal Biochem. 336:138-40, 2005

    2004

    • Kojima C, Hashimoto A, Yabuta I, Hirose M, Hashimoto S, Kanaho Y, Sumimoto H, Ikegami T, Sabe H. Regulation of Bin1 SH3 domain binding by phosphoinositides. EMBO J. 23:4413-22, 2004
    • K. Itoh, M. Watanabe, K. Yoshikawa, Y. Kanaho, L.J. Berliner, and H. Fujii. Magnetic resonance and biochemical studies during pentylenetetrazole-kindling development -the relationship between NO, nNOS and seizures. Neurosci. 129:757-66, 2004
    • Okahara F, Ikawa H, Kanaho Y, Maehama T. Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J Biol Chem. 279:45300-3, 2004
    • Watanabe H, Yokozeki T, Yamazaki M, Miyazaki H, Sasaki T, Maehama T, Itoh K, Frohman MA, Kanaho Y. Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells. J Biol Chem. 279:37870-7, 2004
    • Maehama T, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon JE, Kanaho Y. Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Lett. 565:43-7, 2004
    • Watanabe H, Yamazaki M, Miyazaki H, Arikawa C, Itoh K, Sasaki T, Maehama T, Frohman MA, Kanaho Y. Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons. J Neurochem. 89:142-51, 2004
    • Zhang Y, Huang P, Du G, Kanaho Y, Frohman MA, Tsirka SE.Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth. Glia. 46:74-83, 2004

    2003

    • M. Nogami, M. Yamazaki, H. Watanabe, Y. Okabayashi, Y. Kido, M. Kasuga, T. Sasaki, T. Maehama, and Y. Kanaho.Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase Cg1 for membrane ruffling formation. FEBS Lett. 536:71-6, 2003

    2002

      Y. Kanaho, T. Katada, K. Hanaoka, and T. Shimizu. Requirement of phosphatidylinositol 3-kinase activation and Ca influx for leukotriene B4-induced enzyme release. J. Biol. Chem. 277:44898-904, 2002
    • M. Yamazaki, H. Miyazaki, H. Watanabe, T. Sasaki, T. Maehama, M. Frohman & Y. Kanaho. Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J. Biol. Chem. 277:17226-30, 2002

    2001

    2000

    1999

    • Honda, A., Nogami, M., Yokozeki, T., Yamazaki, M., Nakamura, H., Watanabe, H., Kawamoto, K., Nakayama, K., Morris, A.J., Frohman, M.A., and Kanaho, Y. Phosphatidylinositol 4-phosphate 5-kinasea is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation. Cell 99:521-32, 1999
    • Yamazaki M, Zhang Y, Watanabe H, Yokozeki T, Ohno S, Kaibuchi K, Shibata H, Mukai H, Ono Y, Frohman MA, Kanaho Y. Interaction of the Small G Protein RhoA with the C Terminus of Human Phospholipase D1. J. Biol. Chem. 274:6035-8, 1999
    • Toda K, Nogami M, Murakami K, Kanaho Y, Nakayama K. Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes. FEBS Lett. 442:221-5, 1999

    総説

    1. MF. Bader, and MA. Frohman(翻訳:横関健昭、渡邉寛、金保安則):ホスホリパーゼD1による調節性エキソサイトーシスの制御機構.実験医学 印刷中
    2. 金保安則、佐々木純子、佐々木雄彦、宮崎秀幸、中野亜希子、横関健昭、山崎正和:ホスファチジルイノシトール 4-リン酸 5-キナーゼと細胞膜ダイナミクス.実験医学 印刷中
    3. Kanaho Y, Miyazaki H, Yamazaki M: Activation of PI(4)P 5-kinase by small G proteins. Adv Enzyme Regul. 43:107-19, 2003
    4. 金保安則、宮崎秀幸、中野亜希子、山崎正和(2003) ホスファチジルイノシトール4-リン酸5-キナーゼの活性調節機構と生理機能.細胞工学22,1360-1365
    5. Kanaho Y, Suzuki T. Phosphoinositide Kinases as Enzymes that Produce Versatile Signaling Lipids, Phosphoinositides. J Biochem (Tokyo) 131:503-9, 2002 
    6. 金保安則、野上真宏、本田晶: 細胞膜リン脂質代謝と細胞運動. 蛋白質核酸酵素 45: 1219-1228. 2000 
    7. 金保安則、本田晶: フォスファチジルイノシトール 4-リン酸 5-キナーゼの活性化機構と生理的役割. 細胞工学 17: 526-529, 2000
    8. 金保安則: 細胞内シグナル伝達酵素ホスホリパーゼDをめぐる新しい研究の展開. ファルマシア 12: 1218-1222, 1998
    9. 金保安則: 細胞内シグナル伝達酵素ホスホリパーゼDの活性調節機構. Radioisotopes 47: 65-68, 1998
    10. 横関健昭、金保安則: 細胞内シグナル伝達酵素ホスホリパーゼDに関する最近の話題と今後の展望. 生化学 70: 285-290, 1998
    11. 金保安則: 低分子量GTP結合蛋白質によるホスホリパーゼDの活性調節. 実験医学14: 256-259,1996
    12. 本宮綱記、金保安則: 低分子量Gタンパク質Arf6の個体における多彩な生理機能. 生化学88: 78-85, 2016

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