辻 省次 (東京大学・医学部附属病院・神経内科)
- Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S,
Ross CA, Takahashi H: Synphilin-1 is present in Lewy bodies in Parkinson’s
disease. Ann Neurol 47: 521-523,
2000
- Yamada M, Piao
Y-S, Toyoshima Y, Tsuji S, Takahashi H: Ubiquitinated filamentous inclusions in
cerebellar dentate nucleus neurons in dentatorubral-pallidoluysian atrophy
contain expanded polyglutamine stretches. Acta
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- Koide T, Yamada M,
Takahashi T, Igarashi S, Masuko M, Furukawa T, Kuroha T, Koike T, Sato M,
Tanaka R, Tsuji S, Takahashi H: Cyclosporine A-associated fatal central nervous
system angiopathy in a bone marrow transplant recipient: an autopsy case. Acta Neuropathol 99: 680-684, 2000
- Shibasaki Y, Tanaka H, Iwabuchi K, Kawasaki S,
Kondo H, Uekawa K, Ueda M, Kamiya T, Katayama Y, Nakamura A, Takashima H,
Nakagawa M, Masuda M, Utsumi H, Nakamuro T, Tada K, Kurohara K, Inoue K, Koike
F, Sakai T, Tsuji S, Kobayashi H: Linkage of autosomal recessive hereditary spastic
paraplegia with mental impairment and thin corpus callosum to chromosome
15q13-15. Ann Neurol 48: 108-112,
2000
- Yamashita I,
Sasaki H, Yabe I, Fukazawa T, Nogoshi S, Komeichi K, Takada A, Shiraishi K,
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for dominant cerebellar ataxia (SCA14) maps to a 10.2-cM interval flanked by
D19S206 and D19S605 on chromosome 19q13.4-qter. Ann Neurol 48: 156-163, 2000
- Maruyama M,
Ikeuchi T, Saito M, Ishikawa A, Yuasa T, Tanaka H, Hayashi S, Wakabayashi K,
Takahashi H, Tsuji S: Novel mutations, pseudo-dominant inheritance, and
possible familial affects in patients with autosomal recessive juvenile
parkinsonism. Ann Neurol 48:
245-250, 2000
- Takano H, Koike R,
Onodera O, Tsuji S.: Mutational analysis of X-linked adrenoleukodystrophy gene.
Cell Biochem Biophys 32: 177-185,
2000
- Shimohata T,
Nakajima T, Yamada M, Uchida C, Onodera O, Naruse S, Kimura T, Koide R, Nozaki
K, Sano Y, Ishiguro H, Sakoe K, Ooshima T, Sato A, Ikeuchi T, Oyake M, Sato T,
Aoyagi Y, Hozumi I, Nagatsu T, Takiyama Y, Nishizawa M, Goto J, Kanazawa I,
Davidson I, Tanese N, Takahashi H, Tsuji S: Expanded polyglutamine stretches
associated with CAG repeat diseases interact with TAFII130, interfering with
CREB-dependent transcription. Nat Genet
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- Tsuchiya K,
Shintani S, Nakabayashi H, Kikugawa K, Nakano R, Haga C, Nakano I, Ikeda K,
Tsuji S: Familial amyotrophic lateral sclerosis with onset in bulbar sign,
benign clinical course, and Bunina bodies: a clinical, genetic, and pathological
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- Hayashi S,
Wakabayashi L, Ishikawa A, Nagai H, Saito M, Maruyama M, Takahashi T, Ozawa T,
Tsuji S, Takahashi H: An autopsy case of autosomal-recessive juvenile
parkinsonism with a homozygous exon 4 deletion in the parkin gene. Mov Disord 15: 884-888, 2000
- Shimohata T,
Onodera O, Tsuji S: Interaction of expanded polyglutamine stretches with
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- Yamada M, Wood JD,
Shimohata T, Hayashi S, Tsuji S, Ross CA, Takahashi H: Widespread occurrence of
intranuclear atrophin-1 accumulation in the central nervous system neurons of
patients with dentatorubral-pallidoluysian atrophy. Ann Neurol 49: 14-23, 2001
- Gaspar C,
Lopes-Cendes I, Hayes S, Goto J, Arvidsson K, Dias A, Silveira I, Maciel P,
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Riess O, Sasaki H, Hsieh M, Nicholson GA, Brunt E, Higgins JJ, Lauritzen M,
Tranebjaerg L, Volpini V, Wood N, Ranum L, Tsuji S, Brice A, Sequeiros J,
Rouleau GA: Ancestral origins of the Machado-Joseph disease mutation: A
worldwide haplotype study. Am J Hum
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- Yamada M, Hayashi
S, Tsuji S, Takahashi H: Involvement of the cerebral cortex and autonomic
ganglia in Machado-Joseph disease. Acta
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- Kawachi I, Nozaki
H, Watanabe M, Sato A, Tsuji S: Spontaneous spinal cord herniation. Neurology 56: 977, 2001
- Shimohata T,
Onodera O, Tsuji S: Expanded polyglutamine stretches lead to aberrant
transcriptional regulation in polyglutamine diseases. Hum Cell 14: 17-25, 2001
- Nakamura K, Jeong
SE, Uchihara T, Anno M, Nagashima K, Nagashima T, Ikeda S, Tsuji S, Kanazawa I:
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded
polyglutamine in TATA-binding protein. Hum
Mol Genet 10: 1441-1448, 2001
- Sekine M, Nagata
H, Tsuji S, Hirai Y, Fujimoto S, Hata M, Kobayashi I, Fujii T, Nagata I,
Ushijima K, Obata K, Suzuki, M, Yoshinaga M, Umesaki N, Sato S, Enomoto T,
Motoyama S, Tanaka K: The Japanese familial ovarian cancer study group:
Localization of a novel susceptibility gene for familial ovarian cancer to
chromosome 3p22-p25. Hum Mol Genet
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- Date H, Onodera O,
Tanaka H, Iwabuchi K, Uekawa K, Igarashi S, Koike R, Hiroi T, Yuasa T, Awaya Y,
Sakai T, Takahashi T, Nagatomo H, Sekijima Y, Kawachi I, Takiyama Y, Nishizawa
M, Fukuhara N, SaitoK, Sugano S, Tsuji S: Early-onset ataxia with ocular motor
apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily
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- Yamada M, Sato T,
Shimohata T, Hayashi S, Igarashi S, Tsuji S, Takahashi H: Interaction between
neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and
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- Takahashi H, Egawa
H, Piao Y-S, Hayashi S, Yamada M, Shimohata T, Oyanagi K, Tsuji S: Brain Res 919: 12-19, 2001
- Wakabayashi K,
Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H:
Immunocytochemical localization of synphilin-1, an a-synuclein-associated
protein, in neurodegenerative disorders. Acta
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- Nozaki K, Onodera
O, Takano H, Tsuji S: Amino acid sequences flanking polyglutamine stretches
influence their potential for aggregate formation. NeuroReport 12: 3357-3364, 2001
- Asaka T, Ikeuchi
K, Okino S, Takizawa Y, Satake R, Nitta E, Komai K, Endo K, Higuchi S, Oyake T,
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Takada H, Honke K, Nishina M, Tanaka H, Shinagawa M, Tanaka K, Matsushima A,
Tsuji S, Takamori M: Homozygosity and linkage disequilibrium mapping of
autosomal recessive distal myopathy (Nonaka distal myopathy). J Hum Genet 46: 649-655, 2001
- Nucifora FC Jr,
Sasaki M, Peters MF, Huang H, Cooper JK, Yamada, M, Takahashi H, Tsuji S,
Troncoso J, Dawson VL, Dawson, TM, Ross CA: Interference by huntingtin and
atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291: 2423-2428, 2001
- Funayama M,
Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F: A new locus for Parkinson’s
disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol 51: 296-301, 2002
- Takahashi T,
Igarashi S, Kimura T, Hozumi I, Kawachi I, Onodera O, Takano H, Saito M, Tsuji
S: Japanese cases of familial hemiplegic migraine with cerebellar ataxia
carrying a T666M mutation in the CACNA1A gene. J Neurol Neurosurg Psychiat 72: 675-680, 2002
- Toyoshima I,
Sugawara M, Kato K, Wada C, Shimohata T, Koide R, Onodera O, Tsuji S: Time
course of polyglutamine aggregate body formation and cell death: Enhanced
growth in nucleus and an interval for cell death. J Neurosci Res 68: 442-448, 2002
- Shimohata T, Sato
A, Burke JR, Strittmatter WJ, Tsuji S, Onodera O: Expanded polyglutamine
stretchers form an ‘aggresome’. Neurosci
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- Shimazaki H,
Takiyama Y, Sakoe K, Ikeguchi K, Niijima K, Kaneko J, Namekawa M, Ogawa T, Date
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- Arai A, Tanaka K,
Igarashi S, Kobayashi H, Asaka T, Date H, Saito M, Tanaka H, Kawasaki S, Uyama
E, Mizusawa H, Fukuhara N, Tsuji S: A novel mutation in the GNE gene and a
linkage disequilibrium in Japanese pedigrees. Ann Neurol 52: 516-519, 2002
- Silveria I, Miranda C, Guimarães L, Moreira M-C, Alonso I, Mendonça P,
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- Ikeuchi T, Nomura
Y, Segawa M, Ozelius LJ, Shimohata T, Tsuji S: Multiple founder effects in
Japanese families with primary torsion dystonia harboring the GAG deletion in
the Tor1A (DYT1) gene. Neurogenetics 4:
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- Wakabayashi
K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H:
Immunocytochemical localization of synphilin-1, an α-synuclein-associated
protein, in neurodegenerative disorders. Acta
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- Yamada M, Sato T,
Tsuji S, Takahashi H: Oligodendrocytic polyglutamine pathology in
dentatorubral-pallidoluysian atrophy. Ann
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- Yamada M, Tsuji S,
Takahashi H: Involvement of lysosomes in the pathogenesis of CAG repeat
diseases. Ann Neurol 52: 498-503,
2002
- Yamada M, Tsuji S,
Takahashi H: Genotype-phenotype correlation in CAG-repeat diseases. Neuropathology 22: 317-322, 2002
- Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N: Alpha-synuclein
degradation by serine protease neurosin: Implication for pathogenesis of
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2625-2635, 2003
- Sanpei K, Ikeuchi
T, Tsuji S: DIRECT technologies for molecular cloning of genes containing
expanded CAG repeats. Methods Mol Biol 217:
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- Sekijima Y,
Hashimoto T, Onodera O, Date H, Okano T, Naito K, Tsuji S, Ikeda S: Severe
generalized dystonia as a presentation of a patient with aprataxin gene
mutation. Mov Disord 18: 1198-1200,
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- Yabe I, Sasaki H,
Chen DH, Raskind WH, Bird TD, Yamashita I, Tsuji S, Kikuchi S, Tashiro K:
Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma. Arch Neurol 60: 1749-1751, 2003
- Shimohata T,
Kimura T, Nishizawa M, Onodera O, Tsuji S: Five year follow up of a patient
with spinal and bulbar muscular atrophy treated with leuprorelin. J Neurol Neurosurg Psychiat 75:
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- Sano Y, Date H,
Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi
H, Makifuchi T, Fukuhara N, Tsuji S: Aprataxin, the causative protein for
early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear
protein with a potential role as a nucleotide repair protein. Ann Neurol 55: 241-249, 2004
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Y, Tsuji S, Pericak-Vance MA, Quattrone A, Battaloglu E, Polyakov AV, Timmerman
V, Schröder JM, Vance JM, Battologlu E: Mutations in the mitochondrial GTPase
mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet 36: 449-451, 2004
- Yamada M, Tan S-H,
Inenaga C, Tsuji S, Takahashi H: Sharing of polyglutamine transport by the
neuronal nucleus and cytoplasm in CAG-repeat diseases. Neuropathol Appl Neurobiol 30: 665-675, 2004
- Date H, Igarashi
S, Sano Y, Takahashi T, Takahashi T, Takano H, Tsuji S, Nishizawa S, Onodera O:
The FHA domain of aprataxin (APTX) interacts with the C terminal region of
XRCC1. Biochem Biophys Res Commun
325: 1279-1285, 2004
- Shimohata M,
Shimohata T, Igarashi S, Naruse S, Tsuji S: Interference of CREB-dependent
transcriptional activation by expanded polyglutamine stretches - Augmentation
of transcriptional activation as a potential therapeutic strategy for
polyglutamine diseases. J Neurochem 93: 654-663, 2005
岩坪 威 (東京大学・大学院薬学系研究科)
- Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer
L, Kahle P, Haass C: Constitutive phosphorylation of the Parkinson’s
disease associated α-synuclein. J Biol Chem 275: 390-397,
2000
- Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe
Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi
H: Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz
disese) with diffuse neurofibrillary and Lewy body pathology. Acta
Neuropathol 99: 331-336, 2000
- Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC,
Mori H, Ishiura S: Molecular interactions between presenilin and calpain:
Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage
of presenilin-1 by m-calpain. Int J Mol Med 5: 269-273, 2000
- Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T: Molecular
cloning and characterization of a novel CLIC-related protein, parchorin,
expressed in water-secreting cells. J Biol Chem 275: 11164-11173,
2000
- Yasuda M, Takamatsu J, D’Souza I, Crowther RA, Kawamata T, Hasegawa
M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Iwatsubo
T, Goedert M, Schellenberg G, Tanaka C: A novel mutation at position
+12 in the intron following exon 10 of the tau gene in familial frontotemporal
dementia (FTD-Kumamoto). Ann Neurol 47: 422-429, 2000
- Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M,
Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal
dementia and parkinsonism with an N279K mutation of tau gene. Neurology
54: 1787-1795, 2000
- Saura CA, Tomita T, Soriano S, Takahashi M, Leem J-Y, Honda T, Koo
EH, Iwatsubo T, Thinakaran G: The non-conserved hydrophilic loop domain
of presenilin is neither required for presenilin endoproteolysis nor
enhanced Aβ42 production mediated by FAD-linked PS variants.
J Biol Chem275: 17136-17142, 2000
- Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA,
Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in
the brains of patients with Down’s syndrome. Alz Rep 3: 77-82,
2000
- Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa
M,Mann DMA, Hyman BT, Iwatsubo T: Age-related amyloid b deposition
in transgenic mice overexpressing both presenilin 1 and amyloid β
precursor protein Swedish mutant is not associated with global neuronal
loss. Am J Pathol157: 331-339, 2000
- Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi
K: α-Synuclein inclusions in amygdala in the brains of patients
with Parkinsonism-Dementia Complex of Guam. J Neuropathol Exp Neurol
59: 585-591, 2000
- Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi
S, Morit T, Iwatsubo T, Takahashi H: Primary progressive aphasia with
focal glial tauopathy. Neuropathol Appl Neurobiol 26: 477-481,
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- Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B,
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- Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt
DR, Iwatsubo T, Kim S-H, Thinakaran G, Sisodia SS, Snyder SH: Amyloid
precursor proteins inhibit heme oxygenase activity and augument neurotoxicity
in Alzheimer’s disease. Neuron 28: 461-473, 2000
- Pickering-Brown S, Baker M, Yen S-H, Liu W-K, Hasegawa M, Cairns
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Owen F, Hardy J, Mann D, Hutton M: Pick’s disease is associated with
mutations in the tau gene. Ann Neurol 48: 859-867, 2000
- Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama
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transport, and uptake of D-aspartate in the rat adrenal and pituitary
glands. Arch Biochem Biophys 385: 242-249, 2001
- Lambert J-C, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T,
Lendon CL, Chartier-Harlin M-C: Effect of the APOE promoter polymorphisms
on cerebral amyloid peptide deposition in Alzheimer’s disease. Lancet
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- Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T,
Imaizumi Y: Molecular cloning and expression of the novel splice variants
of K+ channel-interacting protein 2 (KChIP2). Biochem
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M, Ishikawa A, Iwatsubo T, Takahashi T: Co-localization of a-synuclein
and phosphorylated tau in neuronal and glial cytoplasmic inclusions
in a patient with multiple system atrophy of long duration. Acta
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- Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M,
Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia
complex of the Kii peninsula of Japan: clinical and neuropathological
study and tau analysis. Ann Neurol 49: 501-511, 2001
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effectively among thiorphan- and phosphoramidon-sensitive endopeptidases.
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a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51:
525-530, 2002
- Lambert J-C, Thaker U, Green EK, Harris JM, McDonagh AM, Iwatsubo
T, Chartier-Harlin MC, Pickering-Brown SM, Lendon CL, Mann DMA: The
-48 C/T polymorphism within the promotor region of the presenilin-1
gene does not influence the extent of tau pathology within the brain
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- Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi
N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization
of CALP/KChIP4, a novel EF-hand protein interacting with presenilin
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patients with sporadic Alzheimer's disease, nor does it influence
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- Green EK, Harris JM, Lemmon H, Lambert JC, Chartier-Harlin MC, St
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- Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss
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in transgenic mouse oligodendrocytes. EMBO Rep 3: 583-588,
2002
- Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I,
Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear
aggregates formed by expressing an expanded polyglutamine. Biochem
Biophys Res Commun 294: 429-440, 2002
- Araria-Goumidi L, Lambert JC, Mann DMA, Lendon C, Frigard B, Iwatsubo
T, Cottel D, Amouyel P, Chartier-Harlin MC: Association study of three
polymorphisms of TGF-β1 gene with Alzheimer’s disease. J Neurol
Neurosurg Psychiat 73: 62-64, 2002
- Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin
MC, Iwatsubo T, Pickering-Brown SM, Mann DMA: The angiotensin 1-converting
enzyme insertion (I)/deletion (D) polymorphism does not influence
the extent of amyloid or tau pathology in patients with sporadic Alzheimer’s
disease. Neurosci Lett 328: 314-318, 2002
- Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo
T: A clinical and neuropathological study of an unusual case of sporadic
tauopathy. A variant of corticobasal degeneration? Neurosci Lett
330: 84-88, 2002
- OkochiM, SteinerH, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo
T, Kudo T, Haass C, Takeda M: Presenilins mediate a dual intramembranous
γ-secretase cleavage of Notch-1. EMBO J 21: 5408-5416,
2002
- Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J,
Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo
T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak TW, Penninger
JM, Nishina H, Katada T: SEK1/MKK4-mediated SAPK/JNK signaling participates
in embryonic hepatoblast proliferation via a pathway different from
NF-kB-induced anti-apoptosis. Dev Biol250: 332-347, 2002
- Hayes A, Thakera U, Iwatsubo T, Pickering-Brown SM, Mann DMA: Pathological
relationships between microglial cell activity and tau and amyloid
β protein in patients with Alzheimer’s disease.Neurosci Lett
331: 171-174, 2002
- Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi Matsui T, Murayama
M, Iwatsubo T, Higuchi S: Clinical and biomarker investigation of
a patient with a novel PS-1 mutation (A431V) in the mild cognitive
impairment stage of Alzheimer’s disease. Biol Psychiat 52:
907-910, 2002
- Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W,
Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski
JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and
hyperphosphorylated α-synuclein in aged transgenic mice and in
Lewy body disease patients. J Clin Invest 110: 1429-1439, 2002
- Leem JY, Saura CA, Pietrzik C, Kim S-H, Veselits ML, Christianson
J, Wanamaker C, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN,
Koo E-H, Thinakaran G: A role for presenilin 1 in regulating the delivery
of amyloid precursor protein to the cell surface. Neurobiol Dis
11: 64-82, 2002
- Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee
VM-Y, Trojanowski JQ, Mann DMA, Iwatsubo T: Phosphorylated α-synuclein
is ubiquitinated in α-synucleinopathy lesions. J Biol Chem
277: 49071-49076, 2002
- Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T: The
mechanism of γ-secretase activities through high molecular weight
complex formation of presenilins is conserved in Drosophila melanogaster
and mammals. J Biol Chem 277: 50198-50205, 2002
- Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M,
Iwatsubo T: Phosphorylation of α-synuclein characteristic of
synucleinopathy lesions is recapitulated in α-synuclein transgenic
Drosophila. Neurosci Lett 336: 155-158, 2003
- Thaker U, McDonagh AM, Iwatsubo T, Lendon CL, Pickering-Brown SM,
Mann DMA: Tau load is associated with apolipoprotein E genotype and
the amount of amyloid β protein Aβ40 in sporadic and familial
Alzheimer’s disease. Neuropathol Appl Neurobiol 29: 35-44,
2003
- Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T,
De Strooper B, Yumoto E, Saya H: Presenilin-dependent γ-secretase
activity mediates the intramembranous cleavage of CD44.Oncogene
22: 1511-1516, 2003
- Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi
Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the
γ-secretase complex. Nature 422: 438-441, 2003
- Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo
T, Sisodia S, Malinow R: APP processing and synaptic function. Neuron
37: 925-937, 2003
- Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan
T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide
is a non-competitive γ-secretase inhibitor that preferentially
reduces Aβ42 generation. J Biol Chem 278: 18664-18670,
2003
- Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M,
Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S:
Accumulation of phosphorylated α-synuclein in aging human brain.
J Neuropathol Exp Neurol 62: 644-654, 2003
- Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M,
Iwatsubo T, Takahashi H, Wakabayashi K: α-synuclein accumulates
in purkinje cells in Lewy body disease but not in multiple system
atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003
- Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M,
Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I: Analysis of neurons
created from wild-type and Alzheimer’s mutation knock-in embryonic
stem cells by a highly efficient differentiation protocol. J Neurosci
23: 8513-8525, 2003
- Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo
T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: highly
efficient incorporation of biotin-tag and cross-linking groups. Chem
Commun 17: 2244-2245, 2003
- Schroeter EH, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-M, Xu M,
Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo
T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R: A presenilin
dimer at the core of the γ-secretase enzyme? Insights from parallel
analysis of Notch 1 and APP proteolysis.Proc Natl Acad Sci USA
100: 13075-13080, 2003
- Soderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B,
Iwatsubo T, Lee VM-Y, Trojanowski JQ, Naslund J: Molecular identification
of AMY, and Alzheimer disease amyloid-associated protein. J Neuropathol
Exp Neurol 62: 1108-1117, 2003
- Taniguchi S, McDonaghAM, Pickering-Brown SA, Umeda Y, Iwatsubo T,
Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration
with respect to the cytological and biochemical characteristics of
tau protein. Neuropathol Appl Neurol 30: 1-18, 2004
- Matsubayashi H, Sese S, Lee J-S, Shirakawa T, Iwatsubo T, Tomita
T, Yanagawa S-i: Biochemical characterization of Drosophila Wingless
signaling pathway based on RNA interference. MolCell Biol 24:
2012-2024, 2004
- Lambert JC, Mann D, Harris J, Araria-Goumidi L, Chartier-Harlin
MC, Cottel D, Iwatsubo T, Amouyel P, Lendon C: Association study of
Notch 4 polymorphisms with Alzheimer’s disease. J Neurol Neurosurg
Psychiat 75: 377-381, 2004
- Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian M: Aggresomes
formed by α-synuclein and synphilin-1 are cytoprotective. J
Biol Chem 279: 4625-4631, 2004
- Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama
T, Natsugari H: Highly efficient synthesis of medium-sized lactams
via intramolecular Staudinger-aza-Wittig reaction of w-azido pentafluorophenyl
ester: synthesis and biological evaluation of LY411575 analogues.
Tetrahedron Lett 45: 2323-2396, 2004
- Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo
T, Takahashi H, Wakabayashi K: Accumulation of phosphorylated α-synuclein
in the brain and peripheral ganglia of patients with multiple system
atrophy. Acta Neuropathol 107: 292-298, 2004
- Umeda Y, Taniguchi S, Arima K, Piao Y-SH, Takahashi H, Iwatsubo
T, Mann D, Hasegawa M: Alterations in human tau transcripts correlate
with those of neurofilament in sporadic tauopathies. Neurosci Lett
359: 151-154, 2004
- Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita
T, Iwatsubo T, Fukuyama T: Parallel synthesis of DAPT derivatives
and their γ-secretase-inhibitory activity. Bioorg Med Chem
Lett 14: 1983-1985, 2004
- Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic
D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM,
Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth
P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton
J, Mann D, Janssens B, Hardy J, O’Donovan M, Jones L, Williams J,
Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van
Roy F, Lovestone S: α-T-catenin is expressed in human brain and
interacts with the Wnt signalling pathway but is not responsible for
linkage to chromosome 10 in Alzheimer’s disease. Neuromolecular
Med 5: 133-146, 2004
- Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara
J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K: Targeted
introduction of V642I mutation in amyloid precursor protein gene causes
functional abnormality resembling early stage of Alzheimer’s disease
in aged mice. Eur J Neurosci 19: 2826-2838, 2004
- Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya
H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor
protein missense mutation (D678N) in familial Alzheimer’s disease.
J Neurol Neurosurg Psychiat 75: 1039-1042, 2004
- Zhang Y, Hayes A, Pritchard A, Haque MS, Lemmon H, Harris J, Cumming
A, Lambert JC, Chartier-Harlin MC, St Clair D, Iwatsubo T, Mann DM,
Lendon CL: Interleukin-6 promoter polymorphism: risk and pathology
of Alzheimer’s disease. Neurosci Lett 362: 99-102, 2004
- Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DMA, Duf K,
Tsuji S, Hashimoto T, Iwatsubo T: Mostly separate distributions of
CLAC- versus Aβ40- or thioflavin S-reactivities in senile plaques
reveal two distinct subpopulations of β-amyloid deposits. Am
J Pathol 165: 273-281, 2004
- Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo
T, Nakajima M, Shinohara M, Saya H: Cell-matrix interaction via CD44
is independently regulated by different metalloproteinases activated
in response to extracellular Ca2+ influx and PKC activation. J
Cell Biol 165: 893-902, 2004
- Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M: Phosphorylated α-synuclein
in normal mouse brain. FEBS Lett 572: 227-232, 2004
- Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita
T, Iwatsubo T: Selective reconstitution and recovery of functional
γ-secretase complex on budded baculovirus particles. J Biol
Chem 279: 38040-38046, 2004
- Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H: Overexpression of α-synuclein
in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation
of α-synuclein and activation of caspase-9. Resemblance to pathogenetic
changes in Parkinson’s disease. J Neurochem 91: 451-461, 2004
- Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo
T, Aebischer P: Lentiviral vector delivery of parkin prevents dopaminergic
degeneration in an α-synuclein rat model of Parkinson’s disease.
Proc Natl Acad Sci USA 101: 17510-17515, 2004
- Nonaka T, Iwatsubo T, Hasegawa M: Ubiquitination of α-synuclein.
Biochemistry 44: 361-368, 2005
- Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert
M, Hasegawa M: Inhibition of heparin-induced tau filament formation
by phenothiazines, polyphenols and porphyrins. J Biol Chem
280: 7614-7623, 2005
- Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo
T: CLAC binds to amyloid β peptides through the positively-charged
amino acid cluster within the collagenous domain 1 and inhibits formation
of amyloid fibrils. J Biol Chem 280: 8596-8605, 2005
- Niimura M, Isoo N, Takasugi N, Tsuruoka M, Tei-Ui K, Saigo K, Morohashi
Y, Tomita T, Iwatsubo T: Aph-1 contributes to the stabilization and
trafficking of the γ-secretase complex through mechanisms involving
inter- and intramolecular interactions. J Biol Chem 280: 12967-12975,
2005
- Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita
T, Iwatsubo T, Hamakubo T, Kodama T: Association of active γ-secretase
complex with lipid rafts. J Lipid Res 46: 904-912, 2005
- Iseki E, Marui W, Yamamoto R, Togo T, Katsuse O, Kato M, Iwatsubo
T, Kosaka K, Arai H: The nigro-striatal and nigro-amygdaloid pathways
undergo different degeneration processes in brains of dementia with
Lewy bodies. Neurosci Lett 380: 161-165, 2005
- Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N,
Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno
Y, Hattori N: Common anti-apoptotic roles of parkin and α-synuclein
in human dopaminergic cells. Biochem Biophys Res Commun 332:
233-240, 2005
- Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert
JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon
C: Association study and meta-analysis of low-density lipoprotein
receptor related protein in Alzheimer’s disease. Neurosci Lett
382: 221-226, 2005
- Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson
TM, Iwatsubo T, Ross CA: α-Synuclein phosphorylation enhances
Lewy body-like inclusion formation in SH-SY5Y cells. J Neurosci
25: 5544-5552, 2005
祖父江 元 (名古屋大学・大学院医学研究科)
- Mizuno K, Wakai M, Takeda A, Sobue G: Medial temporal atrophy and
memory impairment in early stage of Alzhermer’s disease: an MRI volumetric
and memory assessment study. J Neurol Sci 173: 18-24, 2000
- Takeuchi H, Misu K, Hattori N, Nagamatsu M, Sobue G: Immunoglobulin
therapy for idiopathic chronic sensory ataxic neuropathy. Neurology
54: 1008-1010, 2000
- Kobayashi Y, Kume A, Li M, Doyu M, HataM, Ohtsuka K, Sobue G: Chaperones,
Hsp70 and Hsp40, suppress aggregate formation and apoptosis in cultured
neuronal cells expressing truncated androgen receptor protein with
expanded polyglutamine tract. J Biol Chem 275: 8772-8778, 2000
- Inukai A, Kuru S, Liang Y, Takano A, Kobayashi Y, Sakai M, Doyu
M, Sobue G: Expression of HLA-DR and its enhancing molecules in muscle
fibers in polymyositis. Muscle Nerve 23: 385-392, 2000
- Mutoh T, Sobue G, Hamano T, Kuriyama M, Hirayama M, Yamamoto M,
Mitsuma T: Decreased phosphorylation levels of TrkB neurotrophin receptor
in the spinal cords from patients with amyotrophic lateral sclerosis.
Neurochem Res 25: 239-245, 2000
- Kuru S, Inukai A, Liang Y, Doyu M, Takano A, Sobue G: Tumor necrosis
factor-α expression in muscles of polymyositis and dermatomositis.
Acta Neuropathol 99: 585-588, 2000
- Takano A, Bönneman CG, Honda H, Sakai M, Feener CA, Kunkel
LM, Sobue G: Intrafamilial phenotype variation in limb-girdle muscular
dystrophy type 2c with compound heterozygous mutations. Muscle
Nerve 23: 807-810, 2000
- Terao S, Takeda A, Miura N, Izumi M, Ito E., Mitsuma T, Sobue G:
Clinical and pathophysiological features of amaurosis fugax in Japanese
stroke patients. Intern Med 39: 118-122, 2000
- Yoshihara T, Yamamoto M, Doyu M, Misu K, Hattori N, Hasegawa Y,
Mokuno K, Mitsuma T, Sobue G: Mutations in the peripheral myelin protein
zero and connexin 32 genes detected by non-isotopic RNase cleavage
assay and their phenotype in Japanese patients with Charcot-Marie-Tooth
disease. Hum Mutat 16: 177-178, 2000
- Hishikawa N, Hashizume Y, Hirayama M, Imamura K, Washimi Y, Koike
Y, Mabuchi C, Yoshida M, Sobue G: Brainstem-type Lewy body disease
presenting with progressive autonomic failure and lethargy. Clin
Auton Res 10: 139-143, 2000
- Misu K, Hattori N, Ando Y, Ikeda S, Sobue G: Anticipation in early-but
not late onset familial amyloid polyneurolathy (TTR Met 30) in Japan.
Neurology 55: 451-452, 2000
- Terao S, Miura N, Osano Y, Takatsu S, Mitsuma T, Sobue G: Cerebellar
infarction in the territory of the medial branch of the posterior
inferior cerebellar artery. J Aichi Med Univ Assoc 28: 83-88,
2000
- Terao S, Miura N, Takeda A, Takahashi A, Miura T, Sobue G: Course
and distribution of facial corticobulbar tract fibres in the lower
brain stem. J Neurol Neurosurg Psychiat 69: 262-265, 2000
- Inukai A, Doyu M, Kato T, Liang Y, Kuru S, Yamamoto M, Kobayashi
Y, Sobue G: Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy
msucle. Muscle Nerve 23: 1421-1426, 2000
- Terao S, Osano Y, Fukuona T, Miura N, Mitsuma T, Sobue G: Coexisting
vertical and horizontal one and a half syndrome. J Neurol Neurosurg
Psychiat 69: 401-402, 2000
- Koike H, Misu K, Yasui K, Kameyama T, Ando T, Yanagi T, Sobue G:
Differential response to corticosteroid therapy of MRI findings and
clinical manifestations in spinal cord sarcoidosis. J Neurol
247: 544-549, 2000
- Kato T, Tanaka F, Yoshida E, Indo T, Watanabe H, Yoshihara T, Doyu
M, Sobue G: Sisters homozygous for the spinocerebellar associated
with different clinical phenotype. Clin Genet 58: 69-73, 2000
- Liang Y, Inukai A, Kuru S, Kato T, Doyu M, Sobue G: The role of
lymphotoxin in pathogenesis of polymyositis. Acta Neuropathol
100: 521-527, 2000
- Sawada K, Doyu M, Tanaka F, Sobue G, Kato K: Detection of triplet
repeat expansion in the human genome by use of hybridization signal
intensity. Anal Biochem 286: 59-66, 2000
- Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, Doyu M., Suzumura
A, Mitsuma T, Sobue G: Temporal expression of mRNAs for neuropoietic
cytokine, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1
(CT-1) and their receptors (IL-11Rα and OSMRb) in peripheral
nerve injury. Neurochem Res 25: 1113-1118, 2000
- Watanabe H, Tanaka F, Doyu M, Riku S, Yoshida M, Hashizume Y, Sobue
G: Differential somatic CAG repeat instability in variable brain cell
lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured
microdissection (LCM)-based analysis. Hum Genet 107: 452-457,
2000
- Ishigaki S, Niwa J, Yoshihara T, Mitsuma N, Doyu M, Sobue G: Two
novel genes, human neugrin and mouse m-neugrin, are upregulated with
neuronal differentiation in neuroblastoma cells. Biochem Biophys
Res Commun 279: 526-533, 2000
- McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J,
Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH: CREB-binding protein
sequestration by expanded polyglutamine. Hum Mol Genet 9: 2197-2202,
2000
- Misu K, Yoshihara T, Shikama Y, Awaki E, Yamamoto M, Hattori N,
Hirayama M, Takegami T, Nakashima K, Sobue G: An axonal form of Charcot-Marie-Tooth
disease showing distinctive features in association with mutations
in the periheral myelin protein zero gene (Thr124Met or Asp75Val).
J Neurol Neurosurg Psychiat 69: 806-811, 2000
- Ito Y, Yamamoto M, Mitsuma N, Li M, Hattori N, Sobue G: Expression
of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory
factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα,
LIFRβ, IL-6Rα, and gp130) in human peripheral neuropathies.
Neurochem Res 26: 51-58, 2001
- Takeda A, Wakai M, Niwa H, Dei R, Yamamoto M, Li M, Goto Y, Yasuda
T, Nakagomi Y, Watanabe M, Inagaki T, Yasuda Y, Miyata T, Sobue G:
Neuronal and glial advanced glycation end product 「Nε-(carboxymethl)lysine」n
Alzheimer’s disease brains. Acta Neuropathol 101: 27-35, 2001
- Doyu M, Sawada K, Mitsuma N, Niwa J, Yoshimoto M, Fujii Y, Sobue
G, Kato K: Gene expression profile in Alzheimer’s brain screened by
molecular indexing. Mol Brain Res 87: 1-11, 2001
- Qiao S, Iwashita T, Furukawa T, Yamamoto M, Sobue G, Takahashi M:
Differential effects of LAR on biochemical and biological activities
of RET-MEN2A and RET-MEN2B mutant protein. J Biol Chem 276:
9460-9467, 2001
- Hattori N, Misu K, Koike H, Ichimura M, Nagamatsu M, Hirayama M,
Sobue G: Age of onset influences clinical features of chronic inflammatory
demyelinating polyneuropathy. J Neurol Sci 184: 57-63, 2001
- Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G: A novel
centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase
activity. Biochem Biophys Res Commun 281: 706-713, 2001
- Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N,
Chihara K, Sobue G: A novel missense mutation in the early growth
response 2 gene associated with late-onset Charcot-Marie-Tooth disease
type 1. J Neurol Sci 184: 149-153, 2001
- Ochi K, Nozaki H, Tanaka F, Kato S, Fukuzawa R, Sobue G, Fukuchi
Y, Toyama Y, Hata J, Umezawa A: Specific bisulfite modification of
CTG triplet repeats of the androgen receptor gene, a gene associated
with the triplet repeat disease. X-linked spinal and bulbar muscular
atrophy (Kennedy disease). Neurosci Res Commun 28: 1-10, 2001
- Adachi H, Kume A, Li M, Nakagami Y, Niwa H, Do J, Sang C, Kobayashi
Y, Doyu M, Sobue G: Transgenic mice with an expande CAG repeat controlled
by the human AR promoter show polyglutamine nuclear inclusions and
neuronal dysfunction without neuronal cell death. Hum Mol Genet
10: 1039-1048, 2001
- Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, Hirayama
M, Sobue G: Cardiac I-meta-iodobenzylguanidine (MIBG) uptaken in dementia
with Lewy bodies: comparison with Alzheimer’s disease. J Neurol
Neurosurg Psychiat 70: 781-783, 2001
- Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G: Pathology-related
differential expression regulation of NGF, GDNF, CNTF, and IL-6 mRNAs
in human vascultic neuropathy. Muscle Nerve 24: 830-833, 2001
- Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G:
Painful alcoholic polyneuropathy with predominant small-fiber loss
and normal thiamine status. Neurology 56: 1727-1732, 2001
- Koike H, Misu K, Hattori N, Ito S, Ichimura M, Ito H, Hirayama M,
Nagamatsu M, Sasaki I, Sobue G: Postgastrectomy polyneuropathy with
thiamine deficiency. J Neurol Neurosurg Psychiat 71: 357-362,
2001
- Yamamoto M, Li M, Mitsuma N, Ito S, Kato M, Takahashi M, Sobue G:
Preserved phosphorylation of RET receptor protein in spinal motor
neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical
study by a phosphorylation-specific antibody at tyrosine 1062. Brain
Res 912: 89-94, 2001
- Mori K, Koike H, Misu K, Hattori N, Ichimura M, Sobue G: Spinal
cord magnetic resonance imaging demonstrates sensory neuronal involvement
and clinical severity in neuronopathy associated with Sjögren’s
syndrome. J Neurol Neurosurg Psychiat 71: 488-492, 2001
- Watanabe H, Misu K, Hirayama M, Hattori N, Yoshihara T, Doyu M,
Sobue G: Low cardiac 123I-MIBG uptake in lateonset familial
amyloid polyneuropathy type I (TTR Met 30). J Neurol 248: 627-629,
2001
- Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita
Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang
J, Kurokawa K, Nishimoto I: A rescue factor abolishing neuronal cell
death by a wide spectrum of familial Alzheimer’s disease genes and
Aβ. Proc Natl Acad Sci USA 98: 6336-6341, 2001
- Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Widespread occurrence
of argyrophilic glial inclusions in Parkinson’s disease. Neuropathol
Appl Neurobiol 27: 362-337, 2001
- Yoshihara T, Ishigaki S, Yamamoto M, Liang Y, Niwa J, Takeuchi H,
Doyu M, Sobue G: Differential expression of inflammation-and apoptosis-related
genes in spinal cords of a mutant SOD1 trangenic mouse model of familial
amyotrophic lateral sclerosis. J Neurochem 80: 158-167, 2002
- Yamamoto M, Kobayashi Y, Li M, Niwa H, Mitsuma N, Ito Y, Mutamatsu
T, Sobue G: In Vivo gene electroporation of glial cell line-derived
neurotrophic factor (GDNF) into skeletal muscle of SOD1 mutant mice.
Neurochem Res 26: 1201-1207, 2002
- Watanabe H, Misu K, Kobayashi T, Hattori N, Doyu M, Yokoyama I,
Ando Y, Nakao A, Sobue G: ABO-incompatible auxiliary partial orthotopic
liver transplant for late-onset familial amyloid polyneuropathy. J
Neurol Sci 195: 63-66, 2002
- Katsuno M, Ando T, Hakusui S, Yanagi T, Sobue G: Motor conduction
studies in miller fisher syndrome with severe tetraparesis. Muscle
Nerve 25: 378-382, 2002
- Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G: Parallel
expression of neurotrophic factors and their receptors in chronic
inflammatory demyelinating polyneuropathy. Muscle Nerve 25:
601-604, 2002
- Mori K, Hattori N, Sygiura M, Koike H, Misu K, Ichimura M, Hirayama
M, Sobue G: Chronic inflammatory demyelinating polyneuropathy presenting
with features of GBS. Neurology 58: 979-982, 2002
- Ikeda S, Nakazato M, Ando Y, Sobue G: Familial transthyretin-type
amyloid polyneuropathy in Japan. Neurology 58: 1001-1007, 2002
- Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba K,
Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G: Progression and prognosis
in multiple system atrophy. An analysis of 230 Japanese patients.
Brain 125: 1070-1083, 2002
- Kato M, Takeda K, Kawamoto Y, Iwashita Akhand AA, Senga T, Yamamoto
M, Sobue G, Hamaguchi M, Takahashi M, Nakashima I: Repair by src kinase
of function-impaired RET with multiple endocrine neoplasia type 2A
mutation with substitutions of tyrosines in the COOH-terminal kinase
domain for phenylalanine. Cancer Res 62: 2414-2422, 2002
- Iwai K, Yamamoto M, Yoshihara T, Sobue G: Anticipation in familial
amyotrophic lateral sclerosis with SOD1-G93S mutation. J Neurol
Neurosurg Psychiat 72: 819-820, 2002
- Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M, Inagaki T,
Washimi Y, Yasuda Y, Horie K, Toshio M, Sobue G: Lipid peroxidation
and advanced glycation and products in the brain in normal aging and
in Alzheimer’s disease. Acta Neuropathol 104: 113-122, 2002
- Hattori N, Mori K, Misu K, Koike H, Ichimura M, Sobue G: Mortality
and morbidity in peripheral neuropathy associated Churg-Strauss syndrome
and microscopic polyangiitis. J Rheumatol 29: 1408-1414, 2002
- Ishigaki S, Liang Y, Yamamoto M, Niwa J., Ando Y, Yoshihara T, Takeuchi
H., Doyu M, Sobue G: X-linked inhibitor of apoptosis protein is involved
in mutant SOD-1 mediated neuronal degeneration. J Neurochem
82: 576-584, 2002
- Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi
Y, Doyu M, Sobue G: Teststerone reduction prevents phenotypic expression
in a transgenic mouse model of spinal and bulbar muscular atrophy.
Neuron 35: 843-854, 2002
- Niwa H, Hayakawa K, Yamamoto M, Itoh T, Mitsuma T, Sobue G: Differential
age-dependent trophic responses of nodose, sensory, and sympathetic
neurons to neurotrophins and GDNF: potencies for neurite extension
in explant culture. Neurochem Res 27: 485-496, 2002
- Kato T, Indo T, Yoshida E, Iwasaki Y, Sone M, Sobue G: Contrast-enhanced
2D cine phase MR angiography for measurement of basilar artery blood
flow in posterior circulation ischemia. Am J Neuroradiol 23:
1346-1351, 2002
- Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka
K, Taniguchi N, Sobue G: Dorfin ubiquitylates mutant SOD1 and prevents
mutant SOD1-mediated neurotoxicity. J Biol Chem 277: 36793-36798,
2002
- Takeuchi H, Kobayashi Y, Yoshihara T, Niwa J, Doyu M, Ohtsuka K,
Sobue G: Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic
aggregate formation in cultured neuronal cells expressing mutant SOD1.
Brain Res 949: 11-22, 2002
- Takeuchi H, Kobayashi Y, Ishigaki S, Doyu M, Sobue G: Mitochondrial
localization of mutant superoxide dismutase 1 triggers caspase-depenent
cell death in a cellular model of familial amyotrophic lateral sclerosis.
J Biol Chem 277: 50966-50972, 2002
- Sang C, Kobayashi Y, Du J, Katsuno M, Adachi H, Doyu M, Sobue G:
c-Jun N-terminal kinase pathway mediates lactacustin-induced cell
death in a neuronal differentiated neuro2a cell line. Mol Brain
Res 108: 7-17, 2002
- Ishigaki S, Niwa J, Ando Y, Yoshihara T, Sawada K, Doyu M, Yamamoto
M, Kato K, Yotsumoto Y, Sobue G: Differentially expressed genes in
sporadic amyotrophic lateral sclerosis spinal cords -screening by
molecular indexing and subsequent cDNA microarray analysis. FEBS
Lett 531: 354-358, 2002
- Koike H, Misu K, Ikeda S, Ando Y, Nakazato M, Ando E, Yamamoto M,
Hattori N, Sobue G: Type I (transthyretin Met30) familial amyloid
polyneuropathy in Japan: early- vs late-onset form. Arch Neurol
59: 1771-1776, 2002
- Ito Y, Kato T, Suzuki T, Yokokawa Y, Aiba I, Arahata Y, Ito E, Ito
K, Yasuda T, Sobue G: Neuroradiologic and clinical abnormalities in
dementia of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama
disease). J Neurol Sci 209: 105-109, 2002
- Kuru S, Inukai A, Kato T, Liang Y, Kimura S, Sobue G: Expression
of tumor factor-α in regenerating muscle fibers in inflammatory
and non-inflammatory myopathies. Acta Neuropathol 105: 217-224,
2003
- Kobayashi R, Koike Y, Hirayama M, Ito H, Sobue G: Skin sympathetic
nerve function sleep-a study with effector responses. Anton Neurosci
103: 121-126, 2003
- Hattori N, Yamamoto M, Yoshihara T, Koike H, Nakagawa N, Yoshikawa
H, Ohnishi A, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakashima
K, Kira J, Kaji R, Oka N, Sobue G, the Study Group for Hereditary
Neuropathy in Japan: Demyelinating and axonal features of Charcot-Marie-Tooth
disease with mutations of myelin-related proteins (PMP22, MPZ and
Cx32): a clinicopathological study of 205 Japanese patients. Brain
126: 134-151, 2003
- Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Clinical and neuropathological
correlates of Lewy body disease. Acta Neuropathol 105:
341-350, 2003
- Yamada T, Nakamura A, Horibe K, Washimi Y, Bundo M, Kato T, Ito
K, Kachi T, Sobue G: Asymmetrical enhancement of middle-latency auditory
evoked fields with aging. Neurosci Lett 337: 21-24, 2003
- Hamada K, Hirayama M, Watanabe H, Kobayashi R, Ito H, Ieda T, Koike
Y, Sobue G: Onset age and severity impairment are associated with
reduction of myocardial 123I-MIBG uptake in Parkinson’s
disease. J Neurol Neurosurg Psychiat 74: 423-426, 2003
- Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatous G, Angelidis
C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G: Heat shock
protein 70 chaperone overexpression ameliorates phenotypes of the
spinal and bulbar muscular atrophy transgenic mouse model by reducing
nuclear-localized mutant androgen receptor protein. J Neurosci
23: 2203-2211, 2003
- Hirayama M, Fukatsu H, Watanabe H, Koike Y, Noda A, Ito H, Kobayashi
R, Sobue G: Sequential constriction of upper airway and vocal cords
in sleep apnoea of multiple system atrophy: low field magnetic resonance
fluoroscopic study. J Neurol Neurosurg Psychiat 74: 642-645,
2003
- Abe Y, Kachi T, Arahata Y, Yamada T, Washimi Y, Iwai K, Ito K, Yanagisawa
N, Sobue G: Occipital hypoperfusion in Parkinson’s disease without
dementia: correlation to impaired cortical visual processing. J
Neurol Neurosurg Psychiat 74: 419-422, 2003
- Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, Hirayama
M, Sobue G: Alcoholic neuropathy is clinicopathologically distinct
from thiamine-deficiency neuropathy. Ann Neurol 54: 19-29,
2003
- Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Reply to K. Jellinger.
Acta Neuropathol 106: 109, 2003
- Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y,
Inukai A, Sobue G: Leuprorelin rescue polyglutamine-dependent phenotypes
in a transgenic mouse model of spinal and bulbar muscular atrophy.
Nat Med 9: 768-773, 2003
- Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, Sobue
G: Dorfin localizes to the ubiquitilated inclusions in Parkinson’s
disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic
lateral sclerosis. Am J Pathol 163: 609-619, 2003
- Hishikawa N, Hashizume Y, Ujihara N, Okada Y, Yoshida M, Sobue G:
α-Synuclein-positive structures in associations with diffuse
neurofibrillary tangles with calcification. Neuropathol Appl Neurobiol
29: 280-287, 2003
- Ishihara K, Yamagishi N, Saito Y, Adachi H, Kobayashi Y, Sobue G,
Ohtsuka K, Hatayama T: Hsp 105α suppresses the aggregation of
truncated androgen receptor with expanded CAG repeats and cell toxicity.
J Biol Chem 278: 25143-25150, 2003
- Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G: Dorfin
localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol
Chem 278: 29106-29114, 2003
- Mori K, Iijima M, Sugiura M, Koike H, Hattori N, Ito H, Hirayama
M, Sobue G: Sjögren’s syndrome associated painful sensory neuropathy
without sensory ataxia. J Neurol Neurosurg Psychiat 74: 1320-1322,
2003
- Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto
M, Doyu M, Sobue G: Caspase-1 and -3 are differentially upregulated
in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal
cord: a study usign laser microdissection and real time RT-PCR. Neurochem
Res 28: 839-846, 2003
- Katsuno M, Adachi H, Inukai A, Sobue G: Transgenic mouse models
of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome
Res 100: 243-251, 2003
- Sobue G, Koike H, Misu K, Hattori N, Yamamoto M, Ikeda S, Ando Y,
Nakazato M, Inukai A: Clinicopathologic and genetic features of early-
and late-onset FAP type I (FAP ATTR Val30Met) in Japan. Amyloid
1: 32-38, 2003
- Nodera H, Bostock H, Kuwabara S, Sakamoto T, Asanuma K, Jia-Ying
S, Ogawara K, Hattori N, Hirayama M, Sobue G, Kaji R: Nerve excitability
properties in Charcot-Marie-Tooth disease type 1A. Brain 127:
203-211, 2003
- Wada M, Kimura M, Daimon M, Kurita K, Kato T, Johmura Y, Johkura
K, Kuroiwa Y, Sobue G: An unusual phenotype of Mcleod syndrome with
late onset axonal neuropathy. J Neurol Neurosurg Psychiat 74:
1697-1699, 2003
- Watanabe H, Fukatsu H, Katsuno M, Sugiura M, Hamada K, Okada Y,
Hirayama M, Ishigkai T, Sobue G: Multiple regional 1H-MR spectroscopy
in multiple system atrophy: NAA/Cr reduction in pontine base as a
valuable diagnostic marker. J Neurol Neurosurg Psychiat 75:
103-109, 2004
- Watanabe H, Fukatsu H, Hisikawa N, Hashizume Y, Sobue G: Field strengths
and sequences influence putaminal MRI findings in multiple system
atrophy. Neurology 62: 671, 2004
- Yamamoto M, Yoshihara T, Hattori N, Sobue G: Glu528del in NEFL is
a polymorphic variant rather than a disease-causing mutant for Charcot-Marie-Tooth
disease in Japan. Neurogenetics 5: 75-77, 2004
- Konagaya M, Matsumoto A, Takase S, Mizutani T, Sobue G, Konishi
T, Hayabara T, Iwashita H, Ujihira T, Miyata T, Matsuoka Y: Clinical
analysis of longstanding substance myelo-optico-neuropathy: sequelae
of clioquinol at 32 years after its ban. J Neurol Sci 218:
85-90, 2004
- Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue
G: Dorfin prevents cell death by reducing mitochondrial localiaing
mutant superoxide dismutase 1 in a neuronal cell model of familial
amyotrophic lateral sclerosis. J Neurochem 89: 64-72, 2004
- Yamada S, Matsuo K, Hirayama M, Sobue G: The effects of levodopa
on apraxia of lid opening: A case report. Neurology 62: 830-831,
2004
- Terao S, Miura N, Osano Y, Noda A, Sobue G: Rapidly progressive
fatal respiratory failure (Ondine’s curse) in the lateral medullary
sundrome. J Stroke Cerebrovasc Dis 13: 41-44, 2004
- Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y,
Tanaka F, Doyu M, Inukai A, Sobue G: Sodium butyrate ameliorates phenotypic
expression in a transgenic mouse model of spinal and bulbar muscular
atrophy. Hum Mol Genet 13: 1183-1192, 2004
- Ohmori H, Ando Y, Makita Y, Onouchi Y, Nakajima T, Saraiva MJM,
Terazaki H, Suhr O, Sobue G, Nakamura M, Yamaizumi M, Munar-Ques M,
Inoue I, Uchino M, Hata A: Common origin of the Val30Met mutatioin
responsible for the amyloidogenic transthyretin type of familial amyloidotic
polyneuropathy. J Med Genet 41: 1-5, 2004
- Koike H, Misu K, Sugiura M, Iijima M, Mori K, Yamamoto M, Hattori
N, Mukai E, Ando Y, Ikeda S, Sobue G: Pathology of early- vs late-onset
TTR Met30 familial amyloid polyneuropathy. Neurology 63: 129-138,
2004
- Kurihara S, Adachi Y, Imai C, Araki H, Hattori N, Numakura C, Lin
Y, Hayasaka K, Sobue G, Nakashima K: Charcot-Marie-Tooth families
in Japan with MPZ Thr124Met mutation. J Neurol Neurosurg Psychiat
75: 1492-1494, 2004
- Mitsuma N, Yamamoto M, Iijima M, Hattori N, Ito Y, Tanaka F, Sobue
G: Wide range of lineages of cells expressing nerve growth factor
mRNA in the nerve lesions of patients with vasculitic neuropathy:
An implication of endoneurial macrophage for nerve regeneration. Neuroscience
129: 109-117, 2004
- Mabuchi N, Watanabe H, Atsuta N, Hirayama M, Ito H, Fukatsu H, Kato
T, Ito K, Sobue G: Primary lateral sclerosis presenting parkinsonian
symptoms without nigrostriatal involvement. J Neurol Neurosurg
Psychiat 75: 1768-1771, 2004
- Ishigaki S, Hishikawa N, Niwa J, Iemura S, Natsume T, Hori S, Kakizuka
A, Tanaka K, Sobue G: Physical and functional interaction between
Dorfin and Valosin-containing protein that are colocalized in ubiquitylated
inclusions in neurodegenerative disorders. J Biol Chem 279:
51376-51385, 2004
- Koike H, Iijima M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G:
Postgastrectomy polyneuropathy with thiamine deficiency is identical
to beriberi neuropathy. Nutrition 20: 961-966, 2004
- Okada Y, Shimazaki T, Sobue G, Okano H: Retinoic-acid-concentration-dependent
acquisition of neural cell identity during in vitro differentiation
of mouse embryonic stem cells. Dev Biol 275: 124-142, 2004
- Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S,
Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu
M, Yoshida M, Hashizume Y, Sobue G: Gene expression profile of motor
neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol
57: 236-251, 2005
- Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi
Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G: Widespread
nuclear and cytoplasmic mutant androgen receptor accumulation in spinal
and bulbar muscular atrophy. Brain 128: 659-670, 2005
- Iijima M, Yamamoto M, Hirayama M, Tanaka F, Katsuno M, Mori K, Koike
H, Hattori N, Arimura K, Nakagawa M, Yoshikawa H, Hayasaka K, Onodera
O, Baba M, Yasuda H, Saito T, Nakazato M, Nakashima K, Kira J, Kaji
R, Oka N, Sobue G: Clinical and electrophysiologic correlates of IVIg
responsiveness in CIDP. Neurology 64: 1471-1475, 2005
水野 美邦 (順天堂大学・医学部・脳神経内科)
- Lu CS, Wu JC, Tsai CH, Chen RS, Chou WYH, Hattori N, Yoshino H,
Mizuno, Y: Clinical and genetic studies on familial parkinsonism:
The first report on a parkin gene mutation in a Taiwanese family.
Mov Disord 16: 164-166, 2001
- Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R: An unfolded
putative transmembrane polypeptide, which can lead to endoplasmic
reticulum stress, is a substrate of parkin. Cell 105: 891-902,
2001
- Jeon BS, Kim JM, Lee DS, Hattori N, Mizuno Y: An apparently sporadic
case with parkin gene mutation in a Korean woman. Arch Neurol
58: 988-989, 2001
- Nisipeanu P, Inzelberg R, Abo Mouch S, Carasso RL, Blumen SC, Zhang
J, Matsumine H, Hattori N, Mizuno Y: Parkin gene causing benign autosomal
recessive juvenile parkinsonism. Neurology 56: 1573-1577, 2001
- Mellick GD, Buchanan DD, Hattori N, Brookes AJ, Mizuno Y, Le Couteur
DG, Silburn PA: The parkin gene S/N167 polymorphism in Australian
Parkinson's disease patients and controls. Parkinsonism Relat Disord
7: 89-91, 2001
- Mogi M, Togari A, Kondo T, Mizuno Y, Kogure O, Kuno S, Ichinose
H, Nagatsu T: Glial cell line-derived neurotrophic factor in the substantia
nigra from control and parkinsonian brains. Neurosci Lett 300:
179-181, 2001
- Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima
S, Shimizu N, Mizuno Y, Hattori N: Parkin is associated with cellular
vesicles. J Neurochem 78: 42-54, 2001
- Miwa H, Kagohashi M, Noda K, Miyashita N, Tanaka S, Mizuno Y: Eyelid
motor extinction. J Neurol 248: 343-344, 2001
- Miwa H, Fuwa T, Nishi K, Kondo T: Subthalamo-pallido-striatal axis:
a feedback system in the basal ganglia. NeuroReport 12: 3795-3798,
2001
- Miwa H, Mizuno Y: Capgras syndrome in Parkinson's disease. J
Neurol 248: 804-805, 2001
- Miwa H, Furuya T, Tanaka S, Mizuno Y: Neurosarcoidosis associated
with interferon therapy. Eur Neurol 45: 288-289, 2001
- Miwa H, Miwa T, Imai H, Mizuno Y: Obsessive compulsive disorder-like
behavioral changes in pure akinesia. Parkinsonism Relat Disord
7: 315-317, 2001
- Miwa H, Iijima M, Tanaka S, Mizuno Y: Generalized convulsions after
consuming a large amount of Gingko nuts. Epilepsia 42: 280-281,
2001
- Noda K, Okuma Y, Fukae J, Fujishima K, Sadamasa H, Yoshiike T, Mizuno
Y: Sweet’s syndrome associated with encephalitis. J Neurol Sci
188: 95-97, 2001
- Noda K, Miwa H, Miyashita N, Tanaka S, Mizuno Y: Monoataxia of upper
extremity in motor cortical infarction. Neurology 56: 1418-1419,
2001
- Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A,
Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura
M, Mizuno Y: An AAV-derived apaf-1 dominant negative inhibitor prevents
MPTP toxicity as antiapoptotic gene therapy for Parkinson’s disease.
Proc Natl Acad Sci USA 98: 10918-10923, 2001
- Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T,
Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy.
Neurosci Lett 309: 89-92, 2001
- Nohara C, Akiba H, Nakajima A, Inoue A, Koh CS, Ohshima H, Yagita
H, Mizuno Y, Okumura Y: Amelioration of experimental autoimmune encephalomyelitis
with anti-OX40 ligand monoclonal antibody: A critical role for OX40
ligand in migration, but not development, of pathogenic T cells.
J Immunol 166: 2108-2115, 2001
- Okuma Y, Tanaka R, Fujishima K, Kobayashi T, Mizuno Y: Cortical
reflex action myoclonus in neurosyphilis. Eur Neurol 45: 193-194,
2001
- Okuma Y, Mizuno Y: Myoclonic tremor in patients with parkinsonian-type
multiple system atrophy. Mov Disord 16: 378-379, 2001
- Okuma Y, Fujishima K, Machida Y, Inagaki N, Sugita Y, Mizuno Y:
Propriospinal negative myoclonus. Eur Neurol 46: 99-101, 2001
- Shimo-Nakanishi Y, Urabe T, Hattori N, Watanabe Y, Nagao T, Yokochi
M, Hamamoto M, Mizuno Y: Polymorphism of the lipoprotein lipase gene
and risk of atherothrombotic cerebral infarction in the Japanese.
Stroke 32: 1481-1486, 2001
- Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher
A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ: Ubiquitination of a
new form of α-synuclein by parkin from human brain: Implications
for Parkinson's disease. Science 293: 263-269, 2001
- Takanashi M, Mochizuki H, Yokomizo K, Hattori N, Mori H, Yamamura
Y, Mizuno Y: Iron accumulation in the substantia nigra of autosomal
recessive juvenile parkinsonism (ARJP). Parkinsonism Relat Disord
7: 311-314, 2001
- Tanaka K, Suzuki T, Chiba T, Shimura H, Hattori N, Mizuno Y: Parkin
is linked to the ubiquitin pathway. J Mol Med 79: 482-494,
2001
- Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka
K, Mizuno Y, Hattori N: Developmental changes in the expression of
parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme,
in rat brain. J Neurochem 77: 1561-1568, 2001
- Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner
P: Effect of wild-type or mutant Parkin on oxidative damage, nitric
oxide, antioxidant defenses, and the proteasome. J Biol Chem 277:
28572-28577, 2002
- Kobayashi T, Mori H, Okuma Y, Dickson DW, Cookson N, Tsuboi Y, Motoi
Y, Tanaka R, Miyashita N, Anno M, Narabayashi H, Mizuno Y: Constrasting
genotypes of the tau gene in two phenotypically distinct patients
with P301L mutation of frontotemporal dementia and parkinsonism linked
to chromosome 17. J Neurol 249: 669-675, 2002
- Miwa H, Kajimoto M, Kondo T: Chorea in motor neuron disease. Move
Disord (letter) 17: 1397, 2002
- Miwa H, Kondo T, Mizuno Y: Bell's palsy-induced blepharospasm. J
Neurol 249: 452-454, 2002
- Miwa H, Mizuno Y: Enlargements of somatosensory-evoked potentials
in progressive supranuclear palssy. Acta Neurol Scand 106:
209-212, 2002
- Miwa H, Mizuno Y, Kondo T: Familial hemifacial spasm: report of
cases and review of literature. J Neurol Sci 193: 97-102, 2002
- Mori H, Oda M, Komori T, Arai N, Takanashi M, Mizutani T, Hirai
S, Mizuno Y: Lewy bodies in progressive supranuclear palsy. Acta
Neuropathol 104: 273-278, 2002
- Ohizumi H, Okuma Y, Fukae J, Fujishima K, Goto K, Mizuno Y: Head
tremor in dentatorubral-pallidoluysian atrophy. Acta Neurol Scand
106: 319-321, 2002
- Okuma Y, Mizuno Y, Lee RG: Reciprocal Ia inhibition in patients
with asymmetric spinal spasticity. Clin Neurophysiol 113: 292-297,
2002
- Schossmacher MG, Frosch MP, Ping-Gai W, Medina M, Sharma N, Forno
L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno
Y, Hyman BT, Selkoe DJ, Kosik K: Parkin localizes to the Lewy bodies
of Parkinson disease and dementia with Lewy bodies. Am J Pathol
160: 1655-1667, 2002
- Suzuki A, Obi K, Urabe T, Hayakawa H, Yamada M, Kaneko S, Onodera
M, Mizuno Y, Mochizuki H: Feasibility of ex vivo gene therapy
for neurological disorders using the new retroviral vector GCDNsap
packaged in the vesicular stomatitis virus G protein. J Neurochem
82: 953-960, 2002
- Takanashi M, Mori H, Arima K, Mizuno Y, Hattori N: Expression pattern
of tau mRNA isoforms correlates with susceptible lesions in progressive
supuranuclear palsy and corticobasal degeneration. Mol Brain Res
104: 210-219, 2002
- Takanashi M, Ohta S, Matsuoka S, Mori H, Mizuno Y: Mixed multiple
system atrophy and progressive supranuclear palsy: a clinical and
pathological report of one case. Acta Neuropathol 103: 82-87,
2002
- Tanaka M, Fuku N, Takeyasu T, Guo L-J, Hirose R, Kurata M, Borgeld
HJ, Yamada Y, Maruyama W, Arai Y, Hirose N, Oshida Y, Sato Y, Hattori
N, Mizuno Y, Iwata S, Yagi K: Golden mean to longevity: Rareness of
mitochondrial cytochrome b variants in centenarians but not in patients
with Parkinson’s disease. J Neurosci Res 70: 347-355, 2002
- Tanaka R, Mochizuki H, Suzuki A, Ishitani R, Katsube N, Mizuno Y,
Urabe T: Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
expression in rat brain after focal ischemia/reperfusion. J Cereb
Blood Flow Metab 22: 280-288, 2002
- Tsuboi Y, Baker M, Hutton ML, Uitti RJ, Rascol O, Delisle MB, Soulages
X, Murrell JR, Ghetti B, Yasuda M., Komure O. Kuno S, Arima K, Sunohara
N, Kobayashi T, Mizuno Y, Wszolek ZK: Clinical and genetic studies
of families with the tau N279K mutation (FTDP-17). Neurology
59: 1791−1793, 2002
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木村 洋子 (東京都臨床医学総合研究所)
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青木 正志 (東北大学・医学部附属病院・神経内科)
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荒若 繁樹 (山形大学・医学部)
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有賀 寛芳 (北海道大学・大学院薬学研究科)
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池谷 裕二 (東京大学・薬学部)
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田邊 勉 (東京医科歯科大学・大学院医歯学総合研究科)
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程 久美子 (東京大学・大学院理学系研究科)
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遠山 正彌 (大阪大学・大学院医学系研究科)
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中井 彰 (山口大学・大学院医学研究科)
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永井 義隆 (大阪大学・大学院医学系研究科)
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長野 精一 (大阪大学・大学院医学系研究科)
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松井 秀樹 (岡山大学・大学院医歯学総合研究科)
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松山 知弘 (兵庫医科大学・医学部・総合内科)
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三浦 正幸 (東京大学・大学院薬学系研究科)
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