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平成12年度〜平成16年度
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ゲノム班

朝田　隆　（筑波大学・臨床医学系） Ohkubo T, Sakasegawa Y, Asada T, Kinoshita T, Goto Y, Kimura H, Mizusawa H, Hachiya NS, Kaneko K: Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer’s disease in Japan. Ann Neurol 54: 553-554, 2003 Matsuda H, Ohnishi T, Asada T, Zhi-jie Li, Kanetaka H, Imabayashi E, Tanaka F, Nakano S: Correction for partial-volume effects on brain perfusion SPECT in healthy men. J Nucl Med 44: 1243-1252, 2003 Sakamoto S, Matsuda H, Asada T, Ohnishi T, Nakano S, Kanetaka H, Takasaki M: Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study. J Neuroimaging 13: 113-123, 2003 Tanaka N, Kinoshita T, Asada T, Ohashi Y: Long-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein E (apoE) gene in Alzheimer’s disease. J Hum Genet 48: 520-524, 2003 Sakasegawa Y, Kishida H, Sakurai M, Asada T, Kinoshita T, Goto Y, Kimura H, Kuroiwa Y, Hachiya NS, Kaneko K: Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer’s disease in a Japanese population. Neurosci Lett 353: 49-52, 2003 Yamaguchi M, Suzuki T, Seki T, Namba T, Juan R, Arai H, Hori T, Asada T: Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus. Ann NY Acad Sci 1025: 351-362, 2003 Zhi-Jie L, Matsuda H,Asada T, Ohnishi T, Kanetaka H, Imabayashi E, Tanaka F: Gender difference in brain perfusion 99m-ECD SPECT in aged healthy volunteers after correction for partial volume effects. Nucl Med Commun 25: 999-1005, 2004 Imabayashi E, Matsuda H, Asada T, Ohnishi T, Sakamoto S, Nakano S, Inoue T: Superiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer’s disease from controls using brain perfusion SPECT. J Nucl Med 45: 1450-1457, 2004 Kanetaka H, Matsuda H, Asada T, Ohnishi T, Yamashita F, Tanaka F, Nakano S, Takasaki Y: Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT. Eur J Nucl Med Mol Imaging 31: 975-980, 2004 Tanahashi H, Asada T, Tabira T: Association between tau polymorphism and male early-onset Alzheimer’s disease. NeuroReport 15: 175-180, 2004 Ishikawa M, Mizukami K, Iwakiri M, Hidaka S, Kamma H, AsadaT: Alterations of heterogeneous nuclear RNP A2 and B1 in the hippocampus of the rat after perforant pathway lesion. Acta Neuropathol 107: 144-148, 2004 Cichocki A, Shishkin SL, Musha T, Leonowicz Z, Asada T, Kurachi T: EEG fitering based on blind source separation (BSS) for early detection of Alzheimer’s disease. Clin Neurophysiol 116: 729-737, 2005 Tamura Y, Sakasegawa Y, Omi K, Kishida H, Asada T, Kimura H, Tokunaga K, Hachiya NS, Kaneko K, Hohjoh H: Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. Neurosci Lett 379: 149-151, 2005 Hirata Y, Matsuda H,Nemoto K, Ohnishi T, Hirano K, Yamashita F, Asada T, Iwabuchi S, Samejima H: Voxel-based morphometry to discriminate early Alzheimer’s disease from controls. Neurosci Lett 382: 269-274, 2005 Iwakiri M, Mizukami K, Ikonomovic MD, Ishikawa M, Hidaka S, Abrahamson EE, Dekosky ST, Asada T: Changes in hippocampal GABA(B)R1 subunit expression in Alzheimer’s patients: association with Braak staging. Acta Neuropathol 109: 467-474, 2005 荒井　啓行　（東北大学・大学院医学系研究科） Nakagawa T, Sekizawa K, Kosaka Y, Arai H, Sasaki H: Silent cerebral infarction: a potential risk for pneumonia in the elderly. J Intern Med 247: 255-259, 2000 Nakajoh K, Nakagawa T, Sekizawa K, Matsui T, Arai H, Sasaki H: Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral and tube feeding. J Intern Med 247: 39-42, 2000 Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, Itoh M, Shin R-W, Trojanowski JQ, Sasaki H: Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 162: 247-256, 2000 Wang Q, Iwasaki K, Suzuki T, Arai H, Ikarashi Y, Yabe T, Toriizuka K, Hanawa T, Yamada H, Sasaki H: Potentiation of brain acethylcholine neurons by Kami-Untan-To (KUT) in aged mice: Implication for a possible antidementia drug. Phytomedicine 7: 253-258, 2000 Iwasaki K, Wang Q, Seki H, Satoh K, Takeda A, Arai H, Sasaki H: The effects of the traditional Chinese medicine “Banxia Houpo Tang (Hange-Koboku To)” on the swallowing reflex in Parkinson’s disease. Phytomedicine 7: 259-263, 2000 Saito Y, Kawai M, Inose K, Sasaki R, Arai H, Namba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S: Widespread expression of a-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. J Neurol Sci 177: 48-59, 2000 Matsui T, Usuda N, Arai H, Nakazawa A, Matsushita S, Higuchi S, Sasaki H: Rapid non-radioactive in-situ hybridization for mRNA detection of calcineurin in rat brain using PCRDNA probe. Acta Histochem Cytochem 33: 115-122, 2000 Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: a2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer’s disease. NeuroReport 11: 1167-1171, 2000 Arai H. Ishiguro K, Ohno H, Moriyama M, Itoh N, Okamura N, Matsui T, Morikawa Y, Hirikawa E, Kohno H, Sasaki H, Imahori K: CSF phosphorylated tau protein and mild cognitive impairment: A prospective study. Exp Neurol 166: 201-203, 2000 Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H: NOS3 polymorphism not associated with Alzheimer’s disease in Japanese. Ann Neurol 48: 685, 2000 Hu XS, Okamura N, Arai H, Higuchi M, Matsui T, Shinkawa M, Itoh M, Ido T, Sasaki H: 18F-DOPA PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology 55: 1575-1576, 2000 Higuchi S, Yoshino A, Matsui T, Matsushita S, Satoh A, Iimura T, Ishikawa M, Arai H, Shirakura K: A novel PS1 mutation (W165G) in a Japanese family with early-onset Alzheimer’s disease. Alz Rep 3: 227-231, 2000 Kimpara T, Takeda A, Yamaguchi T, Arai H, Okita N, Takase S, Sasaki H, Itoyama Y: Increased bilirubins and their derivatives in cerebrospinal fluid in Alzheimer’s disease. Neurobiol Aging 21: 551-554, 2000 Ikeda K, Urakami K, Arai H, Wada K, Wakutani Y, Ji Y, Adachi A, Kowa H, Sasaki H, Ohno K, Ohtsuka Y, Ishikawa Y, Nakashima K: The expression of presenilin-1 mRNA in skin fibroblasts and brains from sporadic Alzheimer’s disease. Dement Geriatr Cogn Disord 11: 245-250, 2000 Higuchi M, Yanai K, Okamura N, Meguro K, Arai H, Itoh M, Iwata R, Ido T, Watanabe T, Sasaki H: Histamine H1 receptors in patients with Alzheimer’s disease assessed by positron emission tomography. Neuroscience 99: 721-729, 2000 Manabe K, Matsui T, Yamaya M, Sato-Nakagawa T, Okamura N, Arai H, Sasaki H: Sleep patterns and mortality among elderly patients in geriatric hospital. Gerontology 46: 318-322, 2000 Kanda A, Ebihara S, Arai H, Takeda A, Sasaki H: Parkinson’s disease and impaired chemosensitivity to hypoxia. Lancet 356: 2099-2100, 2000 Kimura M, Matsushita S, Arai H, Matsui T, Yuzuriha T, Higuchi S: No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer’s disease in Japanese. J Neural Transm 107: 1449-1456, 2000 Okamura N, Hu X-S, Arai H, Maruyama M, Higuchi M, Tashiro M, Matsui T, Itoh M, Sasaki H: Assessment of nitrostriatal dopaminergic function in patients with dementia with Lewy bodies. CYRIC Ann Rep: 116-118, 2000. Okamura N, Arai H, Higuchi M, Tashiro M, Maruyama M, Matsui T, Hu X-S, Itoh M, Sasaki H: Regional glucose hypometabolism in brain nof patients with dementia with Lewy bodies and Alzheimer’s disease. CYRIC Ann Rep: 119-122, 2000 Matsui T, Morikawa Y, Tojo M, Okamura N, Maruyama M, Hirai H, Chiba H, Matsushita S, Higuchi S, Arai H, Sasaki H: Cathepsin D polymorphism not associated with Alzheimer’s disease in Japanese. Ann Neurol 49: 544-545, 2001 Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Hu X-S, Takeda A, Itoh M, Sasaki H: [18F]FDG-PET study in dementia with Lewy bodies and Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiat 25: 447-456, 2001 Matsui T, Arai H, Yuzuriha T, Yao H, Miura M, Hashimoto S, Higuchi S, Matsushita S, Morikawa M, Kato A, Sasaki H: Elevated plasma homocysteine levels and a risk for silent brain infarction in elderly people. Stroke 32: 1116-1119, 2001 Wada H, Nakajoh K, Satoh-Nakagawa T, Suzuki T, Ohrui T, Arai H, Sasaki H: Risk factors of aspiration pneumonia in Alzheimer’s disease patients. Gerontology 47: 271-276, 2001 Matsushita S, Arai H, Yuzuriha T, Kato M, Matsui T, Urakami K, Higuchi S: No association between DLST gene and Alzheimer’s disease or Wernicke-Korsakoff syndrome. Neurobiol Aging 22: 569-574, 2001 Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido CT: Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci 13: 1-15, 2001 Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of Apolipoprotein E mRNA in the brains with sporadic Alzheimer’s disease. Dement Geriatr Cogn Disord 12: 57-62, 2001 Kimura M, Matsushita S, Arai H, Takeda A, Higuchi S: No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson’s disease. Ann Neurol 49: 276-277, 2001 Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller H-J, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multi-center study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease. Ann Neurol 50: 150-156, 2001 Okamura N, Arai H, Maruyama M, Matsui T, Tanji H, Yoshida H, Sugita M, Sasaki H: Serum cholesterol and cerebrospinal fluid amyloid β protein in Alzheimer’s disease. J Am Geriatr Soc 49: 1738-1739, 2001 Takeda M, Tanaka T, Arai H, Sasaki H, Shiji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid1-42 in cerebrospinal fluid as a diagnostic marker for Alzheimer’s disease and related disorders: Multi-center study in Japan. Psychogeriatrics 1: 56-63, 2001 Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikase C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001 Nakazawa A, Usuda N, Matsui T, Hanai T, Matsushita S, Arai H, Sasaki H, Higuchi S: Localization of calcineurin in the mature and developing retina. J Histochem Cytochem 49: 187-195, 2001 Maruyama M, Arai H, Sugita M, Tanji H, Higuchi M, Okamura N, Matsui T, Higuchi S, Matsushita S, Yoshida H, Sasaki H: Cerebrospinal fluid amyloid β1-42 in the mild cognitive impairment stage of Alzheimer’s disease. Exp Neurol 172: 433-436, 2001 Sato E, Ohrui T, Matsui T, Arai H, Sasaki H: Folate deficiency and risk of pneumonia in older people. J Am Geriatr Soc 49: 1739-1740, 2001 Yamaya M, Yanai M, Ohrui T, Arai H, Sekizawa K, Sasaki H: Antithrombotic therapy for prevention of pneumonia. J Am Geriatr Soc 49: 687-688, 2001 Suzuki T, Arai H, Iwasaki K, Tanji H, Higuchi M, Okamura N, Matsui T, Maruyama M, Yabe T, Toriizuka K, Yamada H, Hanawa T, Ikarashi Y, Sasaki H: A Japanese herbal medicine (Kami-Untan-To) in the treatment of Alzheimer’s disease: A pilot study. Alz Rep 4: 177-182, 2001 Yamagata K, Wakutani Y, Urakami K, Wada K, Arai H, Sasaki H, Higuchi S, Sato K, Nakashima K: Apolipoprotein E promotor -186G/T polymorphism and Japanese Alzheimer’s disease. Alz Rep 4: 161-165, 2001 Wakutani Y, Ito T, Wada K, Yamagata K, Adachi Y, Taniguchi M, Arai H, Sasaki H, Higuchi S, Sato K, Urakami K, Nakashima K: Identification of aberrant tau mRNA in brain tissue. Alz Rep 4: 145-150, 2001 Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol 52: 501-509, 2001 Tashiro M, Itoh M, Kubota K, Kumano H, Masud MM, Moser EM, Arai H, Sasaki H: Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary PET study. Psycho-Oncology 10: 541-546, 2001 Okamura N, Arai H, Maruyama M, Higuchi M, Matsui T, Tanji H, Seki T, Hirai H, Chiba H, Itoh M, Sasaki H: Combined analysis of CSF-tau and [123I]Iodoamphetamine-SPECT in mild cognitive impairment: Implications for a novel predictor of Alzheimer’s disease. Am J Psychiat 159: 474-476, 2002 Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi K, Matsui T, Maruyama M, Iwatsubo T, Higuchi S: Clinical and bio-marker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild impairment stage of Alzheimer’s disease. Biol Psychiat 52: 907-1910, 2002 Buerger K, Zinkowski R, Teipel SJ, Tapiola T, Arai H, Blennow K, Andreasen N, Hofmann-Kiefer K, DeBernardis J, Kerkman D, McCulloch C, Kohnken R,Padberg F, Pirttilä P, Schapiro MB, Rapoport SI, Möller H-J, Davies P, Hampel H: Differential diagnosis of Alzheimer’s disease with CSF tau proteinphosphorylated at threonine 231. Arch Neurol 59: 1267-1272, 2002 Ebihara T, Yamaya M, Ohrui T, Arai H, Sasaki H: Comparison of disabled older people in the USA and Japan. Geriatr Gerontol Int 2: 53-56, 2002 Ohrui T, Arai H, Ichinose M, Matsui T, Yamaya M, Sasaki H: Relationship between asthma severity and progression of Alzheimer’s disease. Thorax 57: 561, 2002 Matsui T, Yamaya M, Ohrui T, Arai H, Sasaki H: Sitting position to prevent aspiration in bed-ridden patients. Gerontology 48: 194-195. 2002 Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Fujii T, Komemushi S, Itoh M, Sasaki H, Watanabe T, Yanai K: Differential cognitive effects of ebastine and (+)-chorphenilamine in healthy subjects: correlation between cognitive impairment and plasma drug concentrations. Br J Clin Pharmacol 53: 296-304, 2002 Hu XiaSheng, Okamura N, Arai H, Higuchi M, Maruyama M, Itoh M, Yamaguchi K, Sasaki H: Neuroanatomical correlates of low body weight in Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiat 26: 1285-1289, 2002 Buerger K, Teipel SJ, Zinkowski R, Blennow K, Arai H, Engel R, Hofman K: CSF-tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 59: 627-629, 2002 Li JQ, Jia YX, Yamaya M, Arai H, Ohrui T, Sekizawa T, Sasaki H: Neurochemical regulation of cough response to capsaicin in guinea-pig. Auton Autacoid Pharmacol 22: 57-63, 2002 Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathologcal study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neurosci Lett 300: 84-88, 2002 Shinkawa M, Yamaya M, Ohrui T, Arai H, Sasaki H: Depression in older people. Geriatr Gerontol Int 2: 215-216, 2002 Maruyama M, Arai H, Okamura N, Matsui M, Sasaki H: Biomarkers in subjects with amnestic mild cognitive impairment. J Am Geriatr Soc 51: 1671-1672, 2003 Arai H, Matsui T, Maruyama M, Okamura N, Sasaki H: Classification of dementias. Lancet 361: 1227-1228, 2003 Kanda A, Matsui T, Ebihara S, Arai H, Sasaki H: Periventricular white matter lesions and sleep alternation in older people. J Am Geriatr Soc 51: 432-433, 2003 Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinson’s disease. Ann Neurol 54: 276-277, 2003 Seki T, Kurusu M, Haruko Tanji, Arai H, Sasaki H: Acupuncture and swallowing reflex in poststroke patients. J Am Geriatr Soc 51: 726-727, 2003 Buerger K, Zinkowski R, Teipel SJ, Arai H, DeBernardis J, Kerkman D: Differentiation between geriatric major depression and Alzheimer’s disease with CSF tau protein phosphorylated at threonine 231. Am J Psychiat 160: 376-379, 2003 Clark CM, Ewbank D, Peskind E, Galasko D, Morris JC, Farlow M, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, DeCarli C, Leight S, Lee VM-Y, Trojanowski JQ: Cerebrospinal fluid tau and β-amyloid: How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Arch Neurol 60: 1696-1702, 2003 Itoh N, Ishiguro K, Arai H, Kokubo Y, Sasaki R, Narita Y, Kuzuhara S: Biochemical and ultrastructual study of neurofibrillary tangles in amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii peninsula of Japan. J Neuropathol Exp Neurol 62: 791-798, 2003 Matsui T, Arai H, Nakajo M, Maruyama M, Ebihara S, Sasaki H, Yoshida Y: Role of chronic sinusitis in cognitive functioning in the elderly. J Am Geriatr Soc 51: 1818-1819, 2003 Kosaka Y, Satoh-Nakagawa T, Ohrui T, Yamaya M, Arai H, Sasaki H: Tube feeding in terminal care. Geriatr Gerontol Int 3: 172-174, 2003 Ebihara S, Saito H, Kanda A, Nakajoh M, Takahashi H, Arai H, Sasaki H: Impaired efficacy of cough in patients with parkinson’s disease. Chest 124: 1009-1015, 2003 Okamura N, Maruyama M, Ebihara T, Arai H, Sasaki H: Aspiration pneumonia and insular hypoperfusion in patients with cerebrovascular disease. J Am Geriatr Soc 52: 645-646, 2004 Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H. Cyong J-C, Sasaki H: A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine Ba Wei Di Huang Wan in the treatment of dementia. J Am Geriatr Soc 52: 1518-1521, 2004 Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, Sasaki H, Kudo Y, Sawada T: Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci 24: 2535-2541, 2004 Okamura N, Suemoto T, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Arai H, Sasaki H, Yanai K, Staufenbiel M, Kudo Y, Sawada T: A novel imaging probe for in vivo detection of neuritic and duffuse plaques in the brain. J Mol Neurosci 24: 247-256, 2004 Maruyama M, Matsui T, Tanji H, Memoto M, Tomita N, Ootsuki M, Arai H, Sasaki H: Cerebrospinal fluid tau protein and periventricular white matter lesions in aging, stable and progressive mild cognitive impairment: Implications for two major pathways. Arch Neurol 61: 716-720, 2004 Ohrui T, Matsui T, Yamaya M, Arai H, Ebihara S. Maruyama M, Sasaki H: Angiotensin converting enzyme inhibitors and incidence of Alzheimer’s disease in Japan. J Am Geriatr Soc 52: 649-650, 2004 Seki T, Kurusu M, Arai H, Sasaki H: Acupuncture for gait disorders in the elderly. J Am Geriatr Soc 52: 643-644, 2004 Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H, Cyong J-C, Sasaki H: Effects of the Chinese herbal medicine “Ba Wei Di Huang Wan” in the reatment of dementia: A SPECT cerebral blood flow examination and a randomized, double-blind, placebo-controlled clinical trial for cognitive function and ADL. Geriatr Gerontol Int 4: S124-128, 2004 Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L-O, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, De Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack A, Jorm A, Richie K, Van Dubin C, Visser P, Petersen RC: Mild cognitive impairment-beyond controversies towards consensus: report of the international working group on Mild cognitive impairment. J Intern Med 256: 240-246, 2004 Kikuchi A, Takeda A, Fujihara K, Kimpara T, Shiga Y, Tanji H, Nagai M, Ichinose H, Urano F, Okamura N, Arai H, Itoyama Y: Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: A case report. Mov Disord 19: 590-593, 2004 Horikawa E, Okamura N, Tashiro M, Sakurada Y, Maruyama M, Arai H, Yamaguchi K, Sasaki H, Yanai K, Itoh M: The neural correlates of driving performance identified using positron emission tomography. Brain Cogn 58: 166-171, 2004 Nakagawasai O, Yamadera F, Iwasaki K, Arai H, Taniguchi R, Tan-no K, Sasaki H, Tadano T: Effect of Kami-Untan-To on the impairment of leaning and memory induced by thiamine-deficient feeding in mice. Neuroscience 125: 233-241, 2004 Ohrui T, Tomita N, Satoh-Nakagawa T, Matsui T, Maruyama M, Niwa K, Arai H, Sasaki H: Effects of brain-penetrating ACE inhibitors on Alzheimer’s disease progression. Neurology 63: 1324-1325, 2004 Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H: A randomized observer-blind controlled trial of a traditional chinese medicine, Yi-Gan San, on behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiat 66: 248-252, 2005 Tanji H, Ootsuki M, Matsui T, Maruyama M, Nemoto M, Tomita N, Seki T, Iwasaki K, Arai H, Sasaki H: Caregiver’s burden and use of public services among dementia caregivers. Geriatr Gerontol Int 5：94-98, 2005 Arai H, Maruyama M: The heterogeneity and natural history of mild cognitive impairment. Arch Neurol 62: 163-164, 2005 Yamada M, Ohrui T, Asada M, Ishizawa K, Ebihara S, Arai H, Sasaki H: Acarbose attenuates hypoglycemia from dumping syndrome in an elderly man with gastrectomy. J Am Geriatr Soc 53: 58-359, 2005 Mochizuki H, Masaki T, Matsushita S, Ugawa Y, Kamakura K, Arai H, Motoyoshi K, Higuchi S: Cognitive impairment and diffuse white matter atrophy in alcoholics. Clin Neurophysiol 116: 223-228, 2005 Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease. J Neural Transms 112: 703-711, 2005 Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Kurayama S, Kohriyama T, Katayama S, Yamashita M, Mamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M: Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease. Neurology 64: 643-648, 2005 Seki T, Iwasaki K, Arai H, Sasaki H, Hayashi H, Yamada S, Toba K: Acupuncture for dysphasia in poststroke patients: A videofluoroscopic study. J Am Geriatr Soc 53: 1083-1084, 2005 新井　平伊　（順天堂大学・医学部） Maruyama H, Toji H, Harrington CR, Sasaki K, Izuka Y, Ohnuma T, Arai H, Yasuda M, Tanaka C, Emson PC, Nakamura S, Kawakami H: Lack of an association of estrogen reseptor α gene polymorphisms and transcriptional activity with Alzheimer’s Disease. Arch Neurol 57: 236-240, 2000 Shibata N, Ohnuma T, Takahasi T, Ohtsuka E, Ueki A, Nagao M, Arai H: No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer’s disease. Neurosci Lett 290: 154-156, 2000 Ishizuka T，Baba H, Higashi H, Arai H: Circulating natural killer cell activity and cytokine production in Alzheimer’s disease. Alz Rep 4: 81-85, 2001 Higashi H, Ohnuma T, Shibata N, Ishizuka T, Higashi M, Ohtuka E, Ueki A, Nagao M, Arai H: Association of transforming growth factor-β1 gene polymorphisms in Japanese sporadic Alzheimer’s disease. Alz Rep 5: 21-24, 2002 Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet 114: 436-439, 2002 Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer's disease. Neurosci Lett 323: 161-163, 2002 Matsubara Y, Ohnuma T, Shibata N, Takahashi T, Arai H: Plasma concentration of risperidone showed a correlation with daily dose,but not with age nor cytochrome P-450 2D6 gene polymorphisms in Japanese schizophrenics. Psychogeriatrics 2: 284-288, 2002 Ohnuma T, Shibata N, Matsubara Y, Arai H: Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6. Br J Clin Pharmacol 56: 315-320, 2003 植木　彰　（自治医科大学・大宮医療センター） Kamino K, Nagasaka K, Yamamoto H, Yoneda H, Miki T, Imagawa M, Ueki A, Kitamura S, Namekata K, Ohta S: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in Japanese population. Biochem Biophys Res Commun 273: 192-196, 2000 Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: Alzheimer's disease and 5-HTTLRP polymorphism of the serotonin transporter gene: No evidence for an association. Am J Med Genet 96: 307-309, 2000 Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer’s disease. J Neural Transm 107: 1081-1084, 2000 Shibata N, Ohnuma T, Takahashi T, Otsuka E, Ueki A, Nagao M, Arai H: No genetic association between α-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer’s disease. Neurosci Lett 290: 154-156, 2000 Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabita T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiat 6: 83-86, 2001 Shibata N, Ohnuma T, Takahasi T, Baba H, Ishizuka T, Otsuka M, Ueki A, Nagao M, Arai H: The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer’s disease. Neurosci Lett 323: 161-163, 2002 Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet 114: 436-439, 2002 浦上　克哉　（鳥取大学・医学部） Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Down’s syndrome. Alz Rep 3: 77-82, 2000 Urakami K, Wada-Isoe K, Wakutani Y, Ikeda K, Ji Y, Yamagata K, Kowa H, Okada A, Adachi Y, Nakashima K: Lipoprotein(a) phenotypes in patients with vascular dementia. Dement Geriatr Cogn Disord 11: 135-138, 2000 Ikeda K, Urakami K, Arai H, Wada K, Wakutani Y, Ji Y, Adachi Y, Okada A, Kowa H, Sasaki H, Ohno K, Ohtsuka Y, Ishikawa Y, Nakashima K: The expression of presenilin 1 mRNA in skin fibroblasts and brains from sporadic Alzheimer’s disease. Dement Geriatr Cogn Disord 11: 245-250, 2000 Ji Y, Urakami K, Wada-Isoe K, Adachi Y, Nakashima K: Estrogen receptor gene polymorphisms in patients with Alzheimer’s disease, vascular dementia and alcohol-associated dementia. Dement Geriatr Cogn Disord 11: 119-122, 2000 Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K: The homozygous C677T mutation in the methylenetetrahydrifolate reductase gene is a genetic risk factor for migraine. Am J Med Genet 96: 762-764, 2000 Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: α2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer’s disease. NeuroReport 11: 1167-1171, 2000 Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer’s disease. Dement Geriatr Cogn Disord 12: 57-62, 2001 Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H: NOS3 polymorphism not associated with Alzheimer’s disease in Japanese. Ann Neurol 48: 685, 2000 Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid (1-42) in cerebrospinal fluid as a diagnostic marker for Alzheimer’s disease and related disorders: multi center study in Japan. Psychogeriatrics 1: 56-63, 2001 Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller HJ, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease. Ann Neurol 50: 150-156, 2001 Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K. Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001 Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002 Wakutani Y, Kowa H, Kusumi M, Yamagata K, Wada-Isoe K, Adachi Y, Takeshima T, Urakami K, Nakashima K: Genetic analysis of vascular factors in Alzheimer’s disease. Ann NY Acad Sci 977: 232-238, 2002 Watanabe Y, Shimizu Y, Urakami K, Matsushima E, Nakashima K: Vertical ophthalmoplegia in a demented patient with striatopallidodentate calcification. Psychiat Clin Neurosci 57: 447−450，2003 Inoue M, Suyama A, Kato T, Urakami K, Nakashima K, Meshitsuka S: Development of computerized Kana pick out test for the neuropsychological examination. Comput Methods Programs Biomed 70: 271-276, 2003 Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y, Mori M, Kawashima M, Kowa H, Adachi Y, Urakami K, Nakashima K: Population based door-to-door survey of migraine in Japan: the Daisen study. Headache 44: 8-19, 2004 Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimer’s disease. Dement Geriatr Cogn Disord 17: 147-150, 2004 Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer’s disease. Neurobiol Aging 25: 291-294, 2004 Wakutani Y, Watanabe K, Adachi Y, Isoe-Wada K, Urakami K, Ninomiya H, Hashimoto H, Saido TC, Iwatsubo T, Nakashima K: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer’s disease. J Neurol Neurosurg Psychiat 75: 1039-1042, 2004 Wada-Isoe K, Wakutani Y, Urakami K, Nakashima K: Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients. Acta Neurol Scand 110: 124-127, 2004 Hattori S, Sakuma K, Wakutani Y, Wada K, Shimoda M, Urakami K, Kowa H, Nakashima K: A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimer’s disease with spastic paraparesis. Neurosci Lett 368: 319-322, 2004 Urakami K: Vascular factors in Alzheimer’s disease. Psychogeriatrics 4: 123-125, 2004 Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aβ homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004 Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease．J Neural Transm 112: 703-771, 2005 Urakami K: Early diagnostic marker for Alzheimer’s disease. World J Biol Psychiat 6: 46, 2005 太田　成男　（日本医科大学・老人病研究所） Asoh S, Ohtsu T, Ohta, S: The Super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J Biol Chem 275: 37240-37245, 2000 Hatanaka Y, Kamino K, Fukuo K, Mistuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T: Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer’s disease in a Japanese population. Clin Genet 58: 319-323, 2000 Yasukawa T, Hino T, Suzuki T, Watanabe K, Ueda T, Ohta S: A pathogenic point mutation reduces stability of mitochondrial mutant tRNAlle. Nucl Acids Res 28: 3779-3784, 2000 Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer’s disease in the Japanese population. Biochem Biophys Res Commun 273: 192-196, 2000 Nanbu-Wakao R, Asoh S, Nishimaki K, Tanaka R, Ohta S: Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNaseE mutant that functions in an anti-oxidant pathway. 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Neurology 54: 950-955, 2000 Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S: The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently. Neurobiol Aging 22: 209-215, 2001 Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid(1-42) in cerebraospinal fluid as a diagnositic marker for Alzheimer’s disease and related disorders: multi center study in Japan. Psychogeriatrics 1: 56-63, 2001 Dobrogowska DH, Vorbrodt AW, Wegiel J, Wang KC, Shoji M, Mondadori C, Polatis G, Giovanni A, Wisniewski HM: Cytochemical study of the involvement of cell organelles in formation and accumulation of fibrillar amyloid in the pancreas of NORβ transgenic mice. Histol Histopathol 16: 1047-1056, 2001 Manabe Y, Warita H, Murakami T, Shiote M, Hayashi T, Nagano I, Shoji M, Abe K: Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene. Brain Res 915: 104-107, 2001 Manabe Y, Wang JM, Murakami T, Warita H, Hayashi T, Shoji M, Abe K: Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite. J Neurosci Res 65: 371-377, 2001 Paganelli AR, Ocana OH, Prat MI, Franco PG, Lopez SL, Morelli L, Adamo AM, Riccomagno MM, Matsubara E, Shoji M, Affranchino JL, Castano EM, Carrasco AE: The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mech Dev 107: 119-131, 2001 Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M: Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol 194: 500-506, 2001 Murakami T, Nagano I, Hayashi T, Manabe Y, Shoji M, Setoguchi Y, Abe K: Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene. Neurosci Lett 308: 149-152, 2001 Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001 Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park JM, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M: Aβ amyloidosis induces the initial stage of tau accumulation in APP (sw) mice. Neurosci Lett 299: 169-172, 2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer’s disease. J Neurosci 21: 372-381, 2001 Manabe Y, Murakami T, Iwatsuki K, Narai H, Warita H, Hayashi T, Shoji M, Imai Y, Abe K: Nocturnal blood pressure dip in CADASIL. J Neurol Sci 193: 13-16, 2001 Murakami T, Iwatsuki K, HayashiT, Sato K, Matsubara E, Nagano I, Manabe Y, Shoji M, Abe K: Two Japanese CADASIL families with a R141C mutation in the Notch3 gene. Int Med 40: 1144-1148, 2001 Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K: Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiat 70: 386-389, 2001 Shoji M, Kanai M: Cerebrospinal fluid Aβ40 and Aβ42: natural course and clinical usefulness. J Alz Dis 3: 313-321, 2001 Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe W, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ich K, Yoshida H, Toji, H Nakamura S, Hirai H: Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002 Shoji M, Fukushima K, Wakayama M, Shizuka-Ikeda M, Ikeda Y, Kawakami A, Sakazume Y, Ikeda M, Harigaya Y, Matsubara E, Kawarabayashi T, Murakami T, Nagano I, Manabe Y, Abe K: Intellectual faculities in patients with Alzheimer’s disease regress to the level of a 4-5-year old child. Geriat Gerontol Int 2: 143-147, 2002 Matsubara E, Shoji M, Murakami T, Abe K, Frangione B, Ghiso J: Platelet microparticles as carriers of soluble Alzheimer’s amyloid β (Aβ). Ann NY Acad Sci 977: 340-348, 2002 Abe K, Murakami T, Matsubara E, Manabe Y, Nagano I, Shoji M: Clinical Features of CADASIL. Ann NY Acad Sci 977: 266-272, 2002 Kamada H, Sato K, Iwai M, Zhang WR, Nagano I, Manabe Y, Shoji M, Abe K: Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats. Ann NY Acad Sci 977: 115-22, 2002 Jin G, Omori N, Li F, Sato K, Nagano I, Manabe Y, Shoji M, Abe K: Activation of cell-survival signal Akt by GDNF in normal rat brain. Brain Res 958: 429-33, 2002 Li F, Omori N, Sato K, Jin G, Nagano I, Manabe Y, Shoji M, Abe K: Coordinate expression of survival p-ERK and proapoptotic cytochrome c signals in rat brain neurons after transient MCAO. Brain Res 958: 83-88, 2002 Omori N, Jin G, Li F, Zhang WR, Wang SJ, Hamakawa Y, Nagano I, Manabe Y, Shoji M, Abe K: Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Brain Res 954: 317-322, 2002 Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neuritis. Virchows Arch 441: 358-367, 2002 Wang SJ, Omori N, Li F, Zhang WR, Jin G, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Enhanced expression of phospho-Akt by electro-acupuncture in normal rat brain. Neurol Res 24: 719-724, 2002 Sato K, Murakami T, Hamakawa Y, Kamada H, Nagano I, Shoji M, Takata H, Nobukuni K, Ihara Y, Namba R, Hayabara T, Hirose S, Abe K: Selective colocalization of transglutaminase-like activity in ubiquitinated intranuclear inclusions of hereditary dentatorubral-pallidoluysian atrophy. Brain Res 952: 327-330, 2002 Wang SJ, Omori N, Li F, Jin G, Zhang WR, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats. Neurosci Lett 331: 115-8, 2002 Sato K, Iwai M, Nagano I, Shoji M, Abe K: Temporal and spatial changes of BrdU immunoreactivity in amygdala kindling development. Neurol Res 24: 593-596, 2002 Warita H, Manabe Y, Murakami T, Shiote M, Shiro Y, Hayashi T, Nagano I, Shoji M, Abe K: Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1. Neurol Res 24: 577-581, 2002 Sato K, Iwai M, Nagano I, Shoji M, Abe K: Changes of localization of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in rat hippocampus with exposure to repeated kindled seizures. Brain Res 946: 323-327, 2002 Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Setoguchi Y, Abe K: Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Apoptosis 7: 329-334, 2002 Manabe Y, Warita H, Murakami T, Shiote M, Hayashi T, Omori N, Nagano I, Shoji M, Abe K: Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis. Brain Res 935: 124-128, 2002 Prat MI, Adamo AM, Gonzalez SA, Affranchino JL, Ikeda M, Matsubara E, Shoji M, Smith MA, Castano EM, Morelli L: Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein : relevance for neurodegeneration. Neurosci Lett 326: 9-12, 2002 Sato K, Iwai M, Nagano I, Shoji M, Abe K: Expression of highly polysialylated neural cell adhesion molecule in rat subventricular zone with exposure to repeated kindled seizures. Neurosci Lett 323: 244-246, 2002 Iwai M, Sato K, Omori N, Nagano I, Manabe Y, Shoji M, Abe K: Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia. J Cereb Blood Flow Metab 22: 411-419, 2002 Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castano EM, St George-Hyslop P, Shoji M: Generation of amyloid beta protein from a presenilin-1 and βAPP complex. Biochem Biophys Res Commun 292: 571-578, 2002 Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE: Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9: 11-23, 2002 Ohta Y, Hayashi T, Sasaki C, Shiote M, Manabe Y, Shoji M, Abe K: Cauda equina syndrome caused by idiopathic sacral epidural lipomatosis. Intern Med 41: 593-594, 2002 Ohta Y, Manabe Y, Sasaki C, Shiote M, Hayashi T, Shoji M, Abe K: A case of paroxysmal kinesigenic dyskinesia with spastic paraparesis. Neurol Res 24: 684-686, 2002 Manabe Y, Narai H, Warita H, Hayashi T, Shiro Y, Sakai K, Kashihara K, Shoji M, Abe K: Benign adult familial myoclonic epilepsy (BAFME) with night blindness. Seizure 11: 266-268, 2002 Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem 278: 51901-51910, 2003 Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. J Neurochem 85: 1101-1108, 2003 Kamada H, Sato K, Zhang WR, Omori N, Nagano I, Shoji M, Abe K: Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain. J Neurosci Res 73: 545-556, 2003 Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K: Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein. J Neurol Sci 215: 57-62, 2003 Wang SJ, Omori N, Li F, Jin G, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats. Neurol Res 25: 516-521, 2003 Murakami T, Ilieva H, Shiote M, Nagata T, Nagano I, Shoji M, Abe K: Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene. Brain Res 989: 231-237, 2003 Manabe Y, Wang JM, Shiote M, Murakami T, Nagano I, Shoji M, Abe K: Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats. Neurol Res 25: 312-316, 2003 Omori N, Maruyama K, Jin G, Li F, Wang SJ, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferring. Neurol Res 25: 275-259, 2003 Jin G, Omori N, Li F, Nagano I, Manabe Y, Shoji M, Abe K: Protection against ischemic brain damage by GDNF affecting cell survival and death signals. Neurol Res 25: 249-253, 2003   Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Abe K: Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 25: 195-200, 2003 Iwai M, Sato K, Kamada H, Omori N, Nagano I, Shoji M, Abe K: Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils. J Cereb Blood Flow Metab 23: 331-341, 2003 Sato K, Iwai M, Nagano I, Shoji M, Abe K: Temporal and spatial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development. Neurol Res 25: 79-82, 2003 Li F, Omori N, Jin G, Wang SJ, Sato K, Nagano I, Shoji M, Abe K: Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO. Brain Res 962: 21-26, 2003 Ohta K, Iwai M, Sato K, Omori N, Nagano I, Shoji M, Abe K: Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. Neurosci Lett 335: 159-162, 2003 Kamada H, Sato K, Iwai M, Zhang WR, Nagano I, Manabe Y, Shoji M, Abe K: Temporal and spatial changes of free cholesterol and neutral lipids in rat brain after transient middle cerebral artery occlusion. Neurosci Res 45: 91-100, 2003 Moreira MC, Klur S, Watanabe M, Nemeth AH, Ber IL, Moniz JC, Tranchant C, Aubourg P, Tazir M, Schols L, Pandolfo M, Schulz JB, Pouget J, Calvas P, Shizuka-Ikeda M, Shoji M, Tanaka M, Izatt L, Shaw CE, M'Zahem A, Dunne E, Bomont P, Benhassine T, Bouslam N, Stevanin G, Brice A, Guimaraes J, Mendonca P, Barbot C, Coutinho P, Sequeiros J, Durr A, Warter JM, Koenig M: Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet 69: 225-227, 2004 Ikeda Y, Dalton JC, Moseley ML, Gardner KL, Bird TD, Ashizawa T, Seltzer WK, Pandolfo M, Milunsky A, Potter NT, Shoji M, Vincent JB, Day JW, Ranum LP: Spinocerebellar ataxia type 8: molecular genetic comparisons and haplotype analysis of 37 families with ataxia. Am J Hum Genet 75: 3-16, 2004 Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric Aβ rapidly accumulates in lipid rafts followed by ApoE and phosphorylated tau as memory is impaired in the Tg2576 mouse model of Alzheimer’s Disease. J Neurosci 24: 3801-3809, 2004 Murakami T, Shoji-M, Imai Y, Inoue H, KawarabayashiT, Matsubara E, Harigaya Y, SasakiA, Takahashi R, AbeK: Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Ann Neurol 55: 439-442, 2004 Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25: 483-490, 2004 Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aβ homeostasis in AD and DS : impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004 Li F, Omori N, Hayashi T, Jin G, Sato K, Nagano I, Shoji M, Abe K: Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046. J Neurosci Res 76: 383-389, 2004 Hamakawa Y, Omori N, Ouchida M, Nagase M, Sato K, Nagano I, Shoji M, Fujita T, Abe K: Severity dependent up-regulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats. Neurol Res 26: 767-773, 2004 Morimoto N, Nagano I, Deguchi K, Murakami T, Fushimi S, Shoji M, Abe K: A case of Leber’s hereditary optic neuropathy (LHON) with chorea and dementia resembling Huntington’s disease. Neurology 63: 2451-2452, 2004 Kurata T, Matsubara E, Yokoyama M, Nagano I, Shoji M, Abe K: Improvement of SSPE by intrathecal infusion of α-IFN. Neurology 63: 398-399, 2004 Yamashita T, Matsubara E, Nagano I, Shoji M, Abe K: Bilateral extraocular muscle atrophy in myotonic dystrophy type 1. Neurology 63: 759-760, 2004 Ohta Y, Nagano I, Niiya D, Fujioka H, Kishimoto T, Shoji M, Abe K: Nonparaneoplastic limbic encephalitis with relapsing polychondritis. J Neurol Sci 220: 85-88, 2004 Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Davies P, Chishti M A, Harigaya Y, Okamoto K, Abe K, Carlson GA, St.George-Hyslop P, Westaway D: Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol 166: 521-531, 2005 Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T: Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease. FASEB J 19: 255-257, 2005 Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St. George-Hyslop P, Nishimura M: Random mutagenosis of presenilin 1 identifies novel mutation exclusively generating long amyloid β peptides. J Biol Chem 280: 19070-19077, 2005 Nagotani S, Hayashi T, Deguchi K, Nagano I, Shoji M, Abe K: Reduction of cerebral infarction in SHR-SP by statins associated with amelioration of oxidative stress. Stroke 6: 670-672, 2005. Jin G, Hayashi T, Kawagoe J, Takizawa T, Nagata T, Nagano I, Shoji M, Abe K: Deficiency of PAR-2 gene increases acute focal ischemic brain injury. J Cereb Blood Flow Metab 25: 302-313, 2005 Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K: Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 132: 175-182, 2005 Kamada H, Hayashi T, Sato K, Iwai M, Nagano I, Shoji M, Abe K: Up-regulation of low-density lipoprotein receptor expression in the ischemic core and the peri-ischemic area after transient MCA occlusion in rats. Mol Brain Res 134: 181-188, 2005 Deguchi K, Takaishi M, Hayashi T, Oohira A, Nagotani S, Li F, Jin G, Nagano I, Shoji M, Miyazaki M, Abe K, Huh NH: Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain. Brain Res 1037: 194-199, 2005 Hayashi T, Hamakawa K, Nagotani S, Jin G, Li F, Deguchi K, Sehara Y, Zhang H, Nagano I, Shoji M, Abe K: HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons. Brain Res 1037: 52-58, 2005 Hayashi T, Iwai M, Ikeda T, Jin G, Deguchi K, Nagotani S, Zhang H, Sehara Y, Nagano I, Shoji M, Ikenoue T, Abe K: Neural precursor cells division and migration in neonatal rat brain after ischemic/hypoxic injury. Brain Res 1038: 41-49, 2005 南光　進一郎　（帝京大学・医学部） Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. J Neural Transm107: 1081-1084, 2000 Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association. Am J Med Genet 96: 307-309, 2000 Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer’s disease. Mol Psychiat 6: 83-86, 2001 Kunugi H, Kato T, Fukuda R, Tatsumi M, Sakai T, Nanko S: Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders. J Neural Transm 109: 213-218, 2002 Hattori M, Kunugi H, Akahane A, Tanaka H, Ishida S, Hirose T, Morita R, Yamakawa K, Nanko S: Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. Am J Med Genet 114: 304-309, 2002 Hata T, Kunugi H, Nanko S, Fukuda R, Kaminaga T: Possible effect of the APOE varepsilon 4 allele on the hippocampal volume and asymmetry in schizophrenia. Am J Med Genet 114: 641-642, 2002 Akahane A, Kunugi H, Tanaka H, Nanko S: Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia. Schizophr Res 58: 37-41, 2002 Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N: No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans. Neurosci Lett 338: 21-24, 2003 Nanko S, Kunugi H, Hirasawa H, Kato N, Nabika T, Kobayashi S: Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62: 281-283, 2003 Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T: Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet 35: 171-175, 2003 Washizuka S, Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T: Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am J Med Genet 120: 72-78, 2003 樋口　進　（国立病院機構・久里浜アルコール症センター） Yamaya N, Nakayama K, Ebihara S, Hirai H, Higuchi S, Sasaki H: Relationship between microsatellite polymorphism in the haem oxynase-1 gene promoter and longevity of the normal Japanese population. J Med Genet 40: 146-148, 2003 Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K: Diabetic vasculopathy and alcohol torelance trait in type 2 diabetes. Diabetes Care 26: 246-247, 2003 Nakamura Y, Ishikawa A, Sekiguchi S, Kuroda M, Imazeki H, Higuchi S: Spirits and gastrectomy increase risk for chrnonic pancreatitis in Japanese male alcoholics. Pancreas 26: 27-31, 2003 Suzuki Y, Matsuura N, Suzuki S, Muramatsu T, Taniyama T, Ohta S, Higuchi S, Atusmi Y, Matsuoka K: Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Diabetes Res Clin Pract 60: 139-141, 2003 Mochizuki H, Masaki T, Kamakura K, Matsushita S, Kusunoki S, Higuchi S: Acute axonal polyneuropathy associated with alcoholism. Eur Neurol 50: 183-184, 2003 Mochizuki H, Masaki T, Miyakawa T, Nakane J, Yokoyama A, Nakamura Y, Okuyama K, Kamakura K, Motoyoshi K, Matsushita S, Higuchi S: Benign type of central potine myelinolysis in alcoholism: clinincal neuropathological and electrophysiological findings. J Neurol 250: 1077-1083, 2003 Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinson’s disease. Ann Neurol 54: 276-277, 2003 Yokoyama A, Yokoyama T, Muramatsu T, Omori T, Matsushita S, Higuchi S, Maruyama K, Ishii H: Macrocytosis, a new predictor of esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 24: 1773-1778. 2003 Miyatake R, Furukawa A, Matsushita S, Higuchi S, Suwaki H: Functional polymorphisms in the s1 receptor gene associated with alcoholism. Biol Psychiat 55: 85-90, 2004 Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Maruyama K, Niino N, Ando F, Shimokata H, Ohta S, Funakoshi A: Association of chelocystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol Alcohol 39: 25-28, 2004 Nakamura Y, Yokoyama H, Higuchi S, Hara S, Kato S, Ishii H: Acetaldehyde accumulation suppresses Kupffer cell release of TNF-α and modifies acute hepatitis in rats. J Gastroenterol 39: 140-147, 2004 Maruyama K, Higuchi S: The Japanese society of alcohol-related problems. Addiction 99: 419-424, 2004 Miyasaka K, Yoshida Y, Matsushita S,Higuchi S,Shirakawa O, Shimokata H, Funakoshi A: Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese. Am J Med Genet 127B: 78-80, 2004 Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S, Koike K, Okamura N, Matsushita S, Suzuki K, Murayama M, Higuchi S, Iyo M: Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders. Am J Med Genet 127B: 125-127, 2004 Adachi J, Matsushita S, Yoshioka N, Funae R, Fujita T, Higuchi S, Ueno Y: Plasma phosphatidylcholine hydroperoxidase as a new marker of oxidative stress in alcoholic patients. J Lipid Res 45: 967-971, 2004 Nakamura Y, Kobayshi Y, Ishikawa A, Maruyama K, Higuchi S: Severe chronic pancreatitis and severe cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics. J Gastroenterol 39: 879-887, 2004 Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, Shirakawa O, Higuchi S: Serotonin transporter regulatory region polymorphism is associated with “core” anorexia nervosa. Am J Med Genet 128B: 114-117, 2004 Masaki T, Mochizuki H, Matsushita S, Yokoyama A, Kamakura K, Higuchi S: Association of aldehyde dehydrogenase-2 polymorphisms with alcoholic polyneuropathy in humans. Neurosci Lett 363: 288-290, 2004 Mochizuki H, Masaki T, Yokoyama A, Matsushita S, Kamakura K, Motoyoshi K, Higuchi S: Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2. Neurosci Res 50: 233-236, 2004 Nakamura Y, Ohmori T, Ishikawa A, Kobayashi Y, Imazeki H, Higuchi S, Maruyama K: Homozygous (TG)11 allele in intron 8 of th cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against biocarbonate decrease in pure pancreatic juice among Japanese male alcoholics. Intern Med 43: 1131-1137, 2004 Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S: Association study of brain-derived neurotrophic factor (BDNF) gene polymorphism and alcoholism. Alcohol Clin Exp Res 28: 1609-1612, 2004 Mochizuki H, Masaki T, Matsushita S, Ugawa Y, Kamakura K, Arai H, Motoyoshi K, Higuchi S: Cognitive impairment and diffuse white matter atrophy in alcoholics. Clin Neurophysiol 116: 223-228, 2005 Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimer’s disease. J Neural Transm 112: 703-711, 2005 Miyasaka K, Ohta M, Takano S, Hayashi H, Higuchi S, Maruyama K, Tando Y, Nakamura T, Takata Y, Funakoshi A: Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis. Pancreas 30: e87-91, 2005 前田　潔　（神戸大学・大学院医学系研究科） Yamamoto Y, Sengo M, Yasuda M, Maeda K: No association between presenilin 1 intron gene or butyrylcholinesterase K variant and Alzheimer’s disease in Japanese populations. Psychogeriatrics. 1: 108-118, 2001 Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, Maeda K: No evidence of an association between 5HT1B receptor gene polymorphisim and suicide victims in a Japanese population. Am J Med Genet 105: 343-345, 2001 Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K: Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiat Res 35: 173-176, 2001 Lin X.H, Hashimoto T, N Kitamura, Murakami N, Shirakawa O, Maeda K: Decreased signal transmission via calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. 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J Neurol Neurosurg Psychiat 72: 788-791, 2002 Toyooka K, Iritani S, Makifuchi T, Shirakawa O, Kitamura N, Maeda K, Nakamura R, Niizato K, Watanabe M, Kakita A, Takahashi H, Someya T, Nawa H: Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J Neurochem 83: 797-806, 2002 Aoyama S, Shirakawa O, Ono H, Hashimoto T, Kajimoto Y, Maeda K: A novel polymorphism in the coding region of the DAP-1 gene (hDLG and PSD-95associated protein-1 gene): analysis of association with schizophrenia. Psychiat Clin Neurosci 57: 545-547, 2003 Kajimoto Y, Shirakawa O, Lin X-H, Hashimoto T, Kitamura, N, Murakami N, Takumi T, Maeda K: Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in the nucleus accumbens of phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia. Neuropsychopharmacology. 28: 1831-1839, 2003

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