論文

2017

Kato T, Khanh VC, Sato K, Takeuchi K, Carolina E, Yamashita T, Sugaya H, Yoshioka T, Mishima H, Ohneda O. SDF-1 improves wound healing ability of glucocorticoid-treated adipose tissue-derived mesenchymal stem cells. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1010-1017. doi:10.1016/j.bbrc.2017.09.100. Epub 2017 Sep 20. PubMed PMID: 28942150.

Khanh VC, Ohneda K, Kato T, Yamashita T, Sato F, Tachi K, Ohneda O . Uremic Toxins Affect the Imbalance of Redox State and Overexpression of Prolyl Hydroxylase 2 in Human Adipose Tissue-Derived Mesenchymal Stem Cells Involved in Wound Healing. Stem Cells Dev. 2017 May 24. doi: 10.1089/scd.2016.0326. [Epub ahead of print] PubMed PMID: 28537846.
Cover Article に選ばれました.

Medina RJ, Barber CL, Sabatier F, Dignat-George F, Melero-Martin JM, Khosrotehrani K, Ohneda OOhneda O, Randi AM, Chan JK, Yamaguchi T, Van Hinsbergh VW, Yoder MC, Stitt AW. Endothelial Progenitors: A Consensus Statement on Nomenclature. Stem Cells Transl Med. 2017 Mar 10. doi: 10.1002/sctm.16-0360. [Epub ahead of print] PubMed PMID: 28296182.

 

2016

Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, Yamashita T, Bando H, Hara H, Ohneda O. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2016 Dec 23. doi:10.1111/cas.13147. [Epub ahead of print] PubMed PMID: 28012234.

Fukuda S, Okuda K, Kishino G, Hoshi S, Kawano I, Fukuda M, Yamashita T, Beheregaray S, Nagano M, Ohneda O, Nagasawa H, Oshika T. In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe. Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2373-2385. PubMed PMID: 27572140.

Tu TC, Yamashita T, Kato T, Nagano M, Trinh NT, Hamada H, Sato F, Ohneda K, Matsuo-Takasaki M, Ohneda O. Microvesicles derived from Alde-Low EPCs support the wound healing capacity of AT-MSCs. Biochem Biophys Res Commun. 2016 Jun 6. pii: S0006-291X(16)30940-8. doi: 10.1016/j.bbrc.2016.06.022. [Epub ahead of print] PubMed PMID: 27282479.

Trinh NT, Yamashita T , Tu TC, Kato T, Ohneda K, Sato F, Ohneda O. Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo. Biochem Biophys Res Commun. 2016 Apr 7. pii: S0006-291X(16)30520-4. doi:10.1016/j.bbrc.2016.04.025. [Epub ahead of print] PubMed PMID: 27063802.

Trinh NT, Yamashita T , Tu TC, Kato T, Ohneda K, Sato F, Ohneda O. Microvesicles enhance the mobility of human diabetic adipose tissue-derived mesenchymal stem cells in vitro and improve wound healing in vivo. Biochem Biophys Res Commun. 2016 Apr 7. pii: S0006-291X(16)30520-4. doi:10.1016/j.bbrc.2016.04.025. [Epub ahead of print] PubMed PMID: 27063802.

Trinh NT, Yamashita T, Ohneda K, Kimura K, Salazar G, Sato F, Ohneda O. Increased expression of EGR-1 in diabetic human adipose tissue-derived mesenchymal stem cells reduces their wound healing capacity. Stem Cells Dev. 2016 Mar 17. [Epub ahead of print] PubMed PMID: 26988763

2015

Tu TC, Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Ohneda O. A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2 alpha, Is Crucial for Functional EPC Migration to Ischemic Tissue and Wound Repair. Stem Cells Dev. 2015 Dec 31.PubMed PMID: 26620723

Tachi K, Shiraishi A, Bando H, Yamashita T, Tsuboi I, Kato T, Hara H, Ohneda O. FOXA1 expression affects to the proliferation activity of luminal breast cancer stem cell populations. Cancer Sci. 2015 Dec 28. doi: 10.1111/cas.12870. PubMed PMID: 26708273.

Tsuboi I, Yamashita T, Nagano M, Kimura K, To'a Salazar G, Ohneda O. Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia. J Cell Physiol. 2015 Jul;230(7):1534-48. doi: 10.1002/jcp.24899. PubMed PMID: 25557133.

Ohmori S, Moriguchi T, Noguchi Y, Ikeda M, Kobayashi K, Tomaru N, Ishijima Y, Ohneda O, Yamamoto M, Ohneda K. GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow. Blood. 2015 May 21;125(21):3306-15. doi: 10.1182/blood-2014-11-612465. Epub 2015 Apr 8. PubMed PMID: 25855601.

Sato K, Itoh T, Kato T, Kitamura Y, Kaul SC, Wadhwa R, Sato F, Ohneda O. Serum-free isolation and culture system to enhance the proliferation and bone regeneration of adipose tissue-derived mesenchymal stem cells. In Vitro Cell Dev Biol Anim. 2015 May;51(5):515-29. doi: 10.1007/s11626-014-9860-0. Epub 2015 Jan 15. PubMed PMID: 25588776.

Kobayashi S, Yamashita T, Ohneda K, Nagano M, Kimura K, Nakai H, Poellinger L, Ohneda O. Hypoxia-inducible factor-3α promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene. Genes Cells. 2015 Mar;20(3):224-41. doi: 10.1111/gtc.12215. Epub 2015 Jan 28. PubMed PMID: 25626335.

 

2014

Zhao Y, Matsuo-Takasaki M, Tsuboi I, Kimura K, Salazar GT, Yamashita T, Ohneda O. Dual functions of hypoxia-inducible factor 1 alpha for the commitment of mouse embryonic stem cells toward a neural lineage. Stem Cells Dev. 2014 Sep 15;23(18):2143-55. doi: 10.1089/scd.2013.0278. Epub 2014 Feb 7. PubMed PMID: 24236637.

Fukuda S, Ohneda O, Oshika T. Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice. Graefes Arch Clin Exp Ophthalmol. 2014 Mar;252(3):411-6. doi: 10.1007/s00417-013-2551-9. Epub 2013 Dec 21. PubMed PMID: 24362812.

Kimura K, Nagano M, Salazar G, Yamashita T, Tsuboi I, Mishima H, Matsushita S, Sato F, Yamagata K, Ohneda O. The role of CCL5 in the ability of adipose tissue-derived mesenchymal stem cells to support repair of ischemic regions. Stem Cells Dev. 2014 Mar 1;23(5):488-501. doi: 10.1089/scd.2013.0307. Epub 2013 Dec 14. PubMed PMID: 24171667; PubMed Central PMCID: PMC3928761.

2013

Iwata K, Ikami K, Matsuno K, Yamashita T, Shiba D, Ibi M, Matsumoto M, Katsuyama M, Cui W, Zhang J, Zhu K, Takei N, Kokai Y, Ohneda O, Yokoyama T, Yabe-Nishimura C. Deficiency of NOX1/nicotinamide adenine dinucleotide phosphate, reduced form oxidase leads to pulmonary vascular remodeling. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):110-9. doi: 10.1161/ATVBAHA.113.302107. Epub 2013 Nov 14. PubMed PMID: 24233492.

Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes Cells. 2013 Nov;18(11):921-33. doi: 10.1111/gtc.12086. Epub 2013 Aug 1. PubMed PMID: 23911012.

Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M. Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. Genes Cells. 2013 Oct;18(10):886-98. doi: 10.1111/gtc.12084. Epub 2013 Jul 25. PubMed PMID: 23890289.

Fukuda S, Nagano M, Yamashita T, Kimura K, Tsuboi I, Salazar G, Ueno S, Kondo M, Kunath T, Oshika T, Ohneda O. Functional endothelial progenitor cells selectively recruit neurovascular protective monocyte-derived F4/80(+) /Ly6c(+) macrophages in a mouse model of retinal degeneration. Stem Cells. 2013 Oct;31(10):2149-61. doi: 10.1002/stem.1469. PubMed PMID: 23843337.

Akimoto K, Kimura K, Nagano M, Takano S, To'a Salazar G, Yamashita T, Ohneda O. Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation. Stem Cells Dev. 2013 May 1;22(9):1370-86. doi: 10.1089/scd.2012.0486. Epub 2013 Feb 4. PubMed PMID: 23231075; PubMed Central PMCID: PMC3696928.

 

2012

Nakamura K, Tsurushima H, Marushima A, Nagano M, Yamashita T, Suzuki K, Ohneda O, Matsumura A. A subpopulation of endothelial progenitor cells with low aldehyde dehydrogenase activity attenuates acute ischemic brain injury in rats. Biochem Biophys Res Commun. 2012 Feb 3;418(1):87-92. doi: 10.1016/j.bbrc.2011.12.139. Epub 2012 Jan 5. PubMed PMID: 22244888.

Ono M, Hamada Y, Horiuchi Y, Matsuo-Takasaki M, Imoto Y, Satomi K, Arinami T, Hasegawa M, Fujioka T, Nakamura Y, Noguchi E. Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector. PLoS One. 2012;7(8):e42855. doi: 10.1371/journal.pone.0042855. Epub 2012 Aug 13. PubMed PMID: 22912751; PubMed Central PMCID: PMC3418281.

 

2011

Tran TC, Kimura K, Nagano M, Yamashita T, Ohneda K, Sugimori H, Sato F, Sakakibara Y, Hamada H, Yoshikawa H, Hoang SN, Ohneda O. Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization. J Cell Physiol. 2011 Jan;226(1):224-35. doi: 10.1002/jcp.22329. PubMed PMID: 20658518.

 

2010

Takano S, Mashiko R, Osuka S, Ishikawa E, Ohneda O, Matsumura A. Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity. Brain Tumor Pathol. 2010 Oct;27(2):89-94. doi: 10.1007/s10014-010-0271-y. Epub 2010 Nov 3. PubMed PMID: 21046310.

Nagano M, Kimura K, Yamashita T, Ohneda K, Nozawa D, Hamada H, Yoshikawa H, Ochiai N, Ohneda O. Hypoxia responsive mesenchymal stem cells derived from human umbilical cord blood are effective for bone repair. Stem Cells Dev. 2010 Aug;19(8):1195-210. doi: 10.1089/scd.2009.0447. PubMed PMID: 20345248.

Takano S, Yamashita T, Ohneda O. Molecular therapeutic targets for glioma angiogenesis. J Oncol. 2010;2010:351908. doi: 10.1155/2010/351908. Epub 2010 Apr 18. PubMed PMID: 20414463; PubMed Central PMCID: PMC2857608.

 

2009

Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo PH, Leboulch P, Chretien S. Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis. PLoS Biol. 2009 Jun 9;7(6):e1000123. doi: 10.1371/journal.pbio.1000123. Epub 2009 Jun 9. PubMed PMID: 19513100; PubMed Central PMCID: PMC2684697.

Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood. 2008 Aug 15;112(4):1482-92. doi: 10.1182/blood-2007-11-122648. Epub 2008 May 1. PubMed PMID: 18451309.

Yamashita T, Ohneda K, Nagano M, Miyoshi C, Kaneko N, Miwa Y, Yamamoto M, Ohneda O, Fujii-Kuriyama Y. Hypoxia-inducible transcription factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J Biol Chem. 2008 Jul 4;283(27):18926-36. doi: 10.1074/jbc.M709133200. Epub 2008 Apr 23. PubMed PMID: 18434321.

 

2008

Hoshino T, Shimizu R, Ohmori S, Nagano M, Pan X, Ohneda O, Khandekar M, Yamamoto M, Lim KC, Engel JD. Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb;13(2):159-70. doi: 10.1111/j.1365-2443.2007.01158.x. PubMed PMID: 18233958.

Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M. Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. Mol Cell Biol. 2008 Feb;28(4):1285-97. Epub 2007 Dec 10. PubMed PMID: 18070924; PubMed Central PMCID: PMC2258751.

Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, Wataya T, Nishiyama A, Muguruma K, Sasai Y. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell. 2008 Nov 6;3(5):519-32. doi: 10.1016/j.stem.2008.09.002. PubMed PMID: 18983967.

 

2007

Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Fujii-Kuriyama Y, Ohneda O, Yamamoto M, van Ypersele de Strihou C, Hirayama N, Miyata T. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54. Epub 2007 Oct 11. PubMed PMID: 17932321.

Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood. 2007 Jul 1;110(1):151-60. Epub 2007 Mar 22. PubMed PMID: 17379743.

Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol. 2007 Apr;18(4):1218-26. Epub 2007 Mar 7. PubMed PMID: 17344427.

Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S, Ito Y, Yamamoto M. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 2007 Jan 10;26(1):184-96. Epub 2006 Dec 7. PubMed PMID: 17159898; PubMed Central PMCID: PMC1782368.

Ohneda O, Nagano M, Fujii-Kuriyama Y. Role of hypoxia-inducible factor-2alpha in endothelial development and hematopoiesis. Methods Enzymol. 2007;435:199-218. Review. PubMed PMID: 17998056.