Name
  Hiroshi TAKUMA
   
Affiliation
 

University of Tsukuba (Institute of Clinical Medicine, University of Tsukuba) Neurology, Field of Clinical Pathophysiology of the Neurological Disorders, Doctoral Program in Medical Sciences for Control of Pathological Processes, Graduate School of Comprehensive Human Sciences

   
Title
 

Assistant Professor

   
Academic degrees
 

MD (Osaka City University)
PhD (University of Tokyo)
   
Research Fields
 

Neurology, Neurobiology

   
Research Subjects
 

Molecular mechanisms involved in the Neurodegenerative disease, Molecular mechanisms of neural circuit formation

   
Academic Society Membership
 

-The Japanese Society of Neurology
-The Japanese Society of Internal Medicine
   
Academic Publications
  Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. A mouse model of amyloid b oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neuroscience 7:30(14):4845-56, 2010
  Tamaoka A, Arai M, Itokawa M, Arai T, Hasegawa M, Tsuchiya K, Takuma H, Tsuji H, Ishii A, Watanabe M, Takahashi Y, Goto J, Tsuji S, Akiyama H. TDP-43 M337V mutation in familial amyotrophic lateral sclerosis in Japan. Intern Med. 49(4):331-4, 2010
  Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazawa Y, Shigemoto R, Kuhl D, Waters J, Seeburg PH, Osten P. TgArc/Arg3.1-d4EGFP indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J Neurosci Methods 184(1): 25-36, 2009
  Takuma H, Teraoka R, Mori H, Tomiyama T. Amyloid b E22D variant induces synaptic alteration in mouse hippocampal slices. Neuroreport. 2008;19(6):615-619
  Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H. A new amyloid b variant favoring oligomerization in Alzheimer-type dementia. Ann Neurol. 2008;63:377-387
  Kobayashi S, Takuma H, Murayama S, Sakurai M, Kanazawa I. A Japanese family with early-onset ataxia with motor and sensory neuropathy. J Neurol Sci. 2007;254(1-2):44-8
   
Awards
 

2005 Mayer's Award, Osaka City Medical Center

   
telEfax
  tel : 029-853-3224
  fax : 029-853-3224
   
E-mail Address
 

htakumamd.tsukuba.ac.jp
[Education and Experience]
1985.3
Graduated from Faculty of Engineering Science, University of Osaka
1991.3
Graduated from Osaka City University Medical School
1991.6
Junior Resident, Osaka City University Hospital
1998.3
Graduated from Graduate School of Medicine, University of Tokyo
1998.4
Chief Resident, Osaka City University Hospital
2000.4
Research Associate, Osaka City University Medical School
2005.6
Researcher, Dept. Molecular Neurobiology, Max-Planck Institute for Medical Research ( Heidelberg )
2007.1
Assistant Professor, University of Tsukuba