（財団法人）東京都医学総合研究所 蛋白質代謝研究室

所長

生化学、分子生物学

細胞内蛋白質の代謝研究

Saeki, Y., Toh-e, A., Kudo, T., Kawamura, H., and Tanaka, K. Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell 137, 900-913, 2009.

Kimura, Y., Yashiroda, H., Kudo, T., Koitabashi, S., Murata, S., Kakizuka, A., and Tanaka, K. An inhibitor of deubiquitinating enzyme regulates ubiquitin homeostasis. Cell 137, 549-559, 2009.

Komatsu, M., Waguri, S., Koike, M., Sou, Y., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamazaki, J., Nishito, Y., Iemura, S., Natsume, N., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., and Tanaka, K. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-1163, 2007.

Murata, S., Sasaki, K., Kishimoto, T., Niwa, S., Hayashi, H., Takahama, Y., and Tanaka, K. Regulation of CD8+ T cell development by thymus-specific proteasomes. Science 316, 1349-1353, 2007.

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., and Tanaka, K. Loss of autophagy in the central nervous system causes neurodegeneration. Nature 441, 880-884, 2006.

1988　日本生化学会奨励賞
2003　内藤記念科学振興賞
2004　上原賞
2004　朝日賞
2007　東レ科学技術賞
2009　武田医学賞
2010　日本学士院賞