University of Tsukuba ( Institute of Community Medicine , University of Tsukuba ) Environmental Medicine, Field of Environmental Medicine, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences

Professor

PhD (Fukuoka University)

Molecular Environmental Toxicology, Environmental Epidemiology

Post-translational modification of sensor proteins by environmental electrophiles and cellular systems regulating electrophile signaling

-Committee member, Japanese Society for Hygiene
- Standing committee member , Pharmaceutical Society of Japan, Special Section on Pharmaceutical Health Science and Environmental Toxicology
-Executive member, Japanese Society of Toxicology
-Committee member, Japanese Society for Biomedical Research on Trace Elements
-Committee member, Japanese Society for Molecular Preventive and Environmental Medicine

Iwamoto N et al. Chemical knockdown of protein tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. J Biol Chem 2007; 282: 33396-33404.

Taguchi K et al. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radic Biol Med 2007; 43: 789-799.

Kikuno S et al. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicol Appl Pharmacol 2006; 210: 47-54.

-(1990) Special Investigator's Award, Merck Sharp & Dohme Research Laboratories, USA
-(2002) Young Investigator's Award, Japanese Society for Hygiene
-(2009) The Pharmaceutical Society of Japan Award for Divisional Scientific Promotions
-The Japanese Society of Toxicology Tanabe Award（2010.6）

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