シラバス Syllabus Doctoral Program in Biomedical Sciences
科目名・科目番号
Subjects・Course Number
 Lecture and Discussion in Molecular Medical Sciences I /02EW401  Seminar in Molecular Medical Sciences I/02EW403  Practice  in Molecular Medical Sciences I/02EW405
Lecture and Discussion in Molecular Medical Sciences II/  02EW402 Seminar in Molecular Medical Sciences II/  02EW404 Practice  in Molecular Medical Sciences Ⅱ/  02EW406
研究分野
Laboratories		 Gene regulation Gene regulation Gene regulation
使用言語
Language used （Japanese,  English,  Bilingual）		 English English English
他研究室学生の受け入れの可否（〇×）
Availability for Students from Other Lab.		 ○ possible ○ possible TBD upon request.
他研究室学生の参加に関する問い合わせ先
Contact Information for Students from Other  Lab.		 kojihisa at画像 kojihisa at画像 kojihisa at画像
授業形態
Course Type		 Lecture, presentation and discussion Seminar Practice 
標準履修年次
Year		 1 or 2 1 or 2 1 or 2
実施学期・曜時限等
Semester,Day and Period		 ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester
開講場所
Room Number		 Conference room, other Conference room, other Conference room, other
単位数
Credit		 Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等 （make an appointment by E-mail） （make an appointment by E-mail） （make an appointment by E-mail）
Faculty Members and E-mail　　　 HISATAKE Koji: kojihisa at画像 HISATAKE Koji: kojihisa at画像 HISATAKE Koji: kojihisa at画像
NISHIMURA Ken: ken-nishimura at画像 NISHIMURA Ken: ken-nishimura at画像 NISHIMURA Ken: ken-nishimura at画像
FUKUDA Aya: fukudaa at画像  FUKUDA Aya: fukudaa at画像  FUKUDA Aya: fukudaa at画像 
UCHIDA Kazuhiko: kazuhiko.uchida at画像cbiri.org UCHIDA Kazuhiko: kazuhiko.uchida at画像cbiri.org UCHIDA Kazuhiko: kazuhiko.uchida at画像cbiri.org
授業概要
Course Overview		 • We are doing research and experiments on transcription factors and chromatin remodering factors in gene regulation to understand molecular mechanisms of gene expression.            • We are doing research and experiments on genome instability in tumorigenicity and searching on diagnosis and drug target of cancer.  By reading abstracts of original papers in English, we understand the contents and standards of leading research on the molecular mechanisms of transcriptional regulation in reprogramming and differentiation or cancer markers or important research that we need to understand. You will be able to understand your research trends and plan your own creative and valuable research projects. As a basic researcher in molecular biology, develop the ability to plan, conduct and evaluate experimental research based on global trends and standards. Learn the principles and methods of the experiments required for research on the molecular mechanisms of transcriptional regulation in reprogramming and differentiation or cancer markers, and learn safe handling. Develop skills as a basic researcher in molecular biology by acquiring high skills to obtain stable results each time and evaluating the reliability of the results.
授業の到達目標（学修成果）
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives		 1. To be able to give a presentation about your own research objectives, methods, results, and future directions.
2. To be able to explain originality and creativity of your own research project.
3. To be able to accept criticisms from other participants to improve your own research project.
4. To be able to understand the presentations ofother speakers, and provideconstructive criticism.
5. To be able to design and perform experiments of recombinant DNA according to the Act concerning recombinant DNA experiment.
6. To be able to design and perform the animal experiments according to the bioethical rule.
7. To build abilities to presentand publish your own experimental results.		 1． To develop an ability to select important articles from latest ones by using online search service.
2． To develop an ability to introduce research topics to a general audience in time given.
3． To be able to discuss the unclear points and significances of the articles which are explained by other paticipants.
4． To develop an ability to evaluatethe significance of the selected articles in the related field of research.		 1. To be able to perform cell culture.
2. To be able to detect and quantify target genes by using PCR and quantitative PCR, respectively.
3. To be able to understand the basis of molecular biology and to construct recombinant genes according to the Act concerning recombinant DNA experiment.
4. To be able to prepare recombinant proteins expressed using appropriate plasmids. 
5. To be able to detect specific proteins by Western blotting etc.
キーワード
Keyword		 Gene, iPS cell, differentiation, Cancer, regulation of gene expression Gene, iPS cell, differentiation, Cancer, regulation of gene expression Gene, iPS cell, differentiation, Cancer, regulation of gene expression
授業計画
Course Schedule

第1回（月日、時限）担当教員名　講義内容など
 • We are doing research and experiments on transcription factors and chromatin remodering factors in gene regulation to understand molecular mechanisms of gene expression.            • We are doing research and experiments on genome instability in tumorigenicity and searching on diagnosis and drug target of cancer.  By reading abstracts of original papers in English, we understand the contents and standards of leading research on the molecular mechanisms of transcriptional regulation in reprogramming and differentiation or cancer markers or important research that we need to understand. You will be able to understand your research trends and plan your own creative and valuable research projects. As a basic researcher in molecular biology, develop the ability to plan, conduct and evaluate experimental research based on global trends and standards. Learn the principles and methods of the experiments required for research on the molecular mechanisms of transcriptional regulation in reprogramming and differentiation or cancer markers, and learn safe handling. Develop skills as a basic researcher in molecular biology by acquiring high skills to obtain stable results each time and evaluating the reliability of the results.
履修条件
Course prerequisite		 None None None
成績評価方法
Grading Criteria		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved under supervision in the SBOs 1 and 2:  Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4:  Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved  in the SBOs 1 and 2:  Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3:  Pass (B).
Based on written summary of papers (A4 1 page, twice a month).  good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Skills to obtain reliable experimental results （50%）
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
学修時間の割り当て及び授業外における学修方法
Learning method		 Lecture 100% Training (Seminar) 100% Experiment, Practice 100%
教材・参考文献
Textbook		 　 　 　
単位取得要件
Requirement to earn credit		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
その他（受講上の注意点等）
Notes		 Students from Genr regulation lab have to attend the course of Practice in Infection Biology.
Students should resolve the questions immediately.
Students should thoroughly discuss scientifically, logically, and properly.		 Students should resolve the questions immediately.
Students should thoroughly discuss scientifically, logically, and properly.		 Students should contact a responsible faculty member, and get permission beforehand.
Students should resolve the questions immediately.
他の授業科目との関連
Relation to Other Courses		 Seminar in Molecular Medical SciencesI, II
Practice  in Molecular Medical Sciences I, II		 Lecture and Discussion in Molecular Medical Sciences I, II
Practice  in Molecular Medical Sciences I, II		 Lecture and Discussion in Molecular Medical Sciences I, II
Seminar in Molecular Medical Sciences I, II

 

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