シラバス Syllabus Doctoral Program in Biomedical Sciences
科目名・科目番号
Subjects・Course Number
 02EW411 /   Lecture and Discussion in Human Medical Biology I  02EW413  / Seminar in Human Medical Biology  02EW415  / Practice  in Human Medical Biology I
02EW412 / Lecture and Discussion in Human Medical Biology II 02EW414  / Seminar in Human Medical Biology II 02EW416　/ Practice  in Human Medical Biology Ⅱ
研究分野
Laboratories		 Kidney and Vascular Pathology Kidney and Vascular Pathology Kidney and Vascular Pathology
使用言語
Language used （Japanese,  English,  Bilingual）		 English English English
他研究室学生の受け入れの可否（〇×）
Availability for students from other lab.		 ○ possible ○ possible TBD upon request.
他研究室学生の問い合わせ先
Contact Information for Students from Other  Lab.		 nagatam at画像 nagatam at画像 nagatam at画像
授業形態
Course Type		 Lecture, presentation and discussion Seminar Practice 
標準履修年次
Year		 1 or 2 1 or 2 1 or 2
実施学期・曜時限等
Semester,Day and Period		 ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester
開講場所
Room Number		 4A-660 4A-661 4A-662
単位数
Credit		 Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等 （make an appointment by E-mail） （make an appointment by E-mail） （make an appointment by E-mail）
Faculty Members and E-mail　 NAGATA Michio: nagatam at画像 NAGATA Michio: nagatam at画像 NAGATA Michio: nagatam at画像
KAWANISHI Kunio: kukawanishi at画像 KAWANISHI Kunio: kukawanishi at画像 KAWANISHI Kunio: kukawanishi at画像
授業概要
Course overview		 Pathogenesis of Vascular sclerosis and chronic kidney disease will be discussed. Understanding and construct the basic methods to solve the scientific questions.  To read and discuss the cutting-edge reserch paper about kidney and vascular pathology, atherosclerosis, end-stage of renal disease (ESRD) and renal cell carcinoma in ESRD. To understant the principles and methods of the experiments needed to solve the individual questions.
To ensure the skill to interpret the experimental results obtained, students learn the methods to evaluate significance and reliability of them.
授業の到達目標（学修成果）
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives		 1. To be able to explain the pathogenesis of vascular and kidney diseases.
2. To have an interest in the kidney pathology and able to evaluate the pathology and pathophysiology.
3. To be able to explain the background of your own research theme and summarize the most updated knowledge in literature. 
4. To be able to understand experimental methods and proceed experiments.
5. To be able to assess problems in your experiments and plan how to solve them.
6. To be able to understand topics of another field from the presentation of your colleagues.
7. To be able to understand ethics for experimental animals and conduct animal model experiments.
8. To be able to understand the composition of scientific article and write your own paper. 		 1. To be able to select an adequate paper for the journal club audiences.
2. To be able to present the selected paper in the journal club.
3. To be able to understand other papers from your colleagues in the journal club.
4. To be able to discuss the detail and possibilities to apply the new methods from the paper to your own experiments. 		 1. To be able to read pathology and interpret pathophysiology.
2. To be able to fix, dehydrate and embed tissues in paraffin and cut thin sections.
3. To be able to perform and evaluate the results of immunohistochemistry and electron microscopy.
4. To be able to do the biochemical and molecular biological analysis and evaluate the results.
5. To be able to handle genetically modified animals (mice) and conduct animal model experiments. 
キーワード
Keyword		 Kidney, pathology, glomerulus, atherosclerosis, end-stage of renal disease (ESRD), carcinogenesis in ESRD. Kidney, pathology, glomerulus, atherosclerosis, end-stage of renal disease (ESRD), carcinogenesis in ESRD. Kidney, pathology, glomerulus, atherosclerosis, end-stage of renal disease (ESRD), carcinogenesis in ESRD.
授業計画
Course Schedule

第1回（月日、時限）担当教員名　講義内容など
 1. Pathology, overview
2. Structure and function of the kidney and vasculature
3. Molecular pathology, overview
4. Front of kidney and vascular pathology
5. Pathophysiology and pathology of atherosclerosis
6. Pathophysiology and pathology of end-stage renal disease (ESRD)
7. Pathology and carcinogenic mechanism of renal cell carcinoma in ESRD		 1. How to read and understand the scientific articles.
2. Methods of scientific presentation.
3. Background and theory of experimental methods. 		 1. How to read the histopathology.
2. How to make pathological sections.
3. How to perform and evaluate immunopathlogy.
4. Howto detect and measure specific proteins and gene products.
5. How to handle experimental animals and learn its ethical process.
履修条件
Course prerequisite		 None None None
成績評価方法
Grading Criteria		 Grading will be based on the levels of achievements of SBO evaluated by presentations and discussions in the class and the reports on own presentations. ・General achievements in SBO 1-3 with supervisors’ instructions will be evaluated to pass (C or upper). ・ General achievements in SBO 1-3 with supervisors’ instructions and active participation in 4 will be evaluated as B or upper. ・Excellent achievements in SBO 1-4 and 7 by students by themselves and successful achievements in 5 and/or 6 with supervisors’ instructions will be evaluated as A. ・Excellent achievements in SBO 1-7 and 8 by students by themselves will be evaluated as A+.  Grading will be based on the levels of achievements of SBO evaluated by presentations, discussion and 3 submitted reports on the studied papers. ・General achievements in SBO 1-2 with supervisors’ instructions and 3 reports on the studied papers will be evaluated to pass (C or upper). ・General achievements in SBO 1-2 with supervisors’ instructions, active participation in SBO 3 and 3 reports on the studied papers will be evaluated as B or upper. ・General achievements in SBO 1-3 and excellent 3 reports on the studied paperswill be evaluated as A or upper. ・General achievements in SBO 1-3 and excellent 4 reports on the studied papers will be evaluated as A+. Evaluation by the quality and reliability of the experimental results（50 %） Evaluation of daily notes, ability to explain the research results and planning of next experiments（50%）.
学修時間の割り当て及び授業外における学修方法
Learning method		 Lecture 100% Training (Seminar) 100% Experiment, Practice 100%
教材・参考文献
Textbook		 Textbook：『Robbins and Cotran Pathologic Basis of Disease』 10th Edition, Chapter 7, Neoplasia. Kumar, Abbas, Aster ed., Elsevier Saunders, 2018.
 PDF files of the original paper will be sent to the attendants on every Monday. The protocol of each experiment will be provided.
単位取得要件
Requirement to earn credit		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
その他（受講上の注意点等）
Notes		 　 　 　
他の授業科目との関連
Relation to Other Courses		 Seminar in Human Medical Biology I, II
Practice  in Human Medical Biology I, II		 Lecture and Discussion in Human Medical Biology I, II
Practice  in Human Medical Biology I, II		 Lecture and Discussion in Human Medical Biology I, II
Seminar in Human Medical Biology I, II

 

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