シラバス Syllabus	Doctoral Program in Clinical Sciences
科目名・科目番号 Subjects・Course Number	Lecture and Discussion in Clinical Pathophysiology Ⅰ/ 02EX260	Seminar in Clinical Pathophysiology I / 02EX262	Practice  in Clinical Pathophysiology I / 02EX264
	Lecture and Discussion in Clinical Pathophysiology Ⅱ / 02EX261	Seminar in Clinical Pathophysiology II / 02EX263	Practice  in Clinical PathophysiologyⅡ / 02EX265
研究分野 Laboratories	Biostatistics	Biostatistics	Biostatistics
使用言語 Language used （Japanese,  English,  Bilingual）	Bilingual	Bilingual	Bilingual
他研究室学生の受け入れの可否（〇×） Availability for students from other lab.
他研究室学生の問い合わせ先 Contact Information for Students from Other  Lab.
授業形態 Course Type	Lecture, presentation and discussion	Seminar	Practice
標準履修年次 Year	1 or 2	1 or 2	1 or 2
実施学期・曜時限等 Semester,Day and Period	ⅠSpring semester / ⅡAutumn semester	ⅠSpring semester / ⅡAutumn semester	ⅠSpring semester / ⅡAutumn semester
開講場所 Room Number	Conference room, other	Conference room, other	Conference room, other
単位数 Credit	Spring and Autumn semester, 2 x 2 credits	Spring and Autumn semester, 2 x 2 credits	Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等	（make an appointment by E-mail）	（make an appointment by E-mail）	（make an appointment by E-mail）
Faculty Members and E-mail	GOSHO Masahiko, mgosho	GOSHO Masahiko, mgosho	GOSHO Masahiko, mgosho
	MARUO Kazushi, maruo	MARUO Kazushi, maruo	MARUO Kazushi, maruo
授業概要 Course overview	The course overviews classical and modern methods on biostatistics. Lectures cover current statistical methodologies and their performance.	The course overviews on classical and modern methods on biostatistics. Lectures cover the principle and properties of statistical methodologies. Students also discuss the significances and issues of the methods.	The course overviews Monte Carlo simulation studies in clinical trials. Lectures cover the simulation methods and showing the simulation results.
授業の到達目標（学修成果） Course Objectives (Learning Outcomes) ←SBO(Specific Behavior Objectives	1. To be able to preset the statistical methods for planning of medical researches. 2. To be able to preset the statistical methods for data analyses. 3. To be able to explain the indexes and criteria for evaluating the performance of the statistical methods.	1. To be able to select appropriate articles. 2. To be able to understand the articles and explain the outline of the articles. 3. To be able to discuss the significances and issues of the articles.	1. To be able to design simulation studies for evaluating the performance of statistical methods. 2. To be able to general the random numbers based on actual clinical trials. 3. To be able to provide efficient program codes. 4. To be able to explain and summarize simulation results.
キーワード Keyword	Unbiasedness, consistency, asymptotic normality, asymptotic efficiency of estimates, test size, power	Unbiasedness, consistency, asymptotic normality, asymptotic efficiency of estimates, test size, power	Test size, power, bias, coverage probability, standard error, empirical standard deviation, mean squared error
授業計画 Course Schedule 第1回（月日、時限）担当教員名　講義内容など	Statistical method for designing the intervention and observational studies Statistical method for data analysis	Selection of articles Structure of the articles for biostatistics Principle and property of statistical methods Simulation studies for evaluating the performance of statistical methods Application and data analysis	Designing simulation studies Investigating examples and simulation scenarios Random numbers and probability distributions Mean and error models
履修条件 Course prerequisite	If students want to attend the course, you should be contact the responsible teacher.	If students want to attend the course, you should be contact the responsible teacher.	If students want to attend the course, you should be contact the responsible teacher.
成績評価方法 Grading Criteria	Grading will be based on the levels of achievements of SBO evaluated by presentations and discussions in the class. General achievements in SBO 1-2 with supervisors' instructions will be evaluated to pass (C or upper). General achievements in SBO 1-3 with supervisors' instructions will be evaluated as B or upper. In addition to the above, active participation and sufficient understanding will be evaluated as A.	Grading will be based on the levels of achievements of SBO evaluated by presentations and discussions in the class. General achievements in SBO 1-2 with supervisors' instructions will be evaluated to pass (C or upper). General achievements in SBO 1-3 with supervisors' instructions will be evaluated as B or upper. In addition to the above, active participation and sufficient understanding will be evaluated as A.	Grading will be based on the levels of achievements of SBO evaluated by presentations and discussions in the class. General achievements in SBO 1-2 with supervisors' instructions will be evaluated to pass (C or upper). General achievements in SBO 1-3 with supervisors' instructions will be evaluated as B or upper. In addition to the above, active participation and sufficient understanding will be evaluated as A.
学修時間の割り当て及び授業外における学修方法 Learning method	Lecture, Discussion 100% Out-of-class study: None	Training (Seminar) 100% Out-of-class study:  None	Experiment, Practice 100% Out-of-class study:  None
教材・参考文献 Textbook	Text books will be specified every class.	Original articles of Biometrics，Statistics in Medicine，Biometrika，Statistics Methods in Medical Research, etc.	Rubinstein, R. Y. and Kroese, D. P. (2016). Simulation and the Monte Carlo method, 3rd edition. John Wiley & Sons. Chang, M. (2010). Monte Carlo simulation for the pharmaceutical industry: concepts, algorithms, and case studies. CRC Press.
単位取得要件 Requirement to earn credit	Requirement to earn credit: Attendance 80％ or more and presentation.	Requirement to earn credit: Attendance 80％ or more and presentation.	Requirement to earn credit: Attendance 80％ or more and presentation.
その他（受講上の注意点等） Notes	Students majoring in biostatistics are eligible.	Students majoring in biostatistics are eligible.	Students majoring in biostatistics are eligible.
他の授業科目との関連	Seminar in Clinical Pathophysiology　I, II Practice  in Clinical Pathophysiology  I, II	Lecture and Discussion in Clinical Pathophysiology I, II Practice in Clinical Pathophysiology I, II	Lecture and Discussion in Clinical Pathophysiology I, II Seminar in Clinical Pathophysiology I, II

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