Subjects・Course Number
Seminar in Clinical Pathophysiology II / 02EX263
Practice in Clinical PathophysiologyⅡ / 02EX265
Laboratories
Language used （Japanese, English, Bilingual）
Availability for students from other lab.
Contact Information for Students from Other Lab.
Course Type
Year
Semester,Day and Period
Room Number
Credit
Course overview
1. Pharmacokinetic analysis for drug disposition
2. Assessing the drug metabolizing enzymes and drug transporters
3. Assessing adverse events including drug interaction in pharmacotherapy
1. How to select papers for abstract: Historicity and creativity in scientific papers
2. Structure of scientific papers
3. How to read experimental results
4. Logical structure and summary of scientific papers
1. In vitro experiments of drug metabolism using liver microsomes.
2. Analyses of genetic polymorphisms and mRNA expression associated with drug metabolism and transport.
3. Determination of drug concentration in biological fluids using HPLC or LC/MS/MS.
4. Collection of the patient data required for pharmacokinetic analysis using hospital information system.
5. Pharmacokinetic analysis using software including WinNonlin, NLME, and Simcyp.
6. Statistical analysis using software.
（学位P共通）
【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills
【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills
【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives
2. To be able to explain the originality and peculiarity of the own research in the related research fields in the world.
3. To be able to understand questions and comments related to students’ presentations, and to use them for the discussion to improve students’ own research.
4. To be able to understand the advantage and weak points of other students’ presentations, ask questions and give useful comments to improve the others’ research.
5. To be able to understand the methods and regulations for clinical research, and to make plan, apply and perform them ethically and acceptably.
6. To be able to search the appropriate information required for pharmacokinetic analysis, and to perform pharmacokinetic and statistical analyses.
7. To be able to plan and carry out the analytical, biochemical and molecular biological experiments required for pharmacokinetic analysis.
2. To be able to understand the selected papers, and to explain the overview to other students in limited time.
3. To be able to understand other students’ explanation of the papers, and to discuss the scientific value and problems of the research.
4. To be able to discuss the impact and application of original paper studied in the seminar in students’ own research.
2. To be able to understand the basic techniques for the evaluation of genetic polymorphisms and mRNA expression associated with drug metabolism and transport, and to perform appropriate ways.
3. To be able to understand the basic techniques for determination of parent drug and its metabolites in biological fluids and body tissue, and to perform appropriate ways.
4. To be able to understand the information required for pharmacokinetic analysis, and to accurately calculate the pharmacokinetic parameters using analysis software including WinNonlin, NLME, and Simcyp.
5. To be able to accurately evaluate the results of experiments and analysis using statistical software.
Keyword
Course Schedule
第1回（月日、時限）担当教員名 講義内容など
Course prerequisite
Grading Criteria
- Good achieved under supervision in the SBOs 1 and 2: Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4: Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
- Good achieved in the SBOs 1 and 2: Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3: Pass (B).
Based on written summary of papers (A4 1 page, twice a month). good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
Learning method
Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.
Out-of-class study: Write summary on papers (2 per month) together with own opinion.
Textbook
No textbook is required.
Requirement to earn credit
Notes
Practice in Clinical Pathophysiology I, II
Practice in Clinical Pathophysiology I, II
Seminar in Clinical Pathophysiology I, II