シラバス Syllabus	Doctoral Program in Clinical Sciences
科目名・科目番号 Subjects・Course Number	Lecture and Discussion in Clinical Pathophysiology Ⅰ/ 02EX260	Seminar in Clinical Pathophysiology I / 02EX262	Practice  in Clinical Pathophysiology I / 02EX264
	Lecture and Discussion in Clinical Pathophysiology Ⅱ / 02EX261	Seminar in Clinical Pathophysiology II / 02EX263	Practice  in Clinical PathophysiologyⅡ / 02EX265
研究分野 Laboratories	Emergency and Critical Care Medicine	Emergency and Critical Care Medicine	Emergency and Critical Care Medicine
使用言語 Language used （Japanese,  English,  Bilingual）	Bilingual	Bilingual	Bilingual
他研究室学生の受け入れの可否（〇×） Availability for students from other lab.	○	○	○
他研究室学生の問い合わせ先 Contact Information for Students from Other  Lab.	er-icu	er-icu	er-icu
授業形態 Course Type	Lecture, presentation and discussion	Seminar	Practice
標準履修年次 Year	1 or 2	1 or 2	1 or 2
実施学期・曜時限等 Semester,Day and Period	ⅠSpring semester / ⅡAutumn semester	ⅠSpring semester / ⅡAutumn semester	ⅠSpring semester / ⅡAutumn semester
開講場所 Room Number	Conference room, other	Conference room, other	Conference room, other
単位数 Credit	Spring and Autumn semester, 2 x 2 credits	Spring and Autumn semester, 2 x 2 credits	Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等	（make an appointment by E-mail）	（make an appointment by E-mail）	（make an appointment by E-mail）
Faculty Members and E-mail	INOUE Yoshiaki, yinoue	INOUE Yoshiaki, yinoue	INOUE Yoshiaki, yinoue
	KAWANO Satoru, kawano_s	KAWANO Satoru, kawano_s	KAWANO Satoru, kawano_s
	SHIMOJYO Nobutake, nkshimojo	SHIMOJYO Nobutake, nkshimojo	SHIMOJYO Nobutake, nkshimojo
	MARUSHIMA Aiki, aiki.marushima	MARUSHIMA Aiki, aiki.marushima	MARUSHIMA Aiki, aiki.marushima
授業概要 Course overview	1) Clinical and basic research on emergency medicine, multiorgan failure, and toxicology to develop novel treatment strategies. 2) Research on emergency medical system, triage, and disaster medicine.	1) To discuss a new elucidation method based on the previous research on the relationship between defense response and organ damage during invasion of living organisms. 2) Discuss how to assess and elucidate post-intensive care syndrome (PICS) resulting from intensive care of severe conditions in terms of physical, mental and cognitive function.	1) Planning and assessing biological intrusions, quantitative severity of response, and the impact of therapeutic interventions in the areas of emergency and intensive care. 2) Analyze various biological data and search for biomarkers that can be used to assess prognosis and the effectiveness of the intervention.
授業の到達目標（学修成果） Course Objectives (Learning Outcomes) ←SBO(Specific Behavior Objectives	・ Explain the mechanism of biological reactions and organ damage when biological invasion is given.　　　　　　　　　　　・ Explain the therapeutic target based on the above mechanism and the site of action of therapeutic intervention.	・Explain the pathogenesis of complications resulting from bioinvasive and intensive care. ・Explain the quantitative evaluation of severity  and  various complications, and explain establish therapeutic intervention methods and possible countermeasures.	・Explain biomarkers and quantification methods for evaluating the severity of biological invasion and the effects of terapeutic intervention. ・ Has an eye for the science of emergency, intensive care and disaster medicine, and can propose models and develop biomarkers.
キーワード Keyword	sepsis, organ injury, multiple organ failure	post intensive care syndrome (PICS), delilium	biomaarker, clinical translational research
授業計画 Course Schedule 第1回（月日、時限）担当教員名　講義内容など	every Wednesyday, 1:00 pm, 1hour	first and third Wednesday, 6:30 pm〜, 1hour	second and forth Wednesday, 6:30 pm〜, 1hour
履修条件 Course prerequisite	Desirable to understand Japanese	Desirable to understand Japanese	Desirable to understand Japanese
成績評価方法 Grading Criteria	Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved under supervision in the SBOs 1 and 2:  Pass (C). - Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4:  Pass (B). SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion. - Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A) - Outstanding achievement with enough evidence in all SBOs : Pass (A+)	Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved  in the SBOs 1 and 2:  Pass (C). - Good achieved in the SBOs 1 - 2, and actively conducted SBO 3:  Pass (B). Based on written summary of papers (A4 1 page, twice a month).  good achievement including SBO 4 is confirmed,: Pass (A). - Outstanding achievement with enough evidence in all SBOs : Pass (A+)	Skills to obtain reliable experimental results （50%） Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%） A+: Superior (more than 90: top 10%) A: Excellent (80-89: upper 20%) B: Good (70-79) C: Average (60-69) D: Failure (less than 60)
学修時間の割り当て及び授業外における学修方法 Learning method	Lecture 100% Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.	Training (Seminar) 100% Out-of-class study:  Write summary on papers (2 per month) together with own opinion.	Experiment, Practice 100%
教材・参考文献 Textbook
単位取得要件 Requirement to earn credit	Requirement to earn credit: Attendance 80％ or more. Attendance of 5 hours or more to other lab's classes.	Requirement to earn credit: Attendance 80％ or more. Attendance of 5 hours or more to other lab's classes.	Requirement to earn credit: Attendance 80％ or more.
その他（受講上の注意点等） Notes
他の授業科目との関連	Seminar in Clinical Pathophysiology　I, II Practice  in Clinical Pathophysiology  I, II	Lecture and Discussion in Clinical Pathophysiology I, II Practice  in Clinical Pathophysiology I, II	Lecture and Discussion in Clinical Pathophysiology I, II Seminar in Clinical Pathophysiology I, II

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