Subjects・Course Number
Seminar in Clinical Pathophysiology II / 02EX263
Practice in Clinical PathophysiologyⅡ / 02EX265
Laboratories
Language used （Japanese, English, Bilingual）
Availability for students from other lab.
Contact Information for Students from Other Lab.
Course Type
Year
Semester,Day and Period
Room Number
Credit
Course overview
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives
Biology: LQ model and a/b ratio, LET and RBE, radiation sensitivity, therapeutic ratio, dose rate effect, recovery from radiation trauma, modification of radiation therapeutic effect, dose fractionation.
Physics: Radiation dose unit, dose distribution curve, dosimetry, verification of radiation field, QC, QA.
② Understand indications for radiation therapy and prepare a therapeutic plan together with a supervisory physician.
③ List clinicopathological characteristics of individual tumors.
④ Explain indications for other therapeutic methods, including surgery, chemotherapy, and immunotherapy.
1) Select therapeutic policy (radical/palliative/symptomatic radiation).
2) Explain the definitions of GTV, CTV, ITV, PTV.
3) Explain the normal tissue tolerance dose.
4) Predict possible acute and delayed adverse responses.
5) Explain general external beam radiation methods and dose distribution (single field irradiation, portal irradiation, crossfiring, rotational irradiation).
6) Explain the significance of methods of dose division and their indications (conventionally fractionated, multifractionated, hypofractionated radiation).
7) Explain radiation methods and their indications (brachytherapy, stereotactic irradiation, intraoperative irradiation, total-body irradiation, corpuscular radiation).
8) Explain the indications for emergency irradiation.
9) Explain epidemiology, stage, therapeutic methods, and therapeutic results for representative diseases in individual organs; and methods, therapeutic results, and adverse events in radiation therapy.
10) Refer patients for end-of-life care and mental health care.
2. Understand the selected report and explain the outline of the report to other students within a set time.
3. Read a report selected by another student, understand the report after hearing an explanation, and discuss the questions and significance of the study.
4. Explain the historical significance of individual original reports and how the report is ranked among all articles.
5. Further understand the concept of evidence-based medicine, especially in clinical reports, and explain the methods used to test hypotheses and for experimental planning in a radiation oncology study performed under supervision.
2. Evaluate stimulatory and inhibitory effects on cell proliferation quantitatively.
3. Prepare thin sliced samples by fixing, dehydrating and embedding tissues.
4. Analyze the effects of radiation on cultured cells using chemoradiation methods.
5. Analyze expression of specific molecules (proteins, genes) in cultured cells or tissues.
6. Predict therapeutic effects by performing DVH analysis based on data from a radiation therapeutic plan.
7. Promote development of new irradiation techniques using protons, working with supervisory physicians.
8. Perform statistical analysis of the results of their own study.
Keyword
Course Schedule
第1回（月日、時限）担当教員名 講義内容など
Hideyuki Sakurai et al.
Radiation therapy for malignant tumors: presentation and discussion performed to foster learning of setting of study objectives, selection of methods, understanding of importance of results, and selection of the next study to be performed, in addition to increasing the creativity and independence of students from radiobiological and physical perspectives.
General knowledge is reinforced based on discussion of specific areas.
Hideyuki Sakurai et al.
Selection of a report:
Historical characteristics and originality of the scientific report
Composition of the scientific report
How to interpret experiment results
Reasoning and organization of a scientific report
Hideyuki Sakurai et al.
1. Basic techniques of cell culture
2. Practical training on colony formation and cell proliferation measurements
3. Practical training in fixation, dehydration, embedding, and thin slicing of tissues
4. Practical training in quantitation (ESR, HPLC) and modification of radicals
5. Practical training in immunohistochemistry, fluorescence antibody techniques, western blotting, and flow cytometry
6. Practical training in DVH analysis
7. Practical training in irradiation techniques using protons and development of spot scanning
8. Practical training in medical statistics
Course prerequisite
Grading Criteria
- Good achieved under supervision in the SBOs 1 and 2: Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4: Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
- Good achieved in the SBOs 1 and 2: Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3: Pass (B).
Based on written summary of papers (A4 1 page, twice a month). good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
Learning method
Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.
Out-of-class study: Write summary on papers (2 per month) together with own opinion.
Textbook
Requirement to earn credit
Attendance of 5 hours or more to other lab's classes.
Attendance of 5 hours or more to other lab's classes.
Notes
Practice in Clinical Pathophysiology I, II
Practice in Clinical Pathophysiology I, II
Seminar in Clinical Pathophysiology I, II