シラバス Syllabus Doctoral Program in Clinical Sciences
科目名・科目番号
Subjects・Course Number
 Lecture and Discussion in Surgery Ⅰ/ 02EX270 Seminar in Surgery  I / 02EX272　 Practice in Surgery  I/02EX274
Lecture and Discussion in Surgery  Ⅱ　/ 　02EX271 Seminar in Surgery  II/　02EX273 Practice  in Surgery Ⅱ/　02EX275
研究分野
Laboratories		 Gastrointestinal and Hepato-biliary-pancreatic Surgery Gastrointestinal and Hepato-biliary-pancreatic Surgery Gastrointestinal and Hepato-biliary-pancreatic Surgery
使用言語
Language used （Japanese,  English,  Bilingual）		 Bilingual Bilingual Bilingual
他研究室学生の受け入れの可否（〇×）
Availability for Students from Other Lab.		 x x x
他研究室学生の参加に関する問い合わせ先
Contact Information for Students from Other  Lab.		 　 　 　
授業形態
Course Type		 Lecture Seminar Practice 
標準履修年次
Year		 1 or 2 1 or 2 1 or 2
実施学期・曜時限等
Semester,Day and Period		 ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester
開講場所
Room Number		 Conference room, other Conference room, other Conference room, other
単位数
Credit		 Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等 （make an appointment by E-mail） （make an appointment by E-mail） （make an appointment by E-mail）
Faculty Members and E-mail　　　　　　 HIRAMATSU Yuji , yuji3 at画像 HIRAMATSU Yuji , yuji3 at画像 HIRAMATSU Yuji , yuji3 at画像
SUZUKI Yasuyuki, Ysuzuki at画像 SUZUKI Yasuyuki, Ysuzuki at画像 SUZUKI Yasuyuki, Ysuzuki at画像
MATSUZAKI Kanji, kmatsuzaki at画像 MATSUZAKI Kanji, kmatsuzaki at画像 MATSUZAKI Kanji, kmatsuzaki at画像
SAKAMOTO Hiroaki, sakamotoh at画像 SAKAMOTO Hiroaki, sakamotoh at画像 SAKAMOTO Hiroaki, sakamotoh at画像
OSAKA Motoo, m-oosaka at画像 OSAKA Motoo, m-oosaka at画像 OSAKA Motoo, m-oosaka at画像
MATSUBARA Muneaki, matsubaram at画像 MATSUBARA Muneaki, matsubaram at画像 MATSUBARA Muneaki, matsubaram at画像
KATO Hideyuki, hkato at画像 KATO Hideyuki, hkato at画像 KATO Hideyuki, hkato at画像
授業概要
Course Overview		 Through animated discussions, presentations and lectures over fundamental research subjects and theses in cardiovascular surgery including cardio-physiological examination, cardiovascular imaging, molecular biology, animal experimental models and histological/pathological analysis, students cultivate skills for planning, implementation and evaluation for experimental research as an independent clinical researcher in the field.     Through reading the latest original scientific articles in major journals related to cardiovascular surgery, students recognize the forefront of the science and the trend of world top-ranking researches in the field. Students also cultivate skills for planning attractive original research projects as an independent clinical researcher in the field.

 Learn the principles and methodology for the experiments needed for the research in cardiovascular surgery. Obtain skills for better and stable experimental results, as well as ability to evaluate the relevance of the experimental results.
学位プログラム・コンピテンスとの関係Competence
 【Generic Competence】Intellectual creativity, Communication skills
【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills		 【Generic Competence】Intellectual creativity, Communication skills
【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills		 【Generic Competence】Intellectual creativity,
【Specific Competence】 Cutting-edge research execution skills, Working knowledge in the specialized field
授業の到達目標（学修成果）
SBO(Specific Behavior Objectives		 1. Present hypotheses, objectives, methods and expected results and significances in experimental design.
2. Explain the positioning and originality of the research thesis from a global point of view.
3. Improve the quality of research through active discussion with constructive comments.
4. Understand the significance and pitfalls of research projects presented by other students.
5. Understand the related law, obligation and information security in designing and practicing clinical research.
6. Design, apply and practice animal experiments understanding the rules and ethical issues.
7. Explain the outlines of diseases in cardiovascular surgery based on the pathophysiology in molecules, organs and individuals.		 1. Pick up the appropriate latest articles regarding specific subjects using published major journal copies or online manuscript search system.
2. Understand the text of a manuscript and explain the abstract briefly.
3. Discuss over questions and meanings of presented text of a manuscript and related issues.
4. Explain the historical background and the current position of a manuscript in the research field.		 1. Understand the principle of flow cytometry and handle a cytometer for analyses.
2. Understand the principle of immunohistochemistry and detect specific proteins using an enzyme labeled antibody method for semi-quantitative analyses.
3. Understand the principle of RT-PCR and make quantitative analyses using specific probes for respective RNA.
4. Detect expression of specific proteins using Western blotting method.
5. Prepare and handle electrical microscopes.
6. Conduct ex vivo studies using rat hearts and Langendorf perfusion device.
7. Evaluate peripheral perfusion using Laser Doppler flow meter.
8. Get involved in the experiments of the synchrotron radiation research which visualize microvasculature.
9. Detect cardiac miniature electric potential
10. Get involved in the experiments of in vitro and in vivo monkey cardiopulmonary bypass, then analyze and evaluate the results for thrombosis and hemostasis
キーワード
Keyword		 Myocardial ischemia, Myocardial hypertrophy, Myocardial remodeling, Extracorporeal circulation, Blood coagulation, Cardiac electrophysiology, Regeneration, Imaging, Lung injury Myocardial ischemia, Myocardial hypertrophy, Myocardial remodeling, Extracorporeal circulation, Blood coagulation, Cardiac electrophysiology, Regeneration, Imaging, Lung injury Myocardial ischemia, Myocardial hypertrophy, Myocardial remodeling, Extracorporeal circulation, Blood coagulation, Cardiac electrophysiology, Regeneration, Imaging, Lung injury
授業計画
Course Schedule

第1回（月日、時限）担当教員名　講義内容など
 Monday, 6th period, by above faculty members Tuesday, 7th period, by above faculty members Friday, 2-3th period, by above faculty members
履修条件
Course Prerequisites		 Students need to have basic knowledge regarding cardiovascular surgery or generak surgery Students need to have basic knowledge regarding cardiovascular surgery or generak surgery Students need to have basic knowledge regarding cardiovascular surgery or generak surgery
成績評価方法
Grading Phylosophy		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved under supervision in the SBOs 1 and 2:  Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4:  Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved  in the SBOs 1 and 2:  Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3:  Pass (B).
Based on written summary of papers (A4 1 page, twice a month).  good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Skills to obtain reliable experimental results （50%）
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
学習時間の割り当て及び授業外における学修方法
Learning method		 Lecture 100%
Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.		 Training (Seminar) 100%
Out-of-class study:  Write summary on papers (2 per month) together with own opinion.		 Experiment, Practice 100%
教材・参考文献
Textbook		 Cardiovascular Physiology, David E. Mohrman ed., McGraw-Hill Medical, 2006
Microvascular Research, David Shepro ed., Academic Press, 2006		 Cardiovascular Physiology, David E. Mohrman ed., McGraw-Hill Medical, 2006
Microvascular Research, David Shepro ed., Academic Press, 2006		 Cardiovascular Physiology, David E. Mohrman ed., McGraw-Hill Medical, 2006
Microvascular Research, David Shepro ed., Academic Press, 2006
単位取得要件
Requirement to earn credit		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Requirement to earn credit: Attendance 80％ or more.
その他（受講上の注意点等）
Notes		 To be combined with Seminar in Surgery To be combined with Lecture nand Discussion in Surgery Based on the knowledge in Lecture, Discussion and Seminar in Surgery
他の授業科目との関連 Seminar in Surgery　I, II
Practice  in Surgery  I, II		 Lecture and Discussion in Surgery I, II
Practice  in Surgery I, II		 Lecture and Discussion in Surgery I, II
Seminar in Surgery I, II
その他（受講上の注意点等）
Notes		 　 　 　
他の授業科目との関連 Seminar in Surgery　I, II
Practice  in Surgery  I, II		 Lecture and Discussion in Surgery I, II
Practice  in Surgery I, II		 Lecture and Discussion in Surgery I, II
Seminar in Surgery I, II

 

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