シラバス Syllabus Doctoral Program in Clinical Sciences
科目名・科目番号
Subjects・Course Number
 Lecture and Discussion in Surgery Ⅰ/ 02EX270 Seminar in Surgery  I / 02EX272　 Practice in Surgery  I/02EX274
Lecture and Discussion in Surgery  Ⅱ　/ 　02EX271 Seminar in Surgery  II/　02EX273 Practice  in Surgery Ⅱ/　02EX275
研究分野
Laboratories		 Obstetrics and Gynecology Obstetrics and Gynecology Obstetrics and Gynecology
使用言語
Language used （Japanese,  English,  Bilingual）		 Bilingual Bilingual Bilingual
他研究室学生の受け入れの可否（〇×）
Availability for Students from Other Lab.		 x x x
他研究室学生の参加に関する問い合わせ先
Contact Information for Students from Other  Lab.		 　 　 　
授業形態
Course Type		 Lecture Seminar Practice 
標準履修年次
Year		 1 or 2 1 or 2 1 or 2
実施学期・曜時限等
Semester,Day and Period		 ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester
開講場所
Room Number		 Hospital Keyaki Building, 5th floor, Conference Room Medical Gakkeito Building, Rooms 263, Laboratory of Obstetrics and Gynecology Medical Gakkeito Building, Rooms 262, 263, and 244, Laboratory of Obstetrics and Gynecology
単位数
Credit		 Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等 （make an appointment by E-mail） （make an appointment by E-mail） （make an appointment by E-mail）
Faculty Members and E-mail　　　　　　　　　　　 SATOH Toyomi, toyomi-s at画像 SATOH Toyomi, toyomi-s at画像 SATOH Toyomi, toyomi-s at画像
HAMADA Hiromi, hhamada at画像 HAMADA Hiromi, hhamada at画像 HAMADA Hiromi, hhamada at画像
OKI Akinori, a-oki at画像 OKI Akinori, a-oki at画像 OKI Akinori, a-oki at画像
MINAGUCHI Takeo, minaguchit at画像 MINAGUCHI Takeo, minaguchit at画像 MINAGUCHI Takeo, minaguchit at画像
OBATA Mana, manobata at画像 OBATA Mana, manobata at画像 OBATA Mana, manobata at画像
KAWASAKI Akiko, akawasaki at画像 KAWASAKI Akiko, akawasaki at画像 KAWASAKI Akiko, akawasaki at画像
OCHI Hiroyuki, hochi at画像 OCHI Hiroyuki, hochi at画像 OCHI Hiroyuki, hochi at画像
NAKAO Sari, s.nakao at画像 NAKAO Sari, s.nakao at画像 NAKAO Sari, s.nakao at画像
OHARA Rena, renaohara at画像 OHARA Rena, renaohara at画像 OHARA Rena, renaohara at画像
AKIYAMA Azusa, aakiyama at画像 AKIYAMA Azusa, aakiyama at画像 AKIYAMA Azusa, aakiyama at画像
SHIKAMA Ayumi, ashikama at画像 SHIKAMA Ayumi, ashikama at画像 SHIKAMA Ayumi, ashikama at画像
ABE Haruna, abeharuna at画像 ABE Haruna, abeharuna at画像 ABE Haruna, abeharuna at画像
授業概要
Course Overview		 Through discussions on the subject of the latest findings on molecular biological experiments, animal experiments, and histopathological analyses about researches on gynecologic oncology, perinatal medicine, reproductive endocrinology, and women's healthcare, this course cultivates the ability to plan, conduct, and evaluate experimental researches independently as a specialized researcher. Through reading English original articles, about basic and clinical aspects of development and progression, epidemiologic factors, and diagnosis and treatment of gynecologic cancers in the field of gynecologic oncology, about prenatal diagnosis, perinatal management, and obstetrical management of various obstetrical and hereditary diseases in the field of perinatology, about diagnosis and treatment in the field of reproductive endocrinology, and about diagnosis and treatment for improving women's health according to each lifestage in the field of women's healthcare, students will be able to plan original and valuable research projects on their own based on understanding of the contents and levels of top researches and the world’s trends of research. This course cultivates not only the clinical ability as medical specialists of obstetrics and gynecology, but also the ability of planning, executing, and evaluating experimental researches as basic researchers of obstetrics and gynecology based on the world’s trends and levels. 1. To learn about experimental principles and methods necessary for studies on obstetrics and gynecology (gynecologic oncology, perinatal medicine, reproductive endocrinology, and women's healthcare), and to be able to evaluate experimental results scientifically.
2. To be able to apply those experiments for elucidation of own research subjects.
授業の到達目標（学修成果）
SBO(Specific Behavior Objectives		  1. To be able to give presentations about the purpose, methods, results, significance, and perspectives of own experimental researches.
2. To be able to explain the position and originality of own experiments in the world’s research of the relevant field.
3. To be able to understand questions and comments about own presentations, and to reflect the discussions toward improving the quality of their subsequent studies.
4. To be able to understand presentations by other students, to evaluate the significance and drawback, and to make questions and discussions for improving them.
5. To understand the regulations and methods on recombinant DNA experiments, and to be able to plan, apply for, and conduct appropriate gene recombination experiments.
6. To understand regulations and bioethical issues on animal experiments, and to be able to plan, apply for, and perform appropriate animal experiments.
7. To understand benign and malignant lesions on pathological and whole-body levels, and to be able to explain an outline of pathological structures and protective reactions by hosts.		 1. To be able to select articles to read among reviews and original articles about the latest fields of obstetrics and gynecology from major scientific journals by Web search.
2. To be able to read and understand appropriate review articles about own research theme, to explain the outline and topics to other students within a determined time, and to indicate directions where the research should proceed.
3. To be able to read articles selected by other students beforehand, understand their presentations, and to discuss questions and significances.
4. To be able to explain the historical significance and the position in clinical medicine and basic research of the each article.
5. To be able to understand the contents of the articles, and to extract items for feedback and application for clinical medicine.		 1. To understand basic techniques for cell culture, and to be able to perform cryopreservation, thawing, passage, and observation of cells.
2. To understand basic techniques for gene analyses, and to be able to perform methods of DNA/RNA extraction from single to multiple cells, PCR and RT-PCR, etc.
3. To understand basic techniques for protein analyses, and to be able to perform methods of protein extraction, Western blotting, and immunohistochemistry, etc.                                                                                      4. To understand principles of various experimental methods focusing on gene and protein analyses in the field of obstetrics and gynecology, and to be able to conduct those techniques.
5. To apply learned techniques, to make appropriate experimental plans to achieve own study subjects, and to be able to execute those plans.
キーワード
Keyword		 　 　 　
授業計画
Course Schedule

第1回（月日、時限）担当教員名　講義内容など
 On research themes of gynecologic oncology, perinatal medicine, reproductive endocrinology, and women's healthcare, presentations and discussions will be made in order to develop knowledge, originality, and independence for enabling decision of study purpose, selection of methods, significance of results, and selection of subsequent experiments.
Based on each particular discussion, confirmation of general knowledge will be always conducted.		 How to select articles to read: extraction of problems in accordance with clinical study or basic research
History of study theme and originality behind superior scientific articles
Structure of scientific articles
How to interpret experimental results
Logical structure and conclusion of scientific articles
Consideration about evolution of research after the articles		 1. Basic technique practice of cell culture (1): To learn observation method of cultured cells
2. Basic technique practice of cell culture (2): To learn passage operation of cultured cells
3. Basic technique practice of cell culture (3): To learn cryopreservation and thawing of cultured cells
4. DNA extraction practice: To extract DNA from cultured cells
5. RNA extraction practice: To extract RNA from tissue samples
6. Gene analysis practice (1): To learn actual techniques of PCR
7. Gene analysis practice (2): To learn actual techniques of RT-PCR
8. Protein extraction practice: To extract proteins from cultured cells
9. Protein analysis practice (1): To learn actual techniques of Westerblotting
10. Protein analysis practice (2): Continued
11. Protein analysis practice (3): To learn actual techniques of immunohistochemistry
12. Protein analysis practice (4): Continued          13. Hereafter, practice will be done by individually teaching necessary experimental techniques according to each student’s research subjects.
履修条件
Course Prerequisites		 　 　 　
成績評価方法
Grading Phylosophy		 Achievement levels of SBO are evaluated as marks for class participation.
The students who;
Can do SBO 1 and 2 generally, are evaluated as C or upper grade.
Can do SBO 1 to 3 generally, and are doing 4 actively, are evaluated as B or upper grade. Understanding level of SBO 1 to 3 is judged by presented summary of presentation and discussion in 1 page of A4 paper.
Have excellent ability about SBO 1 to 4, and can do SBO 5 to 7 generally, are evaluated as A.		 Achievement of SBO 1 and 2 is evaluated as marks for class participation.
The students who;
- Can do SBO 1 and 2 generally, are evaluated as C or upper grade.
- Can do SBO 1 and 2 generally, and are doing 3 actively, are evaluated as B or upper grade.
- Have excellent ability of understanding after giving presentations at the meeting of the department of obstetrics and gynecology about the summaries of introduced articles more than 2 times, are evaluated as A.		 Understanding and learning level of experimental techniques and understanding level of experimental results (70 %), and applying ability to own research subjects and planning ability of new experimental designs (30 %) are evaluated by oral examinations.
学習時間の割り当て及び授業外における学修方法
Learning method		 Lecture 100%
Out-of-class study: Discuss with responsible faculty members and other students about your experimental plan, methods, and interpretation of results, and improve own ability for creativity and a sense of independence.		 Training (Seminar) 100%
Out-of-class study: Perform clinical training at the university hospital according to the specialty field or laboratory research, select and read original articles based on the research theme, and extract questions in advance.		 Experiment, Practice 100%                                        Out-of -class study: 1. To repeat the learned experimental techniques, and acquire stable and reliable skills.
2. To read and understand English publications on the relevant experiments.
教材・参考文献
Textbook		 1. DiSaia PJ, Creasman WT ed.: Clinical Gynecologic Oncology, 9th Edition, Elsevier Saunders, 2017.
2. Hoffman B et al. ed.: Williams Obstetrics, 25th Edition, McGraw-Hill, 2018.		 1. DiSaia PJ, Creasman WT ed.: Clinical Gynecologic Oncology, 9th Edition, Elsevier Saunders, 2017.
2. Hoffman B et al. ed.: Williams Obstetrics, 25th Edition, McGraw-Hill, 2018.		 Will be suggested in the practice.
単位取得要件
Requirement to earn credit		 Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 Attendance 80％ or more.
Attendance of 5 hours or more to other lab's classes.		 General achievement of SBO.
Submission of lab notebooks.
その他（受講上の注意点等）
Notes		 It is desirable to take this course in combination with Seminar and Practice in Obstetrics and Gynecology.
Ask and resolve immediately your questions about what you don’t understand.
Have thoroughly scientific, logical, and exact discussions.		 Ask and resolve immediately your questions about what you don’t understand.
Have thoroughly scientific, logical, and exact discussions.		 In principle, only students who major in obstetrics and gynecology can take this course.                    Students who wish to take this course must acquire permissions from the principal faculty member in advance.
It is desirable to take this course in the first year.
他の授業科目との関連 Seminar in Surgery　I, II
Practice  in Surgery  I, II		 Lecture and Discussion in Surgery I, II
Practice  in Surgery I, II		 Lecture and Discussion in Surgery I, II
Seminar in Surgery I, II

 

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