シラバス Syllabus Doctoral Program in Clinical Sciences
科目名・科目番号
Subjects・Course Number
 Lecture and Discussion in Internal Medicine I /　02EX280 Seminar in Internal Medicine I /　02EX282 Practice in Internal Medicine I /　02EX284
Lecture and Discussion in Internal Medicine II/　02EX281 Seminar in Internal Medicine II/　02EX283 Practice in Internal Medicine II/　02EX285
研究分野
Laboratories		 Pulmonology Pulmonology Pulmonology
使用言語
Language used （Japanese,  English,  Bilingual）		 Bilingual Bilingual Bilingual
他研究室学生の受け入れの可否（〇×）
Availability for students from other lab.		 〇 〇 〇
他研究室学生の問い合わせ先
Contact Information for Students from Other  Lab.		 HIZAWA Nobuyuki, nhizawa at画像 HIZAWA Nobuyuki, nhizawa at画像 HIZAWA Nobuyuki, nhizawa at画像
授業形態
Course Type		 Lecture, presentation and discussion Seminar Practice 
標準履修年次
Year		 1 or 2 1 or 2 1 or 2
実施学期・曜時限等
Semester,Day and Period		 ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester ⅠSpring semester / ⅡAutumn semester
開講場所
Room Number		 Conference room, other Conference room, other Conference room, other
単位数
Credit		 Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits Spring and Autumn semester, 2 x 2 credits
担当教員名・オフィスアワー等 （Make an appointment by E-mail） （Make an appointment by E-mail） （Make an appointment by E-mail）
Faculty Members and E-mail　　　　　　　　　 HIZAWA Nobuyuki, nhizawa at画像 HIZAWA Nobuyuki, nhizawa at画像 HIZAWA Nobuyuki, nhizawa at画像
ISHII Yukio, ishii-y at画像 ISHII Yukio, ishii-y at画像 ISHII Yukio, ishii-y at画像
SATOH Hiroaki, hirosato at画像 SATOH Hiroaki, hirosato at画像 SATOH Hiroaki, hirosato at画像
MORISHIMA Yuko, mk01a231 at画像 MORISHIMA Yuko, mk01a231 at画像 MORISHIMA Yuko, mk01a231 at画像
SAKAMOTO Tohru, t-saka at画像 SAKAMOTO Tohru, t-saka at画像 SAKAMOTO Tohru, t-saka at画像
KIWAMOTO Takumi, t-kiwamoto at画像 KIWAMOTO Takumi, t-kiwamoto at画像 KIWAMOTO Takumi, t-kiwamoto at画像
MATSUNO Yosuke, yosukem at画像 MATSUNO Yosuke, yosukem at画像 MATSUNO Yosuke, yosukem at画像
MASUKO Hiroyuki, hironori814 at画像yahoo.co.jp MASUKO Hiroyuki, hironori815 at画像yahoo.co.jp MASUKO Hiroyuki, hironori816 at画像yahoo.co.jp
NAKAZAWA Kensuke, knakazawa at画像 NAKAZAWA Kensuke, knakazawa at画像 NAKAZAWA Kensuke, knakazawa at画像
SHIOZAW Toshihiro, t-shiozawa at画像 SHIOZAW Toshihiro, t-shiozawa at画像 SHIOZAW Toshihiro, t-shiozawa at画像
授業概要
Course overview		 The objective of this course is for students to improve the understanding of the anatomical features
and functions of the respiratory system from the point of view of integrated physiology. Students will
learn several techniques related to molecular biology and genetic epidemiology to elucidate etiologies and pathophysiological
processes of respiratory diseases and to develop novel therapeutic options for them. Furthermore, this
course provides a brief review of skills related to a clinical study for designing and conducting translational
research.        		 The goal of this seminar is for students to improve the critical skills of reading scientific papers to understand the objectives, methods and findings of the research, which are then discussed by the group members to elucidate its significance and limitations. Students will also discuss how to design and conduct experiments to obtain skills that are needed to draw up their own research plans. The goal of this course is for students to learn practically about research principles and methods including life-science techniques to elucidate the etiology and pathophysiology of respiratory diseases. Students will also learn how to analyze and interpret the results of the experiments. Furthermore, through this course, we aim to provide students with research skills and experience that prepare them to be capable of pursuing and developing their subsequent studies on their own.
授業の到達目標（学修成果）
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives		 Upon successful completion of this course, the student will be able to:
1. Understand the anatomy and physiology of the respiratory system, and explain the etiologies and
pathophysiological processes of a wide range of respiratory diseases.
2. Explain appropriate diagnostic and therapeutic options for a wide range of respiratory diseases.
3. Understand various experimental approaches such as molecular biological and genetic
techniques, and apply them to the research projects in the field of pulmonology.
4. Understand ethical and statistical aspects of clinical studies, and plan and carry out researches
properly.		 Upon successful completion of this seminar, the student will be able to:
1. Search, collect and select appropriate scientific papers presenting novel findings on etiology, pathogenesis, diagnostic techniques, or treatment options of respiratory diseases.
2. Explain the scientific background of the research.
3. Explain the scientific characteristics and originality of the research in the field.
4. Understand and explain the methods used in the research and interpretations of the presented findings.
5. Explain the scientific significance and limitations of the research.		 1. Obtain clinical information and specimens such as blood, bronchoalveolar lavage fluid and tissue for molecular biological and genetic research.
2. Extract genomic DNA or RNA from whole blood, tissue and cultured cells.
3. Detect and analyze genetic polymorphism (e.g., allele-specific PCR, DNA sequencing, restriction fragment length polymorphism, etc.).
4. Perform statistical analysis on the association of genetic polymorphism with disease phenotypes.
5. Breed wild-type and genetically modified mice, establish appropriate animal models, and obtain biological specimens for use in research.
6. Passage, freeze and thaw cultured cells.
7. Prepare formalin-fixed paraffin-embedded samples, cut them in thin sections, perform appropriate staining, and observe the stained sections under light microscopes.
8. Detect and analyze the expression of proteins by western blotting.
9. Detect and analyze the expression of mRNA by real time PCR and RNA-seq.
キーワード
Keyword		 Asthma, COPD, Interstitial lung diseases, Infectious lung diseases, Lung cancer, Lung injury and repair Asthma, COPD, Interstitial lung diseases, Infectious lung diseases, Lung cancer, Lung injury and repair Asthma, COPD, Interstitial lung diseases, Infectious lung diseases, Lung cancer, Lung injury and repair
授業計画
Course Schedule

第1回（月日、時限）担当教員名　講義内容など
 Weekly meeting will be held irregularly.
Make contact with a responsible faculty member.		 Weekly meeting will be held irregularly.
Make contact with a responsible faculty member.		 Weekly meeting will be held irregularly.
Make contact with a responsible faculty member.
履修条件
Course prerequisite		 　 　 　
成績評価方法
Grading Criteria		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved under supervision in the SBOs 1 and 2:  Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4:  Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4: Pass (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Students are evaluated by the achievement of the objectives listed in the SBO.
- Good achieved  in the SBOs 1 and 2:  Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3:  Pass (B).
Based on written summary of papers (A4 1 page, twice a month).  good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)		 Skills to obtain reliable experimental results （50%）
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
学修時間の割り当て及び授業外における学修方法
Learning method		 Lecture 100%
Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.		 Training (Seminar) 100%
Out-of-class study:  Write summary on papers (2 per month) together with own opinion.		 Experiment, Practice 100%
Out-of-class study:  Learn and acquire stable and reliable experimental techniques.
教材・参考文献
Textbook		 Richard S. Fraser, Nestor L. Muller, Neil C. Colman and P. D. Paré. (1999) Fraser and Paré’s Diagnosis of Diseases of the Chest, volume 1-4, 4th edition, W.B. Saunders Company.  Ronald G. Crystal, John B. West, Peter J. Barnes and Ewald R. Weibel. (1997) The Lung: Scientific Foundations, volume1-2, 2nd edition, Lippincott Williams & Wilkins. 1. Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter. (2008) Molecular Biology of the Cell: Reference Edition, 5th edition, Garland Science.
2. Tom Strachan and Andrew Read. (2010) Human Molecular Genetics, 4th edition, Garland Science.
単位取得要件
Requirement to earn credit		 Requirement to earn credit: Attendance 80％ or more. Requirement to earn credit: Attendance 80％ or more. Requirement to earn credit: Attendance 80％ or more.
SOB.
その他（受講上の注意点等）
Notes		 Students are encouraged to make a list of discussion points and questions and to come prepared to contribute to the seminar discussion. Students are encouraged to make a list of discussion points and questions and to come prepared to contribute to the seminar discussion. Students are encouraged to make a list of discussion points and questions and to come prepared to contribute to the seminar discussion.
他の授業科目との関連
Related Subjects		 Seminar in Internal Medicice　I, II
Practice  in Internal Medicice  I, II		 Lecture and Discussion in Internal Medicice I, II
Practice  in Internal Medicice I, II		 Lecture and Discussion inInternal Medicice I, II
Seminar in Internal Medicice I, II

 

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