Subjects・Course Number
Laboratories
Language used （Japanese, English, Bilingual）
Availability for students from other lab.
Contact Information for Students from Other Lab.
Course Type
Year
Semester,Day and Period
Room Number
Credit
tokai.or.jptokai.or.jptokai.or.jpCourse overview
1. Investigate the physiologic and pathologic processes of growth and development in terms of molecular mechanism in embryogenesis, differentiation, apoptosis and regeneration.
2. Create methods on the basis of the above results to improve human health and control diseases.
3. Cultivate researchers who can apply ideas of bioethics to improve quality of lives of infants and children.
To be able to do theoretical clinical approach in pediatric medicine.
To be able to contribute to the development of new diagnostic or therapeutic methods for disorders of childhood.
Course Objectives (Learning Outcomes)
←SBO(Specific Behavior Objectives
2. To be able to explain the pathogenic mechanism of pediatric disorders.
3. To understand and to be able to explain the principle of laboratory examinations used in the field of pediatric medicine.
4. To understand and to be able to explain the principle of laboratory examinations used for the diagnosis of pediatric disorders.
5. To understand and to be able to explain the principle of methods to treat pediatric disorders.
6. To understand and to be able to explain the general condition of children and the relationships between the circumstances.
7. To be able to explain the reason of excellence, significance and originality of their study in the world.
8. To be able to apply the results of the discussion in their own study with correct
understanding of its contents.
9. To be able to provide constructive opinion and promote discussion regarding the study results of other students based on the understanding of their meaning and problems.
10. To be able to plan and perform experiments appropriately with the knowledge of rules and ethical problems in the field of life science.
2. To be able to evaluate the significance of the selected original articles and to explain their essence to others during the allotted time period.
3. To be able to discuss the significance and questionable points in the publications.
4. To be able to explain the original articles in the view of the historical significance and current situation in the whole picture of the life sciences.
2. To understand and acquire the principle and techniques for the analysis of gene function through cell culture and by making genetically engineered mice.
3. To be able to make disease-specific iPS cells, and to understand the usefulness of iPS cells for the analysis of pathophysiology and for the establishment of new therapy.
4. To be able to analyze the pathophysiology of arrhythmia of fetuses and children by using magnetocardiography.
Keyword
Course Schedule
第1回（月日、時限）担当教員名 講義内容など
Contents: Pathophysiology of pediatric diseases, genetic analysis, cause and pathophysiology of immunodeficiency, and gene therapy etc.
To select valuable original articles, and to be able to find historical significance and
originality in them.
To grasp the composition of the original articles.
To gain proficiency in reading the original articles.
To interpret the theoretical development and cohesiveness of the original articles.
Self Study
Students are recommended to read specified original articles beforehand, and to prepare to point out questions to solve in the discussion with tutors regarding them.
Students are also encouraged to attend the meeting held from 11:00 on Wednesday, from 13:00 on Thursday, and from 8:00 on Friday.
Contents: Pathophysiology of pediatric diseases, genetic analysis, cause and pathophysiology of immunodeficiency, and gene therapy etc.
1. Learn the methods of Bioinformatics applying next-generation-sequencer and genome-wide association study.
2. Make gene-engineered mice.
3. Make iPS cells and to induce them to differentiated cells of aim based on the knowledge of the methods to recapitulate the disorders and of the methods to search new drugs by drug screening using iPS cells.
4. Be able to perform magnetocardiographic analaysis.
5. Learn how to plan studies of pediatric medicine, important points in the ethical review application and methods of statistical analysis.
Self Study
Students can repeat the technical procedures of experiments to obtain stable and reliable results.
Students are also encouraged to attend the meeting held from 11:00 on Wednesday, from 13:00 on Thursday, and from 8:00 on Friday.
Contents: Pathophysiology of pediatric diseases, genetic analysis, cause and pathophysiology of immunodeficiency, and gene therapy etc.
Course prerequisite
Grading Criteria
- Good achieved under supervision in the SBOs 1 and 2: Pass (C).
- Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4: Pass (B).
SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion.
- Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A)
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
- Good achieved in the SBOs 1 and 2: Pass (C).
- Good achieved in the SBOs 1 - 2, and actively conducted SBO 3: Pass (B).
Based on written summary of papers (A4 1 page, twice a month). good achievement including SBO 4 is confirmed,: Pass (A).
- Outstanding achievement with enough evidence in all SBOs : Pass (A+)
Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion （50%）
A+: Superior (more than 90: top 10%)
A: Excellent (80-89: upper 20%)
B: Good (70-79)
C: Average (60-69)
D: Failure (less than 60)
Learning method
Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence.
Out-of-class study: Write summary on papers (2 per month) together with own opinion.
Out-of-class study: Learn and acquire stable and reliable experimental techniques.
Textbook
Requirement to earn credit
SOB.
Notes
Related Subjects
Practice in Internal Medicice I, II
Practice in Internal Medicice I, II
Seminar in Internal Medicice I, II