シラバス Syllabus | Doctoral Program in Medical Sciences | ||
---|---|---|---|
科目番号 Course Number |
0BTE31 / 0BTE33 | 0BTE35 / 0BTE37 | 0BTE39 / 0BTE3B |
科目名 Subjects |
Lecture and Discussion in Genome and Environmental Medicine I Lecture and Discussion in Genome and Environmental Medicine II |
Seminar in Genome and Environmental Medicine I Seminar in Genome and Environmental Medicine II |
Practice in Genome and Environmental Medicine I Practice in Genome and Environmental Medicine Ⅱ |
研究分野 Laboratories |
Molecular and Genetic Epidemiology | Molecular and Genetic Epidemiology | Molecular and Genetic Epidemiology |
使用言語 Language used (Japanese, English, Bilingual) |
Bilingual | Bilingual | Bilingual |
他研究室学生の受け入れの可否(〇×) Availability for Students from Other Lab. |
○ | ○ | ○ |
他研究室学生の参加に関する問い合わせ先 Contact Information for Students from Other Lab. |
Naoyuki Tsuchiya, tsuchiya | Naoyuki Tsuchiya, tsuchiya | Naoyuki Tsuchiya, tsuchiya |
授業形態 Outline |
Lecture, presentation and discussion | Seminar | Practice |
標準履修年次 Year |
1 or 2 | 1 or 2 | 1 or 2 |
実施学期・曜時限等 Semester,Day and Period |
ⅠSpring semester / ⅡAutumn semester Every Thursday, immediately after “Seminars in Molecular and Genetic Epidemiology” class (approximately 18:15-19:30), except otherwise announced. No class in August, winter and spring breaks. |
ⅠSpring semester / ⅡAutumn semester Every Thursday, 17:15-18:15, except otherwise announced. No class in August, winter and spring breaks. |
ⅠSpring semester / ⅡAutumn semester Intensive |
開講場所 Room Number |
Conact the faculty member | Conact the faculty member | Conact the faculty member |
単位数 Credit |
Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits |
担当教員名・オフィスアワー等 | (make an appointment by E-mail) | (make an appointment by E-mail) | (make an appointment by E-mail) |
Faculty Members and E-mail | Naoyuki Tsuchiya, tsuchiya | Naoyuki Tsuchiya, tsuchiya | Naoyuki Tsuchiya, tsuchiya |
Aya Kawasaki, a-kawasaki | Aya Kawasaki, a-kawasaki | Aya Kawasaki, a-kawasaki | |
授業概要 Study Subjects |
This course consists of the progress reports of the attending students. In this course, the students are requested to present their own reearch progress and research plans from the viewpoint of human genetics and genetic epidemiology, followed by discussion with all students and faculty members. The presentations should be given in English language. Both English and Japanese panguages are used in the discussion. | This course is a journal club. Students are requested to read, summarize and critically review the significance and problems of a recent paper related to human genetics and genetic epidemiology. The presentation should be done in English language. Both English and Japanese may be used in the discussion. | This course is a workshop on how to use basic genome databases and how to perform statistical analysis in human genome analysis. Different subjects are provided for .Practice in Genome and Environmental Medicine I and II. |
学位プログラム・コンピテンスとの関係Competence |
【Generic Competence】Inttelectual Creativity, Communication Skills 【Specific Competence】Research PlammomgSkills, Cutting-edge Research Execution Skills, 、Speciallized knowledge, Information and communication technology Skills |
【Generic Competence】Inttelectual Creativity, Communication Skills 【Specific Competence】Research PlammomgSkills, Cutting-edge Research Execution Skills, 、Speciallized knowledge, Information and communication technology Skills |
【Generic Competence】Inttelectual Creativity 【Specific Competence】Research PlammomgSkills, Cutting-edge Research Execution Skills, 、Speciallized knowledge |
授業の到達目標(学修成果) SBO(Specific Behavior Objectives |
Students are expected to learn the principles and methodology to study human genome diversity and its implications in disease research. As a result, they are expected to acquire the following abilities. 1. The ability to present the purpose, methods, results, interpretation of the results and future research plan. 2. The ability to to discuss the significance and originality of their experimental and/or statistical analyses in relation to the current understanding in the research field. 3. The ability to appreciate questions and comments from your peers and advisors, and to effectively utilize them for the improvement of your future research. 4. The ability to understand the significance and limitation of other students’ presentations, and make useful suggestions for the improvement of their research. 5. The ability able to make research protocols in compliance with the Ethical Guidelines for Human Genome/Gene Analysis Research under the supervision of faculty members. 6. The ability to explain genetic/genomic analysis and statistical analysis in the geneics/genomics esearches. 7. The ability to propose the appropriate research design in accordance with the characteritics of the disease of interest. 8. The abilit y to correctly interpret the results of the human genetics studies and their significance in the basic and clinical medicine. |
By critically reviewing a cutting-edge paper, students will learn the up-to-date researches in the field of human genetics/genomics and its implications in disease research. They will also gain an insight how to design and conduct their own studies in order to be able to publish the results in good scientific journals. As a result, they are expected to acquire the following abilities. 1. The ability to find a suitable paper to review from good scientific journals using online reference search systems. 2. The ability to understand the selected paper, and explain it to other students in a given time period. 3. The ability to ask questions and discuss the problems of the paper presented by other students. 4. The ability to explain the significance of the paper in the specific scientific field. |
By attending this workshop, the students will learn how to use the basic human genome databases to obtain necessary information related to their own research projects. They will also learn the basic principles of statistical genetics essential for the studies related to molecular and genetic epidemiology. As a result, they are expected to acquire the following abilities. "Practice in Genome and Environmental Medicine I" 1. The ability to obtain information on the structure and function of genes using public genome databases. 2. The ability to design PCR primers and experimental conditions. 3. The ability to obtain information on the association between human genome diversity and diseases. 4. The ability to obtain information on the SNPs associated with gene expression by using public genome database. "Practice in Genome and Environmental Medicine II" 5. The ability to detect genetic polymorphisms associated with diseases using appropriate statistical tests. 6. The ability to obtain linkage equilibrium information. 7. The ability to run Hardy-Weinberg equilibrium test and to calculate genotype relative risk. 8. The ability to estimate haplotype frequencies and to calculate linkage disequilibrium parameters. 9. The ability to explain the significance of linkage disequilibrium block in the association study of disease susceptibility genes |
キーワード Keyword |
human genome diversity, variant, polymorphism, autoimmune diseases, systemic rheumatic diseases, genetic association study, disease associated variants | human genome diversity, variant, polymorphism, autoimmune diseases, systemic rheumatic diseases, genetic association study, disease associated variants | genome database, bioinformatics, eQTL, association study, linkage disequilibrium, Hardy-Weinberg equilibrium |
授業計画 Course Schedule 第1回(月日、時限)担当教員名 講義内容など |
Thursday, 18:15-19:30 (with occasional changes)(right after "Seminars in Moleculkar and Genetic Epidemiology")。 Every week, one student makes a presentation on his/her research peogress in English, followed by discussion with peer students and faculty members in English and/or Japanese). |
Thursday, 17:00-18:15 (with occasional changes) Every week, one student critically reviews a journal article related to the molecular and genetic epidemiology fieled in English languiage, followed by discussion with peer students and faculty members in English and/or Japanese. |
intensive |
履修条件 Course Prerequisites |
This subject must be taken in combination with "Seminar in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. | This subject must be taken in combination with "Lecture and Discussion in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. | This subject must be taken in combination with "Lecture and Discussion in Molecular and Genetic Epidemiology" and "Seminar in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. |
成績評価方法 Grading Phylosophy |
Grading Methods and Criteria: Students are evaluated by their achievement of SBO. Students who: -acdieived SBO 1 and 2 are graded C or higher. -achieved SBO 1and 2 and actively practicing 3 are graded B or higher. -achieved 1, 2 and 3, and actively practicing 4-8 are graded A or higher - exhibited exceptional performance are graded A+ (top 10%). |
Grading Methods and Criteria: Students are evaluated by their achievement of SBO Students who: -acdieived SBO 1 and 2 are graded C or higher. -achieved SBO 1and 2 and actively practicing 3 are graded B or higher. -achieved 1, 2 and 3, and actively practicing 4 are graded A or higher - exhibited exceptional performance are graded A+ (top 10%). |
Grading Methods and Criteria: Students are evaluated by the achievement of SBO. In each of the "Practice in Genome and Environmental Medicine I and II", students who: -acdieived two or more SBOs are graded C or higher. -achieved three or more SBOs are graded B or higher. -achieved four or more SBOs are graded A or higher - exhibited exceptional performance are graded A+ (top 10%). |
成績評価方法 Grading Phylosophy |
Lecture 100% (Students' presentation and discussion) Out-of-class learning: Preparation for the presentation in the progress report. |
Lecture 100% (Students' presentation and discussion) Out-of-class learning: Read the distributed paper ahead of the journal club, and think of questions to ask. |
Practice 100% Out-of-class learning: Use the bioinformatic tools and/or statistical methods in your own study. |
教材・参考文献 Textbook |
not rquired | Materials will be distributed. | Handouts will be distributed, |
単位取得要件 Requirement to earn credit |
See "Lecture and Discussion in Genome and Environmental Meedicine I, II") | See "Seminar in Genome and Environmental Meedicine I, II") | See "Practice in Genome and Environmental Meedicine I, II") |
その他(受講上の注意点等) Notes |
This subject must be taken in combination with "Seminar in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. | This subject must be taken in combination with "Lecture and Discussion in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. | This subject must be taken in combination with "Lecture and Discussion in Molecular and Genetic Epidemiology" and "Seminar in Molecular and Genetic Epidemiology". Knowledges on human genome analysis of the Master's program level are required to take this course. |
他の授業科目との関連 | Seminar in Genome and Environmental MedicineI, II Practice in Genome and Environmental Medicine I, II |
Lecture and Discussion in Genome and Environmental Medicine I, II Practice in Genome and Environmental Medicine I, II |
Lecture and Discussion in Genome and Environmental Medicine I, II Seminar in Genome and Environmental Medicine I, II |
ティーチングフェロー(TF)・ティーチングアシスタント(TA) | To be announced, if any. | To be announced, if any. | To be announced, if any. |
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