シラバス Syllabus | Doctoral Program in Medical Sciences | ||
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科目名・科目番号 Subjects・Course Number |
Lecture and Discussion in Clinical Pathophysiology Ⅰ/ 0BTNE51 | Seminar in Clinical Pathophysiology I/ 0BTNE55 | Practice in Clinical Pathophysiology I/ 0BTNE59 |
Lecture and Discussion in Clinical Pathophysiology Ⅱ / 0BTNE53 | Seminar in Clinical Pathophysiology II/ 0BTNE57 |
Practice in Clinical PathophysiologyⅡ/ 0BTNE5B |
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研究分野 Laboratories |
Pharmaceutical Sciences | Pharmaceutical Sciences | Pharmaceutical Sciences |
使用言語 Language used (Japanese, English, Bilingual) |
Bilingual | Bilingual | Bilingual |
他研究室学生の受け入れの可否(〇×) Availability for students from other lab. |
× | × | × |
他研究室学生の問い合わせ先 Contact Information for Students from Other Lab. |
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授業形態 Course Type |
Lecture, presentation and discussion | Seminar | Practice |
標準履修年次 Year |
1 or 2 | 1 or 2 | 1 or 2 |
実施学期・曜時限等 Semester,Day and Period |
ⅠSpring semester / ⅡAutumn semester | ⅠSpring semester / ⅡAutumn semester | ⅠSpring semester / ⅡAutumn semester |
開講場所 Room Number |
Medical Gakkeito Building Room 571-2 | Medical Gakkeito Building Room 571-2 | Medical Gakkeito Building Room 571-2 |
単位数 Credit |
Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits |
担当教員名・オフィスアワー等 | (make an appointment by E-mail) | (make an appointment by E-mail) | (make an appointment by E-mail) |
Faculty Members and E-mail | HOMMA Masato, masatoh | HOMMA Masato, masatoh | HOMMA Masato, masatoh |
DOKI Kosuke, k-doki | DOKI Kosuke, k-doki | DOKI Kosuke, k-doki | |
授業概要 Course overview |
Discussion of the study in detail, and general lectures will be provided based on recent findings of pharmacokinetics. 1. Pharmacokinetic analysis for drug disposition 2. Assessing the drug metabolizing enzymes and drug transporters 3. Assessing adverse events including drug interaction in pharmacotherapy |
Students are requested to read, summarize, and understand the current original and review papers in the field of pharmaceutical sciences, and to discuss the scientific value and problem of the research. 1. How to select papers for abstract: Historicity and creativity in scientific papers 2. Structure of scientific papers 3. How to read experimental results 4. Logical structure and summary of scientific papers |
Students will practically learn the principles and methods of experiments required for pharmacokinetic analysis. 1. In vitro experiments of drug metabolism using liver microsomes. 2. Analyses of genetic polymorphisms and mRNA expression associated with drug metabolism and transport. 3. Determination of drug concentration in biological fluids using HPLC or LC/MS/MS. 4. Collection of the patient data required for pharmacokinetic analysis using hospital information system. 5. Pharmacokinetic analysis using software including WinNonlin, NLME, and Simcyp. 6. Statistical analysis using software. |
学位プログラム・コンピテンスとの関係Competence (学位P共通) |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
授業の到達目標(学修成果) Course Objectives (Learning Outcomes) ←SBO(Specific Behavior Objectives |
1. To be able to give presentations on students’ own research and answer the questions on the objectives, methods, and results of the research. 2. To be able to explain the originality and peculiarity of the own research in the related research fields in the world. 3. To be able to understand questions and comments related to students’ presentations, and to use them for the discussion to improve students’ own research. 4. To be able to understand the advantage and weak points of other students’ presentations, ask questions and give useful comments to improve the others’ research. 5. To be able to understand the methods and regulations for clinical research, and to make plan, apply and perform them ethically and acceptably. 6. To be able to search the appropriate information required for pharmacokinetic analysis, and to perform pharmacokinetic and statistical analyses. 7. To be able to plan and carry out the analytical, biochemical and molecular biological experiments required for pharmacokinetic analysis. |
1. To be able to select the valuable paper among the current original papers using scientific journals in the related research fields and on-line search system. 2. To be able to understand the selected papers, and to explain the overview to other students in limited time. 3. To be able to understand other students’ explanation of the papers, and to discuss the scientific value and problems of the research. 4. To be able to discuss the impact and application of original paper studied in the seminar in students’ own research. |
1. To be able to understand the basic techniques for in vitro experiments to evaluate drug metabolism and transport, and to perform appropriate ways. 2. To be able to understand the basic techniques for the evaluation of genetic polymorphisms and mRNA expression associated with drug metabolism and transport, and to perform appropriate ways. 3. To be able to understand the basic techniques for determination of parent drug and its metabolites in biological fluids and body tissue, and to perform appropriate ways. 4. To be able to understand the information required for pharmacokinetic analysis, and to accurately calculate the pharmacokinetic parameters using analysis software including WinNonlin, NLME, and Simcyp. 5. To be able to accurately evaluate the results of experiments and analysis using statistical software. |
キーワード Keyword |
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授業計画 Course Schedule 第1回(月日、時限)担当教員名 講義内容など |
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履修条件 Course prerequisite |
Only for regular students | Only for regular students | Only for regular students |
成績評価方法 Grading Criteria |
Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved under supervision in the SBOs 1 and 2: Pass (C). - Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4: Pass (B). SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion. - Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A) - Outstanding achievement with enough evidence in all SBOs : Pass (A+) |
Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved in the SBOs 1 and 2: Pass (C). - Good achieved in the SBOs 1 - 2, and actively conducted SBO 3: Pass (B). Based on written summary of papers (A4 1 page, twice a month). good achievement including SBO 4 is confirmed,: Pass (A). - Outstanding achievement with enough evidence in all SBOs : Pass (A+) |
Skills to obtain reliable experimental results (50%) Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion (50%) A+: Superior (more than 90: top 10%) A: Excellent (80-89: upper 20%) B: Good (70-79) C: Average (60-69) D: Failure (less than 60) |
学修時間の割り当て及び授業外における学修方法 Learning method |
Lecture 100% Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence. |
Training (Seminar) 100% Out-of-class study: Write summary on papers (2 per month) together with own opinion. |
Experiment, Practice 100% |
教材・参考文献 Textbook |
Reference book: “Clinical Pharmacology & Therapeutics”4th Edition, The Japanese Society of Clinical Pharmacology and Therapeutics ed., IGAKU-SHOIN, 2017 | Original papers will be distributed to the students in advance. No textbook is required. |
Basic protocols for experiments will be provided. |
単位取得要件 Requirement to earn credit |
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その他(受講上の注意点等) Notes |
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他の授業科目との関連 | Seminar in Clinical Pathophysiology I, II Practice in Clinical Pathophysiology I, II |
Lecture and Discussion in Clinical Pathophysiology I, II Practice in Clinical Pathophysiology I, II |
Lecture and Discussion in Clinical Pathophysiology I, II Seminar in Clinical Pathophysiology I, II |
ティーチングフェロー(TF)・ティーチングアシスタント(TA) | To be announced, if any. | To be announced, if any. | To be announced, if any. |
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