シラバス Syllabus | Doctoral Program in Medical Sciences | ||
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科目名・科目番号 Subjects・Course Number |
Lecture and Discussion in Clinical Pathophysiology Ⅰ/ 0BTNE51 | Seminar in Clinical Pathophysiology I/ 0BTNE55 | Practice in Clinical Pathophysiology I/ 0BTNE59 |
Lecture and Discussion in Clinical Pathophysiology Ⅱ / 0BTNE53 | Seminar in Clinical Pathophysiology II/ 0BTNE57 |
Practice in Clinical PathophysiologyⅡ/ 0BTNE5B |
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研究分野 Laboratories |
Radiation Oncology | Radiation Oncology | Radiation Oncology |
使用言語 Language used (Japanese, English, Bilingual) |
Bilingual | Bilingual | Bilingual |
他研究室学生の受け入れの可否(〇×) Availability for students from other lab. |
〇 | 〇 | 〇 |
他研究室学生の問い合わせ先 Contact Information for Students from Other Lab. |
Hideyuki Sakurai, hsakurai | Hideyuki Sakurai, hsakurai | Hideyuki Sakurai, hsakurai |
授業形態 Course Type |
Lecture, presentation and discussion | Seminar | Practice |
標準履修年次 Year |
1 or 2 | 1 or 2 | 1 or 2 |
実施学期・曜時限等 Semester,Day and Period |
ⅠSpring semester / ⅡAutumn semester | ⅠSpring semester / ⅡAutumn semester | ⅠSpring semester / ⅡAutumn semester |
開講場所 Room Number |
Conference room, other | Conference room, other | Conference room, other |
単位数 Credit |
Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits | Spring and Autumn semester, 2 x 2 credits |
担当教員名・オフィスアワー等 | (make an appointment by E-mail) | (make an appointment by E-mail) | (make an appointment by E-mail) |
Faculty Members and E-mail | SAKURAI Hideyuki, hsakurai | SAKURAI Hideyuki, hsakurai | SAKURAI Hideyuki, hsakurai |
TAMAKI Yoshio, ytamaki | TAMAKI Yoshio, ytamaki | TAMAKI Yoshio, ytamaki | |
OKUMURA Toshiyuki, okumura | OKUMURA Toshiyuki, okumura | OKUMURA Toshiyuki, okumura | |
KUMADA Hiroaki, kumada | KUMADA Hiroaki, kumada | KUMADA Hiroaki, kumada | |
MIZUMOTO Masashi, mizumoto | MIZUMOTO Masashi, mizumoto | MIZUMOTO Masashi, mizumoto | |
TERUNUMA Toshiyuki, terunuma | TERUNUMA Toshiyuki, terunuma | TERUNUMA Toshiyuki, terunuma | |
Kei Nakai,knakai | Kei Nakai,knakai | Kei Nakai,knakai | |
授業概要 Course overview |
A case study on radiation oncology, discussion of the details of the study, and general lectures will be provided based on recent findings. | Original reports in radiation oncology will be used in the course. The significance, problems and remaining work in each study will be discussed after an understanding of the study objectives, methods and results is obtained. | Practical training will be provided on the principles and methods of experiments regarding tumor biology and radiation physics in radiation oncology. |
学位プログラム・コンピテンスとの関係Competence (学位P共通) |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
【Generic Competence】Intellectual creativity, Communication skills 【Specific Competence】Research planning skills, Cutting-edge research execution skills, Working knowledge in the specialized field, Information and communication technology skills |
授業の到達目標(学修成果) Course Objectives (Learning Outcomes) ←SBO(Specific Behavior Objectives |
① Acquire and explain radiation biology and physics required for radiation oncologists. Biology: LQ model and a/b ratio, LET and RBE, radiation sensitivity, therapeutic ratio, dose rate effect, recovery from radiation trauma, modification of radiation therapeutic effect, dose fractionation. Physics: Radiation dose unit, dose distribution curve, dosimetry, verification of radiation field, QC, QA. ② Understand indications for radiation therapy and prepare a therapeutic plan together with a supervisory physician. ③ List clinicopathological characteristics of individual tumors. ④ Explain indications for other therapeutic methods, including surgery, chemotherapy, and immunotherapy. 1) Select therapeutic policy (radical/palliative/symptomatic radiation). 2) Explain the definitions of GTV, CTV, ITV, PTV. 3) Explain the normal tissue tolerance dose. 4) Predict possible acute and delayed adverse responses. 5) Explain general external beam radiation methods and dose distribution (single field irradiation, portal irradiation, crossfiring, rotational irradiation). 6) Explain the significance of methods of dose division and their indications (conventionally fractionated, multifractionated, hypofractionated radiation). 7) Explain radiation methods and their indications (brachytherapy, stereotactic irradiation, intraoperative irradiation, total-body irradiation, corpuscular radiation). 8) Explain the indications for emergency irradiation. 9) Explain epidemiology, stage, therapeutic methods, and therapeutic results for representative diseases in individual organs; and methods, therapeutic results, and adverse events in radiation therapy. 10) Refer patients for end-of-life care and mental health care. |
1. Selection of a report to be read among recent original reports in major journals using an online search system. 2. Understand the selected report and explain the outline of the report to other students within a set time. 3. Read a report selected by another student, understand the report after hearing an explanation, and discuss the questions and significance of the study. 4. Explain the historical significance of individual original reports and how the report is ranked among all articles. 5. Further understand the concept of evidence-based medicine, especially in clinical reports, and explain the methods used to test hypotheses and for experimental planning in a radiation oncology study performed under supervision. |
1. Understand basic procedures of cell culture, and perform preservation, thawing, observation, and passage of cells. 2. Evaluate stimulatory and inhibitory effects on cell proliferation quantitatively. 3. Prepare thin sliced samples by fixing, dehydrating and embedding tissues. 4. Analyze the effects of radiation on cultured cells using chemoradiation methods. 5. Analyze expression of specific molecules (proteins, genes) in cultured cells or tissues. 6. Predict therapeutic effects by performing DVH analysis based on data from a radiation therapeutic plan. 7. Promote development of new irradiation techniques using protons, working with supervisory physicians. 8. Perform statistical analysis of the results of their own study. |
キーワード Keyword |
Radiation Therapy, Cancer, Malignant neoplasm | Radiation Therapy, Cancer, Malignant neoplasm | Radiation Therapy, Cancer, Malignant neoplasm |
授業計画 Course Schedule 第1回(月日、時限)担当教員名 講義内容など |
Second year; full year; 9:15-11:00 a.m. on Thursday; 2 credits for course I and 2 credits for course II Hideyuki Sakurai et al. Radiation therapy for malignant tumors: presentation and discussion performed to foster learning of setting of study objectives, selection of methods, understanding of importance of results, and selection of the next study to be performed, in addition to increasing the creativity and independence of students from radiobiological and physical perspectives. General knowledge is reinforced based on discussion of specific areas. |
First year; full year, 17:30-19:00 on Thursday, 2 credits for course I and 2 credits for course II Hideyuki Sakurai et al. Selection of a report: Historical characteristics and originality of the scientific report Composition of the scientific report How to interpret experiment results Reasoning and organization of a scientific report |
First and second years; full year; as needed; 2 credits for course I and 2 credits for course II. Hideyuki Sakurai et al. 1. Basic techniques of cell culture 2. Practical training on colony formation and cell proliferation measurements 3. Practical training in fixation, dehydration, embedding, and thin slicing of tissues 4. Practical training in quantitation (ESR, HPLC) and modification of radicals 5. Practical training in immunohistochemistry, fluorescence antibody techniques, western blotting, and flow cytometry 6. Practical training in DVH analysis 7. Practical training in irradiation techniques using protons and development of spot scanning 8. Practical training in medical statistics |
履修条件 Course prerequisite |
As a rule, only students with a major in particle ray oncology and those in the training program for cancer specialists will be allowed to participate. | As a rule, only students with a major in particle ray oncology and those in the training program for cancer specialists will be allowed to participate. | As a rule, only students with a major in particle ray oncology and those in the training program for cancer specialists will be allowed to participate. |
成績評価方法 Grading Criteria |
Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved under supervision in the SBOs 1 and 2: Pass (C). - Good achieved under supervision in the SBOs 1 - 3, and actively conducted SBO 4: Pass (B). SBOs 1 - 3 will be evaluated based on a brief report in terms of presentation and dicsussion. - Excellent achievement in SBOs 1-4, and good achievement in SBOs 5-7: (A) - Outstanding achievement with enough evidence in all SBOs : Pass (A+) |
Students are evaluated by the achievement of the objectives listed in the SBO. - Good achieved in the SBOs 1 and 2: Pass (C). - Good achieved in the SBOs 1 - 2, and actively conducted SBO 3: Pass (B). Based on written summary of papers (A4 1 page, twice a month). good achievement including SBO 4 is confirmed,: Pass (A). - Outstanding achievement with enough evidence in all SBOs : Pass (A+) |
Skills to obtain reliable experimental results (50%) Understanding of results, and ability to design next experiments will be evaluated by experimental notebook and discussion (50%) A+: Superior (more than 90: top 10%) A: Excellent (80-89: upper 20%) B: Good (70-79) C: Average (60-69) D: Failure (less than 60) |
学修時間の割り当て及び授業外における学修方法 Learning method |
Lecture 100% Out-of-class study: Read textbooks. Discuss with responsible faculty members and students, and improve own ability for creativity and a sense of independence. |
Training (Seminar) 100% Out-of-class study: Write summary on papers (2 per month) together with own opinion. |
Experiment, Practice 100% |
教材・参考文献 Textbook |
『Principles and Practice of Radiation Oncology』4th Edition, Perez CA, Brady LW, Halperin EC, Schmidt-Ullrich RK ed., Lippincott Williams & Wilkins, Elsevier Saunders, | 『Principles and Practice of Radiation Oncology』4th Edition, Perez CA, Brady LW, Halperin EC, Schmidt-Ullrich RK ed., Lippincott Williams & Wilkins, Elsevier Saunders, | 『Principles and Practice of Radiation Oncology』4th Edition, Perez CA, Brady LW, Halperin EC, Schmidt-Ullrich RK ed., Lippincott Williams & Wilkins, Elsevier Saunders, |
単位取得要件 Requirement to earn credit |
Requirement to earn credit: Attendance 80% or more. Attendance of 5 hours or more to other lab's classes. |
Requirement to earn credit: Attendance 80% or more. Attendance of 5 hours or more to other lab's classes. |
Requirement to earn credit: Attendance 80% or more. |
その他(受講上の注意点等) Notes |
When something is unclear, students must raise questions to solve the problem on site. Scientific, logical and rigorous discussions are expected. | When something is unclear, students must raise questions to solve the problem on site. Scientific, logical and rigorous discussions are expected. | When something is unclear, students must raise questions to solve the problem on site. Scientific, logical and rigorous discussions are expected. |
他の授業科目との関連 | Seminar in Clinical Pathophysiology I, II Practice in Clinical Pathophysiology I, II |
Lecture and Discussion in Clinical Pathophysiology I, II Practice in Clinical Pathophysiology I, II |
Lecture and Discussion in Clinical Pathophysiology I, II Seminar in Clinical Pathophysiology I, II |
ティーチングフェロー(TF)・ティーチングアシスタント(TA) | To be announced, if any. | To be announced, if any. | To be announced, if any. |
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