1)      Gikakis N, Khan MMH, Hiramatsu Y, Gorman JH III, Hack CE, Sun L, Rao AK, Niewiarowski S, Colman RW, Edmunds LHJr.  Effect of factor Xa inhibitors on thrombin formation and complement and neutrophil activation during in vitro extracorporeal circulation.  Circulation 1996; 94 (Suppl II): II-341-6.

2)      Hiramatsu Y, Gikakis N, Anderson HL III, Gorman JH III, Marcinkiewicz C, Gould RJ, Niewiarowski S, Edmunds LHJr. Tirofiban provides “platelet anesthesia” during cardiopulmonary bypass in baboons.  The Journal of Thoracic and Cardiovascular Surgery 1997; 113: 182-93.

3)      Hiramatsu Y, Gikakis N, Gorman JH III, Khan MMH, Hack CE, Velthuis H, Sun L, Marcinkiewicz C, Rao AK, Niewiarowski S, Colman RW, Edmunds LHJr, Anderson HL III.  A baboon model for hematologic studies of cardiopulmonary bypass.  The Journal of Laboratory and Clinical Medicine 1997; 130: 412-20.

4)      Rao AK, Sun L, Hiramatsu Y, Gorman JH III, Edmunds LHJr.  Glycoprotein IIb/IIIa receptor antagonist Tirofiban inhibits thrombin generation during cardiopulmonary bypass in baboons.  Thrombosis and Haemostasis 1999; 82: 140-4.

5)      Shigeta O, Kojima H, Hiramatsu Y, Jikuya T, Terada Y, Atsumi N, Sakakibara Y, Nagasawa T, Mitsui T.  Low-dose protamine based on heparin-protamine titration method reduces platelet dysfunction after cardiopulmonary bypass.  The Journal of Thoracic and Cardiovascular Surgery 1999; 118: 354-60.

6)      Hiramatsu Y, Koishizawa T, Matsuzaki K, Enomoto Y, Sakakibara Y.  Leukocyte-depleted blood cardioplegia reduces cardiac troponin T release in patients undergoing coronary artery bypass grafting.  The Japanese Journal of Thoracic and Cardiovascular Surgery 2000; 48: 625-31.

7)      Yoshimura Y, Hiramatsu Y, Sato Y, Homma S, Kikuchi Y, Enomoto Y, Sakakibara Y. Activated neutrophils and platelet microaggregates impede blood filterability through microchannels during simulated extracorporeal circulation.  Annals of Thoracic Surgery 2003; 75: 1254-60.

8)      Sato Y, Hiramatsu Y, Homma S, Sato S, Onizuka M, Sakakibara Y. Phosphodiesterase type-4 inhibition of activated polymorphonuclear leukocytes in a simulated extracorporeal circulation model.  The Journal of Thoracic and Cardiovascular Surgery 2003; 125: 172-7.

9)      Yoshimura Y, Hiramatsu Y, Sato Y, Homma S, Enomoto Y, Jikuya T, Sakakibara Y. ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.  Annals of Thoracic Surgery 2003; 76: 1234-9.

10)   Kaminishi Y, Hiramatsu Y, Watanabe Y, Yoshimura Y, Sakakibara Y. Effects of nafamostat mesilate and minimal-dose aprotinin on blood-foreign surface interactions in cardiopulmonary bypass.  Annals of Thoracic Surgery 2004; 77: 644-50.





1)      Hiramatsu Y, Atsumi N, Sasaki A, Mitsui T. A successful treatment of serous leakage from a polytetrafluoroethylene Blalock-Taussig shunt with intravenous fibrinogen administration.  The Journal of Thoracic and Cardiovascular Surgery 1999; 117: 1230-1.

2)      Horigome H, Hiramatsu Y, Shigeta O, Nagasawa T, Matsui A. Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia. Journal of American College of Cardiology 2002; 39: 1072-7.

3)      Tokunaga C, Hiramatsu Y, Horigome H, Takahashi-Igari M, Noma M, Sakakibara Y. Palliative open heart surgery in an infant with factor VII deficiency. Annals of Thoracic Surgery 2003; 76: 2093-4.



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Microchannel(模擬毛細血管)を閉塞する活性化白血球(好中球)
Pennsylvania大学(Pennsylvania州, Philadelphia)