研究業績: 井上 明日香 (2008-2015)



1.Matusmoto I, Zhang H, Yasukochi T, Iwanami K, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.:
Therapeutic effects of antibodies to TNF alpha and IL-6 and CTLA-4 Ig in mice with glucose-6-phosphate isomerase-induced arthritis
Arthritis Res Ther10:R66,2008

2.
Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.:
B cell play crucial role as antigen presenting cells and collaborationg with inflammatory cytokines in glucose-6-phoaphate isomerase-induced arthritis.
Clin. Exp. Immunol. 155:285-294,2009

3.Iwanami K, Matsumoto I, Tanaka Y, Inoue A, Goto D, Ito S, Tsutsumi A, Sumida T.:
Arthritogenic T cell epitope in glucose-6-phosphate isomerase (GPI)-induced arthritis.
Arthritis Res Ther 10(6):R130. Epub ,2008

4.Inoue A, Matsumoto I, Tanaka Y, Iwanami K, Kanamori A, Ochiai N, Goto D, Ito S, Sumida T.:
Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis.
Arthritis Res Ther.11(4):R118. Epub 2009 Aug 6

5.Iwanami K, Matsumoto I, Yoshiga Y, Inoue A, Kondo Y, Yamamoto K, Tanaka Y, Minami R, Hayashi T, Goto D, Ito S, Nishimura Y, Sumida T.:
Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide.
Arthritis Res Ther.11:R167,Epub2009 Nov 9

6.Akashi N, Matsumoto I, Tanaka Y,Inoue A, Yamamoto K, Tanaka Y, Umeda N, Hayashi T, Goto D, Ito S, Sekiguchi K, Sumida T.:
Comparative suppressive effect in models of autoimmune arthritis by tyrosine kinase inhibitors imatinib and nilotinib.
Mod. Rheumatol 21:267-275,2011

7.Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T.:
Six-transmembrane epithelial antigen of prostate4(STEAP4) is TNFalpha-induced protein that regulates IL-6, Il-8, and cell proliferation in synovium from patients with rheumatoid arthritis
Mod. Rheumatol.22:128-136,2012

8.Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Umeda N, Tanaka Y, Sugihara M, Hayashi T, Ito S, Sumida T.
Six-transmembrane epithelial antigen of prostate4 (STEAP4) is expressed on monocytes/neutrophils, and is regulated by TNF antagonist in patients with rheumatoid arthritis.
Clin. Exp. Rheumatol.30(1):99-102,2012

9.Inoue A, Matsumoto I, Tanaka Y, Umeda N, Tanaka Y, Mihara M, Takahashi S, Sumida T. :
TIARP (TNFAIP9) deficiency leads to arthritis via IL-6 overproduction with enhanced NF-kB, STAT3 signaling and dysregulated apoptosis of macrophages.
Arthritis Rheum 64(12):3877-85,2012

10.
Horikoshi M, Goto D, Segawa S, Yoshiga Y, Iwanami K, Inoue A, Tanaka Y, Matsumoto I, Sumida T.:
Activation of invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis.
PLoS One 7(12):e51215,2012

11.Umeda N, Matsumoto I, Ito I, Kawasaki A, Tanaka Y, Inoue A, Tanaka Y, Tsuboi H, Suzuki T, Hayashi T, Ito S, Tsuchiya N, Sumida T.:
Anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis are associated with HLA-DRB1 shared epitope alleles and disease activity.
Clin Exp Immunol 172(1):44-53,2013

12.Matsumoto I, Inoue A, Takai C, Umeda N, Tanaka Y, Kurashima Y, Sumida T.:
Regulatory roles of tumor necrosis factor alpha-induced proteins (TNFAIP) 3 and 9 in arthritis.(Review)
Clin Immunol 153(1):73-8,2014

13.Tanaka Y, Matsumoto I, Inoue A, Umeda N, Takai C, Sumida T.:
Antigen-specific overexpression of human cartilage glycoprotein 39 on CD4+CD25+Foxp3+ Treg cells in the generation of glucose-6-phosphate isomerase induced arthritis.
Clin Exp Immunol 177(2):419-27,2014

14.Takai C, Matsumoto I, Inoue A, Umeda N, Tanaka Y, Kurashima Y, Wada Y, Narita I, Sumida T.:
Specific overexpression of TNFAIP9 in CD14+CD16- monocytes in patients
with rheumatoid arthritis- Comparative analysis with TNFAIP3.
Clin Exp Immunol 180(3):458-66,2015

15Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, Tateishi K, Ishigame H, Yabe R, Ikeda S, Seno A, Chi HH, Hashiguchi Y, Kurata R, Tada T, Kubo S, Sato N, Liu Y, Hattori M, Saijo S, Matsushita M, Fujita T, Sumida T, Iwakura Y.
CTRP6, a novel complement regulator, effectively treats induced arthritis.
Nat Commun(in press)