Journal Club

Date
Presented by
Article
2021.12.2 Fumika Honda Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy.
Sokratis A Apostolidis et al.
Nat Med.2021 Nov;27(11):1990-2001.
2021.11.18 Tamaki Iwai ELMO1 signaling is a promoter of osteoclast function and bone loss.
Sanja Arandjelovic et al.
Nat Commun.2021 Aug 17;12(1)
2021.11.11 Hirofumi Toko Arthritis flares mediated by tissue-resident memory T cells in the joint.
Margaret H Chang et al.
Cell Rep.2021 Oct 26;37(4):
2021.11.4 Taihei Nishiyama A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.
Harikesh S Wong et al.
Cell.2021 Jul 22;184(15):3981-3997.
2021.10.21 Yuya Kondo Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.
Masato Ogishi et al.
Med.2021 Sep;27(9):1646-1654.
2021.10.7 Reona Tanimura

Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells.
Li-Jun Du et al.
armacol Sin.2021 Sep 22
2021.9.30 Kotona Furuyama A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORγt Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis.
Lucie Bernard-Raichon et al.
J Immunol.2021 Oct 1;207(7):1857-1870
2021.9.16 Ayako Oyama

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.
Pengchong Li et al.
Nat Immunol.2021 Sep;22(9):1107-1117.
2021.9.2 Masaru Shimizu Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis.
Noriko Komatsu et al.
J Clin Invest.2021 May 17;131(10)
2021.7.29 Saori Abe A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome.
Perrine Soret et al.
Nat Commun.2021 Jun 10;12(1):3523
2021.7.15 Tamaki Iwai TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Rikio Yabe et al.
Nat Commun.2021 Jan 4;12(1)
2021.7.8 Hirofumi Toko Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis.
Yi-Shu Huang et al.
Proc Natl Acad Sci U S A.2021 May 11;118(19)
2021.7.1 Taihei Nishiyama An aged immune system drives senescence and ageing of solid organs.
Matthew J Yousefzadeh et al.
Nature.2021 Jun;594(7861):100-105.
2021.6.24 Fumika Honda Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+T cell perturbations.
David Zemmour et al.
Nat Immunol.2021 May;22(5):607-619.
2021.6.17 Yuya Kondo The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Jasna Friscic et al.
Immunity.2021 May 11;54(5):1002-1021.
2021.6.10 Kotona Furuyama Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.
Ryoji Kawakami. et al.
Immunity.2021 May 11;54(5):947-961.
2021.6.3 Ayako Oyama Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages.
Jennifer K Dowling et al.
Nat Commun.2021 Mar 5;12(1):1460.
2021.5.20 Masaru Shimizu The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation.
Danielle Minns et al.
Nat Commun.2021 Feb 24;12(1)1285
2021.5.6 Reona Tanimura EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice.
Lingling Wu et al.
Front Immunol.2021 Mar 26
2021.4.22 Saori Abe Follicular regulatory T cells produce neuritin to regulate B cells.
Paula Gonzalez-Figueroa et al.
Cell.2021 Apr 1;184(7):1775-1789.
2021.3.11 Fumika Honda

Steroid-resistant human inflammatory ILC2s are marked by CD45RO and elevated in type 2 respiratory diseases.
Esmee K van der Ploeg et al.
Sci Immunol.2021 Jan 29;6(55)
2021.3.4 Ayako Oyama

Directional mast cell degranulation of tumor necrosis factor into blood vessels primes neutrophil extravasation.
Jan Dudeck et al.
Immunity.2021 Mar 9;54(3):468-483
2021.2.18 Masaru Shimizu SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.
Yi Tian et al.
Nat Commun.2021 Jan 20;12(1):481.
2021.2.4 Yuya Kondo CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
Jonathan Martinez-Fabregas et al.
Cell Rep.2020 Dec 22;33(12):108545.
2021.1.28 Kotona Furuyama

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.
Clarissa Campbell et al.
Nature.2020 May;581(7809):475-479
2021.1.21 Hiroyuki Takahashi A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.
Christina Krienke et al.
Science.2021 Jan 8;371(6525):145-153
2021.1.14 Saori Abe Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
Matthew C Woodruff et al.
Nat Immunol. 2020 Dec;21(12):1506-1516
2021.1.7 Fumika Honda Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung.
Lucas D Faustino et al.
Nat Immunol.2020 Nov;21(11):1371-1383
2020.12.10 Atsumu Osada

Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis.
Liam J O'Neil et al.
Sci Adv. 2020 Oct 28;6(44)
2020.12.3 Ayako Oyama FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.
Jonathan J Hubbard et al.
J Exp Med.2020 Oct 5;217(10)
2020.11.26 Izumi Kurata Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Jacob A Turner et al.
Immunity.2020 Oct 20;S1074-7613(20)30414-3
2020.11.12 Yuya Kondo PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance.
Catherine L. Tan et al.
J Exp Med 2021;218 (1)
2020.11.5 Reona Tanimura

TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner.
Sathi Babu Chodisetti et al.
Front Immunol. 28 July 2020
2020.10.22 Hiroyuki Takahashi

TGF-and Eomes control the homeostasis of CD8+regulatory
T cells.
Shruti Mishra et al.
J Exp Med 2021; 218 (1)
2020.10.15 Saori Abe

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice.
Liliane Khoryati et al.
Science Immunology 2020 Aug ;5(50)
2020.10.8 Fumika Honda Fibroblasts as a source of self-antigens for central immune tolerance.
Takeshi Nitta et al.
Nat Immunol 2020;doi 10.1038
2020.10.1 Atsuku Osada Notch signalling drives synovial fibroblast identity and arthritis pathology.
Kevin Wei et al.
Nature. 2020 June;582(7811):259-264
2020.9.24 Masaru Shimizu Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen.
Catherine H Poholek et al.
J Exp Med.2020 Oct 5;217(10)
2020.9.17 Izumi Kurata SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.
Xin Wu et al.
Science.2020 Aug 21;369(6506):984-988
2020.9.10 Ayako Oyama Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Stefano Alivernini et al.
Nat Med.2020 Aug;26(8):1295-1306
2020.9.3 Reona Tanimura

Peptidylarginine Deiminase 4 Promotes the Renal Infiltration of Neutrophils and Exacerbates the TLR7 Agonist-Induced Lupus Mice.
Norio Hanata et al.
Front Immunol.2020;Jun 23(11):1095
2020.7.2 Hiroyuki Takahashi CRISPR screen in regulatory T†cells reveals modulators of Foxp3.
Jessica T. Cortez et al.
Nature 2020;582:416-420
2020.6.18 Saori Abe Complement Genes Contribute Sex-Biased Vulnerability in Diverse Disorders.
Nolan Kamitaki et al.
Nature 2020 Jun;582(7813):577-581
2020.6.11 Fumika Honda

Sialylation of immunoglobulin E is a determinant of allergic pathogenicity.
Kai-Ting C.Shade et al.
Nature 2020 May
2020.6.4 Atsumu Osada

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases.
Renato G. S. Chirivi et al
Cell Mol Immunol 2020Mar
2020.5.21 Ayako Oyama mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.
Soo Seok Hwang et al.
Science 2020 Mar;367(6483):1255-1260
2020.5.14 Izumi Kurata Broad Immune Activation Underlies Shared Set Point Signatures for Vaccine Responsiveness in Healthy Individuals and Disease Activity in Patients With Lupus.
Kotliarov Y et al.
Nat Med 2020 Apr;26(4):618-629