|Environmental and hygienic pharmacy|
|environmental response, electrophile, chemical modification, signal transduction, reactive sulfur species|
Purpose and Background of the Research
In the current study, we examine concentration-specific changes in the redox signal transduction pathways that are promoted by the activation of effecter molecules coupled to the chemical modification of a sensor protein following the reaction of its thiol groups with environmental electrophiles. We also explore the possibility that reactive sulfur species such as hydrogen sulfide, persulfide and polysulfide would negatively regulate environmental electrophiles-mediated redox signaling processes.
- Open the website.
- Cooperative research of reactive sulfur species with Prof. Akaike, Tohoku Univ. has been posted on the PNAS website.