Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y. 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation
of IKKb/NF-kB/NO signaling: an alternative mechanism for the disturbance
of inducible NO synthase-catalyzed NO formation. Journal of Toxicological Sciences 2010; 35: 891-898.
Miura T, Kumagai Y. Immunochemical method to detect proteins that undergo selective modification
by 1,2-naphthoquinone derived from naphthalene through metabolic activation.
Journal of Toxicological Sciences 2010; 35:843-852.
Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H. Diesel exhaust particles induce
a Th2 phenotype in mouse naive mononuclear cells in vitro. Experimental and Therapeutic Medicine 2010: 1:761-767.
Hirooka T, Fujiwara Y, Shinkai Y, Yamamoto C, Yasutake A, Satoh M, Eto K, Kaji T. Resistance of human brain
microvascular endothelial cells in culture to methylmercury: cell-density-dependent
defense mechanisms. Journal of Toxicological Sciences. 2010; 35: 287-294.
Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, Distefano E, Hinds W, Kumagai Y, Cho AK, Froines JR. Redox and electrophilic properties of vapor- and
particle-phase components of ambient aerosols. Environmental Research 2010; 110: 207-212.
Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M. Biochemical and cellular effects
of electrophiles present in ambient air samples. Atmospheric Environment 2010; 44: 1483-1489.
Shinkai Y, Yamamoto C, Kaji T. Lead induces the expression of ER chaperones GRP78
and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicological Sciences 2010; 114: 378-386.
Hirooka T, Fujiwara Y, Minami Y, Ishii A, Ishigooka M, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T.Cell-density-dependent
methylmercury susceptibility of cultured human brain microvascular pericytes. Toxicology In Vitro 2010; 24: 835-841.
Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E,
Muscará MN, Costa SK. Involvement of sensory nerves and TRPV1 receptors
in the rat airway inflammatory response to two environment pollutants:
diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ). Archives of Toxicology 2010; 84: 109-117.
2009
Sumi D, Numasawa Y, Endo A, Iwamoto N, Kumagai Y. Catechol estrogens mediated activation of Nrf2 through covalent modification
of its quinone metabolite to Keap1. Journal of Toxicological Sciences 2009; 34: 627-635.
Hirooka T, Fujiwara Y, Inoue S, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T. Suppression of fibroblast
growth factor-2 expression: possible mechanism underlying methylmercury-induced
inhibition of the repair of wounded monolayers of cultured human brain
microvascular endothelial cells. Journal of Toxicological Sciences 2009; 34: 433-439.
Fujiwara Y, Kitagawa T, Shinkai Y, Kaji T, Satoh M. Cilostazol induces metallothionein expression in vascular
cells. Yakugaku Zasshi 2009; 129: 1415-1422.
Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y,
Eguchi M, Wada Y, Kumagai Y, Yamamoto M. The antioxidant defense system Keap1-Nrf2 comprises a multiple
sensing mechanism for responding to a wide range chemical compounds. Molecular and Cellular Biology; 2009; 29; 493-502.
2008
Shibata T, Nakahara H, Kita N, Matsubara Y, Han CG, Morimitsu Y, Iwamoto
N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K. A food-derived synergist
of NGF signaling: Identification of protein tyrosine phosphatase 1B as
a key regulator of NGF receptor-initiated signal transduction. Journal of Neurochemistry 2008; 107; 1248-1460.
Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y. Reduction of arginase I activity and manganese levels in the liver during
exposure of rats to methylmercury: a possible mechanism. Archives of Toxicology. 2008; 82: 803-808.
Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ,Yamano S, Nishiyama T, Hiratsuka
A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is
terminated through its monoglucuronide conjugation in human pulmonary epithelial
A549 cells. Free Radical Biology & Medicine 2008; 44: 1645-1655.
Matsunaga T, Kamiya T, Sumi D, Kumagai Y, B. Kalyanaraman, Hara A. Xylulose reductase is involved in 9,10-phenanthrenequinone-induced
apoptosis in human T lymphoma cells. Free Radical Biology & Medicine 2008; 44:1191-1202.
Kanda H, Kikushima M, Homma-Takeda S, Sumi D, Endo A, Toyama T, Miura N,
Naganuma A, Kumagai Y. Downregulation of Arginase II and Renal Apoptosis by Inorganic Mercury:
Overexpression of Arginase II Reduces Its Apoptosis. Archives of Toxicology 2008; 82: 67-73.
Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK. On the interaction between glyceraldehyde-3-phosphate
dehydrogenase and airborne particles: Evidence for electrophilic species.
Atmospheric Environment; 2008; 42: 517-529.
2007
Kumagai Y,Taguchi K. Toxicological effects of polycyclic aromatic hydrocarbon quinones
contaminated in diesel exhaust particles. Asian Journal of Atmospheric
Environment 2007; 1: 28-35.
Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y. Chemical knockdown of protein tyrosine phosphatase 1B by 1,2-naphthoquinone
through covalent modification causes persistent transactivation of epidermal
growth factor receptor. Journal of Biological Chemistry 2007; 282: 33396-33404.
Sumi D, Kumagai Y. Chemical biology of 1,2-naphthoquinone, a novel air pollutant, that affects
signal transduction pathways. YAKUGAKU ZASSHI 2007; 127: 1949-1956.
Iida K, Itoh K, Maher JM., Kumagai Y, Oyasu R, Mori Y, Shimazu T, Akaza H, Yamamoto M. Nrf2 and p53 cooperatively
protect against BBN-induced urinary bladder. Carcinogenesis 2007; 28: 2398-2403.
Sumi D, Manji A, Shinkai Y, Toyama T, Kumagai Y. Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase
heavy subunit chain levels and caspase-3-dependent apoptosis during exposure
of primary mouse hepatocytes to diphenylarsinic acid. Toxicology and Appled Pharmacology 2007; 223: 218-224.
Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F,
Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone
and redox activity of the hydroquinone associated with oxidative stress.
Free Radical Biology & Medicine 2007; 43: 789-799.
Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi
D, Hiyoshi K, Kumagai Y. Effects of naphthoquinone on airway responsiveness in the presence or
absence of antigen in mice. Archives of Toxicology 2007; 81: 575-581.
Shinkai Y, Truc DV, Sumi D,Canh D, Kumagai Y. Arsenic and other metal contamination of groundwater in the Mekong River
Delta, Vietnam. Journal of Health Science 2007; 53: 344-346.
Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura
S, Kumagai Y. Naphthoquinone enhances antigen-related airway inflammation in mice.
European Respiratory Journal 2007; 29: 259-267.
Cui RZ, Iso H, Pi JB, Kumagai Y, Yamagishi K, Tanigawa T, Shimamoto T. Metabolic syndrome and urinary
cGMP excretion in general population. Atherosclerosis 2007; 190: 423-428.
2006
Sun Y, Sumi D, Kumagai Y. Serine 1179 phosphorylation of endothelial nitric oxide synthase caused
by 2,4,6-trinitrotoluene through PI3K/Akt signaling in endothelial cells.
Toxicology and Applied Pharmacology 2006; 214:55-60.
Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y. Sulforaphane, an activator of Nrf2, suppresses cellular accumulation
of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Letters 2006; 580: 1771-1774.
Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein
tyrosine phosphorylation, leading to contraction of guinea pig trachea.
Toxicology and Applied Pharmacology 2006; 210: 47-54.
Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y. Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression
of Endothelium-Dependent Vasorelaxation by 1,2-Naphthoquinone, a Component
of Diesel Exhaust Particles. Archives of Toxicology 2006; 80: 280-285.