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筑波大学 医学医療系 環境生物学研究室
環境生物学研究室
〒305-8575 
茨城県つくば市天王台1-1-1
筑波大学医学医療系 
環境生物学研究室
TEL:029-853-3297

English

原著・総説

2010

  1. Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y. 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKb/NF-kB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation. Journal of Toxicological Sciences 2010; 35: 891-898.
  2. Miura T, Kumagai Y. Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation. Journal of Toxicological Sciences 2010; 35:843-852.
  3. Toyama T, Shinkai Y, Sumi D, Kumagai Y. Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells. Toxicology and Applied Pharmacology 2010; 249: 86-90.
  4. Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H. Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro. Experimental and Therapeutic Medicine 2010: 1:761-767.
  5. 安孫子ユミ熊谷嘉人. 地球規模におけるヒ素汚染の現状. ファルマシア 2010; 46: 649-653.
  6. Hirooka T, Fujiwara Y, Shinkai Y, Yamamoto C, Yasutake A, Satoh M, Eto K, Kaji T. Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. Journal of Toxicological Sciences. 2010; 35: 287-294.
  7. Sumi D, Shinkai Y, Kumagai Y. Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells. Toxicology and Applied Pharmacology 2010; 244: 385-392.
  8. Abiko Y, Shinkai Y, Sumi D, Kumagai Y: Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. Journal of Toxicological Sciences 2010; 35: 419-423.
  9. Eiguren-Fernandez A, Shinyashiki M, Schmitz DA, Distefano E, Hinds W, Kumagai Y, Cho AK, Froines JR. Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols. Environmental Research 2010; 110: 207-212.
  10. Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines JR, Cho AK, Shinyashiki M. Biochemical and cellular effects of electrophiles present in ambient air samples. Atmospheric Environment 2010; 44: 1483-1489.
  11. Shinkai Y, Yamamoto C, Kaji T. Lead induces the expression of ER chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicological Sciences 2010; 114: 378-386.
  12. Hirooka T, Fujiwara Y, Minami Y, Ishii A, Ishigooka M, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T.Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes. Toxicology In Vitro 2010; 24: 835-841.
  13. Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscará MN, Costa SK. Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ). Archives of Toxicology 2010; 84: 109-117.


2009

  1. Sumi D, Numasawa Y, Endo A, Iwamoto N, Kumagai Y. Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. Journal of Toxicological Sciences 2009; 34: 627-635.
  2. Hirooka T, Fujiwara Y, Inoue S, Shinkai Y, Yamamoto C, Satoh M, Yasutake A, Eto K, Kaji T. Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells. Journal of Toxicological Sciences 2009; 34: 433-439.
  3. Fujiwara Y, Kitagawa T, Shinkai Y, Kaji T, Satoh M. Cilostazol induces metallothionein expression in vascular cells. Yakugaku Zasshi 2009; 129: 1415-1422.
  4. 熊谷嘉人. ヒ素研究におけるフィールドサイエンスと実験科学の融合. Yakugaku Zasshi, 2009;129:1177-1185.
  5. Kumagai Y. Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere. Journal of Health Sciences 2009; 55: 887-894.
  6. 熊谷嘉人. 親電子シグナル伝達. 実験医学増刊号 2009; 27: 50-55.
  7. Shinkai Y, Sumi D,Toyama T, Kaji T, Kumagai Y. Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicology and Applied Pharmacology 2009; 237: 232-236.
  8. Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range chemical compounds. Molecular and Cellular Biology; 2009; 29; 493-502.


2008

  1. Shibata T, Nakahara H, Kita N, Matsubara Y, Han CG, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K. A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. Journal of Neurochemistry 2008; 107; 1248-1460.
  2. Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y. Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism. Archives of Toxicology. 2008; 82: 803-808.
  3. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ,Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y. Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. Free Radical Biology & Medicine 2008; 44: 1645-1655.
  4. Matsunaga T, Kamiya T, Sumi D, Kumagai Y, B. Kalyanaraman, Hara A. Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. Free Radical Biology & Medicine 2008; 44:1191-1202.
  5. Kanda H, Kikushima M, Homma-Takeda S, Sumi D, Endo A, Toyama T, Miura N, Naganuma A, Kumagai Y. Downregulation of Arginase II and Renal Apoptosis by Inorganic Mercury: Overexpression of Arginase II Reduces Its Apoptosis. Archives of Toxicology 2008; 82: 67-73.
  6. Shinyashiki M, Rodriguez CE, Di Stefano EW, Sioutas C, Delfino RJ, Kumagai Y, Froines JR, Cho AK. On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles: Evidence for electrophilic species. Atmospheric Environment; 2008; 42: 517-529.


2007

  1. Kumagai Y,Taguchi K. Toxicological effects of polycyclic aromatic hydrocarbon quinones contaminated in diesel exhaust particles. Asian Journal of Atmospheric Environment 2007; 1: 28-35.
  2. Jaloszynski P, Murata S, Shinkai Y, Takahashi S, Kumagai Y, Nishimura S, Yamamoto M. Dysfunction of Nrf2 decreases KBrO(3)-induced oxidative DNA damage in Ogg1-null mice. Biochemical Biophysical Research Communication 2007 ; 364: 966-971.
  3. Iwamoto N, Sumi D, Ishii T, Uchida K, Cho AK, Froines JR, Kumagai Y. Chemical knockdown of protein tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor. Journal of Biological Chemistry 2007; 282: 33396-33404.
  4. Sumi D, Kumagai Y. Chemical biology of 1,2-naphthoquinone, a novel air pollutant, that affects signal transduction pathways. YAKUGAKU ZASSHI 2007; 127: 1949-1956.
  5. Toyama T, Sumi D, Shinkai Y, Yasutake A, Taguchi K, Tong KI, Yamamoto M, Kumagai Y. Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. Biochemical and Biophysical Research Communications 2007; 363: 645-650.
  6. Iida K, Itoh K, Maher JM., Kumagai Y, Oyasu R, Mori Y, Shimazu T, Akaza H, Yamamoto M. Nrf2 and p53 cooperatively protect against BBN-induced urinary bladder. Carcinogenesis 2007; 28: 2398-2403.
  7. Sumi D, Manji A, Shinkai Y, Toyama T, Kumagai Y. Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of primary mouse hepatocytes to diphenylarsinic acid. Toxicology and Appled Pharmacology 2007; 223: 218-224.
  8. Li B, Sun Y, Sun X, Wang Y, Li X, Kumagai Y, Sun G. Monomethylarsonous Acid Induced Cytotoxicity and Endothelial Nitric Oxide Synthase Phosphorylation in Endothelial Cells. Bulletin of Environmental Contamination and Toxicology 2007; 78: 455-458.
  9. Endo A, Sumi D, Kumagai Y. 1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification. Biochemical and Biophysical Research Communications 2007; 361: 243-248.
  10. Taguchi K, Fujii S, Yamano S, Cho AK, Kamisuki S, Nakai Y, Sugawara F, Froines JR, Kumagai Y. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. Free Radical Biology & Medicine 2007; 43: 789-799.
  11. Inoue KI, Takano H, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Hiyoshi K, Kumagai Y. Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. Archives of Toxicology 2007; 81: 575-581.
  12. Shinkai Y, Truc DV, Sumi D,Canh D, Kumagai Y. Arsenic and other metal contamination of groundwater in the Mekong River Delta, Vietnam. Journal of Health Science 2007; 53: 344-346.
  13. Inoue KI, Takano H, Hiyoshi K, Ichinose T, Sadakane K, Yanagisawa R, Tomura S, Kumagai Y. Naphthoquinone enhances antigen-related airway inflammation in mice. European Respiratory Journal 2007; 29: 259-267.
  14. Kumagai Y, Sumi D. Arsenic: Signal Transduction, Transcription Factor, and Biotransformation Involved in Cellular Response and Toxicity. Annual Review of Pharmacology and Toxicology 2007; 47: 243-262.
  15. Cui RZ, Iso H, Pi JB, Kumagai Y, Yamagishi K, Tanigawa T, Shimamoto T. Metabolic syndrome and urinary cGMP excretion in general population. Atherosclerosis 2007; 190: 423-428.


2006

  1. Sun Y, Sumi D, Kumagai Y. Serine 1179 phosphorylation of endothelial nitric oxide synthase caused by 2,4,6-trinitrotoluene through PI3K/Akt signaling in endothelial cells. Toxicology and Applied Pharmacology 2006; 214:55-60.
  2. Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y. Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Letters 2006; 580: 1771-1774.
  3. Kikuno S, Taguchi K, Iwamoto N, Yamano S, Cho AK, Froines JR, Kumagai Y. 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea. Toxicology and Applied Pharmacology 2006; 210: 47-54.
  4. Sun Y, Taguchi K, Sumi D, Yamano S, Kumagai Y. Inhibition of Endothelial Nitric Oxide Synthase Activity and Suppression of Endothelium-Dependent Vasorelaxation by 1,2-Naphthoquinone, a Component of Diesel Exhaust Particles. Archives of Toxicology 2006; 80: 280-285.

原著・総説(2001-2005

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