Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y. A strategy for repression of arsenic toxicity through nuclear factor
E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract. Food and Chemical Toxicology 2020 Aug;145:111706. DOI: 10.1016/j.fct.2020.111706
Fujie T, Takahashi A, Takahashi M, Hara T, Soyama A, Makino K, Takahashi
H, Yamamoto C, Kumagai Y, Naka H, Kaji T. Transcriptional induction of cystathionine γ-lyase, a
reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured
vascular endothelial cells. International Journal of Molecular Sciences 2020 Aug;21(17):6053.doi: 10.3390/ijms21176053.
Cho AK, Shinkai Y, Schmitz DA, Stefano ED, Eiguren-Fernandez A, GuarieiroALN, Salinas EM, Froines JR, Melega WP. Chemical and Biological Characterizationof Particulate Matter (PM 2.5) and Volatile Organic Compounds Collectedat Different Sites in the Los Angeles Basin. Applied Sciences 2020 May;10(9):3245.doi: https://doi.org/10.3390/app10093245
Akiyama M, Unoki T, Yoshida E, Ding Y, Yamakawa H, Shinkai Y, Ishii I, Kumagai Y. Repression of mercury accumulation and adverse effects of methylmercury
exposure is mediated by cystathionine g-lyase to produce reactive sulfur
species in mouse brain. Toxicology Letters 2020 May;330:128-133.doi: 10.1016/j.toxlet.2020.05.007.
Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y. Redox cycling of 9,10-phenanthrenequinone activates epidermal growth
factor receptor signaling through S-oxidation of protein tyrosine phosphatase
1B. Journal of Toxicological Sciences 2020 Jun;45(6): 3149-363.doi: 10.2131/jts.45.349.
Zheng F, Gonçalves FM, Abiko Y, Li H, Kumagai Y, Aschner M. Redox Toxicology of Environmental Chemicals Causing Oxidative
Stress. Redox Biology 2020 Apr;34:101475. DOI: 10.1016/j.redox.2020.101475
Shinkai Y, Ding Y, Miura T, Kumagai Y. Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone
is rescued by α-crystallin chaperone. Journal of Toxicological Sciences 2020 Oct;45(1):37-43. doi: 10.2131/jts.45.37.
Henderson CF, Bica I, Long FT, Irwin DD, Stull CH, Baker BW, Vega VS, Taugher ZM, Fletes ED, Bartleson JM, Humphrey ML, Alverez L, Akiyama M, Kumagai Y, Fukuto JM, Lin J. Cysteine trisulfide protects E. coli from electrophile-induced
death through the generation of cysteine hydropersulfide. Chemical Research in Toxicology 2020 Jan;33(2):678-686. doi: 10.1021/acs.chemrestox.9b00494.
Doka E, Ida T, Dagnell M, Abiko Y, Cong NL, Balog N, Takata T, Espinosa B, Nishimura A, Cheng Q, Funato Y, Miki H, Fukuto JM, Prigge JR, Schmidt EE, Arner ESJ, Kumagai Y, Akaike T, Nagy P. Control of protein function through oxidation and reduction
of persulfidated states. Science Advances 2020 Jan;6(1):eaax8358. doi: 10.1126/sciadv.aax8358.
2019
Kumagai Y, Akiyama M, Unoki T. Adaptive responses to electrophilic stress and reactive sulfur
species as their regulator molecules. Toxicological Research 2019 Oct;35(4):303-310. doi: 10.5487/TR.2019.35.4.303.
Fujie T, Takenaka F, Yoshida E, Yasuike S, Fujiwara Y, Shinkai Y, Kumagai Y, Yamamoto C, Kaji T. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. Journal of Toxicological Sciences 2019 Apr;44(5):327-333. doi: 10.2131/jts.44.327.
Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishimura K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M. Depolysulfidation of Drp1 induced by low-dose methylmercury
exposure increases cardiac vulnerability to hemodynamic overload. Science Signaling 2019 Jun 25;12(587):eaaw1920. doi: 10.1126/scisignal.aaw1920.
Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y. Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE,
or Both. Environmental Health Perspectives 2019 Jun;127(6):67002. doi: 10.1289/EHP4949.
Shinkai Y, Kumagai Y. Sulfane sulfur in toxicology: A novel defense system against electrophilic
stress.Toxicological Science 2019 Jul;170(1):3-9. doi: 10.1093/toxsci/kfz091.
Abiko Y, Nakai Y, Luong NC, Bianco CL, Fukuto JM, Kumagai Y. Interaction of quinone-related electron acceptors with hydropersulfide
Na2S2: Evidence for one-electron reduction reaction. Chemical Research in Toxicology 2019 Feb;32(4):551-556. doi: 10.1021/acs.chemrestox.8b00158.
Lin J, Akiyama M, Bica I, Long F, Henderson C, Goddu R, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto J, Kumagai Y. The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological
and Toxicological Implications. Chemical Research in Toxicology 2019 Feb;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340.
Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM. The Reaction of Hydrogen Sulfide
with Disulfides: Formation of a Stable Trisulfide and Implications to Biological
Systems. British Journal of Pharmacology 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372.
Unoki T, Akiyama M, Kumagai Y, Goncalves FM, Farina M, Telxelra Da Rocha JB, Ashner M. Molecular pathways
associated with methylercury-induced Nrf2 modulation. Frontiers Genetics 2018 Sep;9:373. doi: 10.3389/fgene.2018.00373.
Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa
T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. Hypoxia-induced interaction
of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial
senescence. Science Signaling 2018 Nov;11(556):eaat5185. doi: 10.1126/scisignal.aat5185.
Kawaguchi H, Matsumoto I, Osada A, Kurata I, Ebe H, Tanaka Y, Inoue A,
Umeda N, Kondo Y, Tsuboi H, Shinkai Y, Kumagai Y, Ishigami A, Sumida T. Identification of novel biomarker as citrullinated
inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in
sera with experimental and rheumatoid arthritis. Arthritis Research and Therapy 2018 Apr;20(1):66. doi: 10.1186/s13075-018-1562-7.
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott
MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.Biological Hydropersulfides and Related
Polysulfides: A New Concept and Perspective in Redox Biology. FEBS Letters 2018 May;592(12):2140-2152. doi: 10.1002/1873-3468.13090.
2017
Akiyama M, Shinkai Y, Unoki T, Shim I, Ishii I, Kumagai Y. Capture of cadmium by reactive polysulfides attenuates cadmium-induced
adaptive response and hepatotoxicity. Chemcical Research in Toxicology 2017; 30: 2209-2217.
Yoshida E, Kurita M, Eto K, Kumagai Y, Kaji T. Methylmercury promotes prostacyclin release from cultured human
brain microvascular endothelial cells via induction of cyclooxygenase-2
through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine
phosphatase 1B activity. Toxicology 2017; 392: 40-46.
Akaike T, Ida T, Fan-Yan Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita
M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung
M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi
H. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial
bioenergetics. Nature Communications 2017; 8: 1177.
Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki
K, Toyama T, Yoshida E, Abdul Hamid, H, Jung M, Matsunaga T, Fujii Sawa
T, Nishida M, Kumagai Y, Akaike T. Exposure to Electrophiles Impairs Reactive Persulfide-dependent
Redox Signaling in Neuronal Cells. Chemical Research in Toxicology 2017; 30: 1673-1684.
Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura
A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M. TRPC6 counteracts TRPC3-Nox2 protein complex
leading to attenuation of hyperglycemia-induced heart failure in mice.
Scientific Reports 2017; 7: 7511.
Abiko Y, Shinkai Y, Unoki T, Hirose R, Uehara T, Kumagai Y. Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated
by 1,4-naphthoquinone through formation of sulfur adducts. Scientific Reports 2017; 7: 4814.
Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y. 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation
of HSP90 in A431 cells: Negative regulation of the redox signal transduction
pathway by persulfides/polysulfides. Free Radical Biology & Medicine 2017; 104: 118-128.
Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y. Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive
persulfides/polysulfides. Toxicolgical Sciences. 2017; 156: 412-421.
Hara T, Yoshida E, Shinkai Y, Yamamoto C, Fujiwara Y, Kumagai Y, Kaji T. Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates
Syndecan-4 in Cultured Vascular Endothelial Cells. Journal of cellular biochemistry. 2017; 118: 1087-1096.
Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H. Critical contribution of nuclear factor erythroid 2-related
factor 2 (NRF2) to electrophile-induced Interleukin-11 production. Journal of Biological Chemistry. 2017; 292: 205-216.
Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y. Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through
increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon
receptor nuclear translocator. Journal of Toxicological Sciences. 2016; 41: 775-781.
Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y. Methylmercury, an environmental electrophile capable of activation and
disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y
cells. Scientific Reports. 2016; 6: 28944.
Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T,
Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. The chemicall biology of protein
hydropersulfides: Studies of a possible protective function of biological
hydropersulfide generateon. Free Radical Biology and Medicine. 2016; 97: 136-147.
Fujiwara Y, Yamamoto C, Yoshida E, Kumagai Y, Kaji T. Heparan sulfate chains potentiate cadmium cytotoxicity in cultured
vascular endothelial cells. Archives of Toxicology. 2016; 90: 259-267.
Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, Yamamoto C, Kumagai Y, Naka H, Kaji T. Copper diethyldithiocarbamate as an activator of Nrf2
in cultured vascular endothelial cells. Journal of Biological Inorganic Chemistry. 2016; 21: 263-273.
Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T. Partial contribution of the Keap1-Nrf2 system to cadmium-mediated
metallothionein expression in vascular endothelial cells. Toxicology and Applied Pharmacology. 2016; 295: 37-46.
Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuch T, Nakai Y, Shimojo
N, Kumagai Y. NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene
to yield nitrite in mammals. Free Radical Biology and Medicine. 2016; 91: 178-187.