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筑波大学　医学医療系　環境生物学研究室
環境生物学研究室

〒305-8575　
茨城県つくば市天王台1-1-1
筑波大学医学医療系　
環境生物学研究室
TEL:029-853-3297

English

原著・総説

2020

  1. Suzuki T, Hidaka T, Kumagai Y, Yamamoto M. Environmental pollutants and the immune response. Nature Immunology 2020 Oct;21(12):1486-1495. doi: 10.1038/s41590-020-0802-6.
  2. Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y. A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract. Food and Chemical Toxicology 2020 Aug;145:111706. DOI: 10.1016/j.fct.2020.111706
  3. Fujie T, Takahashi A, Takahashi M, Hara T, Soyama A, Makino K, Takahashi H, Yamamoto C, Kumagai Y, Naka H, Kaji T. Transcriptional induction of cystathionine γ-lyase, a reactive sulfur-producing enzyme, by copper diethyldithiocarbamate in cultured vascular endothelial cells. International Journal of Molecular Sciences 2020 Aug;21(17):6053. doi: 10.3390/ijms21176053.
  4. 熊谷嘉人. 酸化ストレスを御する新たな鍵分子の発見. 医学のあゆみ 2020-04;273(3):256-257.
  5. 熊谷嘉人. エクスポソーム. 実験医学増刊号 2020-06;38(10):14-19.
  6. Cho AK, Shinkai Y, Schmitz DA, Stefano ED, Eiguren-Fernandez A, GuarieiroALN, Salinas EM, Froines JR, Melega WP. Chemical and Biological Characterizationof Particulate Matter (PM 2.5) and Volatile Organic Compounds Collectedat Different Sites in the Los Angeles Basin. Applied Sciences 2020 May;10(9):3245. doi: https://doi.org/10.3390/app10093245
  7. 新開泰弘，秋山雅博，熊谷嘉人．カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子を介した制御．硫酸と工業 2020-04; 73(4):41-48.
  8. 神田洋紀, 熊谷嘉人. 親電子ストレスを制御するレドックスシグナル伝達と活性イオウ分子. 薬学雑誌 2020-09;140(9):1119-1128. doi: https://doi.org/10.1248/yakushi.20-00096
  9. Akiyama M, Unoki T, Yoshida E, Ding Y, Yamakawa H, Shinkai Y, Ishii I, Kumagai Y. Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine g-lyase to produce reactive sulfur species in mouse brain. Toxicology Letters 2020 May;330:128-133. doi: 10.1016/j.toxlet.2020.05.007.
  10. Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y. Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B. Journal of Toxicological Sciences 2020 Jun;45(6): 3149-363. doi: 10.2131/jts.45.349.
  11. Akiyama M, Unoki T, Kumagai Y. Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide. Fundamental Toxicological Sciences 2020 Apr;7(3):161-166. doi: https://doi.org/10.2131/fts.7.161
  12. Zheng F, Gonçalves FM, Abiko Y, Li H, Kumagai Y, Aschner M. Redox Toxicology of Environmental Chemicals Causing Oxidative Stress. Redox Biology 2020 Apr;34:101475. DOI: 10.1016/j.redox.2020.101475
  13. Shinkai Y, Ding Y, Miura T, Kumagai Y. Aggregation of β-crystallin through covalent binding to 1,2-naphthoquinone is rescued by α-crystallin chaperone. Journal of Toxicological Sciences 2020 Oct;45(1):37-43. doi: 10.2131/jts.45.37.
  14. Unoki T, Akiyama M, Kumagai Y. Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress. International Journal of Molecular Sciences 2020 Jan;21(2):545. DOI: 10.3390/ijms21020545.
  15. Henderson CF, Bica I, Long FT, Irwin DD, Stull CH, Baker BW, Vega VS, Taugher ZM, Fletes ED, Bartleson JM, Humphrey ML, Alverez L, Akiyama M, Kumagai Y, Fukuto JM, Lin J. Cysteine trisulfide protects E. coli from electrophile-induced death through the generation of cysteine hydropersulfide. Chemical Research in Toxicology 2020 Jan;33(2):678-686. doi: 10.1021/acs.chemrestox.9b00494.
  16. Doka E, Ida T, Dagnell M, Abiko Y, Cong NL, Balog N, Takata T, Espinosa B, Nishimura A, Cheng Q, Funato Y, Miki H, Fukuto JM, Prigge JR, Schmidt EE, Arner ESJ, Kumagai Y, Akaike T, Nagy P. Control of protein function through oxidation and reduction of persulfidated states. Science Advances 2020 Jan;6(1):eaax8358. doi: 10.1126/sciadv.aax8358.

2019

  1. Kumagai Y, Akiyama M, Unoki T. Adaptive responses to electrophilic stress and reactive sulfur species as their regulator molecules. Toxicological Research 2019 Oct;35(4):303-310. doi: 10.5487/TR.2019.35.4.303.
  2. Fujie T, Takenaka F, Yoshida E, Yasuike S, Fujiwara Y, Shinkai Y, Kumagai Y, Yamamoto C, Kaji T. Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. Journal of Toxicological Sciences 2019 Apr;44(5):327-333. doi: 10.2131/jts.44.327.
  3. Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishimura K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M. Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload. Science Signaling 2019 Jun 25;12(587):eaaw1920. doi: 10.1126/scisignal.aaw1920.
  4. Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y. Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both. Environmental Health Perspectives 2019 Jun;127(6):67002. doi: 10.1289/EHP4949.
  5. Shinkai Y, Kumagai Y. Sulfane sulfur in toxicology: A novel defense system against electrophilic stress.Toxicological Science 2019 Jul;170(1):3-9. doi: 10.1093/toxsci/kfz091.
  6. Abiko Y, Nakai Y, Luong NC, Bianco CL, Fukuto JM, Kumagai Y. Interaction of quinone-related electron acceptors with hydropersulfide Na2S2: Evidence for one-electron reduction reaction. Chemical Research in Toxicology 2019 Feb;32(4):551-556. doi: 10.1021/acs.chemrestox.8b00158.
  7. Lin J, Akiyama M, Bica I, Long F, Henderson C, Goddu R, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto J, Kumagai Y. The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications. Chemical Research in Toxicology 2019 Feb;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340.
  8. Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM. The Reaction of Hydrogen Sulfide with Disulfides: Formation of a Stable Trisulfide and Implications to Biological Systems. British Journal of Pharmacology 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372.

2018

  1. Abiko Y, Kumagai Y. Preventive Agents and Phytochemicals for Reducing the Adverse Health Effects of Arsenic. Arsenic Contamination in Asia 2018 Nov;151-161.
  2. Unoki T, Akiyama M, Kumagai Y, Goncalves FM, Farina M, Telxelra Da Rocha JB, Ashner M. Molecular pathways associated with methylercury-induced Nrf2 modulation. Frontiers Genetics 2018 Sep;9:373. doi: 10.3389/fgene.2018.00373.
  3. Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M. Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence. Science Signaling 2018 Nov;11(556):eaat5185. doi: 10.1126/scisignal.aat5185.
  4. Kawaguchi H, Matsumoto I, Osada A, Kurata I, Ebe H, Tanaka Y, Inoue A, Umeda N, Kondo Y, Tsuboi H, Shinkai Y, Kumagai Y, Ishigami A, Sumida T. Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis. Arthritis Research and Therapy 2018 Apr;20(1):66. doi: 10.1186/s13075-018-1562-7.
  5. Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.Biological Hydropersulfides and Related Polysulfides: A New Concept and Perspective in Redox Biology. FEBS Letters 2018 May;592(12):2140-2152. doi: 10.1002/1873-3468.13090.

2017

  1. Akiyama M, Shinkai Y, Unoki T, Shim I, Ishii I, Kumagai Y. Capture of cadmium by reactive polysulfides attenuates cadmium-induced adaptive response and hepatotoxicity. Chemcical Research in Toxicology 2017; 30: 2209-2217.
  2. Yoshida E, Kurita M, Eto K, Kumagai Y, Kaji T. Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity. Toxicology 2017; 392: 40-46.
  3. Akaike T, Ida T, Fan-Yan Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nature Communications 2017; 8: 1177.
  4. Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T. Modulation of unfolded protein response by methylmercury. Biochemical and Pharmaceutical Bulletin 2017; 40: 1595-1598.
  5. Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid, H, Jung M, Matsunaga T, Fujii Sawa T, Nishida M, Kumagai Y, Akaike T. Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells. Chemical Research in Toxicology 2017; 30: 1673-1684.
  6. Sawa T, Kumagai Y, Akaike T. Regulation of redox signaling by nitrated nucleotide and reactive cysteine persulfides. Nitric Oxide: Biology and Pathobiology. 2017; 3: 231-235.
  7. 熊谷嘉人、安孫子ユミ. 環境中親電子物質のレドックスシグナル伝達変動および毒性発現とそれらを制御する活性イオウ分子. 硫酸と工業 2017; 70: 9-16.
  8. 熊谷嘉人. 環境中親電子物質に対する生体応答と捕獲・不活性化因子. 最新医学「エピジェネティックスと環境科学」2017; 72: 77-81.
  9. Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M. TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice. Scientific Reports 2017; 7: 7511.
  10. Abiko Y, Shinkai Y, Unoki T, Hirose R, Uehara T, Kumagai Y. Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Scientific Reports 2017; 7: 4814.
  11. Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y. 1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides. Free Radical Biology & Medicine 2017; 104: 118-128.
  12. Shinaki Y,Masuda A, Akiyama M, Xian M, Kumagai Y. Cadmium-mediated activation of the HSP90/HSF1 pathway regulated by reactive persulfides/polysulfides. Toxicolgical Sciences. 2017; 156: 412-421.
  13. Hara T, Yoshida E, Shinkai Y, Yamamoto C, Fujiwara Y, Kumagai Y, Kaji T. Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells. Journal of cellular biochemistry. 2017; 118: 1087-1096.
  14. Kumagai Y, Abiko Y. Environmental electrophiles: protein adducts, modulation of redox signaling and interaction with persulfides/polysulfides. Chemical Research in Toxicology. 2017; 30: 203-219.
  15. Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H. Critical contribution of nuclear factor erythroid 2-related factor 2 (NRF2) to electrophile-induced Interleukin-11 production. Journal of Biological Chemistry. 2017; 292: 205-216.

2016

  1. Kumagai Y, Abiko Y, Luong CN. Chemical toxicology of reactive species in the atmosphere: two decades of progress in an electron acceptor and an electrophile. Journal of Toxicological Sciences. 2016; 41: SP37-SP47.
  2. Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y. Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator. Journal of Toxicological Sciences. 2016; 41: 775-781.
  3. Unoki T, Abiko Y, Toyama T, Uehara T, Tsuboi K, Nishida M, Kaji T, Kumagai Y. Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells. Scientific Reports. 2016; 6: 28944.
  4. Millikin R, Bianco CL, White C, Saund SS, Henriquez S, Sosa V, Akaike T, Kumagai Y, Soeda S, Toscano JP, Lin J, Fukuto JM. The chemicall biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generateon. Free Radical Biology and Medicine. 2016; 97: 136-147.
  5. Fujiwara Y, Yamamoto C, Yoshida E, Kumagai Y, Kaji T. Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells. Archives of Toxicology. 2016; 90: 259-267.
  6. Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T. Redox signaling regulated by electrophiles and reactive sulfur species. Journal of Clinical Biochemistry and Nutrition. 2016; 58: 91-98.
  7. Fujie T, Murakami M, Yoshida E, Tachinami T, Shinkai Y, Fujiwara Y, Yamamoto C, Kumagai Y, Naka H, Kaji T. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells. Journal of Biological Inorganic Chemistry. 2016; 21: 263-273.
  8. Shinkai Y, Kimura T, Itagaki A, Yamamoto C, Taguchi K, Yamamoto M, Kumagai Y, Kaji T. Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. Toxicology and Applied Pharmacology. 2016; 295: 37-46.
  9. Shinkai Y, Nishihara Y, Amamiya M, Wakayama T, Li S, Kikuch T, Nakai Y, Shimojo N, Kumagai Y. NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals. Free Radical Biology and Medicine. 2016; 91: 178-187.

原著・総説（2011-2015）

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