Department of Hematology

筑波大学大学院人間総合科学研究科
        疾患制御医学専攻血液病態制御医学分野
筑波大学臨床医学系血液内科
筑波大学附属病院血液内科診療グループ

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研究業績

2011年度

  • Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S. Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol: a single center retrospective analysis. J Clin Exp Hematol 51(2)109-114, Nov, 2011
  • Goto M, Onizawa K, Yanagawa T, Yamagata K, Shinozuka K, Nishikii H, Koganemaru H, Chiba S, Bukawa H. Human Immunodeficiency Virus-Associated Burkitt's Lymphoma in Oral Cavity of Japanese Patient. J Oral Maxillofac Surg Nov, 10, 2011 [Epub ahead of print]
  • Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478(7367):64-9, Oct 6, 2011
  • Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K. Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience 195:9-20, 2011
  • Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, Takahashi S. c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver. Blood 118(5):1374-85, Aug 4, 2011
  • Sakurai N, Maeda M, Li M, Lee S-UK, Ishikawa Y, Williams JC, Wang L, Su L, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T. Notch-dependent and -independent regulation of mature B cell lineage fate and humoral immune response by the LRF transcription factor homodimer. J Clin Invest,  121(7):2583-98, Jul 1, 2011
  • Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A. The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 208(8):1661-71, Aug 1, 2011
  • Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H. Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. Br J Hematol 152（5）:631-639, Mar, 2011
  • Yoshida C, Komeno T, Hori M, Kimura T, Fujii M, Okoshi Y, Suzukawa K, Chiba S, Hasegawa Y, Mukai HY, Ito T, Shimizu S, Kamoshita M, Kudo D, Shinagawa A, Chikatsu N, Monma Y, Watanabe N, Kojima H. Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia. Int J Hematol 93(5):618-623, May, 2011
  • Kurita N, Nishikii H, Nakamoto R, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Noguchi M, Chiba S. A highly therapy-resistant case with "B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma" showing strong BCL2 staining, otherwise indistinguishable from Burkitt lymphoma. J Clinical Experimental Hematothology 51(1):37-42, Ｍａｙ, 2011
  • Kurita N, Okoshi Y, Nakamoto R, Sakamoto T, Suzukawa K, Hasegawa Y, Chiba S. Life saving treatment using amphotericin B liposome for a case with fungal meningitis due to orbital cellulitis. Jpn J Antibiot. 64(1):47-8 Feb,2011. Japanese. No abstract available.
  • Yamagata K, Onizawa K, Yanagawa T, Takeuchi Y, Hasegawa Y, Chiba S, Bukawa H. Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111(2):146-152, Feb, 2011
  • Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117(1);128-134, Jan 6, 2011
  • Kamada Y, Suzukawa K, Taoka K, Okoshi Y, Hasegawa Y, Chiba S. Relapse of acute meyloid leukemia with t(16;21)(p11;q22)mimicking autoimmune pancreatitis after second allogeneic bone marrow transplantation. ISRN Hematology 2011:285487, 2011

2010年度

  • Taoka K, Okoshi Y, Sakamoto N, Takano S, Matsumura A, Hasegawa Y, Chiba S. A nonradiation-containing, intermediate-dose methotrexate regimen for elderly patients with primary central nervous system lymphoma. Int J Hematol 92(4):617-623, Nov, 2010
  • Kurosawa S, Yamaguchi T, Miyawaki S, Uchida N, Sakura T, Kanamori H, Usuki K, Yamashita T, Okoshi Y, Shibayama H, Nakamae H, Mawatari M, Hatanaka K, Sunami K, Shimoyama M, Fujishima N, Maeda Y, Miura I, Takaue Y, Fukuda T. Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse. Haematologica 95(11):1857-1864, Nov, 2010
  • Miyake Y, Okoshi Y, Machino T, Chiba S. Treatment of central nervous system lymphoma in rats with intraventricular rituximab and serum. Int J Hematol 92(3):474-480, Oct, 2010
  • Doki K, Homma M, Hori T, Tomita T, Hasegawa Y, Ito S, Fukunaga K, Kaneko M, Chiba S, Sumida T, Ohkohchi N, Kohda Y. Difference in blood tacrolimus concentration between ACMIA and MEIA in samples with low haematocrit values. J Pharm Pharmacol 62(9):1185-1188, Oct, 2010
  • Sugumito K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K. Notch2 signaling is required for potent anti-tumor immunity in vivo. J Immunol 184(9):4673-4678, May 1, 2010
  • Muto H, Ohashi H, Ando M, Akiyama H, Sakamaki H. Cystatin C level as a marker of renal function in allogeneic hematopoietic stem cell transplantation. Int J Hematol　91(3):471-477, Apr, 2010
  • Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood 115(14):2872-2881, Apr 8, 2010
  • Okada S, Nannya Y, Ota S, Takazawa Y, Yamamoto G, Kumano K, Izutsu K, Takahashi T, Chiba S, Kurokawa M. Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant. Br J Dermatol 162(1):229-230, Jan, 2010
  • Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest  120(1):179-190, Jan, 2010
  • Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H. Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol 32:e137-e143, Jan, 2010

2009年度

  • Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H. Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol 32(1 Pt 1):e137-143, Feb, 2010
  • Koshino M, Kudou D, Okoshi Y, Obara N, Simizu S, Mukai HY, Suzukawa K, Hasegawa Y, Kojima H, Nagasawa T, Chiba S. Successful treatment with rituximab in a patient with refractory thrombotic thrombocytopenic purpura refractory to plasma exchange. Rinsho Ketsueki 51(2):127-131, Feb, 2010
  • Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120(1):179-190, Jan 4, 2010
  • Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Sci 100(12):2444-2450, Dec, 2009
  • Matsumoto K, Obara N, Ema M, Horie M, Naka A, Takahashi S, Imagawa S. Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model. Cancer Sci 100(9):1639-1647, Sep, 2009
  • Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 460(7257):904-908, Aug 13, 2009
  • Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci U S A 106(27):11230-11235, Jul 7, 2009
  • Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S. Derivation of functional mature neutrophils from human embryonic stem cells. Blood 113(26):6584-6592, Jun 25, 2009
  • Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S. Frequent inactivation of A20 in B-cell lymphomas. Nature 459(7247):712-716, Jun 4, 2009
  • Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S. Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. J Immunol 182(10):6168-6178, May 15, 2009
  • Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S. Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci 100(5):920-926, May, 2009

2008年度

  • Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. J Immunol 182(6):3566-3572, Mar, 2009
  • Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K, Shibuya A. Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules. Mol Immunol 46(4):749-753, Feb, 2009
  • Kataoka K, Nannya Y, Hangaishi A, Imai Y, Chiba S, Takahashi T, Kurokawa M. Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15(2):195-204, Feb, 2009
  • Ishigaki T, Sudo K, Hiroyama T, Miharada K, Ninomiya H, Chiba S, Nagasawa T, Nakamura Y. Human hematopoietic stem cells can survive in vitro for several months. Adv Hematol 2009(936761), 2009
  • Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Sasazuki T. Japan Marrow Donation Program (JMDP). Exploration of the genetic basis of GVHD by genetic association studies. Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):39-41. No abstract available.
  • Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol 123(1):74-81, Jan, 2009.
  • Kanda Y, Okamoto S, Tauchi T, Kizaki M, Inokuchi K, Yabe M, Yokoyama K, Ito Y, Kimura Y, Higashihara M, Bessho M, Ando K, Chiba S, Kurokawa M, Oshimi K, Dan K, Ohyashiki K, Ikeda Y; for the Tokyo STI Study Group (TSSG). Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: Does body weight matter? Am J Hematol. 2008 Nov;83(11):835-839.
  • Nakagawa K, Kanda Y, Yamashita H, Nakagawa S, Sasano N, Ohtomo K, Oshima K, Kumano K, Ban N, Minamitani Y, Kurokawa M, Chiba S. Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. Bone Marrow Transplant. 2008 Nov;42(10):697-699.
  • Oshima K, Kanda Y, Kako S, Asano-Mori Y, Watanabe T, Motokura T, Chiba S, Shiraki K, Kurokawa M. Case report: persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes. J Med Virol. 2008 Oct;80(10):1769-1775.
  • Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto S, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K. Notch 2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol. 2008 Oct;9(10):1140-1147.
  • Goyama S, Yamamoto G, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell. 2008 Aug;3(2):207-220.
  • Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M. AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. Leukemia. 2008 Jun;22(6):1241-1249.
  • Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, Hirose S, Okumura K, Yagita H. Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol. 2008 Jun:20(6):763-773.
  • Yoshimi A, Izutsu K, Takahashi M, Kako S, Oshima K, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, Kurokawa M. Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation. Am J Hematol. 2008 Jun;83(6):477-481.
  • Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M. Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2008 Jun;83(3);472-476.
  • Tomita T, Homma M, Hasegawa Y, Kojima H, Ohkohchi N, Hori T, Kaneko M, Nakano Y, Tobe T, Kohda Y. Use of sample hematocrit value to correct blood tacrolimus concentration derived by microparticle enzyme immunoassay. Biol Pharm Bull. 2008 Jun;31(6):1250-3.
  • Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S. Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7839-44.
  • Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K. Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction. Proc Natl Acad Sci USA. 2008 May;105(19):7010-7015.
  • Kusakabe M, Suzukawa K, Nanmoku T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Ninomiya H, Nagasawa T. Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding. Eur J Haematol. 2008 May;80(5):444-7.
  • Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008 May 15;111(10):5223-32.
  • Yoshimi A, Nannya Y, Sakata-Yanagimoto M, Oshima K, Takahashi T, Kanda Y, Motokura T, Chiba S, Kurokawa M. A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: Reduced cyclophosphamide combined with etoposide and total body irradiation. Am J Hematol. 2008 Apr;83(8):635-639.
  • Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M. Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Int J Hematol. 2008　Apr; 87(3):310-318.
  • Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 2008 Apr 15;22(8):986-991.
  • Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M. AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis. J Immunol. 2008 Apr 1;180(7):4402-4408.

2007年度

  • Ishii W, Ito S, Kondo Y, Tsuboi H, Mamura M, Goto D, Matsumoto I, Tsutsumi A, Sumida T, Okoshi Y, Hasegawa Y, Kojima H, Sakashita S, Aita K, Noguchi M. Intravascular large B-cell lymphoma with acute abdomen as a presenting symptom in a patient with systemic lupus erythematosus. J Clin Oncol. 2008 Mar 20;26(9):1553-5.
  • Homma M, Inoue Y, Hasegawa Y, Kojima H, Kohda Y. Blood ribavirin concentration in high-dose ribavirin for adenovirus-induced haemorrhagic cystitis - a case report. J Clin Pharm Ther. 2008 Feb;33(1):75-8.
  • Ninomiya H, Sato S, Hasegawa Y, Nagasawa T. Shortened lifespan of paroxysmal nocturnal haemoglobinuria-affected RBC estimated from differences in ratios of CD59-negative populations between reticulocytes and whole RBC. Int J Lab Hematol. 2008 Feb;30(1):41-5.
  • Suzuki N, Obara N, Yamamoto M. Use of gene-manipulated mice in the study of erythropoietin gene expression. Methods Enzymol. 2007 Nov;435:157-77.
  • Katsura Y, Suzukawa K, Nanmoku T, Nemoto N, Machino T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Nagasawa T. Myelodysplastic syndrome accompanied by basophilia and eosinophilia with t(5;12)(q31;p13). Cancer Genet Cytogenet. 2007 Oct 1;178(1):85-8.
  • Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer. 2007 Sep;46(9):813-9.
  • Fu L, Isobe K, Zeng Q, Suzukawa K, Takekoshi K, Kawakami Y. beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes. Eur J Pharmacol. 2007 Aug 13;569(1-2):155-62.
  • Bonini C, Bondanza A, Perna SK, Kaneko S, Traversari C, Ciceri F, Bordignon C. The suicide gene therapy challenge: how to improve a successful gene therapy approach. Mol Ther. 2007 Jul;15(7):1248-52.
  • Kozuma Y, Kojima H, Yuki S, Suzuki H, Nagasawa T. Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. J Thromb Haemost. 2007 Jun;5(6):1274-82.
  • Machino T, Okoshi Y, Kaneko S, Obara N, Mukai HY, Suzukawa K, Hasegawa Y, Yamashita Y, Mori N, Kojima H, Nagasawa T. Hepatosplenic alphabeta T-cell lymphoma successfully treated with allogeneic bone marrow transplantation. Bone Marrow Transplant. 2007 Apr;39(8):513-4.

2006年度

  • Sugita S, Iijima T, Furuya S, Kano J, Yanaka A, Ohta K, Kojima H, Noguchi M. Gastric T-cell lymphoma with cytotoxic phenotype. Pathol Int. 2007 Feb;57(2):108-14.
  • Isobe K, Minowada S, Tatsuno I, Suzukawa K, Nissato S, Nanmoku T, Hara H, Yashiro T, Kawakami Y, Takekoshi K. Novel germline mutations in the SDHB and SDHD genes in Japanese pheochromocytomas. Horm Res. 2007 Feb;68(2):68-71.
  • Sunada K, Hasegawa Y, Kodama T, Anami Y, Satoh H, Ohtsuka M, Sekizawa K. Thymic and pulmonary mucosa-associated lymphoid tissue lymphomas in a patient with Sjogren's syndrome and literature review. Respirology. 2007 Jan;12(1):144-7.
  • Nakahashi C, Tahara-Hanaoka S, Totsuka N, Okoshi Y, Takai T, Ohkohchi N, Honda S, Shibuya K, Shibuya A. Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol. 2007 Jan 15;178(2):765-70.
  • Muto H, Kaneko S, Machino T, Okoshi Y, Mukai HY, Suzukawa K, Hasegawa Y, Imagawa S, Kojima H, Ishii Y, Hitomi S, Nagasawa T. Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma. J Infect Chemother 2006 Dec;12:391-395.
  • Kojima H, Moroi M, Jung SM, Goto S, Tamura N, Kozuma Y, Suzukawa K, Nagasawa T. Characterization of a patient with glycoprotein(GP) VI deficiency possessing neither anti-GPVI autoantibody nor genetic aberration. Journal of Thrombosis and Haemostasis 2006 Nov;4:2433-2442.
  • Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. Nature Biotechnology 2006 Oct;24(10):1255-1256.
  • Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, Nomura S, Kojima T, Yagi H, Ikeda Y. Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study. Journal of Thrombosis and Haemostasis 2006 Sep;4:1936-1943.
  • Nitta T, Kanai M, Sugihara E, Tanaka M, Sun B, Nagasawa T, Sonoda S, Saya H, Miwa M. Centrosome amplification I adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells. Cancer Science 2006 Sep;97(9):836-841.
  • Kojima H, Katsuoka Y, Katsura Y, Suzuki S, Suzukawa K, Hasegawa Y, Nagasawa T. Successful treatment of a patient with POEMS syndrome by tandem high-dose chemotherapy with autologous CD34+ purged stem cell rescue. International Journal of Hematology 2006 Aug;84:182-185.
  • Yamagata K, Onizawa K, Yanagawa T, Hasegawa Y, Kojima H, Nagasawa T, Yoshida H. A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation. Bone Marrow Transplantation 2006 Aug;38:237-242.
  • Sato S, Hasegawa Y, Nagasawa T, Ninomiya H. Reticulocyte-gated flow cytometric analysis of red blood cells in paroxysmal nocturnal hemoglobinuria. Laboratory Hematology 2006 Jun;12(2):82-85.

2005年度以前

  • Nabekura, T., M. Otsu, T. Nagasawa, H. Nakauchi, and M. Onodera, Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap. Mol Ther, 2006 Feb. 13(2): p. 301-9.
  • Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. Refinement of cytokine use in the in vitro expansion of erythroid cells. Human cell 2006 Feb;19(1):30-37.
  • Tomita, T., M. Homma, K. Yuzawa, N. Ohkohchi, T. Hori, M. Kaneko, Y. Hasegawa, H. Kojima, T. Nagasawa, and Y. Kohda, Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring. Ther Drug Monit, 2005. 27(1): p. 94-7.
  • Suzukawa, K., S. Shimizu, N. Nemoto, N. Takei, T. Taki, and T. Nagasawa, Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). Int J Hematol, 2005. 82(1): p. 38-41.
  • Shinagawa, A., H. Kojima, M.C. Berndt, S. Kaneko, K. Suzukawa, Y. Hasegawa, O. Shigeta, and T. Nagasawa, Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. Thromb Haemost, 2005. 93(5): p. 889-96.
  • Shimizu, Y., K. Suzukawa, Y. Hirano, M. Seki, K. Hirayama, K. Yoh, A. Hirayama, K. Yamagata, S. Nagase, T. Nagasawa, and A. Koyama, Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome. Nephrology (Carlton), 2005. 10(2): p. 147-50.
  • Okoshi, Y., S. Tahara-Hanaoka, C. Nakahashi, S. Honda, A. Miyamoto, H. Kojima, T. Nagasawa, K. Shibuya, and A. Shibuya, Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol, 2005. 17(1): p. 65-72.
  • Kitamura, A., Y. Yamashita, Y. Sato, Y. Hasegawa, H. Kojima, T. Nagasawa, and N. Mori, Aggressive Lennert's lymphoma: report of three cases in comparison to non-aggressive Lennert's lymphoma. Pathol Int, 2005. 55(10): p. 626-31.
  • Kitamura, A., Y. Yamashita, Y. Hasegawa, H. Kojima, T. Nagasawa, and N. Mori, Primary lymphoma arising in the nasal cavity among Japanese. Histopathology, 2005. 47(5): p. 523-32.
  • Kaneko, S., T. Nagasawa, H. Nakauchi, and M. Onodera, An in vivo assay for retrovirally transduced human peripheral T lymphocytes using nonobese diabetic/severe combined immunodeficiency mice. Exp Hematol, 2005. 33(1): p. 35-41.
  • Kaneko, S., M. Onodera, and T. Nagasawa, [Gene therapy for leukemia]. Nippon Rinsho, 2005. 63 Suppl 12: p. 637-40.
  • Yoshida, C., K. Suzukawa, Y. Katsura, S. Shimizu, H.Y. Mukai, Y. Hasegawa, S. Imagawa, H. Kojima, and T. Nagasawa, T-cell acute lymphoblastic leukemia with add(1)(p36) and del(12)(p11) following acute myelocytic leukemia with partial deletion of 9p. Cancer Genet Cytogenet, 2004. 150(1): p. 62-5.
  • Yoshida, C., H. Kojima, T. Iijima, Y. Katsura, S. Shimizu, K. Suzukawa, H.Y. Mukai, Y. Hasegawa, M. Abei, and T. Nagasawa, Association of non-alcoholic steatohepatitis (NASH) with chronic neutrophilic leukemia. Eur J Haematol, 2004. 72(3): p. 225-8.
  • Yoshida, C., H. Kojima, T. Ishigaki, Y. Katsura, S. Kaneko, K. Suzukawa, Y. Hasegawa, Y. Kawachi, F. Otsuka, and T. Nagasawa, Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10). Eur J Haematol, 2004. 72(2): p. 149-53.
  • Sato, S., K. Hirayama, A. Koyama, T. Harano, T. Nagasawa, and H. Ninomiya, Pseudoreticulocytosis in a patient with hemoglobin Koln due to autofluorescent erythrocytes enumerated as reticulocytes by the Cell-Dyn 4000. Lab Hematol, 2004. 10(2): p. 65-7.
  • Nakano, Y., S. Imagawa, K. Matsumoto, C. Stockmann, N. Obara, N. Suzuki, T. Doi, T. Kodama, S. Takahashi, T. Nagasawa, and M. Yamamoto, Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. Blood, 2004. 104(13): p. 4300-7.
  • Kojima, H., Y. Hasegawa, K. Suzukawa, H.Y. Mukai, S. Kaneko, T. Kobayashi, M. Kamoshita, A. Shinagawa, T. Komeno, T. Komatsu, S. Mitsuhashi, Y. Kawachi, Y. Yamashita, N. Mori, and T. Nagasawa, Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification. Leuk Res, 2004. 28(12): p. 1287-92.
  • Imagawa, S., Y. Yamaguchi, K. Ogawa, N. Obara, N. Suzuki, M. Yamamoto, and T. Nagasawa, Interleukin-6 and tumor necrosis factor-alpha in patients with obstructive sleep apnea-hypopnea syndrome. Respiration, 2004. 71(1): p. 24-9.
  • Hanai, S., T. Nitta, M. Shoda, M. Tanaka, N. Iso, I. Mizoguchi, S. Yashiki, S. Sonoda, Y. Hasegawa, T. Nagasawa, and M. Miwa, Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia. Cancer Sci, 2004. 95(4): p. 306-10.
  • Shimizu, S., Y. Tamagawa, H. Kojima, N. Mori, M. Nagata, M. Noguchi, and T. Nagasawa, Simultaneous development of lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma--analyses of the clonal relatedness by sequencing CDR3 in immunoglobulin heavy chain genes. Eur J Haematol, 2003. 70(2): p. 119-24.
  • Shimizu, S., H. Kojima, C. Yoshida, K. Suzukawa, H.Y. Mukai, Y. Hasegawa, S. Hitomi, and T. Nagasawa, Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. J Clin Pathol, 2003. 56(11): p. 871-2.
  • Obara, N., S. Imagawa, Y. Nakano, N. Suzuki, M. Yamamoto, and T. Nagasawa, Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2. Arch Toxicol, 2003. 77(5): p. 267-73.
  • Obara, N., S. Imagawa, Y. Nakano, M. Yamamoto, T. Noguchi, and T. Nagasawa, Hematological aspects of a novel 9-aminoanthracycline, amrubicin. Cancer Sci, 2003. 94(12): p. 1104-6.
  • Mukai, H.Y., Y. Okoshi, S. Shimizu, Y. Katsura, N. Takei, Y. Hasegawa, H. Kojima, N. Mori, and T. Nagasawa, Successful treatment of a patient with subcutaneous panniculitis-like T-cell lymphoma with high-dose chemotherapy and total body irradiation. Eur J Haematol, 2003. 70(6): p. 413-6.
  • Kojima, H., N. Takei, Y. Mukai, Y. Hasegawa, K. Suzukawa, M. Nagata, M. Noguchi, N. Mori, and T. Nagasawa, Hemophagocytic syndrome as the primary clinical symptom of Hodgkin's disease. Ann Hematol, 2003. 82(1): p. 53-6.
  • Kojima, H., H. Kanada, S. Shimizu, E. Kasama, K. Shibuya, H. Nakauchi, T. Nagasawa, and A. Shibuya, CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J Biol Chem, 2003. 278(38): p. 36748-53.
  • Kojima, H., S. Shimizu, C. Yoshida, Y. Katsura, K. Suzukawa, H.Y. Mukai, Y. Hasgawa, S. Imagawa, N. Mori, and T. Nagasawa, Rapidly progressive Lennert's lymphoma terminating in fulminant hepatic failure. Leuk Lymphoma, 2003. 44(8): p. 1409-12
  • Katsura, Y., K. Suzukawa, H. Kojima, C. Yoshida, S. Shimizu, H. Mukai, Y. Hasegawa, S. Imagawa, N. Mori, and T. Nagasawa, Cytotoxic T-cell lymphoma arising in Behcet disease. Int J Hematol, 2003. 77(3): p. 282-5.
  • Imagawa, S., Y. Nakano, N. Obara, N. Suzuki, T. Doi, T. Kodama, T. Nagasawa, and M. Yamamoto, A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. Faseb J, 2003. 17(12): p. 1742-4.
  • Horigome, H., T. Murakami, T. Isobe, T. Nagasawa, and A. Matsui, Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis. Thromb Res, 2003. 112(4): p. 223-7.
  • Suzuki, A., Y.W. Zheng Yw, S. Kaneko, M. Onodera, K. Fukao, H. Nakauchi, and H. Taniguchi, Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol, 2002. 156(1): p. 173-84.
  • Suzukawa, K., T.J. Weber, and N.H. Colburn, AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ Health Perspect, 2002. 110(9): p. 865-70.
  • Suzukawa, K. and N.H. Colburn, AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers. Oncogene, 2002. 21(14): p. 2181-90.
  • Sakai, Y., D.K. Kim, S. Iwasa, J. Liang, T. Watanabe, M. Onodera, and H. Nakauchi, Bone marrow chimerism prevents atherosclerosis in arterial walls of mice deficient in apolipoprotein E. Atherosclerosis, 2002. 161(1): p. 27-34.
  • Osawa, M., T. Yamaguchi, Y. Nakamura, S. Kaneko, M. Onodera, K. Sawada, A. Jegalian, H. Wu, H. Nakauchi, and A. Iwama, Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood, 2002. 100(8): p. 2769-77.
  • Okoshi, Y., S. Imagawa, M. Higuchi, C. Yoshida, S. Shimizu, H.Y. Mukai, T. Komeno, Y. Hasegawa, H. Ninomiya, H. Kojima, and T. Nagasawa, A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. Intern Med, 2002. 41(7): p. 589-92.
  • Mukai, H.Y., Y. Hasegawa, H. Kojima, Y. Okoshi, N. Takei, Y. Yamashita, T. Nagasawa, and N. Mori, Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity. Mod Pathol, 2002. 15(11): p. 1131-9.
  • Kojima, H., M. Abei, N. Takei, Y. Mukai, Y. Hasegawa, T. Iijima, and T. Nagasawa, Fatal reactivation of hepatitis B virus following cytotoxic chemotherapy for acute myelogenous leukemia: fibrosing cholestatic hepatitis. Eur J Haematol, 2002. 69(2): p. 101-4.
  • Iwama, A., M. Osawa, R. Hirasawa, N. Uchiyama, S. Kaneko, M. Onodera, K. Shibuya, A. Shibuya, C. Vinson, D.G. Tenen, and H. Nakauchi, Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med, 2002. 195(5): p. 547-58.
  • Inoue, H., G. Kawano, H. Nagasawa, and S. Sakuda, Isolation of elemental sulfur as a self-growth-inhibiting substance produced by Legionella pneumophila. Appl Environ Microbiol, 2002. 68(10): p. 4809-11.
  • Imagawa, S., N. Suzuki, K. Ohmine, N. Obara, H.Y. Mukai, K. Ozawa, M. Yamamoto, and T. Nagasawa, GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter. Int J Hematol, 2002. 75(4): p. 376-81.
  • Imagawa, S., T. Tarumoto, N. Suzuki, H.Y. Mukai, Y. Hasegawa, M. Higuchi, T. Neichi, K. Ozawa, M. Yamamoto, and T. Nagasawa, L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA. Kidney Int, 2002. 61(2): p. 396-404.
  • Horigome, H., Y. Hiramatsu, O. Shigeta, T. Nagasawa, and A. Matsui, Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia. J Am Coll Cardiol, 2002. 39(6): p. 1072-7.
  • Hirasawa, R., R. Shimizu, S. Takahashi, M. Osawa, S. Takayanagi, Y. Kato, M. Onodera, N. Minegishi, M. Yamamoto, K. Fukao, H. Taniguchi, H. Nakauchi, and A. Iwama, Essential and instructive roles of GATA factors in eosinophil development. J Exp Med, 2002. 195(11): p. 1379-86.
  • Urasaki, T., J. Takasaki, T. Nagasawa, and H. Ninomiya, Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. J Leukoc Biol, 2001. 69(1): p. 105-12.
  • Tabata, M., T. Tarumoto, K. Ohmine, Y. Furukawa, K. Hatake, K. Ozawa, Y. Hasegawa, H. Mukai, M. Yamamoto, and S. Imagawa, Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression. J Cell Physiol, 2001. 186(2): p. 260-7.
  • Shinagawa, A., H. Kojima, T. Kobayashi, K. Kawada, and T. Nagasawa, Lupus anticoagulant-like activity observed in a dimeric lambda protein produced by myeloma cells. Int J Hematol, 2001. 73(4): p. 526-31.
  • Okoshi, Y., S. Shimizu, H. Kojima, N. Obara, H.Y. Mukai, T. Komeno, Y. Hasegawa, N. Mori, and T. Nagasawa, Detection of minimal residual disease in a patient having acute myelogenous leukemia with t(16;21)(p11;q22) treated by allogeneic bone marrow transplantation. Acta Haematol, 2001. 105(1): p. 45-8.
  • Ohmine, K., J. Ota, M. Ueda, S. Ueno, K. Yoshida, Y. Yamashita, K. Kirito, S. Imagawa, Y. Nakamura, K. Saito, M. Akutsu, K. Mitani, Y. Kano, N. Komatsu, K. Ozawa, and H. Mano, Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells. Oncogene, 2001. 20(57): p. 8249-57.
  • Miura, K., S. Miyazawa, S. Furuta, J. Mitsushita, K. Kamijo, H. Ishida, T. Miki, K. Suzukawa, J. Resau, T.D. Copeland, and T. Kamata, The Sos1-Rac1 signaling. Possible involvement of a vacuolar H(+)-ATPase E subunit. J Biol Chem, 2001. 276(49): p. 46276-83.
  • Kojima, H., A. Shinagawa, S. Shimizu, H. Kanada, M. Hibi, T. Hirano, and T. Nagasawa, Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function. Exp Hematol, 2001. 29(5): p. 616-22.
  • Kaneko, S., M. Onodera, Y. Fujiki, T. Nagasawa, and H. Nakauchi, Simplified retroviral vector gcsap with murine stem cell virus long terminal repeat allows high and continued expression of enhanced green fluorescent protein by human hematopoietic progenitors engrafted in nonobese diabetic/severe combined immunodeficient mice. Hum Gene Ther, 2001. 12(1): p. 35-44.
  • Imagawa, S., Y. Yamaguchi, M. Higuchi, T. Neichi, Y. Hasegawa, H.Y. Mukai, N. Suzuki, M. Yamamoto, and T. Nagasawa, Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea--hypopnea syndrome. Blood, 2001. 98(4): p. 1255-7.
  • Urasaki, T., J. Takasaki, T. Nagasawa, and H. Ninomiya, Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. Inflamm Res, 2000. 49(4): p. 177-83.
  • Toshima, M., T. Nagai, T. Izumi, T. Tarumoto, M. Takatoku, S. Imagawa, N. Komatsu, and K. Ozawa, All-trans-retinoic acid treatment for chemotherapy-resistant acute adult T-cell leukemia. Int J Hematol, 2000. 72(3): p. 343-5.
  • Tomobe, M., N. Miyanaga, K. Kawai, K. Kikuchi, K. Uchida, H. Takeshima, Y. Hasegawa, T. Nagasawa, and H. Akaza, [Intrascrotal tumors: a clinicopathologic study of 15 cases]. Nippon Hinyokika Gakkai Zasshi, 2000. 91(9): p. 618-22.
  • Tarumoto, T., S. Imagawa, K. Ohmine, T. Nagai, M. Higuchi, N. Imai, N. Suzuki, M. Yamamoto, and K. Ozawa, N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2. Blood, 2000. 96(5): p. 1716-22.
  • Tarumoto, T., S. Imagawa, K. Ohmine, A. Mano, T. Nagai, M. Takatoku, K. Muroi, K. Hatake, and K. Ozawa, A de novo philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minor BCR/ABL mRNA transcripts. Am J Hematol, 2000. 65(1): p. 72-4.
  • Tarumoto, T., S. Imagawa, T. Hotta, K. Ohmine, T. Nagai, M. Takatoku, N. Komatsu, K. Hatake, and K. Ozawa, A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia. Jpn J Clin Oncol, 2000. 30(3): p. 159-62.
  • Tabata, M., S. Imagawa, T. Tarumoto, K. Ohmine, K. Hatake, Y. Miura, and K. Ozawa, Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24; q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea. Jpn J Clin Oncol, 2000. 30(7): p. 310-2.
  • Suzukawa, K., K. Miura, J. Mitsushita, J. Resau, K. Hirose, R. Crystal, and T. Kamata, Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem, 2000. 275(18): p. 13175-8.
  • Suzukawa, K., M. Amoh, Y. Nakamura, Y. Yasuma, and S. Kurokawa, [Spontaneous occlusion of a dissecting aneurysm in the shape of "two dumplings on a skewer" at righ posterior inferior cerebellar artery (PICA): report of a case and neuroradiological findings]. No Shinkei Geka, 2000. 28(6): p. 561-7.
  • Shimizu, S., K. Suzukawa, T. Kodera, T. Nagasawa, T. Abe, M. Taniwaki, F. Yagasaki, H. Tanaka, S. Fujisawa, B. Johansson, T. Ahlgren, J. Yokota, and K. Morishita, Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21). Genes Chromosomes Cancer, 2000. 27(3): p. 229-38.
  • Shimizu, K., I. Kitabayashi, N. Kamada, T. Abe, N. Maseki, K. Suzukawa, and M. Ohki, AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood, 2000. 96(1): p. 288-96.
  • Ohmine, K., T. Izumi, K. Muroi, R. Shimizu, S. Imagawa, N. Komatsu, R. Sasaki, K. Hatake, Y. Miura, and K. Ozawa, [Low-dose prednisolone therapy for idiopathic thrombocytopenic purpura]. Rinsho Ketsueki, 2000. 41(1): p. 8-11.
  • Nishimura, S., S. Takahashi, T. Kuroha, N. Suwabe, T. Nagasawa, C. Trainor, and M. Yamamoto, A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene. Mol Cell Biol, 2000. 20(2): p. 713-23.
  • Ninomiya, H., Y. Kawashima, and T. Nagasawa, Inhibition of complement-mediated haemolysis in paroxysmal nocturnal haemoglobinuria by heparin or low-molecular weight heparin. Br J Haematol, 2000. 109(4): p. 875-81.
  • Nagashima, T., T. Izumi, K. Muroi, A. Miyasato, M. Uchida, S. Imagawa, N. Komatsu, M. Yoshida, K. Hatake, Y. Miura, and K. Ozawa, [Two cases of acute myelogenous leukemia complicated with fatal gastrointestinal tract bleeding after treatment with idarubicin and cytarabine]. Gan To Kagaku Ryoho, 2000. 27(3): p. 487-90.
  • Muroi, K., T. Suzuki, Y. Amemiya, M. Yoshida, C. Kawano, R. Kuribara, T. Otsuki, T. Izumi, H. Tomizuka, N. Komatsu, S. Imagawa, K. Hatake, Y. Miura, and K. Ozawa, Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study. Leuk Lymphoma, 2000. 38(1-2): p. 103-11.
  • Mukai, H.Y., H. Kojima, K. Suzukawa, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, Nasal natural killer cell lymphoma in a post-renal transplant patient. Transplantation, 2000. 69(7): p. 1501-3.
  • Kojima, H., A. Bai, H.Y. Mukai, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, Chronic myelomonocytic leukemia derived from a possible common progenitor of monocytes and natural killer cells. Leuk Lymphoma, 2000. 37(5-6): p. 617-21.
  • Kojima, H., H.Y. Mukai, A. Shinagawa, C. Yoshida, M. Kamoshita, T. Komeno, Y. Hasegawa, Y. Yamashita, N. Mori, and T. Nagasawa, Clinicopathological analyses of 5 Japanese patients with CD56+ primary cutaneous lymphomas. Int J Hematol, 2000. 72(4): p. 477-83.
  • Kawashima, Y., T. Nagasawa, and H. Ninomiya, Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells. Blood, 2000. 96(6): p. 2157-62.
  • Kamoshita, M. and T. Nagasawa, [Immune megakaryocytopenia]. Ryoikibetsu Shokogun Shirizu, 2000(31): p. 146-51.
  • Ishii, M., M. Iwahana, I. Mitsui, M. Minami, S. Imagawa, A. Tohgo, and A. Ejima, Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. Anticancer Drugs, 2000. 11(5): p. 353-62.
  • Ichida, M., S. Imagawa, K. Ohmine, N. Komatsu, K. Hatake, K. Ozawa, and Y. Miura, Successful treatment of multiple myeloma--associated amyloidosis by interferon-alpha, dimethyl sulfoxide, and VAD (vincristine, adriamycin, and dexamethasone). Int J Hematol, 2000. 72(4): p. 491-3.
  • Hasegawa, Y., A. Bai, H. Kojima, T. Komeno, H. Ninomiya, and T. Nagasawa, Priming effects of macrophage colony-stimulating factor on monocytic leukemia cells in combination with chemotherapy: induction of programmed cell death in vivo. Leuk Lymphoma, 2000. 36(5-6): p. 589-93.
  • Hasegawa, Y. and T. Nagasawa, [Thrombotic thrombocytopenic purpura]. Ryoikibetsu Shokogun Shirizu, 2000(31): p. 152-4.
  • Fujiki, Y., M. Onodera, T. Yamaguchi, M. Osawa, K. Sudo, H. Hamada, H. Ema, A. Shibuya, M. Takiguchi, T. Kubo, and H. Nakauchi, Dominant expansion of human T cells in non-obese diabetic/severe combined immunodeficiency mice implanted with human bone fragments. Exp Hematol, 2000. 28(7): p. 792-801.
  • Yamazaki, Y., R. Sanokawa, Y. Fujita, D. Zhou, K. Kawasaki, H. Tanaka, T. Komatsu, T. Nagasawa, and S. Oka, Cytoplasmic elongation and rupture in megakaryoblastic leukemia cells via activation of adhesion and motility by staurosporine on fibronectin-bound substratum. J Cell Physiol, 1999. 179(2): p. 179-92.
  • Urasaki, T., H. Ninomiya, J. Takasaki, Y. Kawauchi, T. Nagasawa, and Y. Masuho, Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. Inflamm Res, 1999. 48(1): p. 36-40.
  • Tanaka, R., K. Fujimori, N. Itoh, N. Okada, T. Nakamura, T. Sooma, H. Yokoi, S. Imagawa, M. Hareyama, and K. Fujita, [Correlation of risk area and reverse redistribution of 99mTc-sestamibi SPECT in acute myocardial infarction following direct PTCA]. Kaku Igaku, 1999. 36(3): p. 229-36.
  • Suzukawa, K., T. Kodera, S. Shimizu, T. Nagasawa, H. Asou, N. Kamada, M. Taniwaki, J. Yokota, and K. Morishita, Activation of EVI1 transcripts with chromosomal translocation joining the TCRVbeta locus and the EVI1 gene in human acute undifferentiated leukemia cell line (Kasumi-3) with a complex translocation of der(3)t(3;7;8). Leukemia, 1999. 13(9): p. 1359-66.
  • Shigeta, O., H. Kojima, Y. Hiramatsu, T. Jikuya, Y. Terada, N. Atsumi, Y. Sakakibara, T. Nagasawa, and T. Mitsui, Low-dose protamine based on heparin-protamine titration method reduces platelet dysfunction after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 1999. 118(2): p. 354-60.
  • Osada, M., T. Komeno, K. Todokoro, M. Takizawa, H. Kojima, K. Suzukawa, H. Ninomiya, T. Abe, and T. Nagasawa, Immature megakaryocytes undergo apoptosis in the absence of thrombopoietin. Exp Hematol, 1999. 27(1): p. 131-8.
  • Ohkoshi, Y., H. Ninomiya, H.Y. Mukai, N. Mochizuki, M. Hori, T. Nagasawa, T. Jikuya, and Y. Saida, Pseudoaneurysm of the subclavian artery due to Xanthomonas pneumonia in a patient with acute myeloid leukemia: its rupture treated by transcatheter coil embolization. Intern Med, 1999. 38(8): p. 671-4.
  • Obara, N., Y. Ohkoshi, H.Y. Mukai, T. Komeno, Y. Hasegawa, H. Kojima, H. Ninomiya, and T. Nagasawa, [T-cell prolymphocytic leukemia with CD4+8+25+ phenotype in a patient presenting with venous thrombosis in the lower leg]. Rinsho Ketsueki, 1999. 40(11): p. 1187-92.
  • Ninomiya, H., Y. Kawashima, Y. Hasegawa, and T. Nagasawa, Complement-induced procoagulant alteration of red blood cell membranes with microvesicle formation in paroxysmal nocturnal haemoglobinuria (PNH): implication for thrombogenesis in PNH. Br J Haematol, 1999. 106(1): p. 224-31.
  • Mukai, H.Y., H. Kojima, K. Suzukawa, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, High-dose chemotherapy with peripheral blood stem cell rescue in blastoid natural killer cell lymphoma. Leuk Lymphoma, 1999. 32(5-6): p. 583-8.
  • Matsumoto, Y., M. Mori, N. Kanai, T. Izumi, M. Takatoku, K. Muroi, S. Imagawa, N. Komatsu, K. Hatake, Y. Sakata, K. Saito, and K. Ozawa, [Systemic lupus erythematosus presenting as fulminant thrombotic thrombocytopenic purpura]. Rinsho Ketsueki, 1999. 40(8): p. 673-7.
  • Ino, M., S. Nagase, T. Nagasawa, A. Koyama, and S. Tachibana, The outer membrane protein I of Pseudomonas aeruginosa PAO1, a possible pollutant of dialysate in hemodialysis, induces cytokines in mouse bone marrow cells. Nephron, 1999. 82(4): p. 324-30.
  • Imagawa, S., [Erythropoietin and hypoxia responsive system]. Tanpakushitsu Kakusan Koso, 1999. 44(15 Suppl): p. 2478-84.
  • Imagawa, S., [Erythropoietin gene regulation]. Seikagaku, 1999. 71(9): p. 1162-6.
  • Hasegawa, Y., T. Itoh, Y. Tamagawa, T. Komeno, H. Kojima, H. Ninomiya, Y. Yatabe, N. Mori, and T. Nagasawa, Non-Hodgkin's lymphoma followed by plasmacytoma, both arising in A thyroid gland with Hashimoto's disease. Leuk Lymphoma, 1999. 35(5-6): p. 613-8.
  • Bai, A., H. Kojima, M. Hori, N. Nara, T. Komeno, Y. Hasegawa, H. Ninomiya, T. Abe, and T. Nagasawa, Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells. Exp Hematol, 1999. 27(2): p. 259-65.
  • Takahashi, S., T. Komeno, N. Suwabe, K. Yoh, O. Nakajima, S. Nishimura, T. Kuroha, T. Nagasawa, and M. Yamamoto, Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo. Blood, 1998. 92(2): p. 434-42.
  • Tabata, M., M. Yoshida, T. Izumi, C. Kawano, R. Kuribara, M. Toshima, K. Omine, M. Takatoku, M. Uchida, K. Kirito, A. Miyazato, H. Takahashi, M. Hoshino, Y. Terui, H. Tomizuka, T. Otsuki, R. Shimizu, J. Tsunoda, K. Muroi, Y. Furukawa, Y. Amemiya, S. Imagawa, N. Komatsu, T. Suzuki, Y. Miura, and et al., [Retrospective analysis of elderly patients > or = 60 years of age with acute leukemia]. Rinsho Ketsueki, 1998. 39(3): p. 176-84.
  • Suzukawa, K., H. Kojima, and T. Nagasawa, [Anaplastic large cell lymphoma]. Ryoikibetsu Shokogun Shirizu, 1998(22 Pt 3): p. 298-300.
  • Suzukawa, K., H. Kojima, N. Mori, H.Y. Mukai, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, and T. Nagasawa, Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement. Ann Hematol, 1998. 77(6): p. 287-90.
  • Nagasawa, T., Y. Hasegawa, S. Shimizu, Y. Kawashima, S. Nishimura, K. Suzukawa, H. Mukai, M. Hori, T. Komeno, H. Kojima, H. Ninomiya, T. Tahara, and T. Abe, Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects. Br J Haematol, 1998. 101(2): p. 242-4.
  • Nagasawa, T., [Amegakaryocytic thrombocytopenia]. Ryoikibetsu Shokogun Shirizu, 1998(21 Pt 2): p. 342-6.
  • Kuroha, T., S. Takahashi, T. Komeno, K. Itoh, T. Nagasawa, and M. Yamamoto, Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption. J Biochem (Tokyo), 1998. 123(3): p. 376-9.
  • Hori, M. and T. Nagasawa, [Intravascular lymphoma (IVL)]. Ryoikibetsu Shokogun Shirizu, 1998(22 Pt 3): p. 294-7. 96. Hasegawa, Y. and T. Nagasawa, [Thrombocytopenia and neutropenia]. Ryoikibetsu Shokogun Shirizu, 1998(21 Pt 2): p. 329-31.
  • Hamazaki, Y., H. Kojima, H. Mano, Y. Nagata, K. Todokoro, T. Abe, and T. Nagasawa, Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Oncogene, 1998. 16(21): p. 2773-9.
  • Abe, F., M. Hirokawa, T. Yamauchi, K. Honda, N. Hayashi, M. Ishii, S. Imagawa, and M. Iwahana, Further investigation of phenanthroindolizidine alkaloids from Tylophora tanakae. Chem Pharm Bull (Tokyo), 1998. 46(5): p. 767-9.
  • Suzukawa, K., T. Taki, T. Abe, H. Asoh, N. Kamada, J. Yokota, and K. Morishita, Identification of translocational breakpoints within the intron region before the last coding exon (exon 12) of the EVI1 gene in two cases of CML-BC with inv(3)(q21q26). Genomics, 1997. 42(2): p. 356-60.
  • Shinagawa, A., T. Itoh, T. Komeno, T. Komatsu, Y. Hasegawa, T. Kobayashi, H. Kozima, H. Ninomiya, T. Nagasawa, and T. Abe, [Allopurinol induced pancytopenia in a patient with myeloproliferative disorder]. Rinsho Ketsueki, 1997. 38(1): p. 64-71.
  • Shigeta, O., H. Kojima, T. Jikuya, Y. Terada, N. Atsumi, Y. Sakakibara, T. Nagasawa, and T. Mitsui, Aprotinin inhibits plasmin-induced platelet activation during cardiopulmonary bypass. Circulation, 1997. 96(2): p. 569-74.
  • Ninomiya, H., Y. Hasegawa, T. Nagasawa, and T. Abe, Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity. Int J Hematol, 1997. 65(3): p. 285-91.
  • Nagata, Y., Y. Shozaki, H. Nagahisa, T. Nagasawa, T. Abe, and K. Todokoro, Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb Haemost, 1997. 77(5): p. 808-14.
  • Mukai, H.Y., H. Ninomiya, T. Nagasawa, and T. Abe, Elevated serum levels of eosinophil major basic protein in patients with myeloproliferative disorders without eosinophilia. Int J Hematol, 1997. 66(2): p. 197-202.
  • Imagawa, S., M. Yamamoto, and Y. Miura, Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood, 1997. 89(4): p. 1430-9.
  • Hamaguchi, H., K. Suzukawa, K. Nagata, K. Yamamoto, F. Yagasaki, and K. Morishita, Establishment of a novel human myeloid leukaemia cell line (HNT-34) with t(3;3)(q21;q26), t(9;22)(q34;q11) and the expression of EVI1 gene, P210 and P190 BCR/ABL chimaeric transcripts from a patient with AML after MDS with 3q21q26 syndrome. Br J Haematol, 1997. 98(2): p. 399-407.
  • Taki, T., Y. Hayashi, M. Taniwaki, M. Seto, R. Ueda, R. Hanada, K. Suzukawa, J. Yokota, and K. Morishita, Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. Oncogene, 1996. 13(10): p. 2121-30.
  • Nagahisa, H., Y. Nagata, T. Ohnuki, M. Osada, T. Nagasawa, T. Abe, and K. Todokoro, Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood, 1996. 87(4): p. 1309-16.
  • Mukai, H.Y., H. Kojima, K. Todokoro, T. Tahara, T. Kato, Y. Hasegawa, T. Kobayashi, H. Ninomiya, T. Nagasawa, and T. Abe, Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thromb Haemost, 1996. 76(5): p. 675-8.
  • Komeno, T., T. Itoh, K. Ohtani, M. Kamoshita, Y. Hasegawa, M. Hori, T. Kobayashi, T. Nagasawa, and T. Abe, Disseminated nontuberculous mycobacteriosis caused by mycobacterium kansasii in a patient with myelodysplastic syndrome. Intern Med, 1996. 35(4): p. 323-6.
  • Komeno, T., K. Ohtani, Y. Hasegawa, A. Shinagawa, H. Mukai, T. Komatsu, T. Nagasawa, and T. Abe, [Appearance of cytoplasmic processes of megakaryocytes in the peripheral blood in a Munchausen syndrome with factitious anemia]. Rinsho Ketsueki, 1996. 37(9): p. 848-52.
  • Kobayashi, T., T. Nagasawa, S. Mitsuhashi, Y. Hasegawa, H. Kojima, H. Ninomiya, N. Mori, and T. Abe, Clinicopathological characteristics of primary Ki-1 anaplastic large cell lymphoma. Int J Hematol, 1996. 63(1): p. 41-50.
  • Izumi, T., T. Ohtsuki, K. Ohya, Y. Ogawa, M. Yoshida, K. Muroi, S. Imagawa, K. Hatake, K. Kuriki, K. Saito, and Y. Miura, Therapy-related leukemia with a novel 21q22 rearrangement. Cancer Genet Cytogenet, 1996. 90(1): p. 45-8.
  • Izumi, T., S. Imagawa, K. Hatake, Y. Miura, T. Ariyama, J. Inazawa, and T. Abe, Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph1-positive chronic myelogenous leukemia. Int J Hematol, 1996. 64(1): p. 73-7.
  • Izumi, T., S. Imagawa, K. Muroi, R. Shimizu, H. Takahashi, Y. Hoshino, H. Tomizuka, T. Kawakami, K. Toya, H. Kurata, J. Tsunoda, Y. Furukawa, T. Suzuki, N. Komatsu, A. Ohsaka, Y. Amemiya, S. Takagi, M. Yoshida, R. Sasaki, K. Hatake, and Y. Miura, [Retrospective analysis on 21 patients with follicular lymphoma]. Rinsho Ketsueki, 1996. 37(1): p. 7-13.
  • Ito, T., H. Kojima, K. Otani, T. Komeno, S. Mitsuhashi, Y. Hasegawa, T. Kobayashi, H. Ninomiya, T. Nagasawa, and T. Abe, Chronic neutrophilic leukemia associated with monoclonal gammopathy of undetermined significance. Acta Haematol, 1996. 95(2): p. 140-3.
  • Imagawa, S., M. Yamamoto, M. Ueda, and Y. Miura, Erythropoietin gene expression by hydrogen peroxide. Int J Hematol, 1996. 64(3-4): p. 189-95.
  • Imagawa, S., M. Yamamoto, and Y. Miura, GATA transcription factors negatively regulate erythropoietin gene expression. Acta Haematol, 1996. 95(3-4): p. 248-56.
  • Hagiwara, T., T. Nagasawa, H. Nagahisa, M. Takizawa, M. Osada, and T. Abe, Expression of adhesion molecules on cytoplasmic processes of human megakaryocytes. Exp Hematol, 1996. 24(6): p. 690-5.
  • Asou, H., K. Suzukawa, K. Kita, K. Nakase, H. Ueda, K. Morishita, and N. Kamada, Establishment of an undifferentiated leukemia cell line (Kasumi-3) with t(3;7)(q27;q22) and activation of the EVI1 gene. Jpn J Cancer Res, 1996. 87(3): p. 269-74.
  • Asou, H., M. Eguchi, K. Suzukawa, K. Morishita, K. Tanaka, M. Date, K. Hamamoto, and N. Kamada, Establishment of a myeloid leukaemia cell line (Kasumi-4) with t(9;22;11)(q34;q11;q13), inv(3)(q21q26) and the EVI1 gene activation from a patient with chronic myelogenous leukaemia in blast crisis. Br J Haematol, 1996. 93(1): p. 68-74.
  • Suzukawa, K., H. Satoh, M. Taniwaki, J. Yokota, and K. Morishita, The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q21q26 syndrome). Leukemia, 1995. 9(8): p. 1328-31.
  • Ohtani, K., H. Ninomiya, Y. Hasegawa, T. Kobayashi, H. Kojima, T. Nagasawa, and T. Abe, Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Br J Haematol, 1995. 91(1): p. 116-20.
  • Nagasawa, T., Y. Hasegawa, T. Komeno, T. Itoh, H. Ninomiya, and T. Abe, Simultaneous measurements of megakaryocyte-associated IgG (MAIgG) and platelet-associated IgG (PAIgG) in chronic idiopathic thrombocytopenic purpura. Eur J Haematol, 1995. 54(5): p. 314-20.
  • Nagasawa, T., Y. Hasegawa, M. Kamoshita, K. Ohtani, T. Komeno, T. Itoh, A. Shinagawa, H. Kojima, H. Ninomiya, and T. Abe, Megakaryopoiesis in patients with cyclic thrombocytopenia. Br J Haematol, 1995. 91(1): p. 185-90.
  • Muroi, K., S. Imagawa, T. Suzuki, Y. Amemiya, and Y. Miura, B-cell lymphoma terminating in acute monoblastic leukemia. Intern Med, 1995. 34(1): p. 36-8.
  • Mukai, H.Y., H. Ninomiya, K. Ohtani, T. Nagasawa, and T. Abe, Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Br J Haematol, 1995. 90(4): p. 892-9.
  • Morishita, K., K. Suzukawa, T. Taki, J.N. Ihle, and J. Yokota, EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN1-28 CTCATCTTC. Oncogene, 1995. 10(10): p. 1961-7.
  • Mitsuhashi, S., T. Nagasawa, M. Kamoshita, K. Otani, Y. Hasegawa, H. Kojima, H. Ninomiya, M. Nakazawa, and T. Abe, [Minimally differentiated hypoplastic leukemia]. Rinsho Ketsueki, 1995. 36(2): p. 115-20.
  • Kojima, H., Y. Hamazaki, Y. Nagata, K. Todokoro, T. Nagasawa, and T. Abe, Modulation of platelet activation in vitro by thrombopoietin. Thromb Haemost, 1995. 74(6): p. 1541-5.
  • Kamoshita, M., K. Suzukawa, T. Kobayashi, Y. Hasegawa, Y. Satoh, H. Ninomiya, T. Nagasawa, and T. Abe, [von Recklinghausen's disease complicated by macroglobulinemia, malignant schwannoma and pheochromocytoma]. Rinsho Ketsueki, 1995. 36(1): p. 59-62.
  • Hasegawa, Y., T. Nagasawa, M. Kamoshita, T. Komeno, T. Itoh, H. Ninomiya, and T. Abe, Effects of anti-platelet glycoprotein Ib and/or IIb/IIIa autoantibodies on the size of megakaryocytes in patients with immune thrombocytopenia. Eur J Haematol, 1995. 55(3): p. 152-7.
  • Hagiwara, S., A. Miwa, M. Yoshida, S. Imagawa, N. Komatu, K. Muroi, R. Sasaki, K. Hatake, S. Sakamoto, and S. Miura, Methicillin-resistant Staphylococcus aureus: colonization and development of infection in patients with haematological disorders. Eur J Haematol, 1995. 55(4): p. 267-71.
  • Suzukawa, K., E. Parganas, A. Gajjar, T. Abe, S. Takahashi, K. Tani, S. Asano, H. Asou, N. Kamada, J. Yokota, and et al., Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26). Blood, 1994. 84(8): p. 2681-8.
  • Okano, M., S. Masuda, H. Narita, S. Masushige, S. Kato, S. Imagawa, and R. Sasaki, Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted rats. FEBS Lett, 1994. 349(2): p. 229-33.
  • Ohyashiki, K., J.H. Ohyashiki, H. Fujieda, T. Shimamoto, K. Kawakubo, S. Nakazawa, K. Suzukawa, K. Morishita, and K. Toyama, EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. Leukemia, 1994. 8(12): p. 2169-73.
  • Kojima, H., K. Suzukawa, Y. Yatabe, M. Hori, T. Nagasawa, and T. Abe, Establishment of a new natural killer (NK) cell line, TKS-1, from a patient with aggressive type of large granular lymphocyte (LGL) leukemia. Leukemia, 1994. 8(11): p. 1999-2004.
  • Izumi, T., K. Muroi, M. Takatoku, S. Imagawa, K. Hatake, and Y. Miura, Development of acute myeloblastic leukaemia in a case of aplastic anaemia treated with granulocyte colony-stimulating factor. Br J Haematol, 1994. 87(3): p. 666-8.
  • Izumi, T., K. Hatake, S. Imagawa, M. Yoshikda, M. Ohta, R. Sasaki, A. Miwa, T. Suda, S. Sakamoto, and Y. Miura, [A case of acute promyelocytic leukemia (APL) with myeloblastoma in the oral cavity developing after receiving all-trans retinoic acid (ATRA)]. Rinsho Ketsueki, 1994. 35(6): p. 598-602.
  • Imagawa, S., T. Izumi, and Y. Miura, Positive and negative regulation of the erythropoietin gene. J Biol Chem, 1994. 269(12): p. 9038-44.
  • Hoshi, M., T. Nagasawa, T. Abe, T. Satoh, and Y. Mitsui, Maturation of human megakaryocytic cell line (CMK-7) on the human umbilical vein endothelial cell (EC) monolayer. Int J Hematol, 1994. 59(3): p. 191-9.
  • Hori, M., S. Mitsuhashi, T. Kobayashi, T. Nagasawa, N. Mori, M. Miwa, and T. Abe, CD30-positive lymphoma in human T-cell leukaemia virus type 1 carrier without monoclonal integration of HTLV-1. Br J Haematol, 1994. 88(2): p. 419-20.
  • Yoshida, M., H. Kurata, S. Tsunoda, A. Iwama, T. Suzuki, M. Akutsu, S. Imagawa, J. Tsunoda, Y. Furukawa, N. Komatsu, and et al., [Treatment of 71 adult acute lymphoblastic leukemia]. Gan To Kagaku Ryoho, 1993. 20(12): p. 1827-33.
  • Suzukawa, K., H. Ninomiya, S. Mitsuhashi, I. Anno, T. Nagasawa, and T. Abe, Demonstration of the deposition of hemosiderin in the kidneys of patients with paroxysmal nocturnal hemoglobinuria by magnetic resonance imaging. Intern Med, 1993. 32(9): p. 686-90.
  • Sato, Y., S. Mituhashi, K. Otani, M. Kamoshita, Y. Hasegawa, H. Ninomiya, T. Nagasawa, and T. Abe, [A study of hypoplastic myelodysplastic syndrome]. Rinsho Ketsueki, 1993. 34(11): p. 1431-7.
  • Ninomiya, H., Y. Muraki, K. Shibuya, T. Nagasawa, and T. Abe, Induction of Fc gamma R-III (CD16) expression on neutrophils affected by paroxysmal nocturnal haemoglobinuria by administration of granulocyte colony-stimulating factor. Br J Haematol, 1993. 84(3): p. 497-503.
  • Nagasawa, T., [Megakaryopoiesis in chronic myeloproliferative disorders]. Rinsho Ketsueki, 1993. 34(5): p. 551-6.
  • Nagasawa, T., H. Yanagisawa, Y. Hasegawa, H. Kanma, and T. Abe, Polycythemia associated with primary systemic amyloidosis: elevated levels of hemopoietic factors and cytokines. Am J Hematol, 1993. 43(1): p. 57-60.
  • Kojima, H., M. Hori, A. Shibuya, T. Nagasawa, M. Miwa, and T. Abe, Successful treatment of a patient with adult T-cell leukemia by daily oral administration of low-dose etoposide. Decrease in the amount of HTLV-I proviral DNA revealed by the polymerase chain reaction method. Cancer, 1993. 72(12): p. 3614-7
  • Kamoshita, M., K. Ohtani, Y. Hasegawa, Y. Satoh, H. Kozima, A. Shibuya, H. Ninomiya, T. Nagasawa, Y. Matsunaga, and T. Abe, [Human parvovirus B19-induced aplastic crisis in an elderly man with intestinal hemorrhage]. Rinsho Ketsueki, 1993. 34(4): p. 493-5.
  • Hatake, K., T. Izumi, S. Imagawa, M. Ohta, and Y. Miura, Macrophage colony-stimulating factor and platelet recovery after chemotherapy. Lancet, 1993. 341(8850): p. 963.
  • Hasegawa, Y., T. Nagasawa, H. Kojima, A. Shibuya, H. Ninomiya, and T. Abe, [Treatment of elderly patients with chronic idiopathic thrombocytopenic purpura]. Rinsho Ketsueki, 1993. 34(4): p. 460-4.
  • Tsunoda, S., M. Yoshida, S. Takagi, R. Sasaki, K. Muroi, M. Hoshino, T. Izumi, S. Imagawa, H. Ema, T. Suzuki, and et al., [Acute undifferentiated leukemia from the viewpoints of diagnosis and therapy]. Rinsho Ketsueki, 1992. 33(9): p. 1136-43.
  • Shibuya, A., Y. Muraki, Y. Satoh, T. Kobayashi, H. Kojima, T. Nagasawa, T. Abe, J. Tomiyama, H. Kudoh, Y. Adachi, and et al., [Clinicopathological study of 6 cases of mantle zone lymphoma]. Rinsho Ketsueki, 1992. 33(6): p. 770-5.
  • Muraki, Y., T. Kobayashi, H. Kojima, A. Shibuya, T. Nagasawa, T. Abe, and N. Mori, [Anorexia nervosa with neutropenia--response of neutrophils to G-CSF]. Rinsho Ketsueki, 1992. 33(3): p. 328-32.
  • Kobayashi, T., Y. Sato, Y. Hasegawa, T. Nagasawa, Y. Yoda, and T. Abe, Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon. Intern Med, 1992. 31(7): p. 936-40.
  • Fukunaga, N., S. Imagawa, T. Sahara, A. Ishii, and M. Suzuki, Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4. J Biochem (Tokyo), 1992. 112(6): p. 849-55.
  • Yanagisawa, H., T. Nagasawa, S. Kuramochi, T. Abe, Y. Ikawa, and K. Todokoro, Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim Biophys Acta, 1991. 1088(3): p. 380-4.
  • Todokoro, K., S. Kuramochi, T. Nagasawa, T. Abe, and Y. Ikawa, Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin. Gene, 1991. 106(2): p. 283-4.
  • Natsuda, H., Y. Muraki, T. Kobayashi, H. Kozima, A. Shibuya, T. Nagasawa, and T. Abe, [Adult T cell lymphoma/leukemia with alopecia, huge tumors of scalp and wide destruction of cerebral bone]. Rinsho Ketsueki, 1991. 32(5): p. 537-41.
  • Nagasawa, T., K. Satoh, and T. Abe, Thrombopoietic factor enhances murine megakaryopoiesis induced by recombinant erythropoietin. Int J Hematol, 1991. 54(2): p. 159-64.
  • Muroi, K., S. Imagawa, T. Suda, E. Kajii, Y. Otuka, I. Sakurabayashi, Y. Amemiya, S. Sakamoto, and Y. Miura, [Multiple myeloma with hemolytic anemia and thrombocytopenia]. Rinsho Ketsueki, 1991. 32(8): p. 909-11.
  • Itoh, M., M. Yoshida, H. Kurata, S. Imagawa, M. Hoshino, J. Tsunoda, H. Ema, S. Tsunoda, T. Suzuki, N. Komatsu, and et al., [Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis]. Rinsho Ketsueki, 1991. 32(2): p. 115-20.
  • Imagawa, S., M.A. Goldberg, J. Doweiko, and H.F. Bunn, Regulatory elements of the erythropoietin gene. Blood, 1991. 77(2): p. 278-85.
  • Goldberg, M.A., S. Imagawa, R.K. Strair, and H.F. Bunn, Regulation of the erythropoietin gene in Hep 3B cells. Semin Hematol, 1991. 28(3 Suppl 3): p. 35-40; discussion 40-1.
  • Ema, H., T. Suda, H. Nakauchi, Y. Nakamura, A. Iwama, S. Imagawa, M. Akutsu, Y. Kano, S. Kato, M. Yabe, and et al., Multipotent and committed CD34+ cells in bone marrow transplantation. Jpn J Cancer Res, 1991. 82(5): p. 547-52.
  • Satoh, K., T. Nagasawa, and T. Abe, Simultaneous assay for megakaryocyte colony-stimulating factor and megakaryocyte potentiator and its application. J Lab Clin Med, 1990. 116(2): p. 162-71.
  • Nagasawa, T., T. Orita, J. Matsushita, M. Tsuchiya, T. Neichi, I. Imazeki, N. Imai, N. Ochi, H. Kanma, and T. Abe, Thrombopoietic activity of human interleukin-6. FEBS Lett, 1990. 260(2): p. 176-8.
  • Nagasawa, T., T. Kobayashi, Y. Satoh, H. Yanagisawa, M. Nakazawa, and T. Abe, [The relationship between responsiveness to splenectomy and clinical course after splenectomy in chronic idiopathic thrombocytopenic purpura (ITP)]. Rinsho Ketsueki, 1990. 31(7): p. 922-8.
  • Kojima, H., Y. Hasegawa, T. Ikegami, T. Nagasawa, and T. Abe, [Chronic myelogenous leukemia with marked thrombocytosis--comparison with essential thrombocythemia with Ph1 in its megakaryokinetics]. Rinsho Ketsueki, 1990. 31(1): p. 35-40.
  • Hanada, T., I. Ono, and T. Nagasawa, Childhood cyclic neutropenia treated with recombinant human granulocyte colony stimulating factor. Br J Haematol, 1990. 75(1): p. 135-7.
  • Tomiyama, J., Y. Hasegawa, T. Nagasawa, T. Abe, H. Horiguchi, and T. Ogata, Bacillus cereus septicemia associated with rhabdomyolysis and myoglobinuric renal failure. Jpn J Med, 1989. 28(2): p. 247-50.
  • Imagawa, S., M.A. Goldberg, and H.F. Bunn, Regulation of the erythropoietin gene. Adv Exp Med Biol, 1989. 271: p. 75-85.
  • Imagawa, S., B.R. Smith, R. Palmer-Crocker, and H.F. Bunn, The effect of recombinant erythropoietin on intracellular free calcium in erythropoietin-responsive cells. Blood, 1989. 73(6): p. 1452-7.
  • Goldberg, M.A., S. Imagawa, P.S. Dunning, and H.F. Bunn, Oxygen sensing and erythropoietin gene regulation. Contrib Nephrol, 1989. 76: p. 39-54; discussion 54-6
  • Shibuya, A., H. Ninomiya, M. Nakazawa, T. Nagasawa, Y. Yoda, and T. Abe, Oxymetholone therapy in patients with familial antithrombin III deficiency. Thromb Haemost, 1988. 60(3): p. 495-7.
  • Ninomiya, H., J. Tomiyama, S. Imagawa, A. Shibuya, T. Hanada, T. Kageoka, T. Nagasawa, Y. Yoda, T. Abe, and T. Fujita, [Recurrence of thromboses and infections in a patient with paroxysmal nocturnal hemoglobinuria (PNH)]. Rinsho Ketsueki, 1988. 29(1): p. 54-8.
  • Nagasawa, T., T. Neichi, K. Satoh, M. Nakazawa, and T. Abe, In vitro regulatory mechanisms for cytoplasmic maturation of murine megakaryocytes derived from colony-forming units megakaryocyte (CFU-M). Exp Hematol, 1988. 16(8): p. 667-73.
  • Hanada, T., K. Koike, T. Takeya, T. Nagasawa, Y. Matsunaga, and H. Takita, Human parvovirus B19-induced transient pancytopenia in a child with hereditary spherocytosis. Br J Haematol, 1988. 70(1): p. 113-5.
  • Hanada, T., K. Saito, T. Nagasawa, T. Kabashima, S. Nakahara, A. Okuyama, and H. Takita, Intravenous gammaglobulin therapy for thromboneutropenic neonates of mothers with systemic lupus erythematosus. Eur J Haematol, 1987. 38(5): p. 400-4.