The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation
→ Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468
(英語 English)
KOnezumi: a web application for automating gene disruption strategies to generate knockout mice
A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.
→ Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090
(英語 English)
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis
→ PDF Download (英語 English)
Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013
マウスの動脈硬化病変部を体外から生きたまま観察する技術の開発 - 動脈硬化の特効薬開発に有用な画期的技術
A Novel iRFP-Incorporated in vivo Murine Atherosclerosis Imaging System
Scientific Reports doi:10.1038/s41598-018-32456-5
(英語 English)
寝ても寝ても眠いマウスの脳内メカニズム 単一遺伝子の単一アミノ酸が、1 日の睡眠時間と睡眠要求量・眠気を制御する
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.
Award Presented for “Compelling Results in Biology and Medicine:Transcriptome analysis of gravitational effects on muscles of mice”
世界で初めて宇宙で1Gコントロールを含めたマウスの飼育を行い、また、日米の研究者間でサンプルシェア―により、生物学/生理学の発展に大きく寄与するデータを取得したことが評価され受賞しました。
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
[Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain]
• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators
転写因子MAFB変異によるデュアン眼球後退症候群(DRS)と巣状糸球体硬化症(FSGS)合併の分子機序の解明
A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome Kidney International DOI: 10.1016/j.kint.2018.02.025 英語 (English)
TMRCセミナー-ハリーパーキンス医学研究所- Kevin Pfleger准教授
TMRC Seminar - Harry Perkins Institute of Medical Research
Associate Professor Kevin Pfleger
Profiling of Receptor Molecule Pharmacology
Innovation and Entrepreneurship in Translating Biomedical Research (Presented in English)
Date: July 13th, 2018 (Friday) 17:00-18:15
Place: Innovation Building, Ground Floor, Room 105