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2019年 3月 26日

The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation

Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468
(英語 English)

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2019年 4月 27日

KOnezumi: a web application for automating gene disruption strategies to generate knockout mice

A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.

Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090
(英語 English)

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2019年 1月 3日

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche


• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis

PDF Download (英語 English)
Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013

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2018年 7月 27日

マウスサンプルシェアの日米協力を通じたISS利用成果創出

Award Presented for “Compelling Results in Biology and Medicine:Transcriptome analysis of gravitational effects on muscles of mice”

世界で初めて宇宙で1Gコントロールを含めたマウスの飼育を行い、また、日米の研究者間でサンプルシェア―により、生物学/生理学の発展に大きく寄与するデータを取得したことが評価され受賞しました。

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2018年 7月 12日

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

[Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain]

• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators

Cell Reports DOI: 10.1016/j.kint.2018.02.025
英語 (English)

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2018年 6月 26日

TMRCセミナー-ハリーパーキンス医学研究所- Kevin Pfleger准教授

TMRC Seminar - Harry Perkins Institute of Medical Research

Associate Professor Kevin Pfleger Profiling of Receptor Molecule Pharmacology
Innovation and Entrepreneurship in Translating Biomedical Research (Presented in English)

Date: July 13th, 2018 (Friday) 17:00-18:15

Place: Innovation Building, Ground Floor, Room 105

→ シンポジウムポスター (241 kB PDF)