Mail Address (English)
Phone (LAB): 029-853-8008
A special postdoctoral position funded by JST for a one year period from April 2011 till April 2012 is available. A background in experimental
biochemistry/biophysics would be an advantage. If interested please send a one page c.v. to email@example.com by February 15th 2011.
My research is concerned with the biophysical study of important biochemical processes related to disease states. The three topics studied in my laboratory are
(i.) Amyloid formation and its relationship to disease.
(ii.) The process of virus adsorption to the epithelial cell membrane.
(iii.) Protein diffusion in the cell cytosol and cell membrane.
Projects for students (visiting undergraduate scholars, M.Sc. or Ph.D. candidates) are available. Please email me to discuss available projects or alternatively you are welcome to suggest your own. If you are at the postdoctoral level and you would like to work together please write to me and we can discuss a number of fellowship options that I can help you apply for. My laboratory is a good environment for scientists interested in performing basic research with the emphasis placed on understanding what you are doing.
Some Recent Publications
Here are few recent papers that describe my general research style which should be downloadable if you are viewing this website from an academic institution. If they are not you can write to me and I will send you these reprints as a block.
‘Effect of macromolecular crowding on intracellular diffusion from a single particle perspective’ Hall, D. and Hoshino, M. 2010, Biophysical Reviews. 2:39-53 – This work outlines some controllable theory suitable for describing the Brownian motion of a single particle in a cell like environment.
‘Effect of heterogeneity on the characterization of cell membrane compartments: I. Uniform size and permeability.’ Hall D. Analytical Biochemistry. 2010, 398:230-244 – This work is concerned with how we extract information about long-range structural order existing in the cell membrane from single particle tracking measurements of diffusion.
‘A model of amyloid's role in disease based on fibril fracture.’ Hall D. and Edskes H. Biophysical Chemistry. 2009, 145:17-28 – This work is concerned with a physical model of the differential cellular toxicity of various types of amyloid.
‘Kinetic Models of Biospecific Interactions at Surfaces’. Hall, D. (2008). Chapter 4 of ‘Handbook of Surface Plasmon Resonance Based Biosensors. Royal Society of Chemistry. Eds. A. Tudos and R.B.M. Schasfoort. – This work describes a physical chemistry perspective of protein adsorption to the cell membrane. (Please write to me to receive this book chapter as a pdf)
‘Expanding to fill the gap: a possible role for inert biopolymers in regulating the extent of the 'macromolecular crowding' effect.’ Hall, D. and Dobson, C.M. FEBS Letters. 2006, 580:2584-2590. – This paper is concerned with the ‘macromolecular crowding’ concept first named as such by Allen P. Minton. Here we describe a new aspect of the macromolecular crowding concept by showing that reversible regulation of the crowding effect posits a new method for controlling the folding state and hence enzymatic activity of other bio-molecules in solution!
Turbidity as a probe of tubulin polymerization kinetics: a theoretical and experimental re-examination. Hall D and Minton AP. Analytical Biochemistry. 2005, 345:198-213. – This paper deals with how we interpret the turbidimetric assay used to quantify the microtubule polymerization reaction.