研究業績


1, Nishikimi, A., Fukuhara, H., Su, W., Hongu, T., Takasuga, S., Mihara, H., Cao, Q., Sanematsu, F., Kanai, M., Hasegawa, H., Tanaka, Y., Shibasaki, M., Kanaho, Y., Sasaki, T., Frohman, M.A., Fukui, Y.
Sequential Regulation of DOCK2 dynamics by two phospholipid during neurtrophil chemotaxis. Science (2009) 324, 384-387

2, Kessler, J.D., Hasegawa, H., Yang, Z.-J., Dutton, J.W., Wang, F., Wechsler-Reya, R.J.
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev (2009) 23, 157-170

3, Que, J., Wilm, B., Hasegawa, H., Wang, F., Bader, D., Hogan, BL.
Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci (2008) 43, 16626-16630

4, Hasegawa, H., Wang, F.
Visualizing Mechanosensory Endings of TrkC-Expressing Neurons in HS3ST-2-hPLAP Mice. J Comp Neurol (2008) 511, 543-556

5, Hasegawa, H., Abbott, S., Han, B.-X., Qi, Y., Wang, F.
Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. J Neurosci (2007) 27, 14404-14414

6, Hasegawa, H., Ashigaki, S., Takamatsu, M., Suzuki-Migishima, R., Ohbayashi, N., Itoh, N., Takada, S., Tanabe, Y.
Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. J Neurosci (2004) 24, 8711-8719

7, Takiguchi-Hayashi, K., Sekiguchi, M., Ashigaki, S., Takamatsu, M., Hasegawa, H., Suzuki-Migishima, R., Yokoyama, M., Nakanishi, S., Tanabe, Y.
Generation of Reelin-positive Marginal Zone Cells from the Caudal-Medial Wall of Telencephalic Vesicles. J Neurosci (2004) 24, 2286-2295

8, Yamamoto, Y., Hasegawa, H., Tanaka, K., Kakizuka, A.
Isolation of neuronal cells with high processing activity for the Machado-Joseph disease protein. Cell Death Differ (2001) 8, 871-873

9, Hasegawa, H., Katoh, H., Fujita, H., Mori, K., Negishi, M.
Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin. Biochem Biophys Res Commun (2000) 276, 350-354

10, Nakamura, K., Kaneko, T., Yamashita, Y., Hasegawa, H., Katoh, H., Negishi, M.
Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J Comp Neurol (2000) 421, 543-569

11, Hasegawa, H., Katoh, H., Yamaguchi, Y., Nakamura, K., Futakawa, S., Negishi, M.
Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures. FEBS Lett (2000) 473, 76-80

12, Fujita, H., Katoh, H., Hasegawa, H., Yasui, H., Aoki, J., Yamaguchi, Y., Negishi, M. Molecular decipherment of Rho effector pathways regulating tight-junction permeability. Biochem J (2000) 346, 617-622

13, Hasegawa, H., Fujita, H., Katoh, H., Aoki, J., Nakamura, K., Ichikawa, A., Negishi, M.
Opposite regulation of transepithelial electrical resistance and paracellular permeability by Rho in Madin-Darby canine kidney cells. J Biol Chem (1999) 274, 20982-20988

14, Aoki, J., Katoh, H., Yasui, H., Yamaguchi, Y., Nakamura, K., Hasegawa, H., Ichikawa, A., Negishi, M.
Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases. Biochem J (1999) 340, 365-369

15, Satoh, S., Chang, C.-s., Katoh, H., Hasegawa, H., Nakamura, K., Aoki, J., Fujita, H., Ichikawa, A., Negishi, M.
The key amino acid residue of prostaglandin EP3 receptor for governing G protein association and activation steps. Biochem Biophys Res Commun (1999) 255, 164-168

16, Nakamura, K., Kaneko, T., Yamashita, Y., Hasegawa, H., Katoh, H., Ichikawa, A., Negishi, M.
Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus. Neurosci Lett (1999) 260, 117-120

17, *Hizaki, H., *Hasegawa, H., Katoh, H., Negishi, M., Ichikawa, A.
Functional role of carboxyl-terminal tail of prostaglandin EP3 receptor in Gi coupling. FEBS Lett (1997) 414, 323-326
*These authors equally contributed to this work.

18, Hasegawa, H., Negishi, M., Katoh, H., Ichikawa, A.
Two isoforms of prostaglandin EP3 receptor exhibiting constitutive activity and agonist-dependent activity in Rho-mediated stress fiber formation. Biochem Biophys Res Commun (1997) 234, 631-636

19, Negishi, M., Hasegawa, H., Ichikawa, A.
Prostaglandin E receptor EP3gamma isoform, with mostly full constitutive Gi activity and agonist-dependent Gs activity. FEBS Lett (1996) 386, 165-168

20, Hasegawa, H., Negishi, M., Ichikawa, A.
Two isoforms of the prostaglandin E receptor EP3 subtype different in agonist-independent constitutive activity. J Biol Chem (1996) 271, 1857-1860