研究業績　依馬　正次　

英文　　和文・総説

-英文-

  1. Ema, M., K, Sogawa., N, Watanabe., Y, Chujoh., N, Matsushita., Y, Funae., O, Gotoh., and Y, Fujii-Kuriyama. cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophy. Res. Comm. 184: 246-253. (1992)
  2. Matsushita, N., K, Sogawa., M, Ema., A, Yoshida., and Y, Fujii-Kuriyama. A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. J. Biol. Chem., 268: 21002-21006. (1993)
  3. Ema, M., N, Matsushita., K, Sogawa., T, Ariyama., J, Inazawa., T, Ota., M, Oshimura., and Y, Fujii-Kuriyama. Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. J. Biochem. 116: 845-851. (1994)
  4. Mimura, J., M, Ema., K, Sogawa.,S, Ikawa., and Y, Fujii-Kuriyama. A complete structure of the mouse Ah receptor gene. Pharmacogenetics. 4: 349-354. (1994)
  5. Fujii-Kuriyama, Y., M, Ema., J, Mimura., and K, Sogawa. Ah receptor: A novel ligand- activated transcription factor. Exp. Clin. Immunogenet. 11: 65-74 .(1994)
  6. Sogawa, K., N. Matsushita., M. Ema., and Y. Fujii-Kuriyama. DNA-binding regulatory factors and inducible expression of the P4501A1 gene. in cytchrome P450. edited by M. C. Lechner. John Libbey Eurotext, Paris. 1994. 678 p75-80.
  7. Ema, M., N, Ohe., M, Suzuki., J, Mimura., K, Sogawa., S, Ikawa., and Y, Fujii-Kuriyama. Dioxin-binding activities of polymorphic forms of mouse and human Ah receptors. J. Biol. Chem. 269: 27337-27343. (1994)
  8. Fujii-Kuriyama, Y., M, Ema., J, Mimura., N, Matsushita., and K, Sogawa. Polymorphic forms of the Ah receptor and induction of the CYP1A1 gene. Pharmacogenetics. 5: S149-153. (1995)
  9. Ema, M., M, Suzuki., K, Hirose., K, Sogawa., Y, Matsuda., O, Gotoh., and Y, Fujii-Kuyiyama. cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development and chromosomal localization. Biochem. Biophys. Res. Comn. 218: 588-594. (1996)
  10. Hirose, K., M, Morita., M, Ema., J, Mimura., H, Hamada. H, Fujii., Y, Saijoh,., O, Gotoh., K, Sogawa, and Y, Fujii-Kuriyama. cDNA cloning and tissue specific expression of a novel bHLH/PAS factor (Arnt2) with close sequence similarity to AhR nuclear translocator (Arnt). Mol. Cell. Biol. 16: 1706-1713.(1996)
  11. Ema, M., M, Morita., S, Ikawa., M, Tanaka., Y, Matsuda., O, Gotoh., Y, Saijoh., H, Fujii, H, Hamada., Y, Kikuchi., and Y. Fujii-Kuriyama. Two new members of the murine sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol. Cell. Biol. 16: 5865-5875.(1996)
  12. Ema, M., S, Taya., N, Yokotani., K., Sogawa., Y, Matsuda., and Y, Fujii-Kuriyama. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1a regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. USA. 94: 4273-4278. (1997)
  13. Dzeletovic, N., J, McGuire., M, Daujat., J, Tholander., M, Ema., Y, Fujii-Kuriyama., J, Bergman., P, Maurel., and L, Poellinger. Regulation of dioxin receptor function by omeprazole. J. Biol. Chem. 272: 12705-12713. (1997)
  14. Mimura, J., K, Yamashita., K, Nakamura., M, Morita., T, N, Takagi., K, Nakao., M, Ema., K, Sogawa., M, Yasuda., M, Katsuki and Y, Fujii-Kuriyama. Loss of teratogenic response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes to Cell. 2, 645- 654
  15. Takahata, S., K, Sogawa, A. Kobayashi, J. Mimura, M.Ema, N. Ozaki, and Y, Fujii-Kuriyama . Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF1a, HLF and Clock. Biochem. biophys. Res. Comn. 248, 789-794. (1998)
  16. Sogawa, KK. Numayama-Tsuruta,M. M. Ema, Abe, H. Abe, and Y. Fujii-Kuriyama. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Proc. Natl. Acad. Sci. USA. 95, 7368-7373. (1998)
  17. Nagata, Y., T. Yamamoto,M. Ema, J. Mimura, Y, Fujii-Kuriyama, T. Suzuki, T. Furukohri, K. Konishi, D. Saito, G. Tajima, and J. Nakamura. cDNA cloning and predict primary structure of scallopo sarcoplasmic reticulum Ca2-ATPase. Comp. Biochem. and Phys. Part B. 119, 777-785. (1998).
  18. Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 1999 13, 20-25.
  19. Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18, 1905-1914. (1999)
  20. Ema M, Ikegami S, Hosoya T, Mimura J, Ohtani H, Nakao K, Inokuchi K, Katsuki M, Fujii-Kuriyama Y. Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome an animal model of Down's syndrome. Hum Mol Genet. 8, 1409-1415.(1999)
  21. Hosoya, T., Oda, Y., Takahashi, S., Morita, M., Kawauchi, S., Ema M., Yamamoto, M., and Y. Fujii-Kuriyama Defective development of secretary neurons in the hypothalamus of Arnt2 knock-out mice. Genes to Cell 6, 361-374. (2001)
  22. Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 17:380-393, (2003)[ Cover & Perspectives ]
  23. Morita M, Ohneda O, Yamashita T, Takahashi S, Suzuki N, Nakajima O, Kawauchi S, Ema M, Shibahara S, Udono T, Tomita K, Tamai M, Sogawa K, Yamamoto M, Fujii-Kuriyama Y. HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 22:1134-1146, (2003)
  24. Kikuchi Y, Ohsawa S, Mimura J, Ema M, Takasaki C, Sogawa K,Fujii-Kuriyama Y. Heterodimers of bHLH-PAS protein fragments derived fromAhR, AhRR, and Arnt prepared by co-expression in Escherichia coli:characterization of their DNA binding activity and preparation of a DNAcomplex. J Biochem (Tokyo),134:83-90.(2003)
  25. Ema M, Rossant J. Cell fate decisions in early blood vessel formation. Trends Cardiovasc Med.13:254-259.(2003)
  26. Haigh JJ, Ema M, Haigh K, Gertsenstein M, Greer P, Rossant J, Nagy A,Wagner EF. Activated Fps/Fes partially rescues the in vivo developmentalpotential of Flk1-deficient vascular progenitor cells. Blood. Fe103:912-920.(2004)[Cover & comment]
  27. Ema M, Takahashi S, Rossant J. Deletion of selection cassette but not cis-acting elements in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood. 107: 111-117. (2006) [commentに採用された]
  28. Eremina V, Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, Ema M, Rossant J, Jothy S, Miner JH, Quaggin SE. Vascular endothelial growth factor A signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol. 17: 724-735. (2006)
  29. Wada T, Haigh J, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D. VEGF directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J. Neurosci, 26: 6803-6812. (2006)
  30. Ema M, Yokomizo T, Wakamatsu A, Terunuma T, Yamamoto M, Takahashi S. Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo. Blood.108:4018-4024. (2006) Epub 2006 Aug 22. [coverに採用された]
  31. Yokomizo T, Takahashi S, Mochizuki N, Kuroha T, Ema M, Wakamatsu A, Shimizu R, Ohneda O, Osato M, Okada H, Komori T, Ogawa M, Nishikawa S I, Ito Y Yamamoto M. Characterization of GATA-1+ hemangioblastic cells in the mouse embryo. EMBO J. 26, 184-196, (2007)
  32. Carvalho RLC, Itoh F, Goumans M-J, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, Marga van Rooijen MV, Bertolino P, Dijke PT, Mummery CL. Compensatory mechanisms activated during vasculogenesis in mice by TGFβ-receptor deletion. J Cell Sci. 120:4269-4277. (2007)
  33. Yokomizo T, Hasegawa K, Ishitobi H, Osato M, Ema M, Ito Y, Yamamoto M, Takahashi S. Runx1 is involved in primitive erythropoiesis in the mouse. Blood Apr 15;111(8):4075-4080 (2008)
  34. Yokomizo T, Yanagida M, Huang G, Osato M, Honda C, Ema M, Takahashi S, Yamamoto M, Ito Y. Genetic evidence of PEBP2beta-independent activation of Runx1 in the murine embryo. Int J Hematol. 88:134-138. (2008)
  35. Ema, M, Mori, D, Niwa, H, Hasegawa, Y, Yamanaka, Y, Hitoshi, S, Mimura, J, Kawabe, Y, Hosoya, T, Morita, M, Shimosato, D, Uchida, K, Suzuki, N, Yanagisawa, J, Sogawa, K, Rossant, J, Yamamoto, M, Takahashi, S, and Fujii-Kuriyama, Y. Kruppel-like factor 5 Is Essential For Blastocyst Development and the Normal Self-Renewal of Mouse ES cells. Cell Stem Cell. 3, 555-567, (2008)
  36. Itoh F., Itoh S., Carvalho RL., Adachi T., Ema M., Goumans MJ., Larsson J., Karlsson S., Takahashi S., Mummery CL., Dijke PT., Kato M.: Poor vessel formation in embryo from ALK5 knock-in mice carrying the mutation in its L45 loop. Lab Invest. 89: 800-810. (2009)
  37. Matsumoto K., Obara N., Ema M., Horie M., Naka A., Takahashi S. Imagawa S. : Anti-tumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model. Cancer Sci. 100: 1639-1647. (2009)
  38. Kojima T., Hirota Y., Ema M., Takahashi S., Miyoshi I., Okano H., Sawamoto K. : Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum. Stem Cells, 28:545-554. (2010)
  39. Ishitobi H., Matsumoto K., Azami T., Itoh F., Itoh S., Takahashi S., Ema M.: Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. Exp. Animals, 59: 615-622. (2010)
  40. Verma M., Asakura Y., Hirai H., Watanabe S., Tastad C., Fong GH., Ema M., Call JA,, Lowe DA,, Asakura A.: Flt-1 haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature in mdx mice. Hum Mol Genet. 19: 4145-4159. (2010)
  41. Sato T., Kudo T., Ikehara Y., Ogawa H., Hirano T., Kiyohara K., Hagiwara K., Togayachi A., Ema M., Takahashi S., Kimata K., Watanabe H., Narimatsu H. *: Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism. J Biol Chem. 286:5803-5812. (2011)
  42. Kuroda T., Murayama A., Katagiri N., Ohta Y., Fujita E., Masumoto H., Ema M., Takahashi S., Kimura K., Yanagisawa J. : RNA content in the nucleolus alters p53 acetylation via MYBBP1A. EMBO J. 30:1054-1066. (2011)
  43. Kubota Y., Takubo K., Hirashima M., Nagoshi N., Kishi K., Okuno Y., Nakamura-Ishizu A., Sano K., Murakami M., Ema M., Omatsu Y., Takahashi S., Nagasawa T., Shibuya M., Okano H., Suda T. : Isolation and function of tissue resident vascular precursors marked by myelin protein zero. J. Exp. Med.. 208:949-960. (2011)
  44. Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A. Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms. Cell Stem Cell. 9:37-49. (2011)
  45. Kumadaki S, Karasawa T, Matsuzaka T, Ema, M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, *Shimano H. Inhibition of Ubiquitin ligase F-box and WD repeat domain-containing 7{alpha} (Fbw7{alpha}) causes hepatosteatosis through the Kruppel-like factor 5 (KLF5)/PPAR{gamma}2 pathway, but not SREBP-1c in mice. J Biol Chem. 286: 40835-40846.（2011）
  46. Kajiro M, Tsuchiya M, Kawabe Y, Furumai R, Iwasaki N, Hayashi Y, Katano M, Nakajima Y, Goto N, Watanabe T, Murayama A, Oishi H, Ema M, Takahashi S, Kishimoto H, Yanagisawa J. PLoS One. 6(10):e25871.(2011)
  47. Ishitobi, H, Wakamatsu A, Liu F, Azami T, Hamada M, MatsumotoK, Kataoka H, Kobayashi M, Choi K, Nishikawa S, -I, Takahashi S, Ema, M, Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse. Development. 138:5357-5368. (2011)
  48. Sano K, Katsuta O, Shirae S, Kubota Y, Ema M, Suda T, Nakamura M, Hirashima M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. Biochem Biophys Res Commun. 420:422-427. (2012)

  49. Matsumoto K, Azami T, Otsu A, Takase H, Ishitobi H, Tanaka J, Miwa Y, Takahashi S, Ema M. Genesis. 50:561-571.(2012)
  50. Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood 120,914-923.(2012).
  51. Avci HX, Lebrun C, Wehrle R. Doulazmi M, Chatonnet F, Morel MP, Ema M, Vodjdani G, Sotelo C, Flamant F, Dusart I. Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and kruppel-like factor 9 in Purkinje cells. Proc Natl Acad Sci U S A 109:14206-14211. (2012)
  52. Oishi H, Itoh S, Matsumoto K, Ishitobi H, Suzuki R, Ema M., Kojima T, Uchida K, Kato M, Miyata T, Takahashi S. Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice. J. Biochem. 152, 549-555. (2012)
  53. Fujishiro SH, Nakano K, Mizukami Y, Azami T, Arai Y, Matsunari H, Ishino R, Nishimura T, Watanabe M, Abe T, Furukawa Y, Umeyama K, Yamanaka S, Ema M, Nagashima H, Hanazono Y. Generation of Naive-like Porcine Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development. Stem Cells Dev. 22: 473-482. (2013)
  54. Lebrun C, Avci HX, Wehrle R, Doulazmi M, Jaudon F, Morel MP, Rivals I, Ema M, Schmidt S, Sotelo C, Vodjdani G, Dusart I. Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture. Mol Cell Neurosci. 2012 Nov 29. doi:pii: S1044-7431(12)00209-6.

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−和文・総説-
  1. 依馬　正次、藤井義明、酸素分圧による遺伝子発現制御機構、2000年10月、共立出版、酸化ストレス・レドックスの生化学、pp.53-61
  2. 依馬　正次、bHLH-PAS 型転写因子群の構造とその生理機能、2001年2月、生化学第７３巻第２号、pp.81-88
  3. 依馬　正次、Flk-1とTal-1の協調的作用による血管内皮・血球発生の制御、細胞工学、vol.22、No.5、560-561、2003
  4. 依馬　正次、bHLH型の転写因子SCL/Tal1の血管内皮・血球細胞の発生・分化における役割、生化学、2003年11月 、生化学第75巻第11号、pp.1461-1464
  5. 依馬　正次、胚性幹細胞の樹立とその自己複製におけるKlf5の役割、2009年4月、実験医学、vol.27、No.7、912-915

  6. 依馬　正次、マウスES細胞におけるKlf 転写因子群の役割、2010年4月、生化学第８２巻第４号、323-326
  7. 依馬　正次、第6項、血球系、モデル動物利用マニュアル、エル・アイ・シー、2010
  8. 松本　健、依馬　正次、「低酸素応答性と血管形成」、実験医学（血管研究の最前線）、羊土社、2010
  9. 松本　健、依馬　正次. 「HIF」、血管生物医学事典、日本血管生物医学会編、pp368-369朝倉書店、2011

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