研究業績

助教授　川上　康

（１）Biochemical and Biophysical Research Communication 221(1): 193-198 （１９９６）
（２）Life Science 59(1): 21-25 （１９９６）
（３）Diabetes Research and Clinical Practice 34(2): 83-88（１９９６）
（４）Life Science 58(3): 239-243　（１９９６）
（５）Diabetes Care 19:1306-1307 （１９９６）
（６）Biochemical and Biophysical Research Communication. 238(2): 512-516 （１９９７）
（７）Prostaglandins;53(6): 395-409 （１９９７）
（８）Diabetologia 40(6): 726-730 （１９９７）
（９）Transplantation 66(11): 1519-1524 （１９９８）
（10）Life Science 63(6): 477-484 （１９９８）
（11）Internal Medicine 38(2): 210-215 （１９９９）
（12）Circulation. 99: 2942-2950（１９９９）
（13）Life Sciences 65:2573-2580（１９９９）

講師　磯部　和正

1. K. Isobe, T. Nakai, Y. Takuwa. Ca2+-Dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffine cells. 　Endocrinology1993;132:1757-1765
2. K. Isobe, F. Nomura, K. Takekoshi, T. Nakai. Pertussis toxin pretreatment enhances catecholamine secretion induced by pituitary adenylate cyclase-activating polypeptide in cultured. Neuropeptides 1994;27:269-275
3. K. Isobe, N. Yukimasa, T. Nakai, Y. Takuwa. Pituitary adenylate cyclase activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine ?hydroxylase, 　　　through 3',5'-cyclic adenosine monophosphate and protein kinase C-dependent. Neuropeptides 1996;30(2):167-175
4. K. Isobe, T. Nakai, N.Yukimasa, T. Nanmoku, K. Takekoshi, F. Nomura. 　Expression of mRNA coding for four catecholamine synthesizing enzymes in 　　human adrenal pheochromocytomas. European J. of Endocrinology 1998;138:388-393
5. N. Yukimasa, K. Isobe, H. Nagai, Y. Takuwa, T. Nakai. Successive occupaney by immediate early transcriptional factors of the tyrosine hydroxylase gene TRE and CRE sites in PACAP-stimulated PC12 pheochromocytoma cells. 　Neuropeptides 1999;33(6):475-482
6. K. Isobe, T. Nakai, T. Yashiro, T. Nanmoku, N. Yukimasa, T. Ikezawa, E. Suzuki, K. Takekoshi, F. Nomura. Enhanced expression of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase in adrenaline-secreting pheochromocytomas. Jounal of Urology 2000;163:357-362
7. T.Nanmoku, K. Isobe, T.Sakurai, A.Yamanaka, K. Takekoshi, Y.Kawakami, K.Ishii, K.Goto, T.Nakai. Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells. Biochem Biophys Res Commun 2000; 274:310-315.

講師　竹越　一博

7. Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nanmoku T, Nakai T. Ca2+ mobilization,tyrosine hydroxylase(TH) activity and signaling mechanisms in cultured porcine adrenal medullary chromaffin cells: effects of leptin. Endocrinology 2001;142:290-298.

6. Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nakai T. Kappa-Opioid Inhibits Catecholamine Biosynthesis in PC12 Rat Pheochromocytoma Cell. FEBS Letters 2000;477:273-277.
5. Takekoshi K, Ishii K, Kawakami Y, Isobe K, Nanmoku T, Nakai T. Angiotensin-Ⅱsubtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured Porcinem adrenal medullary chromaffin cells. Biochem Biophys Res Commun 2000;272:544-550
4. Takekoshi K, Ishii K, Nomura F, Isobe K, Nanmoku T, Nakai T. Effects of natriuretic peptides (ANP, BNP, CNP) on catecholamine synthesis and TH mRNA levels in PC 12cells. Life Sci. 2000; 66: 303-311.
3. Takekoshi K, Motooka M, Isobe K, Nomura F, Manmoku T, Ishii K, Nakai T. Leptin directly stimulates catecholamine secretion and synthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun 1999; 261: 426-31.
2. Takekoshi K, Nomura F, Isobe K, Motooka M, Nakai T. Effects of PAMP on mRNAs coding for catecholamine-synthesizing enzymes in PC 12 cells. Life Sci; 1999; 65: 771-8.
1. Takekoshi K, Isobe K, Nomura F, Motooka M, NanmokeT, Nakai T. Identification and initial characterization of stathmin by the differential display method in nerve growth factor -treated PC12 cells. European Journal of Endocrinology 1998;138 : 707-712

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