Purpose and Background of the Research

Electrophiles, Exposome, Redox signaling,
Reactive sulfur species, Sulfur adduct
 We are exposed to a variety of environmental electrophiles (EEs) through food life, life style and life environment on a daily basis. While it has been reported that such reactive species covalently bind to protein nucleophiles, we found that EEs activate redox signaling pathways at lower doses and disrupt these pathways and substantial cytotoxicity at higher doses. It was also found that reactive sulfur species (RSS) negatively regulate modulation of redox signaling and toxicity caused by exposure to EEs, presumably through formation of their sulfur adducts.
Exposome has been defined as the cumulative environmental exposures, including diet, lifestyle, pollutants, and others across the life span; however, the full characterization of the exposome throughout the whole lifespan remains an outstanding challenge. In the current study, we attempt modeling an exposome specialized for EEs with cultured cells and mice in the absence and presence of RSS. We also explore how sulfur adduct derived from methylmercury (MeHg), a model of EEs, undergoes biotransformation by RSS, and then is excreted into out of the body.

The joint research with Professor Uehara, a reserch collaborator was accepted by Journal of Biological Chemistry.
The joint research with Professor Uehara, a reserch collaborator was accepted by Archives of Toxicology.
A research outcome was opened on 5th, June in 「Environmental Health Perspectives」(IF=8.44) that is a top journal of toxicology fields. Then, we did a press release on the website in University of Tsukuba.
The joint research with Professor Nishida, a reserch collaborator was accepted by Science Signaling.
Open the website.

Grants-in-Aid for Scientific Research (S) Environmental electrophiles exposome and reactive sulfur species as its regulator molecule

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