令和5年度（2023年度）医学医療系業績 | 研究業績 | 筑波大学医学医療系消化器内科

研究業績

令和5年度（2023年度）
医学医療系業績

1. Miura Y, Tsuji Y, Yoshio T, Hatta W, Yabuuchi Y, Hoteya S, Kikuchi D, Tsuji S, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Masamune A, Fujishiro M. Association between perioperative management of antiplatelet agents and risk of post-endoscopic submucosal dissection bleeding in early gastric cancer: an analysis of a nationwide multicenter study. Gastrointest Endosc. 2023 Jan 10:S0016-5107(23)00008-1. doi: 10.1016/j.gie.2022.12.025.
https://www.giejournal.org/article/S0016-5107(23)00008-1/pdf

2. Akiyama, Shintaro, Cohen, Nathaniel A, Kayal, Maia, Dubinsky, Marla C, Colombel, Jean-Frederic, Rubin, David T Treatment of Chronic Inflammatory Pouch Conditions With Tofacitinib: A Case Series From 2 Tertiary IBD Centers in the United States Inflamm Bowel Dis. 2023 Feb 6;izad011. doi: 10.1093/ibd/izad011.

3. Nakase H, Esaki M, Hirai F, Kobayashi T, Matsuoka K, Matsuura M, Naganuma M, Saruta M, Tsuchiya K, Uchino M, Watanabe K, Hisamatsu T; TRADE consensus group.
Treatment escalation and de-escalation decisions in Crohn's disease: Delphi consensus recommendations from Japan, 2021 J Gastroenterol. 2023 Feb 11. doi: 10.1007/s00535-023-01958-z.
575057b1-b019-4eb3-b80c-9829e86f70b5.pdf

4. Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer.Umemoto K, Sunakawa Y, Ueno M, Furukawa M, Mizuno N, Sudo K, Kawamoto Y, Kajiwara T, Ohtsubo K, Okano N, Matsuhashi N, Itoh S, Matsumoto T, Shimizu S, Otsuru T, Hasegawa H, Okuyama H, Ohama H, Moriwaki T, Ohta T, Odegaard JI, Nakamura Y, Bando H, Yoshino T, Ikeda M, Morizane C.
Br J Cancer. 2023 Feb 13. doi: 10.1038/s41416-023-02189-y.
https://www.nature.com/articles/s41416-023-02189-y

5. Evidence of Nrf2/Keap1 Signaling Regulation by Mitochodria-Generated Reactive Oxygen Species in RGK1 Cells. Hiroko P.Indo, Daisuke Masuda, Sompong Sriburee, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Fumitaka Kawakami, Takafumi Ichikawa, Hirofumi Matsui, Jitbanjong Tangpong and Hideyuki J. Majima.
Biomolecules 2023,13,445
https://doi.org/10.3390/biom13030445

6. Shinji Sugiura, Shinya Yamahira, Masato Tamura, Kazumi Shin, Mayu Shibuta, Taku Satoh, Yui Matsuzawa, Gen Fujii, Fumiki Yanagawa, Michihiro Mutoh, Masumi Yanagisawa, Ryuji Kato and Hirofumi Matsui, Automated cell isolation from photodegradable hydrogel based on fluorescence image analysis Biotechnology and Bioengineering, Volume 120, Issue 6, p.1492-1505
https://doi.org/10.1002/bit.28375

7. Shintaro Akiyama ,　Joshua M Steinberg　, Mariko Kobayashi , Hideo Suzuki , Kiichiro Tsuchiya Pregnancy and medications for inflammatory bowel disease: An updated narrative review
World J Clin Cases. Mar 16, 2023; 11(8): 1730-1740
doi: 10.12998/wjcc.v11.i8.1730

8. Sato Y, Aoki T, Sadashima E, Nakamoto Y, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Maehata T, Tateishi K, Kaise M, Nagata N. Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study.
Clin Gastroenterol Hepatol.
2023 Jun 3;S1542-3565(23)00401-9. doi: 10.1016/j.cgh.2023.05.021.
https://www.cghjournal.org/article/S1542-3565(23)00401-9/fulltext

9. Yoshito Yabe, Kanako Chihara, Natsumi Oshida, Takashi Kamimaki, Naoyuki Hasegawa, Tomonori Isobe, Junichi Shoda. Survey of Dietary Habits and Physical Activity in Japanese Patients with Non-Obese Non-Alcoholic Fatty Liver Disease Nutrients. 2023 Jun 16;15(12):2764. doi: 10.3390/nu15122764.
https://www.mdpi.com/2072-6643/15/12/2764

10. Bui Duc Tri, Babita Shashni, Hirofumi Matsui, Yukio Nagasaki, Designing poly(gamma-aminobutyric acid)-based nanoparticles for the treatment of major depressive disorders
Jounal of Controlled Release, 360(2023)110-121
https://doi.org/10.1016/j.jconrel.2023.06.021

11. Hiromi Kurokawa, Thomas Kiran Marella, Hirofumi Matsui, Yutaka Kuroki and M.Watanabe. Therapeutic Potential of Seaweed-Derived Laminaran: Attenuation of Clinical Drug Cytotoxicity and Reactive Oxygen Species Scavenging
antioxidants,2023, 12(7), 1328
https://doi.org/10.3390/antiox12071328

12. Van Thi Hong Doan , Yoshiki Komatsu , Hirofumi Matsui , Naoki Kawazoe , Guoping Chen , Toru Yoshitomi.
Singlet oxygen-generating cell-adhesive glass surfaces for the fundamental investigation of plasma membrane-targeted photodynamic therapy.
Free Radical Biology and Medicine 2023. Jul 25;207:239-246.
doi: 10.1016/j.freeradbiomed.2023.07.028. Online ahead of print.

13. Mariko Kobayashi, Shintaro Akiyama, Toshiaki Narasaka, Katsumasa Kobayashi, Atsushi Yamauchi, Atsuo Yamada, Jun Omori, Takashi Ikeya, Taiki Aoyama, Naoyuki Tominaga, Yoshinori Sato, Takaaki Kishino, Naoki Ishii, Tsunaki Sawada, Masaki Murata, Akinari Takao, Kazuhiro Mizukami, Ken Kinjo, Shunji Fujimori, Takahiro Uotani, Minoru Fujita, Hiroki Sato, Sho Suzuki, Junnosuke Hayasaka, Tomohiro Funabiki, Yuzuru Kinjo, Akira Mizuki, Shu Kiyotoki, Tatsuya Mikami, Ryosuke Gushima, Hiroyuki Fujii, Yuta Fuyuno, Naohiko Gunji, Yosuke Toya, Kazuyuki Narimatsu, Noriaki Manabe, Koji Nagaike, Tetsu Kinjo, Yorinobu Sumida, Sadahiro Funakoshi, Kiyonori Kobayashi, Tamotsu Matsuhashi, Yuga Komaki, Kiichiro Tsuchiya, Mitsuru Kaise and Naoyoshi Nagata. Multicenter propensity score-matched analysis comparing short versus long cap-assisted colonoscopy for acute Hematochezia.
JGH Open: An open access journal of gastroenterology and hepatology 7 (2023) 487–496
http://dx.doi.org/10.1002/jgh3.12936

14. Takashi Iizumi , Toshiyuki Okumura , Naoyuki Hasegawa , Kazunori Ishige , Kuniaki Fukuda , Emiko Seo , Hirokazu Makishima , Hikaru Niitsu , Mizuki Takahashi , Yuta Sekino , Hiroaki Takahashi , Daichi Takizawa , Yoshiko Oshiro , Keiichiro Baba , Motohiro Murakami , Takashi Saito , Haruko Numajiri , Masashi Mizumoto , Kei Nakai , Hideyuki Sakurai . Proton beam therapy for hepatocellular carcinoma with bile duct invasion.
BMC Gastroenterol, 2023; 23: 267.
doi: 10.1186/s12876-023-02897-y.

15. Yoshiki Komatsu, Toru Yoshitomi , Van Thi Hong Doan , Hiromi Kurokawa , Saori Fujiwara , Naoki Kawazoe , Guoping Chen and Hirofumi Matsui.
Locally Administered Photodynamic Therapy for Cancer Using Nano-Adhesive Photosensitizer Pharmaceutics 2023, 15, 2076

16. LONG-HOSP Score: A Novel Predictive Score for Length of Hospital Stay in Acute Lower Gastrointestinal Bleeding - A Multicenter Nationwide Study
Fujita M, Aoki T, Manabe N, Ito Y, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Ayaki M, Murao T, Suehiro M, Shiotani A, Hata J, Haruma K, Kaise M, Nagata N.
Digestion. 2023 Aug 3:1-14. doi: 10.1159/000531646. Online ahead of print.
https://karger.com/dig/article/doi/10.1159/000531646/854958/LONG-HOSP-Score-A-Novel-Predictive-Score-for

17. Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7 Yusuke Seyama, Kazuhiro Sudo, Suguru Hirose, Yukako Hamano, Takeshi Yamada, Takashi Hiroyama, Ryosuke Sasaki, Masami Yokota Hirai, Ichinosuke Hyodo, Kiichiro Tsuchiya, Yukio Nakamura
Hum Cell.2023 Aug 23. doi: 10.1007/s13577-023-00967-7. Online ahead of print.
https://link.springer.com/article/10.1007/s13577-023-00967-7

18. Weekend effect on clinical outcomes of acute lower gastrointestinal bleeding: A large multicenter cohort study in Japan.
Hayasaka J, Kikuchi D, Ishii N, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Odagiri H, Hoteya S, Kaise M, Nagata N.
Dig Dis. 2023 Sep 5. doi: 10.1159/000533744. Online ahead of print.
https://karger.com/ddi/article/doi/10.1159/000533744/862482/Weekend-Effect-on-Clinical-Outcomes-of-Acute-Lower

19. Shrinkage of Enlarged Hepatic Nodules by an Embolizing Congenital Extrahepatic Portosystemic Shunt
Satoshi Fukuda, Naoyuki Hasegawa, Kensaku Mori, Hitomi Kawai, Yusuke Niisato, Masato Endo, Emiko Seo, Noriaki Sakamoto, Daisuke Matsubara, Kiichiro Tsuchiya.
Intern Med. 2023 Sep 8. doi: 10.2169/internalmedicine.2267-23. Online ahead of print.

20. Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance.
Chihara K, Okada K, Uchida F, Miura I, Komine S, Warabi E, Takayama T, Suzuki H, Matsuzaka T, Kanno N, Yamagata K, Yanagawa T, Bukawa H, and Shoda J.
PLoS ONE, 2023, in press.

21. Renal tubular function and morphology revealed in kidney without labeling using three dimensional dynamic optical coherence tomography. Mukherjee1 P,
Fukuda S, Lukmanto D, HangTran T, Okada K, Makita S, El Sadek IA, Lim Y, Yasuno Y.
Sci Rep. 13:15324, 2023.

22. Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease.
To K, Okada K, Watahiki T, Suzuki H, Tsuchiya K, Yamamoto M, Ariizumi S, Shoda J.
Cancer Med., in press.

23. Early feeding reduces length of hospital stay in patients with acute lower gastrointestinal bleeding: A large multicentre cohort study.
Kishino T, Aoki T, Sadashima E, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Gunji N, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Kaise M, Nagata N.
Colorectal Dis. 2023 Oct 3.
doi: 10.1111/codi.16751. Online ahead of print.
https://onlinelibrary.wiley.com/doi/10.1111/codi.16751

24. The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human-Induced Pluripotent Stem Cell-Derived Enterocyte-Like Cells.
Leo S, Kato Y, Wu Y, Yokota M, Koike M, Yui S, Tsuchiya K, Shiraki N, Kume S.
Stem Cells. 2023 Aug 16;41(8):775-791. doi: 10.1093/stmcls/sxad042.　PMID: 37228023

25. Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT.
Watanabe K, Nojima M, Nakase H, Sato T, Matsuura M, Aoyama N, Kobayashi T, Sakuraba H, Nishishita M, Yokoyama K, Esaki M, Hirai F, Nagahori M, Nanjo S, Omori T, Tanida S, Yokoyama Y, Moriya K, Maemoto A, Handa O, Ohmiya N, Tsuchiya K, Shinzaki S, Kato S, Uraoka T, Tanaka H, Takatsu N, Nishida A, Umeno J, Nakamura M, Mishima Y, Fujiya M, Tsuchida K, Hiraoka S, Okabe M, Toyonaga T, Matsuoka K, Andoh A, Hirota Y, Hisamatsu T; J-COMBAT study group.
J Gastroenterol. 2023 Oct;58(10):1015-1029. doi: 10.1007/s00535-023-02029-z. Epub 2023 Aug 10. PMID: 37561155

26. Akiyama S, Hamdeh S, Sakamoto T, Suzuki H, Tsuchiya K :The Feasibility, Safety, and Long-term Outcomes of Endoscopic Submucosal Dissection for Colorectal Neoplasia in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
J Clin Gastroenterol. 2023 Aug 1;57(7):721-730. doi: 10.1097/MCG.0000000000001740.

27. Omori J, Kaise M, Nagata N, Aoki T, Kobayashi K, Yamauchi A, Yamada A, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Iwakiri K: Characteristics, outcomes, and risk factors of surgery for acute lower gastrointestinal bleeding: nationwide cohort study of 10,342 hematochezia cases.
J Gastroenterol. 2024 Jan;59(1):24-33. doi: 10.1007/s00535-023-02057-9. Epub 2023 Nov 25.

28. Aoki M, Kadowaki S, Takahashi N, Suzuki T, Oshima K, Ando T, Yamamoto Y, Kawakami K, Kito Y, Matsumoto T, Shimozaki K, Miyazaki Y, Yamaguchi T, Nagase M, Tamura T, Amanuma Y, Esaki T, Miura Y, Akiyoshi K, Baba E, Makiyama A, Negoro Y, Nakashima K, Sugimoto N, Nagashima K, Shoji H, Boku N. Pattern of disease progression during third-line or later chemotherapy with nivolumab associated with poor prognosis in advanced gastric cancer: a multicenter retrospective study in Japan. Gastric Cancer. 2023 Jan;26(1):132-144.

https://link.springer.com/article/10.1007/s10120-022-01349-y

29. Fukuda S, Niisato Y, Tsuji M, Fukuda S, Hagiwara Y, Onoda T, Suzuki H, Tange Y, Yamada T, Yamamoto Y, Moriwaki T. Relationship Between Safety and Cumulative Bevacizumab Dose in Patients With Metastatic Colorectal Cancer Who Received Long-term Bevacizumab Treatment. Anticancer Res. 2023 May;43(5):2085-2090.

https://ar.iiarjournals.org/content/43/5/2085.long

30. Seyama Y, Yamada T, Suzuki H, Fukuda S, Tsuji M, Niisato Y, Hirose S, Yamamoto Y, Moriwaki T, Hyodo I. Gastric neuroendocrine carcinoma presenting complete durable response by nivolumab treatment for multiple metastases and radiotherapy to oligoprogressive metastasis. Int Cancer Conf J. 2023 May 12;12(4):268-273.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10421835/

31. Izawa N, Masuishi T, Takahashi N, Shoji H, Yamamoto Y, Matsumoto T, Sugiyama K, Kajiwara T, Kawakami K, Aomatsu N, Kondoh C, Kawakami H, Takegawa N, Esaki T, Shimokawa M, Nishio K, Narita Y, Hara H, Sunakawa Y, Boku N, Moriwaki T, Eguchi Nakajima T, Muro K. A Phase II Trial of Trifluridine/Tipiracil in Combination with Cetuximab Rechallenge in Patients with RAS Wild-Type mCRC Refractory to Prior Anti-EGFR Antibodies: WJOG8916G Trial. Target Oncol. 2023 May;18(3):369-381.

https://link.springer.com/article/10.1007/s11523-023-00963-9

32. Shimomura O, Endo M, Makishima H, Yamada T, Hashimoto S, Numajiri H, Miyazaki Y, Doi M, Furuya K, Takahashi K, Moriwaki T, Hasegawa N, Yamamoto Y, Niisato Y, Kobayashi M, Mizumoto M, Nakai K, Saito T, Hoshiai S, Saida T, Mathis BJ, Mori K, Nakajima T, Tsuchiya K, Sakurai H, Oda T. Triple modal treatment comprising with proton beam radiation, hyperthermia, and gemcitabine/nab-paclitaxel for locally advanced pancreatic cancer: a phase I/II study protocol (TT-LAP trial). BMC Cancer. 2023 Jul 4;23(1):624.

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11110-y

33. Kaneko T, Doki K, Yamada T, Yamamoto Y, Moriwaki T, Suzuki Y, Homma M. Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis. Cancer Chemother Pharmacol. 2023 Oct;92(4):271-278.

https://link.springer.com/article/10.1007/s00280-023-04568-x

34. Ando K, Nakamura Y, Kitao H, Shimokawa M, Kotani D, Bando H, Nishina T, Yamada T, Yuki S, Narita Y, Hara H, Ohta T, Esaki T, Hamamoto Y, Kato K, Yamamoto Y, Minashi K, Ohtsubo K, Izawa N, Kawakami H, Kato T, Satoh T, Okano N, Tsuji A, Yamazaki K, Yoshino T, Maehara Y, Oki E. Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study). Br J Cancer. 2023 Oct;129(6):1032-1039.

https://www.nature.com/articles/s41416-023-02378-9

35. Mitani S, Kito Y, Hino K, Kawakami K, Izawa N, Hanamura F, Yamamoto Y, Shoji H, Komori A, Boku S, Tsuchihashi K, Kato K, Nonagase Y, Matsumoto T, Furuta M, Kawakami H. Real-World Treatment Sequencing in Vulnerable Patients with Metastatic Colorectal Cancer: A Multicenter Retrospective Study. Target Oncol. 2023 Sep;18(5):707-715.

https://link.springer.com/article/10.1007/s11523-023-00996-0

36. Kajiwara T, Nishina T, Yamashita R, Nakamura Y, Shiozawa M, Yuki S, Taniguchi H, Hara H, Ohta T, Esaki T, Shinozaki E, Takashima A, Yamamoto Y, Yamazaki K, Yoshino T, Hyodo I. Sidedness-Dependent Prognostic Impact of Gene Alterations in Metastatic Colorectal Cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN). Cancers (Basel). 2023 Oct 27;15(21):5172.

https://www.mdpi.com/2072-6694/15/21/5172