研究業績
令和6年度（2024年度）
医学医療系業績
1. Takayasu's arteritis associated with Crohn's disease treated with infliximab
Hiroyuki Ariga,Yusuke Chino,Takeshi Ojima,Satoshi Suzuki,Kenta Okada,Junya Kashimura.
Clin J Gastroenterol. 2024 Jan 5.
doi: 10.1007/s12328-023-01904-9. Online ahead of print.
2. Clinical Usefulness of Hypoxia Imaging Colonoscopy for the Objective Measurement of Ulcerative Colitis Disease Activity
Shintaro Akiyama, Taku Sakamoto, Mariko Kobayashi, Daisuke Matsubara, Kiichiro Tsuchiya
Gastrointestinal Endoscopy DOI:10.1016/j.gie.2023.12.035
https://www.tsukuba.ac.jp/journal/medicine-health/20240112141500.html
3. Akiyama S, Sakamoto T, Kobayashi M, Matsubara D, Tsuchiya K : Clinical Usefulness of Hypoxia Imaging Colonoscopy for the Objective Measurement of Ulcerative Colitis Disease Activity.
Gastrointest Endosc. 2024 Jan 4:S0016-5107(24)00004-X. doi: 10.1016/j.gie.2023.12.035. Online ahead of print.
4. Kobayashi M, Sawafuji T, Yamada T: Severe cytomegalovirus gastritis due to pembrolizumab-induced agranulocytosis.
Gastrointest Endosc.2024 Feb;99(2):284-286. doi: 10.1016/j.gie.2023.07.037. Epub 2023 Jul 27.
5. Akiyama S, Onoda T, Moue S, Sakamoto N, Sakamoto T, Suzuki H, Enomoto T, MatsubaraD, Oda T, Tsuchiya K: Association of colonic metaplasia of goblet cells and endoscopic phenotypes of the J pouch in patients with ulcerative colitis: a retrospective pilot study.
Intest Res. 2024 Jan;22(1):92-103. doi: 10.5217/ir.2023.00105. Epub 2024 Jan 29.
6. Takayama T, Suzuki H, Okada K, Akiyama S, Narasaka T, Maruo K, Sakamoto T, Seo E, Tsuchiya K: A novel predictive formula for highly accurate discrimination between truly Helicobacter pylori-uninfected and currently infected/spontaneously eradicated individuals for gastric cancer screening.Medicine 103(9):e36335.
7. Akiyama S, Miyatani Y, Rubin DT: The Evolving Understanding of Histology as an Endpoint in Ulcerative Colitis. Intestinal Research. 2024, Mar 13. doi: 10.5217/ir.2023.00120. Online ahead of print.
https://irjournal.org/journal/view.php?doi=10.5217/ir.2023.00120
8. Akiyama S,Yokoyama K,Yagi S,Shinzaki S,Tsuruta K,Yoshioka S,Sako M,Shimizu H,Kobayashi M, Sakurai T,Nomura K,Shibuya T,Takahara M,Hiraoka S,Sugai K,Yanai S,Yoshida A,Koroku M,Omori T, Saruta M,Matsumoto T,Okamoto R,Tsuchiya K,Fujii T:Efficacy and Safety of Filgotinib for Ulcerative Colitis: A Real-World Multicenter Retrospective Study in Japan.
Alimentary Pharmacology & Therapeutics.2024,Mar 17. doi:10.1111/apt.17961.Online ahead of print.
https://onlinelibrary.wiley.com/doi/10.1111/apt.17961
9. Ariga H, Kashimura J, Honda Y, Tamano F, Iso N, Okada K:A Case of Pancreaticobiliary Maljunction with Repeated Pancreatitis Due to Protein Plugs in a Short Period.
Intern Med.2024 Feb 1.
doi: 10.2169/internalmedicine.2612-23. Online ahead of print.
10. Ariga H,Nakashima M,Mikada A,Hashimoto E,Kashimura J:A Case of Atypical Familial Mediterranean Fever With Pseudopolyposis-Like Mucosal Changes in the Ileum.
Cureus.2024 Apr 3;16(4):e57566. doi: 10.7759/cureus.57566.eCollection 2024 Apr.
11. Abe R, Hasegawa N, Suzuki S, Shigeta S, Matsuoka R, Kato T, Niisato Y, Seo E, Matsubara D, Tsuchiya K:Simultaneous occurrence of autoimmune hepatitis and autoimmune hemolytic anemia after COVID-19 infection: case report and literature review.
Clin J Gastroenterol.2024 Apr 23.doi: 10.1007/s12328-024-01972-5. Online ahead of print.
https://link.springer.com/article/10.1007/s12328-024-01972-5
12. Hayashi Y, Hatta W, Tsuji Y, Yoshio T, Yabuuchi Y, Hoteya S, Tsuji S, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Kurakami H, Fujishiro M, Masamune A, Takehara T.
Endoscopic features of synchronous multiple early gastric cancers: Findings from a nationwide cohort
Digestion. 2024 May 2. doi: 10.1159/000538941. Online ahead of print.
https://karger.com/dig/article-abstract/doi/10.1159/000538941/906837/Endoscopic-features-of-synchronous-multiple-early?redirectedFrom=fulltext
13. Tominaga N, Sadashima E, Aoki T, Fujita M, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Miki K, Watanabe K, Kaise M, Nagata N.
A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study.
Sci Rep. 2024 Mar 4;14(1):5367. doi: 10.1038/s41598-024-55889-7.
https://www.nature.com/articles/s41598-024-55889-7
14. Maki Ohkubo, Emiko Seo, Kosuke Doki, Yoshiharu Suzuki, Ikuo Sekine,d and Masato Homma.Impact of Hepatitis B Surface and Core Antibody Levels on Hepatitis B Virus Reactivation.Biol. Pharm. Bull. 47, 941–945 (2024). DOI: https://doi.org/10.1248/bpb.b23-00907
https://doi.org/10.1248/bpb.b23-00907
15. Seyama Y, Sudo K, Yamada T, Tsuchiya K, Nakamura Y.Ascorbic acid predominantly kills cancer stem cell-like cells in the hepatocellular carcinoma cell line Li-7 and is more effective at low cell density and in small spheroids.
Biochem Biophys Res Commun. 2024 May 21;709:149816. doi: 10.1016/j.bbrc.2024.149816. Epub 2024 Mar 22.
https://www.sciencedirect.com/science/article/pii/S0006291X24003528
16. Extensive Disease and Exposure to Multiple Biologics Precolectomy Is Associated with Endoscopic Cuffitis Post-Ileal Pouch-Anal Anastomosis in Patients With Ulcerative Colitis． Posner Hannah, Lombard Rachel, Akiyama Shintaro, Cohen Nathaniel A, Rubin David T,
Dubinsky Marla C, Dalal Sushila, Kayal Maia
Inflammatory bowel diseases
https://doi.org/10.1093/ibd/izae029
17. Endoscopic assessment of the J pouch in ulcerative colitis: A narrative review．
Akiyama Shintaro, Barnes Edward L, Onoda Tsubasa, Ishikawa Naoki, Shiroyama Mamiko, Ito Yuka, Rubin David T, Tsuchiya Kiichiro．
DEN open/5(1)/p.e373,
https://onlinelibrary.wiley.com/doi/10.1002/deo2.373
18. Feasibility and safety of a novel plastic stent designed specifically for endoscopic ultrasound-guided pancreatic duct drainage.
Fukuda S, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Agarie D, Hagiwara Y, Hara H, Okamoto K, Yamashige D, Yagi S, Kuwada M, Chatto M, Kondo S, Morizane C, Ueno H, Saito Y, Okusaka T. Endosc Int Open. 2024 Jun 4;12(6):E715-E722. doi: 10.1055/a-2294-8517.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150017/
19. Efficacy of endoscopic ultrasound-guided gastroenterostomy using self-expandable metallic stent for afferent loop syndrome: A single-center retrospective study. Hagiwara Y, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Kawasaki Y, Takeshita K, Takasaki T, Agarie D, Hara H, Yagi S, Fukuda S, Kuwada M, Yamashige D, Okamoto K, Chatto M, Kondo S,Morizane C, Ueno H, Endo M, Sugawara S, Sone S, Saito Y, Tsuchiya K, Okusaka T. J Gastroenterol Hepatol. 2024 Jun 7. doi: 10.1111/jgh.16649.
Fukuda S, Hijioka S, Nagashio Y, Maruki Y, Ohba A, Agarie D, Hagiwara Y, Hara H, Okamoto K, Yamashige D, Yagi S, Kuwada M, Chatto M, Kondo S, Morizane C, Ueno H, Saito Y, Okusaka T.
Endosc Int Open. 2024 Jun 4;12(6):E715-E722. doi: 10.1055/a-2294-8517.
https://onlinelibrary.wiley.com/doi/10.1111/jgh.16649
20. Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease.
Shintaro Akiyama, Jacob E Ollech, Nathaniel A Cohen, Cindy Traboulsi, Victoria Rai, Laura R Glick, Yangtian Yi, Joseph Runde, Russell D Cohen, Kinga B Skowron Olortegui, Roger D Hurst, Konstantin Umanskiy, Benjamin D Shogan, Neil H Hyman, Michele A Rubin, Sushila R Dalal, Atsushi Sakuraba, Joel Pekow, Eugene B Chang, David T Rubin.
Inflammatory Bowel Diseases,
https://doi.org/10.1093/ibd/izae106
21. A Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J pouch in Patients with Inflammatory Bowel Disease.
Shintaro Akiyama, Nathaniel A Cohen, Jacob E. Ollech, Cindy Traboulsi, Tina Rodriguez, Victoria Rai, Laura R.
Glick, Yangtian Yi, Joseph Runde, Russell D. Cohen, Kinga B.Skowron, Roger D. Hurst, Konstantin Umanskiy, Benjamin D. Shogan, Neil H. Hyman, Michele A. Rubin, Sushila R. Dalal, Atsushi Sakuraba, Joel Pekow, Eugene B. Chang, and David T. Rubin.
Crohns & Colitis 360 , otae045
https://academic.oup.com/crohnscolitis360/article/6/3/otae045/7726349
22. Patients with Ulcerative Colitis who have Normalized Histology are Clinically Stable After De-escalation of Therapy.
Shintaro Akiyama, Joëlle St-Pierre, Cindy Traboulsi, Alexa Silfen, Victoria Rai, Tina G. Rodriguez, Amarachi I. Erondu, Joshua M. Steinberg, Seth R. Shaffer,
Britt Christensen, David T. Rubin. npj Gut Liver 1, 5 (2024).
https://www.nature.com/articles/s44355-024-00005-9
23. Sunakawa Y, Kuboki Y, Watanabe J, Terazawa T, Kawakami H, Yokota M, Nakamura M, Kotaka M, Sugimoto N, Ojima H, Oki E, Kajiwara T, Yamamoto Y, Tsuji Y, Denda T, Tamura T, Ishihara S, Taniguchi H, Nakajima TE, Morita S, Shirao K, Takenaka N, Ozawa D, Yoshino T. Exploratory Biomarker Analysis Using Plasma Angiogenesis-Related Factors and Cell-Free DNA in the TRUSTY Study: A Randomized, Phase II/III Study of Trifluridine/Tipiracil Plus Bevacizumab as Second-Line Treatment for Metastatic Colorectal Cancer. Target Oncol. 2024 Jan;19(1):59-69.
https://link.springer.com/article/10.1007/s11523-023-01027-8
24. Matsumoto T, Yamamoto Y, Kotaka M, Masuishi T, Tsuji Y, Shoji H, Hirata K, Tsuduki T, Makiyama A, Izawa N, Takahashi N, Tsuda M, Yasui H, Ohta T, Kito Y, Otsu S, Hironaka S, Yamazaki K, Boku N, Hyodo I, Yoshimura K, Muro K. A Phase II Study of FOLFIRI Plus Ziv-Aflibercept After Trifluridine/Tipiracil Plus Bevacizumab in Patients with Metastatic Colorectal Cancer: WJOG 11018G. Target Oncol. 2024 Mar;19(2):181-190.
https://link.springer.com/article/10.1007/s11523-024-01043-2
25. Yamamoto Y, Yukami H, Yamaguchi T, Ohori H, Nagasu S, Kagawa Y, Sugimoto N, Sonoda H, Yamazaki K, Takashima A, Okuyama H, Hasegawa H, Kondo C, Baba E, Matsumoto T, Kawamoto Y, Kataoka M, Shindo Y, Ishikawa T, Esaki T, Kito Y, Sato T, Funakoshi T, Yamaguchi T, Shimada Y, Moriwaki T. Real-world outcomes of FOLFOXIRI plus bevacizumab in patients with metastatic colorectal cancer: the JSCCR-TRIPON study. Int J Clin Oncol. 2024 Aug 28. Online ahead of print.
https://link.springer.com/article/10.1007/s10147-024-02613-0
26. Sudo K, Nakamura Y, Ueno M, Furukawa M, Mizuno N, Kawamoto Y, Okano N, Umemoto K, Asagi A, Ozaka M, Ohtsubo K, Shimizu S, Matsuhashi N, Itoh S, Matsumoto T, Satoh T, Okuyama H, Goto M, Hasegawa H, Yamamoto Y, Odegaard JI, Bando H, Yoshino T, Ikeda M, Morizane C. Clinical utility of BRCA and ATM mutation status in circulating tumour DNA for treatment selection in advanced pancreatic cancer. Br J Cancer. 2024 Oct;131(7):1237-1245.
https://www.nature.com/articles/s41416-024-02834-0
27. Hamano J, Higashibata T, Kessoku T, Kajiura S, Hirakawa M, Oyamada S, Ariyoshi K, Yamada T, Yamamoto Y, Takashima Y, Doki K, Homma M, Mathis BJ, Jono T, Ogata T, Tanaka K, Kasai Y, Iwaki M, Fuyuki A, Nakajima A, Hayashi R, Ando T, Izawa N, Kobayashi Y, Horie Y, Morita T. Naldemedine for Opioid-Induced Constipation in Patients With Cancer: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial. J Clin Oncol. 2024 Sep 10:JCO2400381.
https://ascopubs.org/doi/10.1200/JCO.24.00381?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
28. Mizuno E, Oh S, Miura I, Sato T, Sakurai F, Yanagawa N, Mori Y, Okada K, Shoda J, Isobe T. Effects of Hydrogen Water Intake on Lipid Regulation in Mice. International Congress on Obesity and Metabolic Syndrome, Seoul. poster presentation.
https://www.icomes.or.kr/
29. Bando H, Kotani D, Satake H, Hamaguchi T, Shiozawa M, Kotaka M, Masuishi T, Yasui H, Kagawa Y, Komatsu Y, Oki E, Yamamoto Y, Kawakami H, Misumi T, Taniguchi H, Yamazaki K, Muro K, Yoshino T, Kato T, Tsuji A. QUATTRO-II randomized trial: CAPOXIRI+bevacizumab vs. FOLFOXIRI+bevacizumab as first-line treatment in patients with mCRC. Med. 2024 Sep 13;5(9):1164-1177.e3.
https://www.sciencedirect.com/science/article/pii/S2666634024002162?via%3Dihub
30. Takashima A, Ishiguro M, Sasaki K, Machida R, Nagashima F, Imaizumi J, Hamaguchi T, Yamamoto Y, Masuishi T, Asayama M, Ueno H, Shinozaki K, Kudo T, Machida N, Matsuoka H, Ishida H, Yamaguchi T, Nogami H, Yamada T, Takegawa N, Kito Y, Tonoike Y, Sawada R, Tsukamoto S, Kanemitsu Y. Real-world treatment costs of first-line treatment for metastatic colorectal cancer: a survey of the JCOG colorectal cancer study group. Jpn J Clin Oncol. 2024 Oct 3;54(10):1107-1114.
https://academic.oup.com/jjco/article/54/10/1107/7745392?login=true
31. S. Akiyama, H. Shimizu, A. Tamura, K. Yokoyama, T. Sakurai, M. Kobayashi, M. Eizuka, S. Yanai, K. Nomura, T. Shibuya, M. Takahara, S. Hiraoka, M. Sako, A. Yoshida, K. Tsuruta, S. Yoshioka, M. Koroku, T. Omori, M. Saruta, T. Matsumoto, R. Okamoto, K. Tsuchiya, T. Fujii. Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan. Alimentary Pharmacology & Therapeutics. 2024 in press.
32. S. Akiyama, S. Nishijima, Y. Kojima, M. Kimura, M. Ohsugi, K. Ueki, M. Mizokami, M. Hattori, K. Tsuchiya, N. Uemura, T. Kawai, P. Bork, N. Nagata.
Multi-biome analysis identifies distinct gut microbial signatures and their crosstalk in ulcerative colitis and Crohn’s disease. Nature Communications Vol 15, 10291, 2024.
https://www.nature.com/articles/s41467-024-54797-8
33. Visualization of Stress Fiber Formation Induced by Photodynamic Therapy with Porphylipoprotein: Taninaka A, Kurokawa H, Kamiyanagi M, Takeuchi O, Matsui H and Shigekawa H：
Nanomaterials 2024, 14(23), 1862; https://doi.org/10.3390/nano14231862
https://www.mdpi.com/2079-4991/14/23/1862
34. Okabe M, Yamamoto S, Shiokawa M, Hisamatsu T, Yamazaki H, Nakanishi R, Hamada K, Kitamoto H, Kuwada T, Uza N, Sakatani A, Fujii T, Ohno M, Matsuura M, Shibuya T, Ohmiya N, Ooi M, Hoshi N, Moriya K, Tsuchiya K, Yamaguchi Y, Kunisaki R, Takahara M, Takagi T, Takehara T, Hirai F, Kakimoto K, Esaki M, Nakase H, Kinjo F, Torisu T, Kanmura S, Narimatsu K, Matsuoka K, Hiraga H, Yokoyama K, Honzawa Y, Naganuma M, Saruta M, Kodama Y, Chiba T, Seno H. Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study. J Gastroenterol. 2024 Nov 28.
doi: 10.1007/s00535-024-02176-x.Epub ahead of print. PMID: 39607498.
https://link.springer.com/article/10.1007/s00535-024-02176-x
35. Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study.
Suzuki S, Tominaga N, Aoki T, Sadashima E, Miike T, Kawakami H, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Kaise M, Nagata N.
Sci Rep. 2024 Jun 17;14(1):13983. doi: 10.1038/s41598-024-64476-9.
https://pmc.ncbi.nlm.nih.gov/articles/pmid/38886410/
36. Validation of British Society of Gastroenterology guidelines for acute lower gastrointestinal bleeding from 8,956 cases in Japan.
Kinjo K, Aoki T, Kobayashi K, Yamauchi A, Yamada A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Ishii N, Sawada T, Murata M, Takao A, Mizukami K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Narimatsu K, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Watanabe K, Hisabe T, Yao K, Kaise M, Nagata N.
Gastrointest Endosc. 2024 Nov 16:S0016-5107(24)03730-1. doi: 10.1016/j.gie.2024.11.020. Online ahead of print.
https://www.sciencedirect.com/science/article/pii/S0016510724037301?via%3Dihub
37. Impact of long-term trends on outcomes in the management of colonic diverticular bleeding: mediation analyses in a large multicenter study.
Narimatsu K, Ishii N, Yamada A, Aoki T, Kobayashi K, Yamauchi A, Omori J, Ikeya T, Aoyama T, Tominaga N, Sato Y, Kishino T, Sawada T, Murata M, Takao A, Mizukami K, Kinjo K, Fujimori S, Uotani T, Fujita M, Sato H, Suzuki S, Narasaka T, Hayasaka J, Funabiki T, Kinjo Y, Mizuki A, Kiyotoki S, Mikami T, Gushima R, Fujii H, Fuyuno Y, Hikichi T, Toya Y, Manabe N, Nagaike K, Kinjo T, Sumida Y, Funakoshi S, Kobayashi K, Matsuhashi T, Komaki Y, Hokari R, Kaise M, Nagata N.
J Gastroenterol. 2024 Dec 27. doi: 10.1007/s00535-024-02178-9. Online ahead of print.
https://link.springer.com/article/10.1007/s00535-024-02178-9
