研究業績
令和7年度（2025年度）
医学医療系業績
1. Sato T, To K, Sakurai F, Chihara K, Warabi E, Isobe T, Suzuki H, Shoda J, Okada K. Intestinal epithelial cell-specific restoration of Nrf2 gene in whole-body-knockout mice ameliorates acute colitis. Exp Anim. 2025, in press.
Intestinal epithelial cell-specific restoration of Nrf2 gene in whole-body-knockout mice ameliorates acute colitis - PubMed
2. Naganuma M, Shiga H, Shimoda M, Matsuura M, Takenaka K, Fujii T, Yamamoto S, Matsubayashi M, Kobayashi T, Aoyama N, Saito D, Yokoyama K, Moriya K, Tsuchiya K, Shibui S, Kawamoto A, Shimizu H, Okamoto R, Sakamoto K, Yaguchi K, Kunisaki R, Akiyama S, Hayashi R, Hasui K, Kanmura S, Bamba S, Mishima Y, Kakimoto K, Sugimoto S, Nakazawa A, Abe T, Ogata H, Hisamatsu T. First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study. J Gastroenterol. 2025 Jan 30.
First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study | Journal of Gastroenterology
3. Shintaro Akiyama, Ryohei Hayashi, Takeshi Takasago, Kurando Kusunoki, Hiroki Ikeuchi, Kento Takenaka, Kazuhiro Watanabe, Kazutaka Koganei, Nobuhiro Ueno, Mikihiro Fujiya, Naoki Hosoe, Fumikazu Koyama, Yasuhisa Sakata, Motohiro Esaki, Ken Takeuchi, Makoto Naganuma, Kiichiro Tsuchiya. Prevalence and Predictability of the Chicago Classification of Pouchitis in Ulcerative Colitis: A Multicenter Study in Japan,
Journal of Gastroenterology 2025
Prevalence and predictability of the Chicago Classification of Pouchitis in ulcerative colitis: a multicenter study in Japan | Journal of Gastroenterology
4. Toyoshima N, Mizuguchi Y, Takamaru H, Nakamura K, Kakugawa Y, Sakamoto T, Shiroyama M, Kawagoe R, Tsuchiya K, Shinmura K, Ikematsu H, Inaba A, Minakata N, Hotta K, Imai K, Takada K, Ito S, Misawa M, Wakamura K, Kudo SE, Tamai N, Sumiyama K, Ito M, Uraoka T, Tomaru S, Matsuda T, Fujimoto A, Shibata T, Saito Y：The Efficacy of Texture and Color Enhancement Imaging Observation in the Detection of Colorectal Lesions: A Multicenter, Randomized Controlled Trial (deTXIon Study).
Gastroenterology. 2025 Mar 18:S0016-5085(25)00524-4.doi: 10.1053/j.gastro.2025.03.007. Epub ahead of print. PMID: 40113100.
https://www.sciencedirect.com/science/article/pii/S0016508525005244
5. Shiraishi K, Okada M, Yamamoto S, Matsubara Y, Masuishi T, Shimozaki K, Yamamoto Y, Hirose S, Sugiyama K, Furuta M, Machida N, Takahashi N, Yoshii T, Kito Y, Tsuzuki T, Boku S, Tsuchihashi K, Sugaya A, Takayama T, Komori A, Mitani S, Matsumoto T, Nishimura T, Hirata K. The efficacy and safety of FOLFOX therapy for advanced esophageal squamous cell carcinoma. Sci Rep. 2025 Mar 7;15(1):8031.
https://www.nature.com/articles/s41598-025-92657-7
6. Wakabayashi M, Masuishi T, Ogata T, Hanamura F, Furuta M, Yamamoto Y, Kawakami K, Hirano H, Kito Y, Izawa N, Takahashi N, Matsumoto T, Kawakami H, Ando T, Minashi K, Kudo C, Yoshimura K, Muro K. A multicenter Phase II study of mFOLFOX6 plus nivolumab for gastric cancer with severe peritoneal metastases: WJOG16322G. Future Oncol. 2025 Jun 6:1-7. doi: 10.1080/14796694.2025.2514935. Online ahead of print.
https://www.tandfonline.com/doi/full/10.1080/14796694.2025.2514935?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
7. Sato M, Yamamoto Y, Moriwaki T, Fukuda K, Tsuchiya K. Combination of AURKA inhibitor and MEK inhibitor strongly enhances G1 arrest and induces synergistic antitumor effect on KRAS or BRAF mutant colon cancer cells. Biochem Biophys Rep. 2025 Sep; 43 Online ahead of print.
https://www.sciencedirect.com/science/article/pii/S2405580825001608
8. Nemoto Y, Morikawa R, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nakamura T, Takenaka K, Ohtsuka K, Chen X, Okazawa H, Okamoto R, Watanabe M, von Andrian UH.
“Intestinal CD4- CD8αβ-TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice.”
Nat Commun. 16:7072, 2025.
https://www.nature.com/articles/s41467-025-62089-y
9. Akiyama S, Shimizu H, Tamura A, Yokoyama K, Sakurai T, Kobayashi M, Eizuka M, Yanai S, Nomura K, Shibuya T, Takahara M, Hiraoka S, Sako M, Yoshida A, Tsuruta K, Yoshioka S, Koroku M, Omori T, Saruta M, Matsumoto T, Okamoto R, Tsuchiya K, Fujii T. Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis. Inflammatory intestinal diseases/10(1)/pp.180-186, 2025-04-01
https://pubmed.ncbi.nlm.nih.gov/40667521/
10. Olivas A D, Ngai P C M, Schahrer E, Xing J, Ghadiri M, Olortegui K S, Cursio J F, Akiyama S, Chang E B, et al. Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology, 2025-06-24
https://pubmed.ncbi.nlm.nih.gov/40571096/
11. Akiyama S, Ito Y, Shiroyama M, Suzuki S, Ochi M, Kamoshida T, Kashimura H, Iwamoto J, Saito R, Kaneko T, Ikezawa K, Hiroshima Y, Hattori J, Mamiya T, Fukuda S, Ikeda K, Ariga H, Kashimura J, Nishi M, Nagase M, Tsuchiya K. Increasing age at diagnosis raises malignancy risk and aminosalicylate intolerance influences therapeutic strategies in ulcerative colitis: a multicenter I‑BRITE cohort study. Journal of gastroenterology, 2025-07-08
https://pubmed.ncbi.nlm.nih.gov/40627077/
12. ○Shintaro A, Yuka I, Mamiko S, et al . Prevalence and Clinical Outcomes in Ulcerative Colitis Patients with Aminosalicylate Intolerance: A Multicenter Retrospective I-BRITE Study.
The 13th Annual Meeting of Asian Organization for Crohn's & Colitis/2025-07-11
13. ○Shintaro Akiyama, Sang Hyoung P, et al. Prevalence and Clinical Characteristics of Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: An International Multicenter Study Across Asia.
The 13th Annual Meeting of Asian Organization for Crohn's & Colitis/2025-07-12
14. Akiyama S, Fujii T. Letter: Efficacy Versus Effectiveness-An Important Nuance Among Real-World Studies: Authors' Reply. Alimentary pharmacology & therapeutics, 2025-07-31
https://pubmed.ncbi.nlm.nih.gov/40742117/
15. Kaneko T, Doki K, Yamada T, Uda M, Yamamoto Y, Kobayashi M, Tsuchiya K, Homma M. Association of concomitant proton pump inhibitor use with worse survival outcomes in patients with advanced gastric cancer receiving ramucirumab. Br J Clin Pharmacol. 2025 Aug 13. doi: 10.1002/bcp.70202.
https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/bcp.70202
16. Guo X, Suzuki H, Sawafuji T, Fukuda S, Yamada T, Kobayashi M, Suzuki H, Akiyama S, Mathis BJ, Kawai H, Matsubara D, Tsuchiya K. A Clinical Trial to Evaluate the Safety and Efficacy of Centella asiatica for Ulcerative Colitis. JGH Open. 2025 Aug 18;9(8):e70258. doi: 10.1002/jgh3.70258.
https://onlinelibrary.wiley.com/doi/10.1002/jgh3.70258
