12 July 2018

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators

Cell Reports DOI: 10.1016/j.kint.2018.02.025
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