11 Aug 2020

Establishment of technology for inducing functional hematopoietic stem cells in vitro from mouse iPS cells

Key Points
• Continuous activation of HoxB4 protein induces FLK−CD31+CD45+ cells from iPSCs.
• HoxB4 activity is required for generating long-term bone marrow engraftment from iPSC-derived HSCs.
• The intranuclear localization of HoxB4 protein in HSC-precursors controls differentiation arrest through enhanced expression of genes governing hematopoietic development.

→ Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming
Experimental Hematology - DOI:https://doi.org/10.1016/j.exphem.2020.08.003 (英語 English)