27 Aug 2020

Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures

• Hydrogel culture reveals the role of mechanotransduction in cardiac reprogramming.
• ECM comparable with native myocardium promotes cardiac reprogramming.
• Soft ECM promotes cardiac reprogramming via YAP/TAZ/fibroblast signaling inhibition.
• Soft ECM promotes Sendai virus vector-mediated cardiac reprogramming.

Stem Cell Reports (2020) (https://doi.org/10.1016/j.stemcr.2020.07.022)