Generation of a p16ʰⁱᵍʰ Reporter Mouse and Its Use to Characterize and Target p16ʰⁱᵍʰ Cells In Vivo
(Available online Sept 18th, 2020)
• p16high cells are detectable in all tissues, are enriched with age, and do not proliferate.
• p16high cells exhibit heterogenous senescence-associated phenotypes.
• Elimination of p16high cells ameliorates steatosis and inflammation in a NASH model.