18 Sep 2020

Generation of a p16ʰⁱᵍʰ Reporter Mouse and Its Use to Characterize and Target p16ʰⁱᵍʰ Cells In Vivo

(Available online Sept 18th, 2020)

Key Points
• Creation of a p16-CreERT2-tdTomato mouse model to analyze p16high cells in vivo.
• p16high cells are detectable in all tissues, are enriched with age, and do not proliferate.
• p16high cells exhibit heterogenous senescence-associated phenotypes.
• Elimination of p16high cells ameliorates steatosis and inflammation in a NASH model.

Cell Metabolism - https://doi.org/10.1016/j.cmet.2020.09.006