24 Nov 2020

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Key Point

• Transcriptome and methylome analyses revealed that the young niche largely restored the transcriptional profile of aged HSCs, but not their DNA methylation profiles. Therefore, the restoration of the young niche is insufficient for rejuvenating HSC functions, highlighting a key role for age-associated cell-intrinsic defects in HSC aging.

Journal of Experimental Medicine - https://doi.org/10.1084/jem.20192283