Mast4 determines the cell fate of MSCs for bone and cartilage development.
Microtubule Associated Serine/Threonine Kinase Family Member 4 (Mast4) serves as an important mediator of TGF-β and Wnt signal transduction in regulating chondro-osteogenic differentiation of MSCs. Findings uncover essential roles of Mast4 in determining the fate of MSC development into cartilage or bone.
