News and Publications


New Publication

Published:
20 Aug 2020

Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice

Key Points
• ERβ controls muscle growth in young female mice.
• ERβ is essential for muscle regeneration in female mice.
• Inactivation of ERβ causes an increase in apoptosis.
• ERβ is required for satellite cell population expansion




Stem Cell Reports, (2020) (https://doi.org/10.1016/j.stemcr.2020.07.017)

New Publication

Published:
11 Aug 2020

Establishment of technology for inducing functional hematopoietic stem cells in vitro from mouse iPS cells

Key Points
• Continuous activation of HoxB4 protein induces FLK−CD31+CD45+ cells from iPSCs.
• HoxB4 activity is required for generating long-term bone marrow engraftment from iPSC-derived HSCs.
• The intranuclear localization of HoxB4 protein in HSC-precursors controls differentiation arrest through enhanced expression of genes governing hematopoietic development.

Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming
Experimental Hematology - DOI:https://doi.org/10.1016/j.exphem.2020.08.003 (英語 English)

New Publication

Published:
2 Jul 2020

Signal dynamics of midbrain dopamine neurons during economic decision-making in monkeys

Key Points:

  1. 1. Discovery of previously unknown mechanism in which dopamine neurons support rational decision making.
  2. 2. Activity dynamics of dopamine neurons translates "value information" of an option into a "selection command" of whether or not to select an option.
  3. 3. This conversion process was completed faster in dopamine neurons than in the frontal lobe, which was previously thought to be the center of decision making. This indicates that evolutionarily conserved midbrain dopamine neurons are an important neural base supporting rational decision making.

Science Advances (DOI:10.1126/sciadv.aba4962)

Science Advances PDF (DOI:10.1126/sciadv.aba4962)

New Publication

Published:
5 Jun 2020

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

• Mutant ASXL1 and HHEX promote myeloid leukemogenesis via upregulating the expression of MYB and ETV5.
• Inhibition of the HHEX-MYB/ETV5 axis would be a promising therapeutic approach for myeloid malignancies harboring ASXL1 mutations.

→ Journal - Blood 2019 :blood.2019004613

New Publication

Published:
15-04-2020

Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Main Points

• Elucidation of the mechanism that suppresses the development of chronic kidney disease.

• Existing leukemia drug can suppress worsening renal damage.

Kidney International (DOI: 10.1016/j.kint.2020.02.038)

Press Release UoT Webpage (in Japanese only)

PDF Press Release Download (in Japanese only)

New Publication

Published:
17-10-2019

Discovery of lipids that control insulin sensitivity in the liver.

Researchers at TMRC and the University of Tsukuba piece together a complex cascade of events in the liver that could someday help to develop targeted therapies for insulin resistance. Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice).

Hepatology doi:10.1002/hep.30953

Press Release Publication at UoT