Invitation for Joint Research in Production of Genetically Modified Mice
The Transborder Medical Research Center (TMRC) and the Life Science Animal Resource Center is calling for suitable parties who are interested in research collaborations for the production of genetically modified mice. Interested parties may refer to the “Transborder Medical Research Center (TMRC) Joint Research Application Guidelines” linked below and contact Professor Satoru Takahashi for more details.
• Metagenomic and metabolomic markers to discriminate cases of intramucosal carcinoma from healthy controls were identified.
• Data indicates shifts in the microbiome and metabolome from early stages of the development of colorectal cancer.
→ Nature Medicine DOI https://doi.org/10.1038/s41591-019-0458-7
The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation
→ Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468
KOnezumi: a web application for automating gene disruption strategies to generate knockout mice
A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.
→ Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
[Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche]
• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis
Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013
Award Presented at 2018 ISS Conference, San Fransisco, USA, for “Compelling Results in Biology and Medicine：Transcriptome analysis of gravitational effects on muscles of mice”, from mouse research and breeding experiments conducted aboard the International Space Station (ISS)
More details –> (Link information in Japanese only)
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators
→ Cell Reports DOI: 10.1016/j.kint.2018.02.025
(External Link - English)