Main Points
• Existing leukemia drug can suppress worsening renal damage.
Pre-publication Release
(TMRC research collaboration with Tokyo University of Science)
Press release overview:
• Kibo Mouse Rearing System
• Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
• Future JAXA-NASA joint mission
Discovery of lipids that control insulin sensitivity in the liver.
Researchers at TMRC and the University of Tsukuba piece together a complex cascade of events in the liver that could someday help to develop targeted therapies for insulin resistance. Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice).
Invitation for Joint Research in Production of Genetically Modified Mice
The Transborder Medical Research Center (TMRC) and the Life Science Animal Resource Center is calling for suitable parties who are interested in research collaborations for the production of genetically modified mice. Interested parties may refer to the “Transborder Medical Research Center (TMRC) Joint Research Application Guidelines” linked below and contact Professor Satoru Takahashi for more details.
• Metagenomic and metabolomic markers to discriminate cases of intramucosal carcinoma from healthy controls were identified.
• Data indicates shifts in the microbiome and metabolome from early stages of the development of colorectal cancer.
→ Nature Medicine DOI https://doi.org/10.1038/s41591-019-0458-7
The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation
→ Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468
KOnezumi: a web application for automating gene disruption strategies to generate knockout mice
A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.
→ Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
[Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche]
• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis
Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013
