News and Publications

New Publication


Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Main Points

• Elucidation of the mechanism that suppresses the development of chronic kidney disease.

• Existing leukemia drug can suppress worsening renal damage.

Kidney International (DOI: 10.1016/j.kint.2020.02.038)

Press Release UoT Webpage (in Japanese only)

PDF Press Release Download (in Japanese only)

New Publication


Discovery of lipids that control insulin sensitivity in the liver.

Researchers at TMRC and the University of Tsukuba piece together a complex cascade of events in the liver that could someday help to develop targeted therapies for insulin resistance. Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice).

Hepatology doi:10.1002/hep.30953

Press Release Publication at UoT


Sep 3, 2019

Invitation for Joint Research in Production of Genetically Modified Mice

The Transborder Medical Research Center (TMRC) and the Life Science Animal Resource Center is calling for suitable parties who are interested in research collaborations for the production of genetically modified mice. Interested parties may refer to the “Transborder Medical Research Center (TMRC) Joint Research Application Guidelines” linked below and contact Professor Satoru Takahashi for more details.

Click for Details (PDF written in Japanese only)


Mar 26, 2019

The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation

Blood 2019 :blood.2019000468; doi:


6 Feb 2019

KOnezumi: a web application for automating gene disruption strategies to generate knockout mice

A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.

Bioinformatics, btz090,


3 Jan 2019

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

[Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche]

• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis

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Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013